RESUMO
During spatial navigation, some typical parameters of learning have been observed, such as latency or path length. However, these parameters are sensitive to patterns of navigation and orientation that are not easily measurable. In the present study, we used a modified version of the Oasis maze and evaluated different parameters of learning, navigation, and orientation in different animal groups. Through a PCA (Principal component analysis) we found different factors such as learning, navigation, speediness, anxiety, orientation, path variability, and turning behavior. Each factor gathers different groups of behavioral variables. ANOVA analysis of those factors demonstrates that some of them are more strongly modulated by trial progression, while others by animal group differences, indicating that each group of variables is better reflecting one of these dimensions. To understand the nature of these navigation differences, we studied orientation strategies between animal conditions and across trials. We found that the main navigational strategy used by the animals consist of locating the target and directing their behaviors towards this area. When testing how this strategy changed after cognitive impairment or enhancement, we found that AßOs treated animals (Amyloid ß Oligomers, Alzheimer animal model) have strong orientation difficulties at locating the target at longer distances. While animals with learning enhancement (exercised rat) do not show changes in orientation behaviors. These analyses highlight that experimental manipulations affect learning, but also induced changes in the navigational strategies. We concluded that both dimensions can explain the differences observed in typical learning variables, such as latency or path length, motivating the development of new tools that asses this two-dimension as a separate but, interacting phenomenon.
Assuntos
Peptídeos beta-Amiloides/farmacologia , Aprendizagem em Labirinto/fisiologia , Orientação Espacial/fisiologia , Fragmentos de Peptídeos/farmacologia , Navegação Espacial/fisiologia , Animais , Comportamento Animal/efeitos dos fármacos , Comportamento Animal/fisiologia , Região CA3 Hipocampal , Modelos Animais de Doenças , Hipocampo , Masculino , Aprendizagem em Labirinto/efeitos dos fármacos , Orientação Espacial/efeitos dos fármacos , Condicionamento Físico Animal , Análise de Componente Principal , Ratos , Aprendizagem Espacial/fisiologia , Navegação Espacial/efeitos dos fármacosRESUMO
The Stroop-matching task is a variation of the Stroop task in which participants have to compare a Stroop stimulus attribute (color or word) to a second stimulus. The Stroop-matching response conflict (SMRC) represents an interference related to the processes involved in selection/execution of manual responses. In the present study, we developed a variation of the Stroop-matching task in which the Stroop stimuli were matched to graspable objects (a cup) with intact or broken handles laterally oriented (Experiment 1) or to colored bars laterally presented (Experiment 2). It allowed testing the presence of the correspondence effect for lateralized handles and bars and its possible influence on SMRC. Two different intervals (100 and 800 ms) were also included to investigate time modulations in behavioral performance (reaction time and accuracy). Fifty-five volunteers participated in the study. In both experiments, significant SMRC was found, but no interaction occurred between SMRC and correspondence effect, supporting that the hypothesis of different and relatively independent psychological mechanisms is at the basis of each effect. Because significant facilitation for ipsilateral motor responses (correspondence effect) occurred for graspable objects but not for lateralized bars, the attentional shift/spatial-coding view was not able to completely explain our data, and therefore, the grasping affordance hypothesis remained as the most plausible explanation. The time course of facilitation observed in the first experiment and by others indicates the importance of further studies to better understand the time dynamic of facilitation/inhibition of motor responses induced by graspable objects.
Assuntos
Atenção/fisiologia , Cognição/fisiologia , Força da Mão/fisiologia , Inibição Psicológica , Orientação Espacial/fisiologia , Desempenho Psicomotor/fisiologia , Tempo de Reação/fisiologia , Adulto , Feminino , Humanos , Itália , Masculino , Teste de Stroop , Adulto JovemRESUMO
Resumo Este estudo propôs a avaliar o nível de atividade física e o estado cognitivo de idosos usuários das Unidades Básicas de saúde (UBS) do Município de Maringá, Paraná. Trata-se de um estudo epidemiológico descritivo, de corte observacional e transversal, realizado com 654 idosos, de ambos os sexos, usuários das UBS. Foi utilizado um questionário sociodemográfico, o Mini exame do estado mental e o International Activity Questionnaire (IPAQ), versão curta. A análise dos dados foi realizada mediante o teste Kolmogorov-Smirnov, Qui quadrado, Kruskal-Wallis e "U" de Mann-Whitney, adotando significância quando p < 0,05. Os idosos não realizam atividades físicas vigorosas e poucas atividades moderadas durante a semana. Porém, apresentaram alto escore na orientação temporal (Md = 5,0), Orientação espacial (Md = 5,0), memória imediata (Md = 3,0), evocação (Md = 3,0) e linguagem (Md = 8,0). Ao comparar o estado mental em função do nível de atividade física dos idosos verificou-se que os Muito ativo/ativo possuem melhor atenção e cálculo (p = 0,036), evocação (p = 0,001) e estado cognitivo geral (p = 0,002), se comparado aos irregularmente ativos e sedentários. Níveis adequados de atividade física podem estar relacionados a melhores escores de funções cognitivas de sujeitos idosos.
Abstract This study proposed to evaluate the level of physical activity and the cognitive state of elderly users of Primary Care Facilities (UBS) of the Municipality of Maringá, State of Paraná, Brazil. This is a descriptive, cross-sectional, epidemiological study with 654 elderly men and women UBS users. A sociodemographic questionnaire, the Mini Mental State Examination (MMSE) and the short version of the International Physical Activity Questionnaire (IPAQ) were employed. Data was analyzed using the Kolmogorov-Smirnov, Chi-square, Kruskal-Wallis and Mann-Whitney "U" tests, with a significance level of p<0.05. However, they evidenced a high score in temporal orientation (Md = 5.0), spatial orientation (Md = 5.0), immediate memory (Md = 3.0), recall (Md = 3.0) and language (Md = 8.0). When comparing the mental state according to the level of physical activity of the elderly, we observed that very active/active individuals had better attention and calculation (p = 0.036), recall (p = 0.001) and general cognitive status (p = 0.002) against irregularly active and sedentary elderly. Adequate levels of physical activity may be related to better scores of cognitive functions of elderly subjects.
Assuntos
Humanos , Masculino , Feminino , Idoso , Idoso de 80 Anos ou mais , Atenção Primária à Saúde , Exercício Físico/psicologia , Cognição/fisiologia , Rememoração Mental/fisiologia , Brasil , Estudos Transversais , Inquéritos e Questionários , Comportamento Sedentário , Orientação Espacial/fisiologia , Testes de Estado Mental e Demência , Memória/fisiologia , Pessoa de Meia-IdadeRESUMO
This study proposed to evaluate the level of physical activity and the cognitive state of elderly users of Primary Care Facilities (UBS) of the Municipality of Maringá, State of Paraná, Brazil. This is a descriptive, cross-sectional, epidemiological study with 654 elderly men and women UBS users. A sociodemographic questionnaire, the Mini Mental State Examination (MMSE) and the short version of the International Physical Activity Questionnaire (IPAQ) were employed. Data was analyzed using the Kolmogorov-Smirnov, Chi-square, Kruskal-Wallis and Mann-Whitney "U" tests, with a significance level of p<0.05. However, they evidenced a high score in temporal orientation (Md = 5.0), spatial orientation (Md = 5.0), immediate memory (Md = 3.0), recall (Md = 3.0) and language (Md = 8.0). When comparing the mental state according to the level of physical activity of the elderly, we observed that very active/active individuals had better attention and calculation (p = 0.036), recall (p = 0.001) and general cognitive status (p = 0.002) against irregularly active and sedentary elderly. Adequate levels of physical activity may be related to better scores of cognitive functions of elderly subjects.
Este estudo propôs a avaliar o nível de atividade física e o estado cognitivo de idosos usuários das Unidades Básicas de saúde (UBS) do Município de Maringá, Paraná. Trata-se de um estudo epidemiológico descritivo, de corte observacional e transversal, realizado com 654 idosos, de ambos os sexos, usuários das UBS. Foi utilizado um questionário sociodemográfico, o Mini exame do estado mental e o International Activity Questionnaire (IPAQ), versão curta. A análise dos dados foi realizada mediante o teste Kolmogorov-Smirnov, Qui quadrado, Kruskal-Wallis e "U" de Mann-Whitney, adotando significância quando p < 0,05. Os idosos não realizam atividades físicas vigorosas e poucas atividades moderadas durante a semana. Porém, apresentaram alto escore na orientação temporal (Md = 5,0), Orientação espacial (Md = 5,0), memória imediata (Md = 3,0), evocação (Md = 3,0) e linguagem (Md = 8,0). Ao comparar o estado mental em função do nível de atividade física dos idosos verificou-se que os Muito ativo/ativo possuem melhor atenção e cálculo (p = 0,036), evocação (p = 0,001) e estado cognitivo geral (p = 0,002), se comparado aos irregularmente ativos e sedentários. Níveis adequados de atividade física podem estar relacionados a melhores escores de funções cognitivas de sujeitos idosos.
Assuntos
Cognição/fisiologia , Exercício Físico/fisiologia , Atenção Primária à Saúde , Idoso , Idoso de 80 Anos ou mais , Brasil , Estudos Transversais , Feminino , Humanos , Masculino , Memória/fisiologia , Rememoração Mental/fisiologia , Testes de Estado Mental e Demência , Pessoa de Meia-Idade , Orientação Espacial/fisiologia , Comportamento Sedentário , Inquéritos e QuestionáriosRESUMO
BACKGROUND: Right-hemisphere lesions (RHL) may impair inference comprehension. However, comparative studies between left-hemisphere lesions (LHL) and RHL are rare, especially regarding reading comprehension. Moreover, further knowledge of the influence of cognition on inferential processing in this task is needed. OBJECTIVES: To compare the performance of patients with RHL and LHL on an inference reading comprehension task. We also aimed to analyze the effects of lesion site and to verify correlations between cognitive functions and performance on the task. METHODS: Seventy-five subjects were equally divided into the groups RHL, LHL, and control group (CG). The Implicit Management Test was used to evaluate inference comprehension. In this test, subjects read short written passages and subsequently answer five types of questions (explicit, logical, distractor, pragmatic, and other), which require different types of inferential reasoning. The cognitive functional domains of attention, memory, executive functions, language, and visuospatial abilities were assessed using the Cognitive Linguistic Quick Test (CLQT). RESULTS: The LHL and RHL groups presented difficulties in inferential comprehension in comparison with the CG. However, the RHL group presented lower scores than the LHL group on logical, pragmatic and other questions. A covariance analysis did not show any effect of lesion site within the hemispheres. Overall, all cognitive domains were correlated with all the types of questions from the inference test (especially logical, pragmatic, and other). Attention and visuospatial abilities affected the scores of both the RHL and LHL groups, and only memory influenced the performance of the RHL group. CONCLUSIONS: Lesions in either hemisphere may cause difficulties in making inferences during reading. However, processing more complex inferences was more difficult for patients with RHL than for those with LHL, which suggests that the right hemisphere plays an important role in tasks with higher comprehension demands. Cognition influences inferential processing during reading in brain-injured subjects.
Assuntos
Lesões Encefálicas/reabilitação , Cérebro/fisiopatologia , Cognição/fisiologia , Compreensão/fisiologia , Lateralidade Funcional , Leitura , Adulto , Idoso , Atenção/fisiologia , Lesões Encefálicas/diagnóstico por imagem , Lesões Encefálicas/fisiopatologia , Estudos de Casos e Controles , Cérebro/diagnóstico por imagem , Função Executiva/fisiologia , Feminino , Humanos , Idioma , Masculino , Memória de Curto Prazo/fisiologia , Pessoa de Meia-Idade , Neuroimagem , Testes Neuropsicológicos , Orientação Espacial/fisiologia , Percepção Visual/fisiologiaRESUMO
Abstract Introduction: Otolith function can be studied by testing the subjective visual vertical, because the tilt of the vertical line beyond the normal range is a sign of vestibular dysfunction. Benign paroxysmal positional vertigo is a disorder of one or more labyrinthine semicircular canals caused by fractions of otoliths derived from the utricular macula. Objective: To compare the subjective visual vertical with the bucket test before and immediately after the particle repositioning maneuver in patients with benign paroxysmal positional vertigo. Methods: We evaluated 20 patients. The estimated position where a fluorescent line within a bucket reached the vertical position was measured before and immediately after the particle repositioning maneuver. Data were tabulated and statistically analyzed. Results: Before repositioning maneuver, 9 patients (45.0%) had absolute values of the subjective visual vertical above the reference standard and 2 (10.0%) after the maneuver; the mean of the absolute values of the vertical deviation was significantly lower after the intervention (p < 0.001). Conclusion: There is a reduction of the deviations of the subjective visual vertical, evaluated by the bucket test, immediately after the particle repositioning maneuver in patients with benign paroxysmal positional vertigo.
Resumo Introdução: A função do otólito pode ser estudada por meio de testes da vertical visual subjetiva, porque a inclinação da linha vertical além da faixa normal é um sinal de disfunção vestibular. A vertigem postural paroxística benigna é um distúrbio de um ou mais canais semicirculares labirínticos causado por frações de otólitos derivados da mácula utricular. Objetivo: Comparar a vertical visual subjetiva com o teste do balde antes e imediatamente após a manobra de reposicionamento de partículas em pacientes com vertigem posicional paroxística benigna. Método: Foram avaliados 20 pacientes. A posição estimada, onde uma linha de fluorescência dentro de um balde atingia a posição vertical, foi medida antes e imediatamente após a manobra de reposicionamento de partículas. Os dados foram tabulados e analisados estatisticamente. Resultados: Antes da manobra de reposicionamento, nove pacientes (45%) apresentaram valores absolutos de vertical visual subjetiva acima da referência padrão e dois (10%) depois da manobra; a média dos valores absolutos do desvio vertical foi significativamente mais baixa depois da intervenção (p < 0,001). Conclusão: Há uma redução dos desvios da vertical visual subjetiva, avaliada pelo teste do balde, imediatamente após a manobra de reposicionamento de partículas em pacientes com vertigem posicional paroxística benigna.
Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Testes de Função Vestibular/métodos , Percepção Visual/fisiologia , Posicionamento do Paciente/métodos , Vertigem Posicional Paroxística Benigna/fisiopatologia , Vertigem Posicional Paroxística Benigna/terapia , Postura/fisiologia , Padrões de Referência , Valores de Referência , Membrana dos Otólitos/fisiopatologia , Canais Semicirculares/fisiopatologia , Resultado do Tratamento , Estatísticas não Paramétricas , Orientação Espacial/fisiologiaRESUMO
INTRODUCTION: Otolith function can be studied by testing the subjective visual vertical, because the tilt of the vertical line beyond the normal range is a sign of vestibular dysfunction. Benign paroxysmal positional vertigo is a disorder of one or more labyrinthine semicircular canals caused by fractions of otoliths derived from the utricular macula. OBJECTIVE: To compare the subjective visual vertical with the bucket test before and immediately after the particle repositioning maneuver in patients with benign paroxysmal positional vertigo. METHODS: We evaluated 20 patients. The estimated position where a fluorescent line within a bucket reached the vertical position was measured before and immediately after the particle repositioning maneuver. Data were tabulated and statistically analyzed. RESULTS: Before repositioning maneuver, 9 patients (45.0%) had absolute values of the subjective visual vertical above the reference standard and 2 (10.0%) after the maneuver; the mean of the absolute values of the vertical deviation was significantly lower after the intervention (p<0.001). CONCLUSION: There is a reduction of the deviations of the subjective visual vertical, evaluated by the bucket test, immediately after the particle repositioning maneuver in patients with benign paroxysmal positional vertigo.
Assuntos
Vertigem Posicional Paroxística Benigna/fisiopatologia , Vertigem Posicional Paroxística Benigna/terapia , Posicionamento do Paciente/métodos , Testes de Função Vestibular/métodos , Percepção Visual/fisiologia , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Orientação Espacial/fisiologia , Membrana dos Otólitos/fisiopatologia , Postura/fisiologia , Padrões de Referência , Valores de Referência , Canais Semicirculares/fisiopatologia , Estatísticas não Paramétricas , Resultado do TratamentoRESUMO
This paper presents the development of a fusion strategy to integrate and calibrate signals from magnetometers, gyroscopes and accelerometers to implement a magnetic, angular rate and gravity (MARG) sensor system. The aim of such algorithms is to capture signals from the individual sensors and identify, compensate and reduce external and internal errors such as bias, scale factor and drifts, which highly depend on the noise levels. The necessary calibrations to ensure the reliability of captured data are also presented. The orientation data obtained by the proposed algorithm will be compared with a commercial motion capture system, which are currently being used by researchers in biomechanical analysis and in clinical motor rehabilitation studies.