RESUMO
Se revisó la bibliografía disponible sobre la morbilidad y mortalidad neonatales, tanto nacional como foránea y se decidió hacer referencia a importantes aspectos relacionados con el tema, entre los cuales figuraron, además de una reseña histórica: clasificación y registro de las causas de muerte (síndrome de dificultad respiratoria, enfermedad de la membrana hialina, infecciones, displasia broncopulmonar y malformaciones congénitas), tipo de parto (complicaciones y prematuridad), así como bajo peso al nacer. De la información obtenida se infirió que el nacimiento de neonatos con insuficiencia ponderal para la edad gestacional, todavía constituye una grave situación de salud en el mundo de hoy, sobre todo en los países tercermundistas, donde no se dispone de recursos suficientes para brindar una adecuada asistencia sanitaria a la población.
The available literature either national or foreign about the neonate morbidity and mortality was reviewed and it was decided to make reference to important aspects related with the topic, among which there were figured, besides a historical review: classification and register of the death causes (distress syndrome, hyaline membrane disease, infections, bronchopulmonary dysplasia and congenital malformations), delivery type (complications and prematurity), as well as low birth weight. Of the obtained information it was inferred that the neonates birth with ponderal inadequacy for the gestational age, still constitutes a severe health situation in today's world, mainly in the third world countries, where enough resources are nor disposable to offer an appropriate health care to the population.
Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Recém-Nascido , Mortalidade Infantil , Morbidade , Fatores de Risco , Mortalidade Neonatal Precoce , Insuficiência de Crescimento/mortalidade , Mortalidade PerinatalRESUMO
OBJECTIVE: To determine the cause-specific risks of death in children with epidermolysis bullosa (EB). STUDY DESIGN: Data were collected throughout the continental United States between 1986 and 2002 by the National EB Registry. The study design is cross-sectional (n = 3280), containing within it a nested randomly sampled longitudinal subcohort (n = 450). RESULTS: The risk of death during infancy and childhood was greatest in junctional EB (JEB), with cumulative and conditional risks of 40% to 44.7% by age 1 in both JEB subtypes, rising to 61.8% in children with JEB, Herlitz subtype and 48.2% in those with JEB, non-Herlitz subtype (JEB-nH) by age 15. In decreasing order, sepsis, failure to thrive, and respiratory failure were the major causes of death in children with JEB, plateauing by age 2 to 6. A small minority of children with epidermolysis bullosa simplex, Dowling-Meara subtype was at risk for death by age 1 (cumulative risk, 2.8%), with sepsis and respiratory failure accounting for cumulative risks of 1.9% and 0.9%. Only a minority of children with recessive dystrophic epidermolysis bullosa, Hallopeau-Siemens subtype was at risk of death (cumulative risk = 8% by age 15). Renal failure also rarely accounted for death in children with JEB-nH. CONCLUSIONS: Infants and children with inherited EB, particularly those with JEB, are at significant risk of death as a result of disease complications.