RESUMO
Granular cell tumours occur in a variety of sites, including the vulva. Origins from myogenic, histiocytic, fibroblastic and neurogenic elements have been proposed. Female preponderance suggests that oestrogenic hormones are involved. Seven cases of granular cell tumours of the vulva have been studied. In none was the correct diagnosis made preoperatively. They were solitary lesions and local excision was curative. Paraffin sections of these cases were studied by peroxidase-antiperoxidase method for myoglobin, lysozyme, alpha-1-antitrypsin and S-100 protein localization. Antimyoglobin, antilysozyme and anti-alpha-1-antitrypsin antibodies were not localized in these tumours; however, S-100 protein was localized in all of them. These results agree with previous data that suggest a neurogenic origin for granular cell tumours.
Assuntos
Cistos/epidemiologia , Fibroma/epidemiologia , Lipoma/epidemiologia , Neoplasias de Tecido Muscular/epidemiologia , Neoplasias Vulvares/epidemiologia , Adulto , Cistos/patologia , Feminino , Fibroma/patologia , Humanos , Lipoma/patologia , Pessoa de Meia-Idade , Neoplasias de Tecido Muscular/patologia , Trinidad e Tobago , Neoplasias Vulvares/patologiaRESUMO
Among the benign tumors of the esophagus, the discovery of a granular cell tumor is exceptional. Although endoscopy permits recognition of this tumor and supports its benign nature, only histologic examination of the endoscopic biopsy specimen permits one to determine its precise nature. The endoscopic appearance of esophageal granular cell tumor ranges from a plaque-like thickening of the mucosa to a polypoid mass. We describe here seven cases of granular cell tumor of the esophagus diagnosed by histologic examination of endoscopic biopsy specimens. We believe the actual incidence of this tumor in this location might be greater if every esophagus were given as much attention at endoscopic examination and at autopsy.
Assuntos
Neoplasias Esofágicas/diagnóstico , Neoplasias de Tecido Muscular/diagnóstico , Adulto , Brasil , Neoplasias Esofágicas/epidemiologia , Neoplasias Esofágicas/patologia , Esofagoscopia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias de Tecido Muscular/epidemiologia , Neoplasias de Tecido Muscular/patologiaRESUMO
Five cases of granular cell myoblastoma of the breast are reported, all occuring in Negroes. In none was the correct diagnosis made preoperatively. Because this benign tumor has many features of carcinoma, errors in clinical and mammographic assessment may lead to unnecessary mastectomy. Thus, a histological diagnosis must be made on every apparently malignant lump before any form of definitive therapy is performed (Summary)