RESUMO
In normal subjects fed western-mixed diets, in the fasting state, 39.6% of the variance of calciuria is accounted for by net acid excretion and 4% by sulfaturia. In the postprandial period, net acid accounts for 6.9% and sulfaturia for 11.8% of the variance of calciuria. As expected, after a load of ammonium chloride, net acid excretion exceeded the importance of sulfaturia (36.2% vs. 8.4%) and the opposite was observed after DL-methionine load (1.5% and 46.2%). A group of normal subjects fed vegetarian diets was also investigated. The excretion of the three variables measured were significantly reduced in this group when compared with that of the former group. In the fasting state the variance of calciuria was accounted mainly by net acid excretion (85.7%). In the postprandial state net acid (4.9%) and sulfate (2.2%) had much less importance as determinants of calciuria. It is concluded that in spite of their metabolic relationship, net acid and sulfate excretions are independent determinants of calciuria. The relative importance of each variable changes as a function of metabolic circumstances
Assuntos
Humanos , Masculino , Feminino , Ácidos/urina , Cálcio/urina , Dieta , Sulfatos/urina , Adulto , Cloreto de Amônio/urina , Cálcio da Dieta/farmacocinética , Dieta Vegetariana , Proteínas Alimentares/administração & dosagem , Ingestão de Alimentos , Jejum , Pessoa de Meia-Idade , Metionina/urina , Valores de ReferênciaRESUMO
In normal subjects fed western-mixed diets, in the fasting state, 39.6% of the variance of calciuria is accounted for by net acid excretion and 4% by sulfaturia. In the postprandial period, net acid accounts for 6.9% and sulfaturia for 11.8% of the variance of calciuria. As expected, after a load of ammonium chloride, net acid excretion exceeded the importance of sulfaturia (36.2% vs. 8.4%) and the opposite was observed after DL-methionine load (1.5% and 46.2%). A group of normal subjects fed vegetarian diets was also investigated. The excretion of the three variables measured were significantly reduced in this group when compared with that of the former group. In the fasting state the variance of calciuria was accounted mainly by net acid excretion (85.7%). In the postprandial state net acid (4.9%) and sulfate (2.2%) had much less importance as determinants of calciuria. It is concluded that in spite of their metabolic relationship, net acid and sulfate excretions are independent determinants of calciuria. The relative importance of each variable changes as a function of metabolic circumstances (Au)
Assuntos
Humanos , Masculino , Feminino , Estudo Comparativo , RESEARCH SUPPORT, NON-U.S. GOVT , Ácidos/urina , Cálcio/urina , Dieta , Sulfatos/urina , Adulto , Cloreto de Amônio/urina , Cálcio da Dieta/farmacocinética , Proteínas Alimentares/administração & dosagem , Ingestão de Alimentos , Jejum , Metionina/urina , Pessoa de Meia-Idade , Valores de Referência , Dieta VegetarianaRESUMO
In normal subjects fed western-mixed diets, in the fasting state, 39.6% of the variance of calciuria is accounted for by net acid excretion and 4% by sulfaturia. In the postprandial period, net acid accounts for 6.9% and sulfaturia for 11.8% of the variance of calciuria. As expected, after a load of ammonium chloride, net acid excretion exceeded the importance of sulfaturia (36.2% vs. 8.4%) and the opposite was observed after DL-methionine load (1.5% and 46.2%). A group of normal subjects fed vegetarian diets was also investigated. The excretion of the three variables measured were significantly reduced in this group when compared with that of the former group. In the fasting state the variance of calciuria was accounted mainly by net acid excretion (85.7%). In the postprandial state net acid (4.9%) and sulfate (2.2%) had much less importance as determinants of calciuria. It is concluded that in spite of their metabolic relationship, net acid and sulfate excretions are independent determinants of calciuria. The relative importance of each variable changes as a function of metabolic circumstances.
Assuntos
Ácidos/urina , Cálcio/urina , Dieta , Sulfatos/urina , Adulto , Cloreto de Amônio/urina , Cálcio da Dieta/farmacocinética , Dieta Vegetariana , Proteínas Alimentares/administração & dosagem , Ingestão de Alimentos , Jejum , Feminino , Humanos , Masculino , Metionina/urina , Pessoa de Meia-Idade , Valores de ReferênciaRESUMO
Twenty-seven infants from 1 day to 9 months of age with severe intractable diarrhea were fed an oral elemental diet (Vivonex) consisting of crystalline amino acids, glucose, electrolytes, and vitamins by continuous nasogastric drip. Complete control of diarrhea was achieved in 24 patients (89 percent) who had an average weight gain of 28 gm/day. Nitrogen balance and plasma amino acids were measured in five patients while they received 2.25 gm of amino acid/kd/day for two weeks and 4.58 gm of amino acid/kg/day for two weeks; the nitrogen balance and weight gain in three patients was proportional to the amino acid intake. When compared to normal levels, plasma amino acids were not appreciably increased with the lower amino acid intake. With the higher amino acid intake, there were significant increases in plasma values for 11 amino acids.
Assuntos
Diarreia Infantil/dietoterapia , Equilíbrio Ácido-Base , Administração Oral , Alanina Transaminase/sangue , Aminoácidos/administração & dosagem , Aminoácidos/sangue , Nitrogênio da Ureia Sanguínea , Peso Corporal , Eletrólitos/administração & dosagem , Feminino , Glucose/administração & dosagem , Glicina/sangue , Glicina/urina , Hematócrito , Hemoglobinas/análise , Humanos , Lactente , Recém-Nascido , Doenças do Recém-Nascido/dietoterapia , Lipídeos/sangue , Masculino , Metionina/urina , Necessidades Nutricionais , Óleo de Cártamo/administração & dosagem , Vitaminas/administração & dosagemAssuntos
Erros Inatos do Metabolismo dos Aminoácidos , Deficiência de Vitamina B 12/genética , Vitamina B 12/uso terapêutico , Cistationina/sangue , Cistationina/urina , DNA/biossíntese , Sistema Hematopoético/efeitos dos fármacos , Homocisteína/sangue , Humanos , Lactente , Recém-Nascido , Isomerases/metabolismo , Leucócitos/metabolismo , Malonatos/urina , Metionina/sangue , Metionina/urina , Metiltransferases/metabolismo , Oxirredução , Propionatos/sangue , Succinatos/sangue , Vitamina B 12/administração & dosagem , Deficiência de Vitamina B 12/tratamento farmacológicoAssuntos
Alimentos , Fenômenos Fisiológicos da Nutrição do Lactente , Metionina/metabolismo , Aminoácidos/sangue , Feminino , Humanos , Lactente , Alimentos Infantis , Recém-Nascido , Masculino , Metionina/administração & dosagem , Metionina/efeitos adversos , Metionina/sangue , Metionina/urina , Nitrogênio/metabolismo , Glycine maxAssuntos
Homocistinúria/tratamento farmacológico , Piridoxina/uso terapêutico , Adolescente , Adulto , Aminoácidos/análise , Plaquetas/fisiopatologia , Criança , Pré-Escolar , Eritrócitos/análise , Feminino , Cabelo/análise , Homocistina/sangue , Homocistina/urina , Homocistinúria/diagnóstico , Homocistinúria/genética , Humanos , Masculino , Metionina/sangue , Metionina/urina , Urina/análiseRESUMO
The gamma-emitting amino acid [75Se]selenomethionine was given to rats and to human infants, and the rate and route of excertion of 75Se was followed for several weeks by daily measurements in a 4 pi whole body counter. These data were used to calculate the turnover rate of total body protein, and the results were checked against other, technically more difficult, methods.(AU)