RESUMO
It has been demonstrated that chronotropic responses differ in healthy elderly subjects compared to those in younger normal adults. To evaluate the involvement of the autonomic nervous system, we determined the number of neurons in right atrial strips from six elderly individuals (aged 77 + or - 3.4 years) five of whom had died as the result of extracardiac causes, and from younger adult controls (aged 44.0 + or - 6.0 years) who had died in traffic accidents. There was a significant reduction in the number of neurons of the group of hearts from the elderly (3587 + or - 445, mean + or - SEM) compared with the control group (6412 + or - 377) of five hearts from younger adults (P<0.001). It is suggested that this decrease in the number of neurons contributes to the reduced chronotropic responses in the aged. The mechanisms responsible for the neuronal depopulation was not determined
Assuntos
Adulto , Pessoa de Meia-Idade , Humanos , Masculino , Feminino , Envelhecimento/fisiologia , Átrios do Coração/citologia , Neurônios/análise , Idoso de 80 Anos ou mais , Contagem de Células , Frequência CardíacaRESUMO
Foi realizado estudo histológico de dez vesículas biliares, obtidas cinco de indivíduos normais e cinco de portadores de colelitíase. Células nervosas foram contadas separadamente no colo, corpo e fundo. Em vesículas de indivíduos normais o número maior de células nervosas foi encontrado na regiäo do colo (23,48ñ 10,14 por mm2) e menor no corpo (7,7 ñ 8,45) por mm2) e fundo (5,6 ñ 3,66 mm2). Em vesículas biliares com litíase, o número maior de células nervosas foi também encontrado no colo (5,83 ñ 4,92 por mm2) e menor no corpo (2,63 ñ 1,56 por mm2) e fundo (1,03 ñ 0,71 por mm2)
Assuntos
Adulto , Pessoa de Meia-Idade , Humanos , Masculino , Feminino , Colelitíase/patologia , Neurônios/análise , Vesícula Biliar/citologia , Técnicas HistológicasAssuntos
Córtex Cerebral/embriologia , Sinapses/fisiologia , Adolescente , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Córtex Cerebral/crescimento & desenvolvimento , Córtex Cerebral/ultraestrutura , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Pessoa de Meia-Idade , Neurônios/análise , Neurônios/ultraestrutura , Ácido Fosfotúngstico , Gravidez , Sinapses/ultraestruturaRESUMO
The study of the ferruginated neurons in the analysis of 87 cases of cerebral infarcts is reported. The lesion found in 40,3% of the cases was demonstrared to contain iron and calcium. It was found to be more frequent in older patients and predominantly in the cortical necrotic areas. The minerals were also detected in basophilic granules found outside the cells in the necrotic tissue. There was no correlation with the basic disease, although in 17% of the cases there was an association with sickling of the red blood cells. The role of the mineral content of the nervous tissue in the pathogenesis of the incrustation is discussed. The demonstration of other minerals besides the iron in the cells makes the term "mineralization of neurons" more acceptable.