RESUMO

This study links the tumor inhibitory effect of anti-progestins RU486 and ZK98299 to the expression of cell cycle proteins. Medroxyprogesterone acetate-induced ductal mammary adenocarcinoma-bearing female BALB/c mice were treated daily either with RU486 or ZK98299, observing tumor growth retardation. p21 increased after 24 h treatment, peaked at day 4 and returned to control levels at day 7. Cyclin D1, cyclin E, CDK2 and CDK4, did not change during treatment. These results suggest that p21 might play a role in early inhibitory stages of tumor growth induced by RU486 and ZK98299.

Assuntos

Quinases relacionadas a CDC2 e CDC28 , Proteínas de Ciclo Celular/análise , Gonanos/uso terapêutico , Antagonistas de Hormônios/uso terapêutico , Neoplasias Mamárias Experimentais/tratamento farmacológico , Mifepristona/uso terapêutico , Proteínas Proto-Oncogênicas , Animais , Antineoplásicos/uso terapêutico , Divisão Celular/efeitos dos fármacos , Ciclina D1/análise , Ciclina E/análise , Quinase 2 Dependente de Ciclina , Quinase 4 Dependente de Ciclina , Inibidor de Quinase Dependente de Ciclina p21 , Quinases Ciclina-Dependentes/análise , Ciclinas/análise , Inibidores Enzimáticos/análise , Feminino , Neoplasias Mamárias Experimentais/patologia , Camundongos , Camundongos Endogâmicos BALB C , Proteínas Serina-Treonina Quinases/análise , Fatores de Tempo