RESUMO
Gingival overgrowth (GO) is a common side effect of chronic cyclosporine use. The average prevalence of GO is about 30%, ranging from 10% to 85% in various series, due to diverse aggravating risk factors: drug interactions with calcium channel blockers, age, cyclosporine dose, bacterial plaque, and genetic predisposition. Recent studies have demonstrated elevated levels of specific cytokines particularly transforming growth factor-beta (TGF-beta) in hyperplastic gingival tissue, suggesting that this growth factor plays a role in the accumulation of the extracellular matrix. Until recently treatment for this complication was only surgical. Nowadays, several studies have been performed to evaluate the effects of antibiotic treatment on the regression of GO. In the present study, we used roxithromycin, a macrolide antibiotic that has inhibitory effect on TGF-beta production by inflammatory cells. The results suggested that roxithromycin may be an important therapeutic tool to reduce cyclosporine-induced GO.
Assuntos
Ciclosporina/efeitos adversos , Hiperplasia Gengival/prevenção & controle , Transplante de Rim/imunologia , Roxitromicina/uso terapêutico , Adulto , Idoso , Antibacterianos/uso terapêutico , Azatioprina/uso terapêutico , Feminino , Hiperplasia Gengival/induzido quimicamente , Hiperplasia Gengival/patologia , Humanos , Imunossupressores/efeitos adversos , Masculino , Pessoa de Meia-Idade , Prednisona/uso terapêuticoRESUMO
O objetivo deste trabalho foi realizar um levantamento das lesões orais do Hospital Universitário - Unidade Presidente Dutra, da UFMA, no período de 1992 a 2002, sendo analisadas 295 fichas clínicas com seus respectivos laudos de diagnóstico histopatológico. Foram avaliadas a freqüência das lesões orais examinadas, a localização anatômica e a distribuição das mesmas quanto ao tipo, sexo e idade. Cada caso foi classificado em onze diferentes grupos, apresentando-se número e índice percentual das lesões de maiores ocorrências. Os resultados demonstraram um predomínio das lesões proliferativas não neoplásicas, com sessenta casos; a hiperplasia fibrosa inflamatória representou a entidade mais comum, sendo o sexo feminino mais envolvido e na primeira década de vida ocorreu um maior percentual de casos
Assuntos
Humanos , Masculino , Feminino , Adulto , Boca/lesões , Hiperplasia Gengival/diagnóstico , Hiperplasia Gengival/patologia , Hiperplasia Gengival/prevenção & controle , Patologia Bucal , Biópsia/métodos , Diagnóstico Bucal/métodosRESUMO
BACKGROUND: The myelodysplastic syndromes (MDS) are a group of stem cell disorders characterized by a reduction in one or more elements of the peripheral blood. Oral manifestations of the disease and oral complications of medical management may result in significant symptoms and have an impact on the systemic condition of the patient. The removal of the infectious focus, such active teeth infection or severe periodontal disease, remains controversial in these patients, due to the increased risk of bleeding and systemic infection. METHODS: This paper reports a case of MDS with spontaneous gingival hemorrhage and generalized gingival hyperplasia associated with periodontal disease. This patient underwent several platelet transfusions due to these oral complications. The patient received periodontal therapy, resulting in an improvement of the oral clinical situation and a decrease of gingival hyperplasia. RESULTS: The patient did not present any episode of gingival hemorrhage after the periodontal treatment. CONCLUSION: The results of this study suggest that periodontal therapy should be performed in MDS patients presenting thrombocytopenia, gingival hyperplasia, and gingival bleeding, with the intent of preventing further hemorrhagic episodes and possible systemic infection.