RESUMO
1) While the intravenous injection of sodium hydnocarpate may be admitted as the most effective means of administering hydnocarpus preparations, the blocking of veins has hitherto interfered with prolonged administration in this way.2) The sodium salts derived from a special fraction of H. wightiana and also the sodium salts of H. anthelmintica and alpina block the veins less than the salts from the whole H. wightiana oil.3) A new method of mixing the salts prepared from the whole oil of H. wightiana with blood before injection has received vein-blocking to a much more marked extent.4) Alternation of intravenous sodium hydnocarpate with subcutaneous infiltration of hydnocarpus oil with creosote is advised chiefly because of the haemolytic effect of the former preparations.
Assuntos
Chaulmoogra/administração & dosagem , Chaulmoogra/efeitos adversos , Chaulmoogra/uso terapêutico , Hansenostáticos/administração & dosagem , Hansenostáticos/análise , Hansenostáticos/uso terapêutico , Hanseníase/tratamento farmacológicoRESUMO
The constituent fractions of the acids of sapucainha oil have been separated by cold processes as afr as possible and tested for irritant properties. A crystalline acid fraction (chaulmoogric, hydnocarpic and palmitic acids), an oily acid (5 per cent), and a keto-acid (4,5 per cent), gave bland ethyl esters and sodium salts. The only product to exhibit marked irritant properties was a tarry acid fraction (9 per cent), which appeared to consist essentially of a lactonic acid. The ethyl esters of the crystalline acids were not rendered irritant by distillation at 350°/760 mm., but on long exposure in thin layers to ligh and air they change in physical and chemical character and become highly irritant, possibly owing to the production of the lactonic acid above mentioned.