RESUMO
Retinoic acid is a widely used drug in the treatment of cystic acne. It has teratogenic effects that depend on the gestational period in which it is used. We report a seven months old female whose mother was exposed to retinoic acid in both pre-gestational and gestational periods. She had a retardation of psychomotor development and a brain MRI showed frontal atrophy and a malformation of the posterior fossa. We discuss the mechanisms of the teratogenic effects of retinoic acid.
Assuntos
Anormalidades Induzidas por Medicamentos , Anormalidades Múltiplas/induzido quimicamente , Anormalidades Craniofaciais/induzido quimicamente , Isotretinoína/efeitos adversos , Ceratolíticos/efeitos adversos , Teratogênicos , Acne Vulgar/tratamento farmacológico , Atrofia/induzido quimicamente , Fossa Craniana Posterior/anormalidades , Fossa Craniana Posterior/efeitos dos fármacos , Feminino , Lobo Frontal/anormalidades , Lobo Frontal/efeitos dos fármacos , Humanos , Lactente , Exposição Materna/efeitos adversos , Gravidez , Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente , Transtornos Psicomotores/induzido quimicamente , Tretinoína/efeitos adversosRESUMO
Retinoic acid is a widely used drug in the treatment of cystic acné. It has teratogenic effects that depend on the gestational period in which it is used. We report a seven months of female whose mother was exposed to retinoic acid in both pregestational and gestational periods. She had a retardation of psychomotor development and a brain MRI showed frontal atrophy and a malformation of the posterior fossa. We discuss the mechanisms ofthe teratogenic effeets of retinoic acid.