Assuntos
Biomarcadores/urina , Clofazimina/uso terapêutico , Dapsona/uso terapêutico , Fosfatase Alcalina/urina , Hanseníase/fisiopatologia , Hanseníase/tratamento farmacológico , Hanseníase/urina , Microvilosidades/enzimologia , Monitoramento de Medicamentos , Quimioterapia Combinada , Rifampina/uso terapêutico , gama-Glutamiltransferase/uso terapêuticoRESUMO
We have evaluated laboratory and clinical manifestations of renal disease in 96 patients with leprosy, looking for a sensitive and early marker for detection and possibly follow-up of nephropathy in these patients. Microscopic hematuria was observed in 21.9% of the cases (with dysmorphic erythrocytes in 71.4% of them). Abnormal microalbuminuria and urinary beta 2-microglobulin were found in 15.8 and 19.8% of the cases, respectively. We have observed a high frequency of hematuria, abnormal microalbuminuria and elevation of urinary beta 2-microglobulin in these patients still with normal serum creatinine.
Assuntos
Nefropatias/etiologia , Hanseníase/complicações , Adolescente , Adulto , Idoso , Albuminúria/etiologia , Biomarcadores/urina , Criança , Creatinina/sangue , Feminino , Hematúria/etiologia , Humanos , Nefropatias/diagnóstico , Nefropatias/urina , Hanseníase/sangue , Hanseníase/urina , Masculino , Pessoa de Meia-Idade , Microglobulina beta-2/urinaRESUMO
Urinary total gonadotrophins, urinary oestrogens, and plasma-testosterone have been studied in patients with leprosy with and without gynaecomastia and testicular atrophy. Patients with gynaecomastia and testicular atrophy had significantly raised levels of gonadotrophins and lowered plasmatestosterone. It is suggested that leprous orchitis represents a form of acquired Klinefelter's syndrome.