RESUMO
OBJECTIVES: To evaluate the impact of the inclusion of computed tomographic colonography (CTC) involving faecal tagging and no laxatives on the computed tomography (CT) study routinely used in staging patients with colorectal cancer. METHODS: CTC was performed on 25 patients who had a diagnosis of colorectal carcinoma, with pathological correlation. Researchers recorded the accuracy of the CTC for staging colorectal cancer, as well as any changes to the plans for surgery based on this exam. The patients' tolerance of the preparation required and the quality of the exams was also evaluated. RESULTS: All exams were well-tolerated, and only one had unsatisfactory quality. CTC identified all the carcinomas and had an overall accuracy of 80%, 60.1% and 100% for the evaluation of tumour depth, lymph nodes and metastases respectively. CTC identified all polyps greater than 9 mm. Following CTC, changes to surgical plans were observed in 20.8% of the cases, all with incomplete optical colonoscopies. CONCLUSIONS: CTC proved useful for the pre-operative evaluation of patients with a diagnosis of colorectal carcinoma, affecting plans for surgery in a expressive number of patients with an incomplete colonoscopy.
Assuntos
Colonografia Tomográfica Computadorizada/métodos , Neoplasias Colorretais/diagnóstico por imagem , Neoplasias Colorretais/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias Colorretais/patologia , Meios de Contraste , Feminino , Humanos , Iotalamato de Meglumina , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Interpretação de Imagem Radiográfica Assistida por Computador , Sensibilidade e Especificidade , Ácidos Tri-IodobenzoicosRESUMO
OBJECTIVE: To evaluate the effects of iodine contrast media and gadoteric acid in acute necrotizing pancreatitis. METHODS: Fifty rabbits were distributed in 5 groups: 10 rabbits were assigned in the control group (group 5) and 40 rabbits were assigned in the pancreatitis group, wherein acute necrotizing pancreatitis was induced through retrograde injection of 5% sodium taurocholate (1 mL/kg weight) in the main pancreatic duct. After 3 hours, they were randomized to receive endovenous iodinized nonionic contrast medium (group 1), iodinized ionic contrast medium (group 2), gadoteric acid (group 3), and physiological serum at 0.9% (group 4). Six hours after induction of pancreatitis, these animals were reoperated. During surgery, pancreatic tissue flow through laser Doppler, hematometric values, biochemistry, and histopathology analysis by hematoxylin and eosin were done. Statistical analysis using Kruskal-Wallis, Fisher-Freeman-Halton, and parametric t tests was performed. RESULTS: There was statistical significance when comparing tissue flow before and after induction of pancreatitis (P < 0.0001). Ionic and nonionic contrast media and gadoteric acid did not increase the grade of pancreatic necrosis (P > 0.05). CONCLUSIONS: Ionic and nonionic contrast media and gadoteric acid did not produce adverse effects in the present model of acute necrotizing pancreatitis.
Assuntos
Meios de Contraste/farmacologia , Compostos Heterocíclicos/farmacologia , Iohexol/análogos & derivados , Iotalamato de Meglumina/farmacologia , Compostos Organometálicos/farmacologia , Pâncreas/efeitos dos fármacos , Pancreatite Necrosante Aguda/patologia , Animais , Meios de Contraste/administração & dosagem , Meios de Contraste/química , Modelos Animais de Doenças , Compostos Heterocíclicos/administração & dosagem , Injeções Intravenosas , Iohexol/administração & dosagem , Iohexol/química , Iohexol/farmacologia , Iotalamato de Meglumina/administração & dosagem , Iotalamato de Meglumina/química , Fluxometria por Laser-Doppler , Necrose , Compostos Organometálicos/administração & dosagem , Concentração Osmolar , Pâncreas/irrigação sanguínea , Pâncreas/patologia , Pancreatite Necrosante Aguda/induzido quimicamente , Pancreatite Necrosante Aguda/fisiopatologia , Coelhos , Fluxo Sanguíneo Regional/efeitos dos fármacos , Ácido Taurocólico , Fatores de TempoRESUMO
The purpose of this study was to show that the nonionic contrast media of low osmolarity are better tolerated than ionic media of high osmolarity, which to date are most frequently used in the authors hospital. We found that adverse reaction occurred in 80% of the group in which nonionic contrast medium was used. The authors conclude that nonionic, low osmolarity contrast media significantly reduce the frequency of adverse reactions and increase their safe use
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Meios de Contraste/efeitos adversos , Ácidos Tri-Iodobenzoicos , Concentração Osmolar , Estudos Prospectivos , Injeções Intravenosas , Iotalamato de Meglumina/administração & dosagem , Iotalamato de Meglumina/efeitos adversos , Meios de Contraste/administração & dosagemRESUMO
The purpose of this study was to show that the nonionic contrast media of low osmolarity are better tolerated than ionic media of high osmolarity, which to date are most frequently used in the authors hospital. We found that adverse reaction occurred in 80% of the group in which nonionic contrast medium was used. The authors conclude that nonionic, low osmolarity contrast media significantly reduce the frequency of adverse reactions and increase their safe use.
Assuntos
Meios de Contraste/efeitos adversos , Adolescente , Adulto , Idoso , Meios de Contraste/administração & dosagem , Feminino , Humanos , Injeções Intravenosas , Iotalamato de Meglumina/administração & dosagem , Iotalamato de Meglumina/efeitos adversos , Masculino , Pessoa de Meia-Idade , Concentração Osmolar , Estudos Prospectivos , Ácidos Tri-Iodobenzoicos/administração & dosagem , Ácidos Tri-Iodobenzoicos/efeitos adversosRESUMO
The purpose of this study was to verify and compare the different types of reactions to iodinated contrast media available at the Social Security Metropolitan Hospital Complex: Conray 60%, Vascoray and Uromiron. These are ionic, high osmolality compounds. The authors found that, in 400 patients not only the osmolality had an important role in the reactions observed, but that the intrinsic nature of the molecule of the contrast medium used was the determining factor.
Assuntos
Meios de Contraste/efeitos adversos , Iodamida/análogos & derivados , Iotalamato de Meglumina/efeitos adversos , Ácido Iotalâmico/efeitos adversos , Adolescente , Adulto , Idoso , Combinação de Medicamentos , Feminino , Humanos , Iodamida/efeitos adversos , Iodopamida/análogos & derivados , Masculino , Pessoa de Meia-Idade , Concentração Osmolar , Estudos ProspectivosRESUMO
The purpose of this study was to verify and compare the different types of reactions to iodinated contrast media available at the Social Security Metropolitan Hospital Complex: Conray 60%, Vascoray and Uromiron. These are ionic, high osmolality compounds. The authors found that, in 400 patients not only the osmolality had an important role in the reactions observed, but that the intrinsic nature of the molecule of the contrast medium used was the determining factor
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Iodamida/análogos & derivados , Iotalamato de Meglumina/efeitos adversos , Meios de Contraste/efeitos adversos , Ácido Iotalâmico/efeitos adversos , Combinação de Medicamentos , Concentração Osmolar , Estudos Prospectivos , Iodamida/efeitos adversosRESUMO
Foram analisadas as alteraçöes hemodinâmicas, eletrocardiográficas e reaçöes sistêmicas, em 30 pacientes estudados pela cinecoronariografia e ventriculografia esquerda, com o objetivo de comparar os efeitos de dois meios de contraste. Aleatoriamente, foram empregados os meios de contraste AG 64-03 e o iotalamato de meglumina e sódio, em 18 e 12 pacientes (grupo A e B), respectivamente. A freqüência cardíaca (FC) e as pressöes sistólica, diastólica final e média do ventrículo (VE) (PSVE, PD2 VE e PMVE) foram registradas antes e após a ventriculografia esquerda e ao final da cinecoronariografia. Observou-se, após a ventriculografia, maior aumento da FC no grupo B (p < 0,01) e maior aumento da PSVE, após a coronariografia (p < 0,001). As outras variáveis näo apresentaram diferenças significativas. O tempo de recuperaçäo do eletrocardiograma (ECG), no grupo A foi de 14 + ou - 3s, contra 28 + ou - 10s no grupo B (p <0,001). Durante a injeçäo de contraste na coronária esquerda (CE), o grupo B apresentou uma incidência de 40% de arritmias no ECG, enquanto o grupo A nada registrou. Os efeitos colaterais sistêmicos foram discretos em ambos os grupos. Visto que as maiores diferenças dos efeitos colaterais destes dois meios de contraste säo verificadas no ECG, conclui-se que a menor viscosidade (7,5/9,0 cP) e a menor concentraçäo de sal de sódio (9,66/26,00%) do contraste AG 64-03 devem ser os fatores responsáveis pela diminuiçäo de tais efeitos indesejáveis e que o contraste AG 64-03 oferece mais segu