Assuntos
Histoplasmose/diagnóstico , Pneumopatias Fúngicas/diagnóstico , Adulto , Animais , Animais Selvagens/microbiologia , Argentina , Columbidae/microbiologia , Diagnóstico Diferencial , Fezes/microbiologia , Hepatomegalia/etiologia , Histoplasmina/imunologia , Histoplasmose/complicações , Histoplasmose/diagnóstico por imagem , Histoplasmose/patologia , Histoplasmose/transmissão , Humanos , Hipergamaglobulinemia/etiologia , Imunodifusão , Testes Intradérmicos , Pneumopatias Fúngicas/complicações , Pneumopatias Fúngicas/diagnóstico por imagem , Pneumopatias Fúngicas/patologia , Pneumopatias Fúngicas/transmissão , Masculino , Ratos/microbiologia , Esplenomegalia/etiologia , Tomografia Computadorizada por Raios XRESUMO
Histoplasma capsulatum is a dimorphic pathogenic fungus that causes a wide spectrum of disease when mycelial fragments are inhaled. Resistance to H. capsulatum is dependent on cellular immunity mediated by T cells and macrophages. Here we standardized the production of extracts containing cell-free antigens (CFAgs) and observed their efficacy in evaluating cellular immunity during murine histoplasmosis. CFAgs induced a more potent delayed-type hypersensitivity (DTH) response in H. capsulatum-infected mice than did histoplasmin-a classical antigen. This DTH response to CFAgs is able to determine the immune status of infected mice and to predict their death. Moreover, CFAgs stimulated spleen cells from immune mice to produce higher amounts of gamma interferon (IFN-gamma) in vitro. Finally, immunization with CFAgs protected against a lethal inoculum of H. capsulatum. These results demonstrate that CFAgs may be useful for the evaluation of cellular immune response and as a potential source for the development of a vaccine against histoplasmosis.
Assuntos
Antígenos de Fungos/administração & dosagem , Antígenos de Fungos/imunologia , Histoplasma/imunologia , Histoplasmina/imunologia , Histoplasmose/imunologia , Histoplasmose/prevenção & controle , Animais , Antígenos de Fungos/isolamento & purificação , Histoplasma/patogenicidade , Histoplasmina/administração & dosagem , Histoplasmose/microbiologia , Histoplasmose/mortalidade , Humanos , Hipersensibilidade Tardia , Imunidade Celular , Imunização , Interferon gama/biossíntese , Masculino , Camundongos , Camundongos Endogâmicos CBA , Baço/citologia , Baço/imunologiaRESUMO
Since Paracoccidioides brasiliensis and Histoplasma capsulatum are known to be present in similar environments, there have been many epidemiologic investigations regarding the prevalences of these two organisms. However, cross-reactivity can occur in paracoccidioidin and histoplasmin skin tests, and this usually results in the overestimation of the prevalence of P. brasiliensis. The prevalence of infection with P. brasiliensis was evaluated in a cross-sectional study of 298 asymptomatic school children in the Brazilian Amazon region (Mato Grosso State). In this investigation, the reactivity of children to two different P. brasiliensis antigen preparations, paracoccidioidin and a purified 43-kD glycoprotein (gp43), was compared with or without the co-administration of histoplasmin. In the group of individuals receiving paracoccidioidin who had a positive histoplasmin skin test result, the prevalence of exposure to P. brasiliensis was 44% (16 of 36). This reactivity to P. brasiliensis was significantly higher than that observed in other groups, which ranged from 4% to 6% (P < 5 x 10(-4) for each). Overall prevalence was 4.6% (95% confidence interval = 2.5-7.7%). These data suggest that gp43 provides a better estimate of exposure to P. brasiliensis when the co-administration of histoplasmin is desired.
Assuntos
Antígenos de Fungos/análise , Proteínas Fúngicas , Glicosaminoglicanos/análise , Histoplasmina/análise , Paracoccidioides/imunologia , Paracoccidioidomicose/epidemiologia , Adolescente , Brasil/epidemiologia , Criança , Feminino , Proteínas Fúngicas/imunologia , Glicoproteínas/imunologia , Glicosaminoglicanos/imunologia , Histoplasmina/imunologia , Humanos , Testes Intradérmicos , Masculino , Paracoccidioidomicose/diagnóstico , Paracoccidioidomicose/imunologia , Prevalência , Testes CutâneosRESUMO
Paracoccidioidomycosis is a systemic mycoses caused by Paracoccidioides brasiliensis, a dimorphic fungus that infects man through respiratory ducts. It has been accepted that its ecological niche is located in the soil and plants of subtropical forests of Latin America. The Province of Corrientes is located at the northeastern border of Argentina, in a subtropical area where important environmental modifications have been introduced in the last decade as consequence of damming the Paranà river at Yacyretà, one of the biggest hydroelectric dams in the world. Since there are no data on human infection provoqued by this fungal agent in Corrientes, the purpose of this study was to obtain information at present time about infection indexes and to assess if environmental changes introduced in the area could impact on the epidemiology of the disease. Skin tests with paracoccidioidin and histoplasmin were performed on 455 persons of both sexes, from 1 to 73 years of age, who live permanently in the area and voluntarily accepted to be included in the study. Both antigens were employed at the same time in order to evaluate crossed type reactions. Of the 455 persons, 52 (39 males-13 females) were reactive to paracoccidioidin (11.4%), with an increasing prevalence with age. According to previous data, these results would indicate an increase in the index of human infection by P. brasiliensis, and this may be related to the important changes in climatic and environmental conditions introduced in the area in the last years.
Assuntos
Meio Ambiente , Paracoccidioidomicose/epidemiologia , Clima Tropical , Adolescente , Adulto , Idoso , Argentina/epidemiologia , Criança , Pré-Escolar , Feminino , Proteínas Fúngicas/imunologia , Histoplasmina/imunologia , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Paracoccidioidomicose/diagnóstico , Testes CutâneosRESUMO
OBJECTIVE: Histoplasma capsulatum infection is considered to be endemic in the West Indies. Nevertheless, few epidemiologic studies have been conducted in this area. The histoplasmin skin test reflects the frequency of asymptomatic forms of histoplasmosis. We studied the prevalence of positive skin tests in a population of the French West Indies (Martinique). MATERIALS AND METHODS: Forty one patients (24 females and 17 males), age range 29 to 90 years, were tested for histoplasmin skin sensitivity between August and October 1997, in the department of dermatology of Fort de France (French West Indies). Patients with immunosuppression or personal history of histoplasmosis were excluded. RESULTS: Five patients had a positive skin test (12 p. 100). No significative association was found between a positive skin test and diabetes, rural occupations or exposure to bats. DISCUSSION: Despite the small number of cases, related with difficulties in obtaining histoplasmin, our study showed a sensitivity level similar to medium endemic areas of the USA. The positive skin test rate is much higher than the rate reported before in West Indies, in a sample of the population under 25 years of age.
Assuntos
Doenças Endêmicas , Histoplasmina , Histoplasmose/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Feminino , Histoplasmina/imunologia , Histoplasmose/diagnóstico , Histoplasmose/imunologia , Humanos , Testes Intradérmicos , Masculino , Martinica , Pessoa de Meia-Idade , Sensibilidade e Especificidade , Pele/imunologiaRESUMO
The present work was undertaken to obtain epidemiological data on the extent and distribution of Histoplasma capsulatum var. capsulatum and Paracoccidiodes brasiliensis diseases in the Vipos, La Toma and Choromoro areas. Skin test surveys with histoplasmin and paracoccidioidin were carried out in the permanent human population of those localities. Mycological sputum studies and serological tests were performed to skin test reactors to determine if there were signs or symptoms of active mycotic disease. La Toma and Choromoro are highly prevalent areas of histoplasmosis (>30% the histoplasmin positive individuals) whereas Vipos can be relatively considered a highly prevalent area (between 20-30% the histoplasmin reactors) according to the normally accepted range used to define an endemic disease [2]. Early Histoplasma capsulatum infection (<10 years old) is reported for Vipos and Choromoro. La Toma has the highest rate of previous exposure to P. brasiliensis detected in the studied area (10.2%). Vipos residents are not infected with P. brasiliensis.
Assuntos
Histoplasmose/epidemiologia , Paracoccidioidomicose/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Anticorpos Antifúngicos/sangue , Argentina/epidemiologia , Criança , Pré-Escolar , Proteínas Fúngicas/imunologia , Histoplasma/imunologia , Histoplasma/isolamento & purificação , Histoplasmina/imunologia , Humanos , Lactente , Pessoa de Meia-Idade , Paracoccidioides/imunologia , Paracoccidioides/isolamento & purificação , Prevalência , Testes Cutâneos , Escarro/microbiologiaRESUMO
Introducción: El empleo de un antígeno parcialmente purificado denominado complejo polisacárido-proteína desproinizado de Histoplasma capsulatum (CPPD-Histo), utilizado para discriminar la histoplasmosis de diversas micosis pulmonares y otras enfermedades respiratorias en métodos inmunodiagnósticos de alta sensibilidad, ha sido motivo de estudio desde hace años por nuestro grupo de investigación: Objetivo: En este trabajo se planteó conocer la ubicación celular preferencial del antígeno CPPD-Histo, en las diferentes formas y estructuras de las fases micelial y levaduriforme del hongo. Material y métodos: El estudio se desarrolló mediante inmunolocalización con marcaje de oro coloidal para microscopia electrónica, usando anticuerpos primarios CPPD-Histo específicos. Resultados y discusión: La localización en microscopia electrónica mostró mayor concentración del CPPD-Histo en las zonas de mayor grosor de la capa externa de la pared celular de las proyecciones digitiformes de macroconidios, poco marcaje en pared celular de hifas, y una distribución dispersa de la marca en las levaduras. Conclusión: La pared celular de los macroconidios de la fase micelial del hongo es la estructura fúngica con mayor concentración del antígeno CPPD-Histo
Assuntos
Complexo Antígeno-Anticorpo , Coloide de Ouro , Histoplasma/imunologia , Histoplasma/ultraestrutura , Histoplasmina , Histoplasmina/química , Histoplasmina/imunologia , Micelas , Microscopia Eletrônica , Relação Estrutura-Atividade , Testes Imunológicos/métodosRESUMO
O estudo envolve a comparaçäo entre o antigeno polissacaridico de Histoplasma capsulatum com a histoplasmina classica em inquerito epidemiologico, atraves de provas intradermicas de hipersensibilidade do tipo tardio, realizado em 115 individuos da regiäo de Santo Amaro. Os resultados revelaram 46 por cento de provas positivas com a histoplasmina classica e 51,30 por cento de resultados positivos com o antigeno polissacaridico em sua maior concentraçäo. A principal conclusao da pesquisa: e possível utilizar o antigeno polissacaridico como histoplasmina, em substituiçäo ao antigeno filtrado
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Histoplasmina/imunologia , Hipersensibilidade Tardia , Polissacarídeos/imunologia , Brasil , Testes Intradérmicos/métodosRESUMO
Immunologic and occupational aspects of the susceptible population exposed to Histoplasma capsulatum, the causative agent of histoplasmosis were analyzed in the Mexican State of Guerrero. Three areas were studied, Juxtlahuaca, Olinala, and Coyuca; in the first two, their populations refer contact with bat guano and/or avian excreta, which contain nutrients for fungal growth, while the Coyuca population referred no contact with the above mentioned excreta. Previous infection with H. capsulatum was determined by histoplasmin-skin test, and the response was higher in men than in women (93.87, 85.71, and 6.6% for men, and 78.94, 66.6, and 0% for women) in Juxtlahuaca, Olinala, and Coyuca, respectively. Labor activities related to a persistent contact with the fungus were considered as an occupational risk factor, histoplasmin-skin test reached 88.57 and 36.36% of positive response in individuals with high and low risk activities. A high percentage of histoplasmin responses was observed in subjects with constant contact with H. capsulatum, such as, cave-tourist guides, peasants, and game-cock handlers, and generally they developed the largest diameter of skin reactions. Genetic risk factor was determined by studying the gene frequency of the Major Histocompatibility Complex antigens in a sample of individuals and their degree relatives in Juxtlahuaca, Olinala, and Coyuca. Significant differences were found for HLA-B22 and B17 antigens in Juxtlahuaca, and for HLA-B22 in Olinala, in comparison to the usual gene frequency observed in the normal Mexican population. HLA results were important, considering that HLA-B22 was previously found to be possibly related to pulmonary histoplasmosis in Guerrero.
Assuntos
Histoplasmose/epidemiologia , Doenças Profissionais/epidemiologia , Exposição Ocupacional/efeitos adversos , Animais , Aves , Quirópteros , Feminino , Frequência do Gene , Antígenos HLA-A/sangue , Antígenos HLA-A/genética , Antígenos HLA-B/sangue , Antígenos HLA-B/genética , Antígenos HLA-C/sangue , Antígenos HLA-C/genética , Teste de Histocompatibilidade , Histoplasma/imunologia , Histoplasma/patogenicidade , Histoplasmina/imunologia , Histoplasmose/genética , Histoplasmose/imunologia , Humanos , Masculino , México/epidemiologia , Doenças Profissionais/genética , Doenças Profissionais/imunologia , Exposição Ocupacional/estatística & dados numéricos , Fatores de Risco , Saúde da População Rural , Fatores Sexuais , Testes CutâneosRESUMO
This work was planned by taking into account all the knowledge accumulated from the immunological study of paracoccidioidomycosis. It aimed at comparing a polysaccharide antigen from Histoplasma capsulatum to a classic histoplasmin with the help of intradermal tests of delayed type of hypersensitivity. Tests were applied to 115 individuals in Santo Amaro, a town in the State of São Paulo. Positive results using classic histoplasmin were obtained in 46.0% cases whereas positive results using the polysaccharide antigen at its highest concentration were obtained in 51.30% cases. The major conclusion in this investigation is that it is possible to use the polysaccharide antigen as histoplasmin instead of the filtrate antigen.
Assuntos
Antígenos de Fungos/imunologia , Histoplasma/imunologia , Histoplasmina/imunologia , Polissacarídeos/imunologia , Adolescente , Adulto , Idoso , Feminino , Humanos , Hipersensibilidade , Testes Intradérmicos , Masculino , Pessoa de Meia-Idade , Paracoccidioidomicose/imunologiaRESUMO
The enzyme-linked immunoelectrotransfer blot (EITB) method was evaluated as a suitable method for detecting antibodies against M antigen of Histoplasma capsulatum by use of both glycosylated and deglycosylated M protein of histoplasmin (HMIN). Sera from patients with histoplasmosis, paracoccidioidomycosis, blastomycosis, coccidioidomycosis, and aspergillosis were tested by the EITB with glycosylated M protein of HMIN. This assay demonstrated 100% sensitivity with histoplasmosis serum samples, all of which reacted with the 94-kDa glycoprotein (M antigen). Although the EITB is highly sensitive, it is not specific for histoplasmosis when glycosylated M protein is used as an antigen. A total of 81% of paracoccidioidomycosis, 25% of blastomycosis, 33% of coccidioidomycosis, 73% of aspergillosis, and 16% of tuberculosis serum samples cross-reacted with M protein of HMIN and yielded patterns indistinguishable from those obtained with histoplasmosis serum samples. The EITB reactions with both untreated M antigen and M antigen altered by periodate oxidation or by deglycosylation with endoglycosidases were compared. Cross-reactions with heterologous sera in the EITB could be attributed to periodate-sensitive carbohydrate epitopes, as reflected by the increase in the test specificity from 46.1 to 91.2% after periodate treatment of M protein. The EITB for the detection of antibodies to M antigen is a potential diagnostic test for histoplasmosis, provided that periodate-treated M protein is used as an antigen.
Assuntos
Histoplasma/imunologia , Histoplasmina/imunologia , Histoplasmose/diagnóstico , Especificidade de Anticorpos , Reações Cruzadas , Epitopos/imunologia , Glicosilação , Histoplasma/enzimologia , Histoplasmina/metabolismo , Histoplasmose/imunologia , Humanos , Immunoblotting , Técnicas Imunoenzimáticas , Mitógenos , Oxirredução , Ácido Periódico , Testes SorológicosRESUMO
A cross-sectional epidemiological survey for paracoccidioidomycosis and histoplasmosis, including skin tests with paracoccidioidin and histoplasmin, physical examinations and X-rays, was conducted among three Tupí-Mondé Amerindian populations from Brazilian Amazonia. The study followed the diagnosis of an increasing number of cases of paracoccidioidomycosis among the Suruí in recent years. Positivity rates to paracoccidioidin and histoplasmin (> or = 5 mm of intradermal induration 24-48 h post-injection) were 43.8% and 78.7% for the Suruí, 6.4% and 5.8% for the Gavião and 14.9% and 80.5% for the Zoró, respectively. There was no significant difference in the results for males and females but marked differences were noted across age groups. The results of the univariate analysis were confirmed after adjustment for confounding variables by multiple logistic regression analysis: paracoccidioidin positivity was relatively high in the Suruí and histoplasmin positivity was relatively high in the Suruí and Zoró. The Suruí's greater exposure to Paracoccidioides brasiliensis, the causative agent of paracoccidioidomycosis, is probably associated with their adoption of new subsistence practices. The epidemiology of this mycosis among the Tupí-Mondé appears to be related to the environmental and socio-economic changes taking place in Amazonia.
Assuntos
Histoplasmose/epidemiologia , Indígenas Sul-Americanos , Paracoccidioidomicose/epidemiologia , Adolescente , Adulto , Fatores Etários , Idoso , Antígenos de Fungos/imunologia , Brasil/epidemiologia , Criança , Pré-Escolar , Estudos Transversais , Feminino , Proteínas Fúngicas/imunologia , Histoplasmina/imunologia , Histoplasmose/etnologia , Humanos , Lactente , Testes Intradérmicos , Masculino , Pessoa de Meia-Idade , Paracoccidioidomicose/etnologia , Fatores SexuaisRESUMO
Se realizo un estudio prospectivo en 40 trabajadores de una granja avicola (grupo 1) considerados con riesgo de exposicion a Histoplasma capsulatum, agente etiologico de la histoplasmosis, y en 16 individuos sin riesgo profesional de exposicion a dicho agente (grupo 2). En ambos grupos se aplico la prueba intradermica de histoplasmina y se obtuvo el suero antes de su aplicacion y a los 30 y 180 dias despues de realizada dicha prueba...
Assuntos
Humanos , Histoplasmina/imunologia , Histoplasmose/diagnóstico , Testes Cutâneos , Ensaio de Imunoadsorção Enzimática , HistoplasminaRESUMO
Sporotrichosis and histoplasmosis are deep mycosis with a high incidence in human beings in Brazil. In domestic animals histoplasmosis has been described only in dogs, but the occurrence of sporotrichosis among domestic animals in Brazil has been described in dogs, cats, mules and asses. There is also a case of this disease reported in a chimpanzee (Pan troglodites). The purpose of this research was to perform an epidomiological study of these mycoses using delayed hypersensitivity tests (histoplasmin and sporotrichin) in Latin American wild mammals. This research was assayed using 96 healthy animals at Parque Zoológico de São Paulo, Brazil: Primates: 33 Cebus apella--weeping-capuchin and 16 Callithrix jacchus--marmoset; Procyonidae: 37 Nasua nasua--coatimundi and 10 Felidae (Panthera onca--jaguar; Felis pardalis--ocelot Felis wiedii--margay; Felis tigrina--wild cat). For intradermic tests, the following antigens were used: Sporothrix schenkii cell suspension (sporotrichin, histoplasmin-filtrate), Histoplasma capsulatum cell suspension (histoplasmin), and Histoplasma capsulatum (polysaccharide). The positivity to histoplasmin was 44.79% (Cebidae 15.15%; Callithricidae 6.25%; Procyonidae 86.49% and Felidae 50.00%, respectively). With respect to sporotrichin, 30.21% (Cebidae 6.06%, Callithricidae 0.0%; Procyonidae 64.86% and Felidae 30.00% respectively). The pattern of infection is similar to that shown by human beings and this may suggest that these animals could be involved in the epidemiologic chain of sporotrichosis and histoplasmosis, the second most prevalent human deep mycoses in Brazil. It is important to point out the absence of similar studies in Latin American wild animals.
Assuntos
Animais Selvagens , Histoplasmose/veterinária , Doenças dos Macacos/epidemiologia , Esporotricose/veterinária , Animais , Animais Selvagens/imunologia , Brasil/epidemiologia , Callithrix/imunologia , Carnívoros/imunologia , Gatos , Cebus/imunologia , Feminino , Glicosaminoglicanos/imunologia , Histoplasmina/imunologia , Histoplasmose/epidemiologia , Histoplasmose/imunologia , Hipersensibilidade Tardia , Masculino , Testes Cutâneos , Esporotricose/epidemiologia , Esporotricose/imunologiaRESUMO
The natural habitat of Paracoccidioides brasiliensis, the aetiologic agent of paracoccidioidomycosis, has not been determined. Consequently, the events leading to the acquisition of infection remain controversial. To identify factors associated with infection in endemic areas we conducted a survey in three rural communities in Colombia where we had previously diagnosed paracoccidioidomycosis in children. Permanent residents were surveyed taking into consideration environmental and occupational variables. Skin tests were used to classify subjects as infected or non-infected. Variables found associated with infection were: (i) community A: previous residence around Porce river and agriculture in vegetable gardens; (ii) community C: frequent use of specific water sources; (iii) community V: housekeeping activities, and (iv) total group: age > 25 years and contact with bats. Residents in communities with higher prevalence of infection were older, had more complex residence history, and referred more contact with armadillos than residents of communities with lower infection.
Assuntos
Paracoccidioidomicose/etiologia , Adolescente , Adulto , Estudos de Casos e Controles , Criança , Colômbia/epidemiologia , Meio Ambiente , Feminino , Proteínas Fúngicas/imunologia , Histoplasmina/imunologia , Humanos , Masculino , Ocupações , Paracoccidioidomicose/epidemiologia , Dinâmica Populacional , Análise de Regressão , Saúde da População Rural , Testes CutâneosRESUMO
Cation exchange chromatography was evaluated to purify the M antigen from histoplasmin (HMIN). Two H and M antigen-containing fractions, soluble (S) and precipitate (PP), resulted from the initial 0.025 M, pH 3.5 citrate buffer dialysis step. The PP fraction contained 62% of the M antigen activity and was resolubilized. Both fractions were chromatographed on CM Sepharose CL-6B. Polysaccharide C antigen was abundant in the S fraction and most of it did not bind to CM Sepharose. M antigen-enriched fractions were eluted with 0.5 M NaCl. Re-chromatography of the relevant S fraction (S-II) and PP fraction (PP-II) by linear gradient fast protein liquid chromatography (FPLC) removed protein and C impurities. M antigen purified by FPLC from the PP-II fraction was depleted of other antigens when Western blots were probed with anti-M, anti-H and anti-C monoclonal antibodies (Mabs). M antigen was identified as a 94 kDa glycoprotein containing a specific-protein epitope and an epitope that reacted with a Mab against the polysaccharide C antigen. M antigen can be purified from HMIN by tandem cation exchange chromatography of the precipitable fraction on an open CM Sepharose CL-6B column followed by linear gradient FPLC.
Assuntos
Cromatografia por Troca Iônica , Glicoproteínas/isolamento & purificação , Histoplasmina/química , Western Blotting , Cromatografia Líquida , Eletroforese em Gel de Poliacrilamida , Epitopos/imunologia , Epitopos/isolamento & purificação , Estudos de Avaliação como Assunto , Glicoproteínas/imunologia , Histoplasma/imunologia , Histoplasmina/imunologiaRESUMO
An epidemiological survey with histoplasmin skin test was performed in 392 poultry farmers and 265 workers considered without occupational risk of exposition to Histoplasma capsulatum, etiologic agent of histoplasmosis. The results were positive in 28.8% and 13.2% in both groups respectively. Statistically, there was a significant difference between the two groups, so it can be considered that poultry farmers are in occupational risk of infection with H. capsulatum. In the first group, the workers which are more closely related with chicken manure showed a higher reactivity to histoplasmin skin test. The working time in the farms seems to influence in the test reactivity too.
Assuntos
Criação de Animais Domésticos , Histoplasmina/imunologia , Aves Domésticas , Adulto , Distribuição por Idade , Doenças dos Trabalhadores Agrícolas/diagnóstico , Doenças dos Trabalhadores Agrícolas/epidemiologia , Animais , Cuba/epidemiologia , Histoplasmose/diagnóstico , Histoplasmose/epidemiologia , Humanos , Exposição Ocupacional/efeitos adversos , Exposição Ocupacional/estatística & dados numéricos , Fatores de Risco , Testes Cutâneos/estatística & dados numéricosAssuntos
Animais , Humanos , Criação de Animais Domésticos , Histoplasmina/imunologia , Aves Domésticas , Adulto , Distribuição por Idade , Doenças dos Trabalhadores Agrícolas/diagnóstico , Doenças dos Trabalhadores Agrícolas/epidemiologia , Cuba/epidemiologia , Resumo em Inglês , Histoplasmina , Histoplasmose/diagnóstico , Histoplasmose/epidemiologia , Exposição Ocupacional/efeitos adversos , Exposição Ocupacional/estatística & dados numéricos , Fatores de RiscoRESUMO
En el presente trabajo se comunican los resultados de una encuesta epidemiológica llevada a cabo en el norte de la Provincia de Córdoba. Se efectuaron intradermorreacciones con coccidioidina e histoplasmina a 308 personas residentes permanentes en la región. Las tasas de prevalencia obtenidas fueron: reactores positivos con histoplasmina 31,81%; reactores positivos con coccidioidina 16,23%. En algunas localidades los porcentajes de infectados con Histoplasma capsulatum fueron mucho más elevados (40,62%). Se obtuvieron reacciones positivas con los dos antígenos en 11%de los testados; en estos casos se sospecharon infecciones dobles. Las cifras obtenidas de infección por Histoplasma capsulatum son equiparables a las que existen en zonas endémicas bien caracterizadas de la Argentina
Assuntos
Coccidioidomicose/epidemiologia , Estudos Transversais , Inquéritos Epidemiológicos , Histoplasmose/epidemiologia , Testes Cutâneos/estatística & dados numéricos , Antígenos de Fungos/imunologia , Antígenos de Fungos , Quirópteros , Coccidioidina , Coccidioidina/imunologia , Coccidioidomicose/diagnóstico , Histoplasmina , Histoplasmina/imunologia , Histoplasmose/diagnósticoRESUMO
En el presente trabajo se comunican los resultados de una encuesta epidemiológica llevada a cabo en el norte de la Provincia de Córdoba. Se efectuaron intradermorreacciones con coccidioidina e histoplasmina a 308 personas residentes permanentes en la región. Las tasas de prevalencia obtenidas fueron: reactores positivos con histoplasmina 31,81%; reactores positivos con coccidioidina 16,23%. En algunas localidades los porcentajes de infectados con Histoplasma capsulatum fueron mucho más elevados (40,62%). Se obtuvieron reacciones positivas con los dos antígenos en 11%de los testados; en estos casos se sospecharon infecciones dobles. Las cifras obtenidas de infección por Histoplasma capsulatum son equiparables a las que existen en zonas endémicas bien caracterizadas de la Argentina