RESUMO
The aim of this work was to investigate if MCH modifies the feeding and freezing responses in rats exposed to stressful stimuli. We used a basic version of contextual fear, where one group of rats were placed in a novel environment and two different groups were exposed to footshock paradigms, one of them escapable and the other one inescapable. At the end of each treatment, freezing and feeding were measured. Only the animals exposed to inescapable footshock paradigm showed significant increase in the food intake and freezing behavior in comparison to the control animals. The MCH administration (intra-hippocampal or intra-amygdaline) reverted these effects elicited by inescapable footshock. Results presented in this paper lead us to the assumption that the anxiolytic effect of the peptide is responsible for the reversion of the IS effects.
Assuntos
Comportamento Animal/efeitos dos fármacos , Hormônios Hipotalâmicos/uso terapêutico , Melaninas/uso terapêutico , Hormônios Hipofisários/uso terapêutico , Estresse Fisiológico/tratamento farmacológico , Tonsila do Cerebelo/efeitos dos fármacos , Tonsila do Cerebelo/metabolismo , Animais , Diazepam/metabolismo , Diazepam/farmacologia , Ingestão de Alimentos/efeitos dos fármacos , Ingestão de Alimentos/fisiologia , Hipocampo/efeitos dos fármacos , Hipocampo/metabolismo , Masculino , Ratos , Ratos Wistar , Estresse Fisiológico/psicologia , Fatores de TempoRESUMO
PURPOSE: To report a patient with morning glory syndrome in combination with posterior pituitary ectopia and to emphasize the need for early recognition of this syndrome as an important step towards the diagnosis and treatment of the systemic anomalies that may be associated with it. METHODS: We present a 7-year-old boy who showed short stature, nystagmus, inward deviation and low vision. Ophthalmological and general physical examinations, further endocrine evaluation and magnetic resonance imaging (MRI) of the brain and sella turcica were performed. RESULTS: Both fundi showed symptoms of morning glory syndrome. The discs were pink and deeply excavated, and were surrounded by a ring of chorioretinal pigmentary disturbance. Magnetic resonance imaging revealed the absence of the infundibulum and posterior pituitary ectopia. Growth hormone studies confirmed the diagnosis of growth hormone deficiency. Therapy with recombinant human growth hormone was initiated. CONCLUSIONS: Although most cases of morning glory syndrome occur as isolated ocular abnormalities, it may occur in association with systemic anomalies, including posterior pituitary ectopia and hypopituitarism. A complete general physical examination and growth evaluation is important for early detection and treatment, resulting in benefit for these patients.
Assuntos
Anormalidades Múltiplas , Anormalidades do Olho/complicações , Hipopituitarismo/congênito , Disco Óptico/anormalidades , Neuro-Hipófise/anormalidades , Criança , Anormalidades do Olho/diagnóstico , Humanos , Hipopituitarismo/diagnóstico , Imageamento por Ressonância Magnética , Masculino , Disco Óptico/patologia , Neuro-Hipófise/patologia , Hormônios Hipofisários/deficiência , Hormônios Hipofisários/uso terapêutico , SíndromeRESUMO
De 03/97 a 02/00 108 pacientes com câncer de próstata tratados por radioterapia-45Gy e braquiterapia de alta taxa (BATD) foram avaliados quanto controle bioquímico (CB), complicações e agrupados pelo risco de falha: baixo (BR) e alto (AR), sem ou com bloqueio androgênico neoadjuvante (AD) Os BR apresentaram GS<6, Assuntos
Humanos
, Masculino
, Adulto
, Idoso
, Braquiterapia/métodos
, Neoplasias da Próstata/complicações
, Neoplasias da Próstata/radioterapia
, Antígeno Prostático Específico/análise
, Fracionamento da Dose de Radiação
, Seguimentos
, Hormônios Hipofisários/uso terapêutico
RESUMO
O autor com base nas provas dinâmicas de funçäo hormonal faz uma classificaçäo das oligozoospermias de causa endócrina e, baseado na mesma, um resumo das possibilidades de tratamento hormonal dessas oligozoospermias