RESUMO
BACKGROUND: Documentation of lingual tumors is scarce in nonhuman primates. METHODS: Through a multi-institutional retrospective study we compile cases of primary and metastatic neoplasia in non-human primates. RESULTS: We describe five cases of lingual neoplasia. Three cases are primary lingual tumors: chondro-osteoblastic lipoma in a howler monkey, squamous cell carcinoma, and fibroma in two baboons. We describe two cases of metastatic lymphoma in the tongue in rhesus macaques. A literature review of published lingual neoplasia in nonhuman primates is included in this manuscript. CONCLUSION: Lingual neoplasia is seldom reported in non-human primates.
Assuntos
Doenças dos Macacos , Papio , Neoplasias da Língua , Animais , Doenças dos Macacos/patologia , Doenças dos Macacos/diagnóstico , Masculino , Feminino , Neoplasias da Língua/patologia , Neoplasias da Língua/veterinária , Neoplasias da Língua/diagnóstico , Estudos Retrospectivos , Macaca mulatta , Carcinoma de Células Escamosas/veterinária , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/diagnóstico , Lipoma/veterinária , Lipoma/patologia , Lipoma/diagnósticoRESUMO
Background: Hemangiosarcoma is a primary malignant neoplasm of vascular endothelial cells, common in dogs and uncommon in cats. It is characterized by being aggressive and presenting high metastatic behavior. It corresponds to 0.5% to 2% of all feline neoplasms, with more reports in shorthaired cats aged between 8 and 12.2 years old, with no predisposition for sex or breed. Among the diagnostic methods, histopathological and immunohistochemical exams stand out because they are more accurate, since the result of fine-needle aspiration biopsy is usually hidden by blood contamination. This report aims to describe a case of a hemangiosarcoma in a cats tongue. Case: A 9-year-old, female, shorthair cat with a history of weight loss, lethargy, chewing difficulty with the evolution of three months and two-day oral bleeding was attended. Physical examination revealed blood in the oral cavity, enlargement, and darkening of the tongue surface, normalized oral and ocular mucous membranes, estimated dehydration of 7%, a rectal temperature of 38.8OC, and pulmonary and cardiac auscultation without changes. The cat was hospitalized, and euthanasia was elected. Cytological and histopathological exams of the tongue were requested, which revealed a neoplastic proliferation of endothelial cells expanding and replacing the muscular layer of the tongue, forming primitive vascular structures filled with a large number of red blood cells and supported by a delicate fibrovascular stroma. There were moderate anisocytosis and anisocariosis and rare figures of mitosis. Immunohistochemical examination showed the expression of von Willebrand factor, smooth muscle vimentin, and actin in the cytoplasm of neoplastic cells, and negative staining for pancitokeratin. Discussion: According to the results of cytological, histopathological and immunohistochemical (AU)
Assuntos
Animais , Feminino , Gatos , Hemangiossarcoma/patologia , Hemangiossarcoma/veterinária , Neoplasias da Língua/veterinária , Imuno-Histoquímica/veterináriaRESUMO
Background: Hemangiosarcoma is a primary malignant neoplasm of vascular endothelial cells, common in dogs and uncommon in cats. It is characterized by being aggressive and presenting high metastatic behavior. It corresponds to 0.5% to 2% of all feline neoplasms, with more reports in shorthaired cats aged between 8 and 12.2 years old, with no predisposition for sex or breed. Among the diagnostic methods, histopathological and immunohistochemical exams stand out because they are more accurate, since the result of fine-needle aspiration biopsy is usually hidden by blood contamination. This report aims to describe a case of a hemangiosarcoma in a cats tongue. Case: A 9-year-old, female, shorthair cat with a history of weight loss, lethargy, chewing difficulty with the evolution of three months and two-day oral bleeding was attended. Physical examination revealed blood in the oral cavity, enlargement, and darkening of the tongue surface, normalized oral and ocular mucous membranes, estimated dehydration of 7%, a rectal temperature of 38.8OC, and pulmonary and cardiac auscultation without changes. The cat was hospitalized, and euthanasia was elected. Cytological and histopathological exams of the tongue were requested, which revealed a neoplastic proliferation of endothelial cells expanding and replacing the muscular layer of the tongue, forming primitive vascular structures filled with a large number of red blood cells and supported by a delicate fibrovascular stroma. There were moderate anisocytosis and anisocariosis and rare figures of mitosis. Immunohistochemical examination showed the expression of von Willebrand factor, smooth muscle vimentin, and actin in the cytoplasm of neoplastic cells, and negative staining for pancitokeratin. Discussion: According to the results of cytological, histopathological and immunohistochemical
Assuntos
Feminino , Animais , Gatos , Hemangiossarcoma/patologia , Hemangiossarcoma/veterinária , Neoplasias da Língua/veterinária , Imuno-Histoquímica/veterináriaRESUMO
The biological behaviour of the tumours vary according to the species in which they occur, its location within the cavity, clinical stage and histopathological nature. Lingual neoplasms are generally uncommon in companion animals. Rhabdomyosarcomas are malignant, solid, aggressive formations with high metastatic potential. The clinical signs are variable and a definitive diagnosis can only be reached through histopathological analysis of biopsy and necropsy specimen. In some cases, immunohistochemical study may be needed to confirm the diagnosis. This paper aims to highlight important points about this uncommon condition in dogs, using a case report of lingual rhabdomyosarcoma, which showed no evidence of metastasis after diagnosis, nor of local recurrence after surgical excision with a wide safety margin. It was concluded that early diagnosis, the correct interpretation of the complementary tests and the appropriate therapeutic approach contributed to improving the quality of life and survival of the patient in question.(AU)
O comportamento biológico dos tumores varia de acordo com a espécie animal, a localização na cavidade, a fase clínica e a natureza histopatológica. As neoplasias orais são geralmente incomuns em animais de companhia. Os rabdomiossarcomas são formações malignas, sólidas e agressivas, com alto potencial metastático. Os sinais clínicos são variáveis e o diagnóstico definitivo só pode ser alcançado por meio da análise histopatológica do material colhido. Em alguns casos, o estudo imuno-histoquímico pode ser necessário para confirmar o diagnóstico. Este trabalho tem como objetivo destacar pontos importantes sobre essa condição incomum em cães, utilizando um relato de caso de rabdomiossarcoma lingual, no qual não se evidenciaram metástases após o diagnóstico, nem recorrência local após a excisão cirúrgica com ampla margem de segurança. Concluiu-se que o diagnóstico precoce, a correta interpretação dos exames complementares e a abordagem terapêutica adequada contribuíram para melhorar a qualidade de vida e a sobrevida do paciente em questão.(AU)
Assuntos
Animais , Cães , Rabdomiossarcoma/patologia , Rabdomiossarcoma/terapia , Rabdomiossarcoma/veterinária , Neoplasias da Língua/veterináriaRESUMO
The biological behaviour of the tumours vary according to the species in which they occur, its location within the cavity, clinical stage and histopathological nature. Lingual neoplasms are generally uncommon in companion animals. Rhabdomyosarcomas are malignant, solid, aggressive formations with high metastatic potential. The clinical signs are variable and a definitive diagnosis can only be reached through histopathological analysis of biopsy and necropsy specimen. In some cases, immunohistochemical study may be needed to confirm the diagnosis. This paper aims to highlight important points about this uncommon condition in dogs, using a case report of lingual rhabdomyosarcoma, which showed no evidence of metastasis after diagnosis, nor of local recurrence after surgical excision with a wide safety margin. It was concluded that early diagnosis, the correct interpretation of the complementary tests and the appropriate therapeutic approach contributed to improving the quality of life and survival of the patient in question.(AU)
O comportamento biológico dos tumores varia de acordo com a espécie animal, a localização na cavidade, a fase clínica e a natureza histopatológica. As neoplasias orais são geralmente incomuns em animais de companhia. Os rabdomiossarcomas são formações malignas, sólidas e agressivas, com alto potencial metastático. Os sinais clínicos são variáveis e o diagnóstico definitivo só pode ser alcançado por meio da análise histopatológica do material colhido. Em alguns casos, o estudo imuno-histoquímico pode ser necessário para confirmar o diagnóstico. Este trabalho tem como objetivo destacar pontos importantes sobre essa condição incomum em cães, utilizando um relato de caso de rabdomiossarcoma lingual, no qual não se evidenciaram metástases após o diagnóstico, nem recorrência local após a excisão cirúrgica com ampla margem de segurança. Concluiu-se que o diagnóstico precoce, a correta interpretação dos exames complementares e a abordagem terapêutica adequada contribuíram para melhorar a qualidade de vida e a sobrevida do paciente em questão.(AU)
Assuntos
Animais , Cães , Rabdomiossarcoma/patologia , Rabdomiossarcoma/terapia , Rabdomiossarcoma/veterinária , Neoplasias da Língua/veterináriaRESUMO
Acute inflammatory response after photodynamic therapy is frequently described, and increase on mast cell degranulation is also present during this process. The mast cell activation may improve angiogenesis, and this fact has been associated with progression of oral premalignant lesions (OPL). The aim of this study was to evaluate whether photodynamic therapy (PDT) increases mast cell density (MCD) and microvessels density (MVD) in 4-nitroquinoline-1-oxide(4NQO)-induced OPL in rats. 4NQO-induced OPL were treated or not with 5-ALA followed by laser irradiation (PDT group and 4NQO groups, respectively). Mast cells and CD34+ microvessels were counted. Both PDT and 4NQO groups had MCD and MVD that were higher than normal mucosa (p b 0.05). The 4NQO group had the lowest number of non-degranulated MCD in comparison to experimental periods of PDT (PDT 6 h p=0.020; 24 h p=0.016; 48 h p=0.003; 72 h p=0.033). Only in the PDT group did MCD and MVD have a significant correlation (r= 0.6219, p = 0.010). 5-ALA-mediated PDT modified the MCD and MVD in the induced OPL, leading to degranulation of mast cells and angiogenesis. A PDT protocol with an efficient eradication of the OPL must be adopted considering the angiogenesis potential associated with the mast cell activation after the therapy.
Assuntos
Ácido Aminolevulínico/uso terapêutico , Mastócitos/fisiologia , Microvasos/patologia , Fármacos Fotossensibilizantes/uso terapêutico , Neoplasias da Língua/tratamento farmacológico , 4-Nitroquinolina-1-Óxido/toxicidade , Ácido Aminolevulínico/farmacologia , Animais , Antígenos CD34/metabolismo , Degranulação Celular/efeitos dos fármacos , Degranulação Celular/efeitos da radiação , Feminino , Hiperplasia/induzido quimicamente , Hiperplasia/patologia , Lasers , Mastócitos/citologia , Mucosa Bucal/efeitos dos fármacos , Mucosa Bucal/patologia , Neovascularização Fisiológica/efeitos dos fármacos , Neovascularização Fisiológica/efeitos da radiação , Fotoquimioterapia , Fármacos Fotossensibilizantes/farmacologia , Ratos , Ratos Wistar , Língua/patologia , Neoplasias da Língua/induzido quimicamente , Neoplasias da Língua/veterináriaRESUMO
Neoplasia lingual é pouco comum em cães e gatos, porém é a causa mais comum de indicação deglossectomia nesses animais. Representam apenas 2 a 4% das neoplasias orais sendo carcinoma de células escamosase melanoma os tipos mais comuns, seguidos de hemangiossarcoma e fibrossarcoma. Esse artigo relata glossectomia total em um cão diagnosticado com linfoma de células T, e como foi sua recuperação e readaptação após o procedimento cirúrgico.(AU)
Lingual cancer is uncommon in dogs and cats, but is the most common cause of glossectomy indication in these animais. Represents only 2 to 4% of oral cancers are squamous cell carcinoma and melanoma most common types, followed by hemangiosarcoma and fibrosarcoma . This article reports the total glossectomy in a dog diagnosed with T cellymphoma, and how was your recovery and rehabilitation after surgery.(AU)
Lingual cáncer es poco común en perros y gatos, peroes la causa más común de indicación glossectomy en estos animales.Representa sólo el 2 ai 4% de los cánceres orales son los tipos más comunes de carcinoma de células escamosas y melanoma, seguido de hemangiosarcoma y fibrosarcoma. Se informa la glosectomía total en un perrodiagnosticado con linfoma de células T, y la recuperación y rehabilitación después de la cirugía.(AU)
Assuntos
Animais , Feminino , Cães , Glossectomia/veterinária , Linfoma de Células T/veterinária , Linfoma de Células T/reabilitação , Neoplasias da Língua/cirurgia , Neoplasias da Língua/veterináriaRESUMO
Neoplasia lingual é pouco comum em cães e gatos, porém é a causa mais comum de indicação deglossectomia nesses animais. Representam apenas 2 a 4% das neoplasias orais sendo carcinoma de células escamosase melanoma os tipos mais comuns, seguidos de hemangiossarcoma e fibrossarcoma. Esse artigo relata glossectomia total em um cão diagnosticado com linfoma de células T, e como foi sua recuperação e readaptação após o procedimento cirúrgico.
Lingual cancer is uncommon in dogs and cats, but is the most common cause of glossectomy indication in these animais. Represents only 2 to 4% of oral cancers are squamous cell carcinoma and melanoma most common types, followed by hemangiosarcoma and fibrosarcoma . This article reports the total glossectomy in a dog diagnosed with T cellymphoma, and how was your recovery and rehabilitation after surgery.
Lingual cáncer es poco común en perros y gatos, peroes la causa más común de indicación glossectomy en estos animales.Representa sólo el 2 ai 4% de los cánceres orales son los tipos más comunes de carcinoma de células escamosas y melanoma, seguido de hemangiosarcoma y fibrosarcoma. Se informa la glosectomía total en un perrodiagnosticado con linfoma de células T, y la recuperación y rehabilitación después de la cirugía.
Assuntos
Feminino , Animais , Cães , Glossectomia/veterinária , Linfoma de Células T/reabilitação , Linfoma de Células T/veterinária , Neoplasias da Língua/cirurgia , Neoplasias da Língua/veterináriaRESUMO
Background: Primary tongue tumors rarely affect dogs and correspond to 4% of tumors involving the oropharynx. Until now, primary tongue lymphoma had not been reported. However, lymphoma involvement in the skeletal muscle, although quite unusual, was described in the literature in four cases. Cutaneous lymphoma is another rare extranodal manifestation. The objective of this report is to describe a case of T immunophenotype lymphoma occurrence, whose manifestation is atypical, not only because it is situated in the tongue muscle but also because of the subsequent involvement of the striated musculature of the left forelimb and the skin, which showed unfavorable evolution. Case: A female seven-year-old mongrel was seen showing a regular lump in the base of the tongue, 3 cm in diameter, not ulcerated and of firm consistency, with halitosis as the only clinical sign of the disease. Incisional biopsy of the lump was performed and histopathology verified that it was large cell lymphoma. The material was sent for immunohistochemical evaluation and was characterized as T immunophenotype lymphoma by positive CD3 and negative CD79a marking. The CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy protocol was established as treatment and after the first chemotherapy session there was partial remission of the mass, measuring 2 cm in diameter. The lump, however...(AU)
Assuntos
Animais , Cães , Linfoma de Células T/complicações , Linfoma de Células T/veterinária , Neoplasias da Língua/veterinária , Músculo Esquelético/patologiaRESUMO
Background: Primary tongue tumors rarely affect dogs and correspond to 4% of tumors involving the oropharynx. Until now, primary tongue lymphoma had not been reported. However, lymphoma involvement in the skeletal muscle, although quite unusual, was described in the literature in four cases. Cutaneous lymphoma is another rare extranodal manifestation. The objective of this report is to describe a case of T immunophenotype lymphoma occurrence, whose manifestation is atypical, not only because it is situated in the tongue muscle but also because of the subsequent involvement of the striated musculature of the left forelimb and the skin, which showed unfavorable evolution. Case: A female seven-year-old mongrel was seen showing a regular lump in the base of the tongue, 3 cm in diameter, not ulcerated and of firm consistency, with halitosis as the only clinical sign of the disease. Incisional biopsy of the lump was performed and histopathology verified that it was large cell lymphoma. The material was sent for immunohistochemical evaluation and was characterized as T immunophenotype lymphoma by positive CD3 and negative CD79a marking. The CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy protocol was established as treatment and after the first chemotherapy session there was partial remission of the mass, measuring 2 cm in diameter. The lump, however...
Assuntos
Animais , Cães , Linfoma de Células T/complicações , Linfoma de Células T/veterinária , Neoplasias da Língua/veterinária , Músculo Esquelético/patologiaRESUMO
The experimental oral carcinogenesis induced by the chemical 4-nitroquinoline 1-oxide (4NQO) is one of the most frequent in the study of squamous cell carcinoma of the oral cavity (CCEC). The clear advantage is that the model is very similar to the physiological process of malignancy. The model has clear benefits by and is suitable for applications in therapeutic research.
La carcinogénesis oral experimental inducida por el químico 4-nitroquinolina 1-óxido (4NQO) es uno de los métodos más frecuentes en el estudio del carcinoma de células escamosas de la cavidad oral (CCECO). La clara ventaja del modelo radica en el gran parecido al proceso fisiológico de la neoplasia maligna. El modelo tiene beneficios claros y es adecuado para las aplicaciones de la investigación terapéutica.