RESUMO
PURPOSE: Many medicinal plants have been employed during ages to treat urinary stones though the rationale behind their use is not well established. Thus, the present study was proposed to evaluate the effect of coconut water as a prophylactic agent in experimentally induced nephrolithiasis in a rat model. MATERIALS AND METHODS: The male Wistar rats were divided randomly into three groups. Animals of group I (control) were fed standard rat diet. In group II, the animals were administrated 0.75% ethylene glycol in drinking water for the induction of nephrolithiasis. Group III animals were administrated coconut water in addition to ethylene glycol. All the treatments were continued for a total duration of seven weeks. RESULTS AND CONCLUSION: Treatment with coconut water inhibited crystal deposition in renal tissue as well as reduced the number of crystals in urine. Furthermore, coconut water also protected against impaired renal function and development of oxidative stress in the kidneys. The results indicate that coconut water could be a potential candidate for phytotherapy against urolithiasis.
Assuntos
Cocos , Nefrocalcinose/tratamento farmacológico , Fitoterapia , Animais , Creatinina/sangue , Etilenoglicol , Rim/efeitos dos fármacos , Masculino , Nefrocalcinose/induzido quimicamente , Nefrocalcinose/prevenção & controle , Distribuição Aleatória , Ratos , Ratos Wistar , Reação em Cadeia da Polimerase em Tempo Real , Resultado do Tratamento , Ureia/sangue , Urolitíase/tratamento farmacológico , Urolitíase/prevenção & controle , ÁguaRESUMO
Purpose Many medicinal plants have been employed during ages to treat urinary stones though the rationale behind their use is not well established. Thus, the present study was proposed to evaluate the effect of coconut water as a prophylactic agent in experimentally induced nephrolithiasis in a rat model. Materials and Methods The male Wistar rats were divided randomly into three groups. Animals of group I (control) were fed standard rat diet. In group II, the animals were administrated 0.75% ethylene glycol in drinking water for the induction of nephrolithiasis. Group III animals were administrated coconut water in addition to ethylene glycol. All the treatments were continued for a total duration of seven weeks. Results and Conclusion Treatment with coconut water inhibited crystal deposition in renal tissue as well as reduced the number of crystals in urine. Furthermore, coconut water also protected against impaired renal function and development of oxidative stress in the kidneys. The results indicate that coconut water could be a potential candidate for phytotherapy against urolithiasis. .
Assuntos
Animais , Masculino , Ratos , Cocos , Nefrocalcinose/tratamento farmacológico , Fitoterapia , Creatinina/sangue , Etilenoglicol , Rim/efeitos dos fármacos , Nefrocalcinose/induzido quimicamente , Nefrocalcinose/prevenção & controle , Distribuição Aleatória , Ratos Wistar , Reação em Cadeia da Polimerase em Tempo Real , Resultado do Tratamento , Ureia/sangue , Urolitíase/tratamento farmacológico , Urolitíase/prevenção & controle , ÁguaRESUMO
Con el advenimiento de estudios de imagen altamente sensibles, como el ultrasonido y la tomografía computada, la nefrocalcinosis (NC) se diagnostica más frecuentemente. Mientras que en muchos casos la NC puede manifestarse de forma leve y reversible, en otros casos puede ser progresiva, causando inicialmente daño tubular y posteriormente daño glomerular. Por lo tanto, el diagnóstico temprano e intervención apropiada son de crucial importancia. Esta revisión abarcará aspectos de la NC en niños, incluyendo etiología, patogénesis, prevención y tratamiento
Assuntos
Criança , Diagnóstico por Imagem , Diagnóstico Precoce , Nefrocalcinose/diagnóstico , Nefrocalcinose/etiologia , Nefrocalcinose/prevenção & controle , Nefrocalcinose/terapiaRESUMO
Con el advenimiento de estudios de imagen altamente sensibles, como el ultrasonido y la tomografía computada, la nefrocalcinosis (NC) se diagnostica más frecuentemente. Mientras que en muchos casos la NC puede manifestarse de forma leve y reversible, en otros casos puede ser progresiva, causando inicialmente daño tubular y posteriormente daño glomerular. Por lo tanto, el diagnóstico temprano e intervención apropiada son de crucial importancia. Esta revisión abarcará aspectos de la NC en niños, incluyendo etiología, patogénesis, prevención y tratamiento(AU)
Assuntos
Criança , Nefrocalcinose/diagnóstico , Nefrocalcinose/etiologia , Nefrocalcinose/prevenção & controle , Diagnóstico por Imagem , Nefrocalcinose/terapia , Diagnóstico PrecoceRESUMO
La litasis de riñón y vías urinarias representa un grave problema de salud pública, por tanto, merece un abordaje sistematizado para evitar su recurrencia mediante métodos de diagnóstico precisos que orientan terapia eficaz. En este trabajo se revisan los resultados de un protocolo que se diseñó para establecer las causas metabólicas responsables de litogenicidad en 626 pacientes estudiados en dos etapas: I (1979-1987) 185 casos. En la etapa I el protocolo incluyó determinaciones en suero y orina de 24 hs de electrolitos, iones divalentes, fosforo, ácido úrico, cistina, filtración glomerular, evaluación del funcionamiento paratiroideo con hormona paratiroidea, Tm fosfato y a partir de 1982 (Ia) con AMP cíclico antes y después de una carga oral de calcio. En la etapa II se añadieron determinaciones de inhibidores de la nucleación de cristales (magnesio y citrato) y de promotores de la misma (oxalato). En 185 casos de la etapa I se desmostró en el 88.2 por ciento de los pacientes alguna variedad de trastorno metabólico, en la etapa II se detectó alguna alteración metabólica en el 96.2 por ciento de los casos. El 55 por ciento de los casos acudieron dos años al seguimiento y el 39 por ciento acudieron hasta cuatro años. El número de cálculos expulsados por paciente por año antes del estudio fue de 2.8 y durante el tratamiento se redujo a 0.8. La elevada eficiencia diagnóstica y la vigilancia sistematizada del tratamiento durante los tres años que siguieron al diagnóstico, resultaron en un abatimiento significativo de la producción de cálculos en este nutrido grupo de pacientes, lo cual justifica la integración de este protocolo a la Clínica de Litiasis Renal y de Vías Urinarias
Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Cálculos Renais/diagnóstico , Cálculos Renais/prevenção & controle , Cálculos Renais/terapia , Cálculos Urinários/diagnóstico , Cálculos Urinários/prevenção & controle , Cálculos Urinários/terapia , Hiperoxalúria/diagnóstico , Hiperoxalúria/prevenção & controle , Hiperoxalúria/terapia , Nefrocalcinose/diagnóstico , Nefrocalcinose/prevenção & controle , Nefrocalcinose/terapiaRESUMO
Clinical and pathophysiologic studies were performed in five unrelated children with primary distal renal tubular acidosis who were diagnosed during infancy and followed for 3 to 9 1/2 years. All patients had permanent defects in hydrogen ion secretion, sodium reabsorption, and concentrating capacity. A transient, age-related, proximal tubular defect in sodium and bicarbonate reabsorption was also present. Renal bicarbonate wasting was mainly observed during the first years of life and progressively decreased with advancing age. Glomerular filtration rate remained within normal limits. Following sustained therapy with sodium and potassium bicarbonate, the patients had optimal growth, arrest of progression of nephrocalcinosis, and lack of other characteristic features of the disease with the exception of polyuria. Dosage of alkali was mainly determined by the magnitude of the renal bicarbonate loss and decreased progressively from a maximum of 3.9 to 10.0 mEq/kg/day during the first year of life to about 3 mEq/kg/day at or beyond 6 years of age. The total dosage of alkali required could be derived by the sum of the urinary excretion of bicarbonate plus 2 mEq/kg/day, which represents mean endogenous acid production. Although calciuria was normal when metabolic acidosis was corrected, patients with higher urinary sodium excretion had higher urinary excretion of calcium and thus were at greater risk of developing nephrocalcinosis if therapy was not carefully controlled.