RESUMO
OBJECTIVE: Investigate the association of clinical, cytological and genetic characteristics with benign migratory glossitis (BMG). STUDY DESIGN: Sample consisted of 175 patients, 44 with BMG and 131 control patients. Clinical examination and DMFT index were assessed. Cytological evaluation determined cell morphology and morphometry. Genetic evaluation was performed by analysing IL6 polymorphisms by real-time PCR. Univariate and multivariate analyses were performed (p<0.05). RESULTS: There was a higher level of anxiety, DMFT score and a prevalence of fissured tongue in BMG group. A high mean nuclear/cytoplasmic area ratio was observed in patients with BMG. There was predominance of Papanicolaou class II I BMG group. IL6 allele G rs2069843 polymorphism was associated with BMG in the dominant model. In multivariate analysis, DMFT and anxiety scale remained associated with BMG.
Assuntos
Glossite Migratória Benigna/genética , Glossite Migratória Benigna/patologia , Adulto , Alelos , Ansiedade/genética , Ansiedade/patologia , Brasil/epidemiologia , Feminino , Predisposição Genética para Doença , Glossite Migratória Benigna/epidemiologia , Glossite Migratória Benigna/psicologia , Humanos , Interleucina-6/genética , Desequilíbrio de Ligação , Masculino , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único , Prevalência , Fatores Socioeconômicos , Língua Fissurada/epidemiologia , Língua Fissurada/genéticaRESUMO
OBJECTIVE: Benign migratory glossitis (BMG) is a disease that affects the tongue and is considered an inflammatory disorder well recognized. It is characterized by the appearance of erosive areas on the dorsum and lateral border of the tongue that can be isolated or multiple. The aim of this study was to assess whether the perception of taste to the four basic tastes is altered due to the presence of BMG. METHODS: Forty individuals of both sexes with a mean age of 12.1 years were divided into two groups (20 BMG patients and 20 healthy controls) and had their taste function assessed in relation to four basic tastes: bitter, sour, sweet, and salty. RESULTS: All participants in the case group exhibited lesions over the dorsum, edges and tip of the tongue with a possible extension to the surface below. No statistic difference was observed between BMG patients and controls for the taste scores (Mann-Whitney U test: P=0.0955). The percentage of correctly identified taste strips for the highest concentrations was 100% for all tastes. For the lowest concentrations it was 85% for sweet, 50% for sour, 95% for salty, and 95% for bitter. Three patients with BMG and three control subjects showed hypogeusia. CONCLUSION: This study revealed that BMG is not able to change the perception of taste for salty, sweet, sour and bitter.