RESUMO
INTRODUCTION: Background and aims: home enteral nutrition (HEN) is an established treatment for clinically stable patients. The objective of this study was to determine the frequency and the situation of patients in HEN, in the capital city in the south of Brazil. Methods: in this retrospective study, we recorded all new cases of HEN in adults in Curitiba, Brazil, from January 2006 to December 2015. Data were collected by a dietitian from medical records of patients attending public health settings. The following data were analyzed: clinical diagnosis, diet prescribed during hospitalization and at discharge, and feeding access types. Kaplan-Meier and Cox regression analyses were used to calculate survival. Results: a total of 1,231 patients were included. There was a 425% increase in the frequency of HEN over the years studied. The mean age was 66.7 years, and 54.4% were men. Neurological diseases were the most prevalent (46.4%), followed by cancer (33.6%). Eight hundred and one patients (65.1%) died during this period. Mean HEN duration was 180 days (95% CI 163.6-193.4), with a significant difference between neurological diseases (median: 180 days) and cancer (median: 210 days) (p < 0.05). Neurological disease was an independent risk factor for mortality in patients on HEN (HR: 1.17; CI: 1.08-1.27). Conclusions: the study shows an increase in HEN. Neurological diseases prevailed and presented a risk of mortality, and more than half of the patients with NED died in this period.
INTRODUCCIÓN: Introducción y objetivos: la nutrición enteral domiciliaria (NED) es un tratamiento establecido para pacientes clínicamente estables. El objetivo de este estudio fue determinar la frecuencia y la situación de los pacientes con NED en la capital del sur de Brasil. Métodos: en este estudio retrospectivo se registraron todos los nuevos casos de NED en adultos en Curitiba, Brasil, de enero de 2006 a diciembre de 2015. Los datos fueron recolectados por un nutricionista de historiales clínicos de pacientes que frecuentan establecimientos de salud pública. Se analizaron los siguientes datos: diagnóstico clínico, dieta prescrita durante la estancia hospitalaria y en el momento del alta y acceso alimenticio. Se utilizaron los análisis de Kaplan-Meier y regresión de Cox para calcular la supervivencia. Resultados: fueron incluidos 1.231 pacientes. Hubo un aumento del 425% en la frecuencia de NED a lo largo de los años estudiados. La edad media fue de 66,7 años y el 54,4% eran hombres. Las enfermedades neurológicas fueron las más prevalentes (46,4%), seguidas de las neoplasias (33,6%). Durante este periodo murieron 801 pacientes (65,1%). La duración media de la NED fue de 180 días (IC 95%, 163,6-193,4), con una diferencia significativa entre enfermedades neurológicas (mediana: 180 días) y cáncer (mediana: 210 días) (p < 0,05). La enfermedad neurológica fue un factor de riesgo independiente para la mortalidad en pacientes en NED (HR: 1,17; IC: 1,08-1,27). Conclusiones: el estudio muestra un aumento en la NED. Las enfermedades neurológicas prevalecieron y presentaron riesgo de mortalidad y más de la mitad de los pacientes murieron durante la NED.
Assuntos
Nutrição Enteral/estatística & dados numéricos , Política Pública , Idoso , Brasil/epidemiologia , Diabetes Mellitus/epidemiologia , Nutrição Enteral/mortalidade , Nutrição Enteral/tendências , Feminino , Humanos , Hipertensão/epidemiologia , Estimativa de Kaplan-Meier , Masculino , Neoplasias/epidemiologia , Neoplasias/mortalidade , Doenças do Sistema Nervoso/epidemiologia , Doenças do Sistema Nervoso/mortalidade , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Fatores de Tempo , Ferimentos e Lesões/epidemiologiaRESUMO
Introduction: Acute pancreatitis (AP) is an inflammatory disease of the pancreas that spans a wide range ranging from mild to critical forms. Contrary to the progress in the management of severe AP, the MAP has not presented significant changes in recent years. There are also no studies that establish a clear relationship between EEN in MAP and levels of albuminemia and CRP. Material and methods: A randomized, longitudinal and prospective clinical study was conducted. Patients were divided into 2 groups. The experimental group (G1) was indicated from the entrance a diet hyperproteic low in colecistokinetics diet, and to the control group (G2) nothing by mouth. Results: 19 patients were randomly distributed in 57.89% in the G2 and 42.11% in the G1. The G1 presented a higher average hospital stay in relation to the G2, such differences were not significant (p> 0.05). The G1 presented higher values of CRP in relation to the G2 significantly (p ?0.05). There was a decrease in albumin levels in both groups (p ?0.05). It was observed in both groups that, as CRP levels increased, albumin levels decreased significantly (p <0.01). Conclusions: Albuminemia levels decreased significantly in both groups, and this decrease was more marked in the EEN group. The decrease in albuminemia had a direct correlation with CRP levels, which were higher in the G1.
Introducción: La pancreatitis aguda (PA) es una enfermedad inflamatoria del páncreas que abarca un amplio abanico que va desde las formas leves a las críticas. A diferencia de los progresos en el manejo de las PA graves, el de las PAL no ha presentado cambios significativos en los últimos años. Tampoco existen trabajos que establezcan una relación clara entre la NET en PAL y los niveles de albuminemia y PCR. MateriaMaterial y método l y método: Se realizó un estudio clínico aleatorizado, longitudinal y prospectivo. Los pacientes fueron divididos en 2 grupos. El experimental (G1) se le indicó desde el ingreso una dieta hiperproteica baja en colecistokineticos, y al grupo control (G2) nada por boca. Resultados: 19 pacientes fueron distribuidos aleatoriamente en un 57,89% en el G2 y el 42,11% en el G1. El G2 presentó un mayor promedio de estadía hospitalaria en relación con el grupo experimental, tales diferencias no fueron significativas (p >0,05). El G1 presentó valores mayores de PCR, en relación con el G2 de manera significativa (p ?0,05). Se registró un descenso de los niveles de albumina en ambos grupos (p ?0,05). Se observó en ambos, que a medida que aumentaron los niveles de PCR, disminuyeron los de albumina de manera significativa (p<0,01). Conclusiones: Los niveles de albuminemia descendieron de manera significativa en ambos grupos, y dicho descenso fue más marcado en el grupo que recibió NET. El descenso de la albuminemia tuvo una correlación directa con los niveles de PCR, los cuales fueron mayores en el G1.
Assuntos
Nutrição Enteral/métodos , Pancreatite/terapia , APACHE , Doença Aguda , Adulto , Idoso , Proteína C-Reativa/análise , Nutrição Enteral/mortalidade , Feminino , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Pancreatite/sangue , Pancreatite/mortalidade , Estudos Prospectivos , Reprodutibilidade dos Testes , Fatores de Risco , Albumina Sérica/análise , Índice de Gravidade de Doença , Estatísticas não Paramétricas , Fatores de Tempo , Resultado do TratamentoRESUMO
OBJECTIVE: To conduct an economic analysis of enteral and parenteral diet costs according to the type of disease and outcome (survivors versus deaths). METHODS: It is a cross-sectional, observational, retrospective study with a qualitative and quantitative design, based on analysis of hospital accounts from a healthcare insurance provider in the Southern region of Brazil. RESULTS: We analyzed 301 hospital accounts of individuals who used enteral and parenteral diets. The total cost of the diet was 35.4% of hospital account total costs. The enteral modality accounted for 59.8% of total dietary costs. The major costs with diets were observed in hospitalizations related to infections, cancers and cerebro-cardiovascular diseases. The major costs with parenteral diet were with admissions related by cancers (64.52%) and dementia syndromes (46.17%). The highest ratio between total diet costs with the total of hospital account costs was in dementia syndromes (46.32%) and in cancers (41.2%). The individuals who died spent 51.26% of total of hospital account costs, being 32.81% in diet (47.45% of total diet value and 58.81% in parenteral modality). CONCLUSION: Enteral and parenteral nutritional therapies account for a significant part of the costs with hospitalized individuals, especially in cases of cancers and dementia syndromes. The costs of parenteral diets were higher in the group of patients who died. OBJETIVO: Realizar uma análise econômica de custos da terapia nutricional enteral e parenteral, conforme o tipo de doença e o desfecho (sobreviventes versus óbitos). MÉTODOS: Estudo transversal, observacional, retrospectivo, com estratégia qualitativa e quantitativa, a partir da análise de contas hospitalares de uma operadora de saúde da Região Sul do Brasil. RESULTADOS: Foram analisadas 301 contas hospitalares de usuários que utilizaram dieta enteral e parenteral. O custo total com dieta foi de 35,4% do custo total das contas hospitalares. A modalidade enteral representou 59,8% do custo total em dieta. Os maiores custos com dieta foram observados em internações relacionadas a infecções, cânceres e doenças cérebro-cardiovasculares. Os maiores custos com dieta parenteral foram observados nas internações relacionadas aos cânceres (64,52%) e às síndromes demenciais (46,17%). A maior relação entre o custo total com dieta e o custo total da conta foi na síndrome demencial (46,32%) e no câncer (41,2%). Os usuários que foram a óbito consumiram 51,26% dos custos totais das contas, sendo 32,81% com dieta (47,45% do valor total com dieta e 58,81% do custo na modalidade parenteral). CONCLUSÃO: As terapias nutricionais enteral e parenteral representaram uma parte importante dos custos no tratamento de indivíduos hospitalizados, principalmente nos casos dos cânceres e nas síndromes demenciais. O custo com dieta parenteral foi maior no grupo de usuários que foram a óbito.
Assuntos
Nutrição Enteral/economia , Custos de Cuidados de Saúde/estatística & dados numéricos , Nutrição Parenteral/economia , Adulto , Idoso , Idoso de 80 Anos ou mais , Brasil , Doenças Transmissíveis/economia , Estudos Transversais , Demência/economia , Nutrição Enteral/mortalidade , Estudos de Avaliação como Assunto , Feminino , Hospitalização/economia , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias/economia , Nutrição Parenteral/mortalidade , Estudos Retrospectivos , Resultado do TratamentoRESUMO
ABSTRACT Objective To conduct an economic analysis of enteral and parenteral diet costs according to the type of disease and outcome (survivors versus deaths). Methods It is a cross-sectional, observational, retrospective study with a qualitative and quantitative design, based on analysis of hospital accounts from a healthcare insurance provider in the Southern region of Brazil. Results We analyzed 301 hospital accounts of individuals who used enteral and parenteral diets. The total cost of the diet was 35.4% of hospital account total costs. The enteral modality accounted for 59.8% of total dietary costs. The major costs with diets were observed in hospitalizations related to infections, cancers and cerebro-cardiovascular diseases. The major costs with parenteral diet were with admissions related by cancers (64.52%) and dementia syndromes (46.17%). The highest ratio between total diet costs with the total of hospital account costs was in dementia syndromes (46.32%) and in cancers (41.2%). The individuals who died spent 51.26% of total of hospital account costs, being 32.81% in diet (47.45% of total diet value and 58.81% in parenteral modality). Conclusion Enteral and parenteral nutritional therapies account for a significant part of the costs with hospitalized individuals, especially in cases of cancers and dementia syndromes. The costs of parenteral diets were higher in the group of patients who died.
RESUMO Objetivo Realizar uma análise econômica de custos da terapia nutricional enteral e parenteral, conforme o tipo de doença e o desfecho (sobreviventes versus óbitos). Métodos Estudo transversal, observacional, retrospectivo, com estratégia qualitativa e quantitativa, a partir da análise de contas hospitalares de uma operadora de saúde da Região Sul do Brasil. Resultados Foram analisadas 301 contas hospitalares de usuários que utilizaram dieta enteral e parenteral. O custo total com dieta foi de 35,4% do custo total das contas hospitalares. A modalidade enteral representou 59,8% do custo total em dieta. Os maiores custos com dieta foram observados em internações relacionadas a infecções, cânceres e doenças cérebro-cardiovasculares. Os maiores custos com dieta parenteral foram observados nas internações relacionadas aos cânceres (64,52%) e às síndromes demenciais (46,17%). A maior relação entre o custo total com dieta e o custo total da conta foi na síndrome demencial (46,32%) e no câncer (41,2%). Os usuários que foram a óbito consumiram 51,26% dos custos totais das contas, sendo 32,81% com dieta (47,45% do valor total com dieta e 58,81% do custo na modalidade parenteral). Conclusão As terapias nutricionais enteral e parenteral representaram uma parte importante dos custos no tratamento de indivíduos hospitalizados, principalmente nos casos dos cânceres e nas síndromes demenciais. O custo com dieta parenteral foi maior no grupo de usuários que foram a óbito.
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Custos de Cuidados de Saúde/estatística & dados numéricos , Nutrição Enteral/economia , Nutrição Parenteral/economia , Brasil , Doenças Transmissíveis/economia , Estudos Transversais , Estudos Retrospectivos , Resultado do Tratamento , Nutrição Enteral/mortalidade , Nutrição Parenteral/mortalidade , Demência/economia , Estudos de Avaliação como Assunto , Hospitalização/economia , Neoplasias/economiaRESUMO
BACKGROUND: A number of conditions compromise the passage of food along the digestive tract. Nasogastric tube (NGT) feeding is a classic, time-proven technique, although its prolonged use can lead to complications such as lesions to the nasal wing, chronic sinusitis, gastro-oesophageal reflux, and aspiration pneumonia. Another method of infusion, percutaneous endoscopy gastrostomy (PEG), is generally used when there is a need for enteral nutrition for a longer time period. There is a high demand for PEG in patients with swallowing disorders, although there is no consistent evidence about its effectiveness and safety as compared to NGT. OBJECTIVES: To evaluate the effectiveness and safety of PEG compared with NGT for adults with swallowing disturbances. SEARCH METHODS: We searched The Cochrane Library, MEDLINE, EMBASE, and LILACS from inception to January 2014, and contacted the main authors in the subject area. There was no language restriction in the search. SELECTION CRITERIA: We planned to include randomised controlled trials comparing PEG versus NGT for adults with swallowing disturbances or dysphagia and indications for nutritional support, with any underlying diseases. The primary outcome was intervention failure (e.g. feeding interruption, blocking or leakage of the tube, no adherence to treatment). DATA COLLECTION AND ANALYSIS: We used standard methodological procedures expected by The Cochrane Collaboration. For dichotomous and continuous variables, we used risk ratio (RR) and mean difference (MD), respectively with the random-effects statistical model and 95% confidence interval (CI). We assumed statistical heterogeneity when I² > 50%. MAIN RESULTS: We included 11 randomised controlled studies with 735 participants which produced 16 meta-analyses of outcome data. Meta-analysis indicated that the primary outcome of intervention failure, occurred in lower proportion of participants with PEG compared to NGT (RR 0.18, 95% CI 0.05 to 0.59, eight studies, 408 participants, low quality evidence) and this difference was statistically significant. For this outcome, we also subgrouped the studies by endoscopic gastrostomy technique into pull, and push and not reported. We observed a significant difference favouring PEG in the pull subgroup (RR 0.07, 95% CI 0.01 to 0.35, three studies, 90 participants). Thepush subgroup contained only one clinical trial and the result favoured PEG (RR 0.05, 95% CI 0.00 to 0.74, one study, 33 participants) techniques. We found no statistically significant difference in cases where the technique was not reported (RR 0.43, 95% CI 0.13 to 1.44, four studies, 285 participants).There was no statistically significant difference between the groups for meta-analyses of the secondary outcomes of mortality (RR 0.86, 95% CI 0.58 to 1.28, 644 participants, nine studies, very low quality evidence), overall reports of any adverse event at any follow-up time point (ITT analysis, RR 0.83, 95% CI 0.51 to 1.34), 597 participants, 6 studies, moderate quality evidence), specific adverse events including pneumonia (aspiration) (RR 0.70, 95% CI 0.46 to 1.06, 645 participants, seven studies, low quality evidence), or for the meta- analyses of the secondary outcome of nutritional status including weight change from baseline, and mid-arm circumference at endpoint, although there was evidence in favour of PEG for meta-analyses of mid-arm circumference change from baseline (MD 1.16, 95% CI 1.01 to 1.31, 115 participants, two studies), and levels of serum albumin were higher in the PEG group (MD 6.03, 95% CI 2.31 to 9.74, 107 participants).For meta-analyses of the secondary outcomes of time on enteral nutrition, there was no statistically significant difference (MD 14.48, 95% CI -2.74 to 31.71; 119 participants, two studies). For meta-analyses of quality of life measures (EuroQol) outcomes in two studies with 133 participants, for inconvenience (RR 0.03, 95% CI 0.00 to 0.29), discomfort (RR 0.03, 95% CI 0.00 to 0.29), altered body image (RR 0.01, 95% CI 0.00 to 0.18; P = 0.001) and social activities (RR 0.01, 95% CI 0.00 to 0.18) the intervention favoured PEG, that is, fewer participants found the intervention of PEG to be inconvenient, uncomfortable or interfered with social activities. However, there were no significant differences between the groups for pain, ease of learning to use, or the secondary outcome of length of hospital stay (two studies, 381 participants). AUTHORS' CONCLUSIONS: PEG was associated with a lower probability of intervention failure, suggesting the endoscopic procedure may be more effective and safe compared with NGT. There is no significant difference in mortality rates between comparison groups, or in adverse events, including pneumonia related to aspiration. Future studies should include details of participant demographics including underlying disease, age and gender, and the gastrostomy technique.
Assuntos
Transtornos de Deglutição/complicações , Nutrição Enteral/métodos , Gastrostomia/métodos , Desnutrição/terapia , Adulto , Nutrição Enteral/mortalidade , Gastrostomia/efeitos adversos , Gastrostomia/mortalidade , Humanos , Intubação Gastrointestinal/efeitos adversos , Intubação Gastrointestinal/métodos , Intubação Gastrointestinal/mortalidade , Desnutrição/etiologia , Pneumonia/etiologia , Ensaios Clínicos Controlados Aleatórios como Assunto , Falha de TratamentoRESUMO
OBJECTIVE: To determine the association of in-hospital mortality in patients with enteral feeding to their glycemic status (normoglycemia, new hyperglycemia, or diabetes) and their levels of serum albumin. METHODS: This was an observational, retrospective, descriptive, and longitudinal study. The data were from patients hospitalized at Hospital de Clínicas "José de San Martín" during a 4-y period who had received enteral feeding during the hospitalization period. P < 0.05 was considered statistically significant. RESULTS: Of the 1004 included patients, 558 (55.6%) had normoglycemia, 219 (21.8%) had known diabetes, and 227 (22.6%) had newly diagnosed hyperglycemia. The crude mortality rates during hospitalization were more pronounced for the hyperglycemic and diabetic patients. The univariate relative risks for trend were 1.34 and 1.56 for the diabetic and hyperglycemic subjects, respectively. At univariate analysis, in-hospital mortality was associated with age, known diabetes, newly diagnosed hyperglycemia, and albumin level. Hypoalbuminemia (<2.55 g/dL) also was significantly associated with mortality (univariate odds ratio ≈2.7). At multivariate analysis, in-hospital mortality was associated with age, newly diagnosed hyperglycemia, hypoalbuminemia (<2.55 g/dL), and known diabetes. No interactions between hypoalbuminemia and known diabetes or newly diagnosed hyperglycemia were detected at multivariate analysis. CONCLUSION: The results of this study showed that newly diagnosed hyperglycemia can be considered an independent prognostic factor of in-hospital mortality in patients with enteral feeding and that there is no interaction between newly diagnosed hyperglycemia and serum albumin levels.
Assuntos
Nutrição Enteral/mortalidade , Mortalidade Hospitalar , Hiperglicemia/mortalidade , Hipoalbuminemia/mortalidade , Idoso , Idoso de 80 Anos ou mais , Feminino , Hospitalização , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos RetrospectivosRESUMO
BACKGROUND: A number of conditions compromise the passage of food along the digestive tract. Nasogastric tube (NGT) feeding is a classic, time-proven technique, although its prolonged use can lead to complications such as lesions to the nasal wing, chronic sinusitis, gastro-oesophageal reflux, and aspiration pneumonia. Another method of infusion, percutaneous endoscopy gastrostomy (PEG), is generally used when there is a need for enteral nutrition for a longer time period. There is a high demand for PEG in patients with swallowing disorders, although there is no consistent evidence about its effectiveness and safety as compared to NGT. OBJECTIVES: To evaluate the effectiveness and safety of PEG as compared to NGT for adults with swallowing disturbances, by updating our previous Cochrane review. SEARCH METHODS: We searched The Cochrane Library, MEDLINE, EMBASE, and LILACS from inception to September 2011, as well as contacting main authors in the subject area. There was no language restriction in the search. SELECTION CRITERIA: We planned to include randomised controlled trials comparing PEG versus NGT for adults with swallowing disturbances or dysphagia and indications for nutritional support, with any underlying diseases. The primary outcome was intervention failure (e.g. feeding interruption, blocking or leakage of the tube, no adherence to treatment). DATA COLLECTION AND ANALYSIS: Review authors performed selection, data extraction and evaluation of methodological quality of studies. For dichotomous and continuous variables, we used risk ratio (RR) and mean difference (MD), respectively with the random-effects statistical model and 95% confidence interval (CI). We assumed statistical heterogeneity when I² > 50%. MAIN RESULTS: We included nine randomised controlled studies. We did not identify new eligible studies published after our previous review literature search date (August 2009). Intervention failure occurred in 19/156 patients in the PEG group and 63/158 patients in the NGT group (RR 0.24, 95%CI 0.08 to 0.76, P = 0.01) in favour of PEG. There was no statistically significant difference between comparison groups in complications (RR 1.00, 95%CI 0.91 to 1.11, P = 0.93). AUTHORS' CONCLUSIONS: PEG was associated with a lower probability of intervention failure, suggesting the endoscopic procedure is more effective and safe as compared to NGT. There is no significant difference of mortality rates between comparison groups, and pneumonia irrespective of underlying disease (medical diagnosis). Future studies should include previously planned and executed follow-up periods, the gastrostomy technique, and the experience of the professionals to allow more detailed subgroup analysis.
Assuntos
Transtornos de Deglutição/complicações , Nutrição Enteral/métodos , Gastrostomia/métodos , Intubação Gastrointestinal/métodos , Desnutrição/terapia , Adulto , Nutrição Enteral/mortalidade , Gastrostomia/efeitos adversos , Gastrostomia/mortalidade , Humanos , Intubação Gastrointestinal/efeitos adversos , Intubação Gastrointestinal/mortalidade , Desnutrição/etiologia , Pneumonia/etiologia , Ensaios Clínicos Controlados Aleatórios como Assunto , Falha de TratamentoRESUMO
PURPOSE: To compare the effect of parenteral versus enteral nutritional support in severe acute pancreatitis, with respect to efficacy, safety, morbidity, mortality and length of hospitalization. METHODS: The study was comprised of 31 patients, divided into a parenteral group (n=16) and an enteral group (n=15), who met severity criteria for abdominal tomography (Balthazar classes C, D, and E). The patients were compared by demographics, disease etiology, antibiotic prophylaxis, use or not of somatostatin, nutritional support, complications and disease progression. RESULTS: There was no statistical difference in the average duration of nutritional support, somatostatin, or antibiotics in the two groups. Imipenem was the drug of choice for prophylaxis of pancreatic infections in both groups. More complications occurred in the parenteral group, although the difference was not statistically significant (p=0.10). Infectious complications, such as catheter sepsis and infections of the pancreatic tissue, were significantly more frequent in the parenteral group (p=0.006). There was no difference in average length of hospitalization in the two groups. There were three deaths in the parenteral group and none in the enteral group. CONCLUSION: Enteral nutritional support is associated with fewer septic complications compared to parenteral nutritional support.(AU)
OBJETIVO: Comparar o efeito do suporte nutricional parenteral versus enteral, em pancreatite aguda grave, com relação à eficácia, à segurança, à morbi-mortalidade e ao tempo de internação. MÉTODOS: Foram estudados 31 pacientes distribuídos em grupo parenteral (n=16), no período de 1995 a 1998 e grupo enteral (n=15), no período de 1999 a 2002, que preencheram os critérios de gravidade pela tomografia de abdome (Balthazar C,D,E). Os pacientes foram comparados quanto aos dados demográficos, etiologia, antibioticoprofilaxia, somatostatina, suporte nutricional, complicações e evolução. RESULTADOS: A maioria dos pacientes era Balthazar E, principalmente no grupo enteral, porém sem significado estatístico (p=0,21). Também não houve diferença estatística nos dois grupos em relação ao tempo médio de uso de suporte nutricional, somatostatina e antibiótico. O imipenem foi a droga de escolha para profilaxia da infecção pancreática nos dois grupos. Houve mais complicações gerais no grupo parenteral, sem significado estatístico (p=0,10). As complicações infecciosas do tipo sépsis do cateter e infecção do tecido pancreático foram mais frequentes no grupo parenteral, com significância estatística (p=0,06). Não houve diferença na média de internação nos dois grupos. Houve três óbitos no grupo parenteral e nenhum no enteral. CONCLUSÃO: O suporte nutricional enteral está associado à menor taxa de complicações sépticas do que o parenteral.(AU)
Assuntos
Humanos , Nutrição Parenteral/efeitos adversos , Nutrição Parenteral/estatística & dados numéricos , Nutrição Enteral/efeitos adversos , Nutrição Enteral/estatística & dados numéricos , Pancreatite/epidemiologia , Nutrição Parenteral/mortalidade , Nutrição Enteral/mortalidade , Pancreatite/etiologiaRESUMO
PURPOSE: To compare the effect of parenteral versus enteral nutritional support in severe acute pancreatitis, with respect to efficacy, safety, morbidity, mortality and length of hospitalization. METHODS: The study was comprised of 31 patients, divided into a parenteral group (n=16) and an enteral group (n=15), who met severity criteria for abdominal tomography (Balthazar classes C, D, and E). The patients were compared by demographics, disease etiology, antibiotic prophylaxis, use or not of somatostatin, nutritional support, complications and disease progression. RESULTS: There was no statistical difference in the average duration of nutritional support, somatostatin, or antibiotics in the two groups. Imipenem was the drug of choice for prophylaxis of pancreatic infections in both groups. More complications occurred in the parenteral group, although the difference was not statistically significant (p=0.10). Infectious complications, such as catheter sepsis and infections of the pancreatic tissue, were significantly more frequent in the parenteral group (p=0.006). There was no difference in average length of hospitalization in the two groups. There were three deaths in the parenteral group and none in the enteral group. CONCLUSION: Enteral nutritional support is associated with fewer septic complications compared to parenteral nutritional support.
OBJETIVO: Comparar o efeito do suporte nutricional parenteral versus enteral, em pancreatite aguda grave, com relação à eficácia, à segurança, à morbi-mortalidade e ao tempo de internação. MÉTODOS: Foram estudados 31 pacientes distribuídos em grupo parenteral (n=16), no período de 1995 a 1998 e grupo enteral (n=15), no período de 1999 a 2002, que preencheram os critérios de gravidade pela tomografia de abdome (Balthazar C,D,E). Os pacientes foram comparados quanto aos dados demográficos, etiologia, antibioticoprofilaxia, somatostatina, suporte nutricional, complicações e evolução. RESULTADOS: A maioria dos pacientes era Balthazar E, principalmente no grupo enteral, porém sem significado estatístico (p=0,21). Também não houve diferença estatística nos dois grupos em relação ao tempo médio de uso de suporte nutricional, somatostatina e antibiótico. O imipenem foi a droga de escolha para profilaxia da infecção pancreática nos dois grupos. Houve mais complicações gerais no grupo parenteral, sem significado estatístico (p=0,10). As complicações infecciosas do tipo sépsis do cateter e infecção do tecido pancreático foram mais frequentes no grupo parenteral, com significância estatística (p=0,06). Não houve diferença na média de internação nos dois grupos. Houve três óbitos no grupo parenteral e nenhum no enteral. CONCLUSÃO: O suporte nutricional enteral está associado à menor taxa de complicações sépticas do que o parenteral.
Assuntos
Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nutrição Enteral , Tempo de Internação/estatística & dados numéricos , Nutrição Parenteral , Pancreatite/terapia , Doença Aguda , Nutrição Enteral/efeitos adversos , Nutrição Enteral/mortalidade , Nutrição Parenteral/efeitos adversos , Nutrição Parenteral/mortalidadeRESUMO
PURPOSE: To compare the effect of parenteral versus enteral nutritional support in severe acute pancreatitis, with respect to efficacy, safety, morbidity, mortality and length of hospitalization. METHODS: The study was comprised of 31 patients, divided into a parenteral group (n=16) and an enteral group (n=15), who met severity criteria for abdominal tomography (Balthazar classes C, D, and E). The patients were compared by demographics, disease etiology, antibiotic prophylaxis, use or not of somatostatin, nutritional support, complications and disease progression. RESULTS: There was no statistical difference in the average duration of nutritional support, somatostatin, or antibiotics in the two groups. Imipenem was the drug of choice for prophylaxis of pancreatic infections in both groups. More complications occurred in the parenteral group, although the difference was not statistically significant (p=0.10). Infectious complications, such as catheter sepsis and infections of the pancreatic tissue, were significantly more frequent in the parenteral group (p=0.006). There was no difference in average length of hospitalization in the two groups. There were three deaths in the parenteral group and none in the enteral group. CONCLUSION: Enteral nutritional support is associated with fewer septic complications compared to parenteral nutritional support.
Assuntos
Nutrição Enteral , Tempo de Internação/estatística & dados numéricos , Pancreatite/terapia , Nutrição Parenteral , Doença Aguda , Nutrição Enteral/efeitos adversos , Nutrição Enteral/mortalidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nutrição Parenteral/efeitos adversos , Nutrição Parenteral/mortalidadeRESUMO
La terapia nutricional, constituye una técnica de soporte en pacientes traumatizados, por cuanto constituye una opción terapéutica de sostén nutricional en pacientes cuya ingesta nutricional por vía oral es limitada. Varios estudios han demostrado su importancia en relación con la recuperación de este tipo de pacientes. El presente estudio, pretende establecer la relación existente entre aporte nutricional adecuado y temprano con la recuperación, mortalidad y complicaciones de pacientes, ingresados con trauma abdominal penetrante y contuso a la Unidad de Terapia Intensiva del Hospital Eugenio Espejo, aplicando un diseño descriptivo de series de casos clínicos. El total de pacientes estudiados fue de 52, con una promedio de 34 años...