1.
J Pediatr
; 91(3): 481-6, 1977 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-894425
RESUMO
Bathing with soap containing hexachlorophene was instituted during two major staphylococcal epidemics in a Neonatal Intensive Care Unit. Infants who weighed less than 1,200 gm, those with a postconceptional age of less than 35 weeks, and those with large areas of abraded skin were at highest risk to achieve elevated blood HCP concentrations. T 1/2 of HCP ranged from 6.1 to 44.2 hours and appeared to follow first order kinetics. Time of peak blood concentrations of HCP following a bath ranged from 6 to 10 hours. One infant with liver disease achieved a concentration of HCP of 4,350 ng/ml after seven baths and developed clinical symptoms consistent with HCP toxicity.
Assuntos
Hexaclorofeno/metabolismo , Recém-Nascido , Autopsia , Banhos , Peso ao Nascer , Surtos de Doenças/prevenção & controle , Feminino , Idade Gestacional , Meia-Vida , Hexaclorofeno/efeitos adversos , Humanos , Doenças do Recém-Nascido/prevenção & controle , Unidades de Terapia Intensiva , Cinética , Hepatopatias/etiologia , Berçários Hospitalares , Infecções Estafilocócicas/prevenção & controle
2.
J Pediatr
; 82(6): 972-5, 1973 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-4702916