RESUMO

The triterpenes, 22beta-hydroxypristimerin and cognatine, were isolated together with the known compounds pristimerin, maytenin, 20alpha-hydroxymaytenin, 22beta-hydroxymaytenin, netzahualcoyol, netzahualcoyondiol and netzahualcoyone from root bark of Cheiloclinium cognatum. The structures of the isolated compounds were elucidated by interpretation of their spectral data, including gHMQC and gHMBC experiments. The isolates were investigated for their radical scavenging abilities through a spectrophotometric assay involving reduction of 2,2-diphenyl-picryl hydrazyl (DPPH).

Assuntos

Antioxidantes/farmacologia , Hippocrateaceae/química , Triterpenos/farmacologia , Cromatografia Líquida de Alta Pressão , Sequestradores de Radicais Livres/química , Hippocrateaceae/classificação , Espectroscopia de Ressonância Magnética , Modelos Moleculares , Estrutura Molecular , Triterpenos/química , Triterpenos/isolamento & purificação