RESUMO
In this chapter, we describe a multi-purpose, reversed-phase liquid chromatography-high-resolution mass spectrometry (LC-HRMS) workflow for acquiring high-quality, non-targeted exposomics data utilizing data-dependent acquisition (DDA) combined with the use of toxicant inclusion lists for semi-targeted analysis. In addition, we describe expected retention times for >160 highly diverse xenobiotics in human plasma and serum samples. The method described is intended to serve as a generic LC-HRMS exposomics workflow for research and educational purposes. Moreover, it may be employed as a primer, allowing for further adaptations according to specialized research needs, e.g., by including reference and/or internal standards, by expanding to data-independent acquisition (DIA), or by modifying the list of compounds prioritized in fragmentation experiments (MS2).
Assuntos
Espectrometria de Massas , Humanos , Cromatografia Líquida/métodos , Espectrometria de Massas/métodos , Fluxo de Trabalho , Metabolômica/métodos , Xenobióticos/análise , Cromatografia de Fase Reversa/métodos , Espectrometria de Massas em Tandem/métodos , Exposição Ambiental/análiseRESUMO
With the continuous control of anthropogenic emissions, China's air quality has improved significantly in recent years. Given this background, research on how the short-term exposure risks caused by air pollution in China have changed is insufficient. This study utilized hourly concentration data from ground observation stations and the official air quality guidelines of the Ministry of Ecology and Environment of China and the World Health Organization as standards to systematically investigate the spatiotemporal characteristics and short-term exposure risks of air pollution in China from 2015 to 2022. The results indicate that various atmospheric pollutants except for ozone showed a decreasing trend yearly. Nationwide, both single pollutant air pollution days (SAPDs) and multiple pollutant air pollution days (MAPDs) showed varying degrees of reduction within 15 and 25 days, respectively. SAPD was dominated mainly by excessive PM2.5 and PM10 pollutants, while MAPD was dominated mainly by excessive pollutant combinations, including PM2.5 + PM10, CO + PM2.5 + PM10, and SO2 + PM2.5 + PM10. As the concentration of atmospheric pollutants decreased, the total excess risk (ER) decreased yearly from 2015 to 2022, but there were significant regional differences. Now, the ER is less than 0.25% in southern China, in the range of 0.25%-0.5% in the North China Plain and some cities in the northeast, and higher than 1% in the northwest. Particulate matter is currently the primary pollutant posing short-term exposure risk in China, especially due to the impact of sandstorm weather. This study indicates that China's atmospheric cleaning action is significantly beneficial for reducing health risks.
Assuntos
Poluentes Atmosféricos , Poluição do Ar , Exposição Ambiental , Monitoramento Ambiental , Material Particulado , China , Poluição do Ar/estatística & dados numéricos , Poluentes Atmosféricos/análise , Material Particulado/análise , Humanos , Medição de RiscoRESUMO
Endocrine-disrupting chemicals (EDCs) are compounds, either natural or man-made, that interfere with the normal functioning of the endocrine system. There is increasing evidence that exposure to EDCs can have profound adverse effects on reproduction, metabolic disorders, neurological alterations, and increased risk of hormone-dependent cancer. Stem cells (SCs) are integral to these pathological processes, and it is therefore crucial to understand how EDCs may influence SC functionality. This review examines the literature on different types of EDCs and their effects on various types of SCs, including embryonic, adult, and cancer SCs. Possible molecular mechanisms through which EDCs may influence the phenotype of SCs are also evaluated. Finally, the possible implications of these effects on human health are discussed. The available literature demonstrates that EDCs can influence the biology of SCs in a variety of ways, including by altering hormonal pathways, DNA damage, epigenetic changes, reactive oxygen species production and alterations in the gene expression patterns. These disruptions may lead to a variety of cell fates and diseases later in adulthood including increased risk of endocrine disorders, obesity, infertility, reproductive abnormalities, and cancer. Therefore, the review emphasizes the importance of raising broader awareness regarding the intricate impact of EDCs on human health.
Assuntos
Disruptores Endócrinos , Células-Tronco , Disruptores Endócrinos/toxicidade , Humanos , Células-Tronco/efeitos dos fármacos , Poluentes Ambientais/toxicidade , Exposição AmbientalRESUMO
This study investigated environmental distribution and human exposure of polycyclic aromatic hydrocarbons (PAHs) and their derivatives in one Chinese petroleum refinery facility. It was found that, following with high concentrations of 16 EPA PAHs (∑Parent-PAHs) in smelting subarea of studied petroleum refinery facility, total derivatives of PAHs [named as XPAHs, including nitro PAHs (NPAHs), chlorinated PAHs (Cl-PAHs), and brominated PAHs (Br-PAHs)] in gas (mean= 1.57 × 104 ng/m3), total suspended particulate (TSP) (mean= 4.33 × 103 ng/m3) and soil (mean= 4.37 × 103 ng/g) in this subarea had 1.76-6.19 times higher levels than those from other subareas of this facility, surrounding residential areas and reference areas, indicating that petroleum refining processes would lead apparent derivation of PAHs. Especially, compared with those in residential and reference areas, gas samples in the petrochemical areas had higher ∑NPAH/∑PAHs (mean=2.18), but lower ∑Cl-PAH/∑PAHs (mean=1.43 × 10-1) and ∑Br-PAH/∑PAHs ratios (mean=7.49 × 10-2), indicating the richer nitrification of PAHs than chlorination during petrochemical process. The occupational exposure to PAHs and XPAHs in this petroleum refinery facility were 24-343 times higher than non-occupational exposure, and the ILCR (1.04 × 10-4) for petrochemical workers was considered to be potential high risk. Furthermore, one expanded high-resolution screening through GC Orbitrap/MS was performed for soils from petrochemical area, and another 35 PAHs were found, including alkyl-PAHs, phenyl-PAHs and other species, indicating that profiles and risks of PAHs analogs in petrochemical areas deserve further expanded investigation.
Assuntos
Monitoramento Ambiental , Petróleo , Hidrocarbonetos Policíclicos Aromáticos , Hidrocarbonetos Policíclicos Aromáticos/análise , China , Petróleo/análise , Humanos , Indústria de Petróleo e Gás , Exposição Ambiental/análise , Poluentes Atmosféricos/análise , Medição de RiscoRESUMO
Non-ferrous metal smelting poses significant risks to public health. Specifically, the copper smelting process releases arsenic, a semi-volatile metalloid, which poses an emerging exposure risk to both workers and nearby residents. To comprehensively understand the internal exposure risks of metal(loid)s from copper smelting, we explored eighteen metal(loid)s and arsenic metabolites in the urine of both occupational and non-occupational populations using inductively coupled plasma mass spectrometry with high-performance liquid chromatography and compared their health risks. Results showed that zinc and copper (485.38 and 14.00 µg/L), and arsenic, lead, cadmium, vanadium, tin and antimony (46.80, 6.82, 2.17, 0.40, 0.44 and 0.23 µg/L, respectively) in workers (n=179) were significantly higher compared to controls (n=168), while Zinc, tin and antimony (412.10, 0.51 and 0.15 µg/L, respectively) of residents were significantly higher than controls. Additionally, workers had a higher monomethyl arsenic percentage (MMA%), showing lower arsenic methylation capacity. Source appointment analysis identified arsenic, lead, cadmium, antimony, tin and thallium as co-exposure metal(loid)s from copper smelting, positively relating to the age of workers. The hazard index (HI) of workers exceeded 1.0, while residents and control were approximately at 1.0. Besides, all three populations had accumulated cancer risks exceeding 1.0 × 10-4, and arsenite (AsIII) was the main contributor to the variation of workers and residents. Furthermore, residents living closer to the smelting plant had higher health risks. This study reveals arsenic exposure metabolites and multiple metals as emerging contaminants for copper smelting exposure populations, providing valuable insights for pollution control in non-ferrous metal smelting.
Assuntos
Metalurgia , Exposição Ocupacional , Humanos , Exposição Ocupacional/análise , Exposição Ambiental/estatística & dados numéricos , Metais/urina , Metais/análise , Medição de Risco , Arsênio/análise , Monitoramento Ambiental , Adulto , Poluentes Ambientais/análise , Pessoa de Meia-IdadeRESUMO
Personal care products (PCPs) are a class of emerging pollutants that have attracted public concern owing to their harmful effects on humans and the environment. Biomonitoring data is valuable for insight the levels of PCPs in the human body and can be crucial for identifying potential health hazards. To gain a better understanding of timely exposure profiles and health risk of reproductive-age population to PCPs, we determined six parabens, six benzophenone-type ultraviolet filters, and three disinfectants in 256 urine samples collected from young adults aged 18-44 years in Beijing, China. The urinary levels of benzophenone-3 (BP-3) and 4-hydroxybenzophenone (4-OHBP) were significantly higher in summer compared to winter, suggesting these compounds have different seasonal usage patterns. Moreover, the total concentration of 15 PCPs in female was 430 ng/mL, approximately two times higher than that in male. Pchloro-m-xylenol (PCMX), as a new type of antibacterial agent, has the greatest level among all target analytes, indicating the increasingly use of this antibacterial alternative recently. Five potential influencing factors that lead to the elevated exposure level of PCPs were identified. Over 19% of the target population had a high hazard index value (greater than 1) which was attributed to exposure to propyl paraben (PrP), benzophenone-1 (BP-1), BP-3 and PCMX, indicating that PCPs may pose a relatively high exposure risk at environmental levels that should be a cause for concern.
Assuntos
Cosméticos , Exposição Ambiental , Humanos , Adulto , Adulto Jovem , Medição de Risco , Feminino , Masculino , Adolescente , Cosméticos/análise , Exposição Ambiental/estatística & dados numéricos , Exposição Ambiental/análise , Pequim , Poluentes Ambientais/análise , Benzofenonas/urina , Monitoramento AmbientalRESUMO
Growing evidences showed that heavy metals exposure may be associated with metabolic diseases. Nevertheless, the mechanism underlying arsenic (As) exposure and metabolic syndrome (MetS) risk has not been fully elucidated. So we aimed to prospectively investigate the role of serum uric acid (SUA) on the association between blood As exposure and incident MetS. A sample of 1045 older participants in a community in China was analyzed. We determined As at baseline and SUA concentration at follow-up in the Yiwu Elderly Cohort. MetS events were defined according to the criteria of the International Diabetes Federation (IDF). Generalized linear model with log-binominal regression model was applied to estimate the association of As with incident MetS. To investigate the role of SUA in the association between As and MetS, a mediation analysis was conducted. In the fully adjusted log-binominal model, per interquartile range increment of As, the risk of MetS increased 1.25-fold. Compared with the lowest quartile of As, the adjusted relative risk (RR) of MetS in the highest quartile was 1.42 (95% confidence interval, CI: 1.03, 2.00). Additionally, blood As was positively associated with SUA, while SUA had significant association with MetS risk. Further mediation analysis demonstrated that the association of As and MetS risk was mediated by SUA, with the proportion of 15.7%. Our study found higher As was remarkably associated with the elevated risk of MetS in the Chinese older adults population. Mediation analysis indicated that SUA might be a mediator in the association between As exposure and MetS.
Assuntos
Arsênio , Exposição Ambiental , Síndrome Metabólica , Ácido Úrico , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Arsênio/sangue , Arsênio/toxicidade , China/epidemiologia , População do Leste Asiático , Exposição Ambiental/efeitos adversos , Síndrome Metabólica/epidemiologia , Síndrome Metabólica/induzido quimicamente , Síndrome Metabólica/sangue , Ácido Úrico/sangueRESUMO
Arsenic-related oxidative stress and resultant diseases have attracted global concern, while longitudinal studies are scarce. To assess the relationship between arsenic exposure and systemic oxidative damage, we performed two repeated measures among 5236 observations (4067 participants) in the Wuhan-Zhuhai cohort at the baseline and follow-up after 3 years. Urinary total arsenic, biomarkers of DNA oxidative damage (8-hydroxy-2'-deoxyguanosine (8-OHdG)), lipid peroxidation (8-isoprostaglandin F2alpha (8-isoPGF2α)), and protein oxidative damage (protein carbonyls (PCO)) were detected for all observations. Here we used linear mixed models to estimate the cross-sectional and longitudinal associations between arsenic exposure and oxidative damage. Exposure-response curves were constructed by utilizing the generalized additive mixed models with thin plate regressions. After adjusting for potential confounders, arsenic level was significantly and positively related to the levels of global oxidative damage and their annual increased rates in dose-response manners. In cross-sectional analyses, each 1% increase in arsenic level was associated with a 0.406% (95% confidence interval (CI): 0.379% to 0.433%), 0.360% (0.301% to 0.420%), and 0.079% (0.055% to 0.103%) increase in 8-isoPGF2α, 8-OHdG, and PCO, respectively. More importantly, arsenic was further found to be associated with increased annual change rates of 8-isoPGF2α (ß: 0.147; 95% CI: 0.130 to 0.164), 8-OHdG (0.155; 0.118 to 0.192), and PCO (0.050; 0.035 to 0.064) in the longitudinal analyses. Our study suggested that arsenic exposure was not only positively related with global oxidative damage to lipid, DNA, and protein in cross-sectional analyses, but also associated with annual increased rates of these biomarkers in dose-dependent manners.
Assuntos
Arsênio , Exposição Ambiental , Estresse Oxidativo , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , 8-Hidroxi-2'-Desoxiguanosina , Arsênio/toxicidade , Biomarcadores/urina , China , Estudos Transversais , Dano ao DNA , População do Leste Asiático , Exposição Ambiental/efeitos adversos , Poluentes Ambientais/toxicidade , Peroxidação de Lipídeos/efeitos dos fármacos , Estudos Longitudinais , Estresse Oxidativo/efeitos dos fármacosRESUMO
The associations of polycyclic aromatic hydrocarbon (PAH) exposure with serum uric acid (SUA) or hyperuricemia have been rarely assessed. We aimed to investigate the relationships between urinary PAH metabolites and SUA or hyperuricemia among US adults and to explore the mediating role of systemic inflammation in the associations. A total of 10,307 US adults were conducted to assess the associations of seven urinary hydroxyPAH with SUA and hyperuricemia and evaluate the role of C-reactive protein (CRP), a biomarker of systemic inflammation, in such associations. Results showed that each 1-unit increase in ln-transformed 2-hydroxynaphthalene (2-OHNa), 1-hydroxyphenanthrene (1-OHPh), 2&3-hydroxyphenanthrene (2&3-OHPh) and total hydroxyphenanthrene (ΣOHPh) was associated with a 1.68 (95% confidence interval (CI): 0.19 to 3.17), 2.46 (0.78 to 4.13), 3.34 (1.59 to 5.09), and 2.99 (1.23 to 4.75) µmol/L increase in SUA, and a 8% (odds ratio (OR): 1.08, 1.02 to 1.15), 9% (OR: 1.09, 1.02 to 1.18), 13% (OR: 1.13, 1.05 to 1.22), and 12% (OR: 1.12, 95% CI: 1.03, 1.21) increase in hyperuricemia, respectively. Co-exposure of seven PAHs was positively associated with SUA and hyperuricemia, with 2&3-OHPh showing the highest weight (components weights: 0.83 and 0.78, respectively). The CRP mediated 11.47% and 10.44% of the associations of ΣOHPh and 2&3-OHPh with SUA and mediated 8.60% and 8.62% in associations of ΣOHPh and 2&3-OHPh with hyperuricemia, respectively. In conclusion, internal levels of PAH metabolites were associated with elevated SUA levels and the increased risk of hyperuricemia among US adults, and CRP played a mediating role in the associations.
Assuntos
Exposição Ambiental , Hiperuricemia , Inflamação , Hidrocarbonetos Policíclicos Aromáticos , Ácido Úrico , Humanos , Hidrocarbonetos Policíclicos Aromáticos/toxicidade , Ácido Úrico/sangue , Inflamação/sangue , Hiperuricemia/sangue , Adulto , Masculino , Feminino , Exposição Ambiental/estatística & dados numéricos , Exposição Ambiental/efeitos adversos , Pessoa de Meia-Idade , Biomarcadores/sangue , Proteína C-Reativa/análise , Estados Unidos/epidemiologiaRESUMO
BACKGROUND: Per- and poly-fluoroalkyl substances (PFASs) are pervasive synthetic compounds, prompting investigations into their intricate interactions with lifestyle factors and health indicators because of their enduring environmental presence and bioaccumulation. This study aimed to explore the effects of the oxidative balance score (OBS) and PFAS on liver-related indices. METHODS: Twenty dietary and lifestyle factors were used to calculate the OBS. The serum concentrations of PFASs were measured, and their sum was calculated for analysis. The levels of liver markers were also evaluated. Linear regression models and interaction analyses were used to assess the associations between OBS, PFAS concentrations, and liver indices. RESULTS: The results revealed an inverse association between high OBS and perfluorooctane sulfonic acid concentration, as well as the sum of PFAS concentrations. OBS was positively associated with liver markers. The PFAS concentrations were positively associated with total bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels. Interaction analyses revealed significant interactions between OBS and specific PFASs for alkaline phosphatase (interaction P < 0.05). Possible interactions were also found between OBS and specific PFASs for ALT, and AST levels (interaction P < 0.10). CONCLUSIONS: This study clarified the association between total PFAS and OBS. This association was significant mainly for diet-related OBS. PFAS and OBS are associated with liver-related indicators in the blood.
Assuntos
Poluentes Ambientais , Fluorocarbonos , Fígado , Inquéritos Nutricionais , Humanos , Fluorocarbonos/sangue , Masculino , Feminino , Fígado/metabolismo , Adulto , Poluentes Ambientais/sangue , Pessoa de Meia-Idade , Estresse Oxidativo/efeitos dos fármacos , Biomarcadores/sangue , Ácidos Alcanossulfônicos/sangue , Exposição Ambiental/análise , Adulto Jovem , IdosoRESUMO
Over the last three decades, the Arctic Monitoring and Assessment Programme has published five human health assessments. These assessments have summarised the current state of the science regarding environmental contaminants and human health in the Arctic. The 2021 Human Health Assessment Report had a particular focus on dietary transitions, in addition to human biomonitoring levels and trends, health effects, risk assessment methodologies, risk communication and multi-disciplinary approaches to contaminants research. The recommendations and research priorities identified in the latest assessment are summarised here to assist decision- and policy-makers in understanding and addressing the impacts of contaminants on human populations in the Arctic.
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Pesquisa , Humanos , Regiões Árticas , Medição de Risco , Monitoramento Ambiental , Exposição Ambiental/efeitos adversos , Poluentes AmbientaisRESUMO
Purpose: There is limited understanding of the link between exposure to heavy metals and ischemic stroke (IS). This research aimed to develop efficient and interpretable machine learning (ML) models to associate the relationship between exposure to heavy metals and IS. Methods: The data of this research were obtained from the National Health and Nutrition Examination Survey (US NHANES, 2003-2018) database. Seven ML models were used to identify IS caused by exposure to heavy metals. To assess the strength of the models, we employed 10-fold cross-validation, the area under the curve (AUC), F1 scores, Brier scores, Matthews correlation coefficient (MCC), precision-recall (PR) curves, and decision curve analysis (DCA) curves. Following these tests, the best-performing model was selected. Finally, the DALEX package was used for feature explanation and decision-making visualization. Results: A total of 15,575 participants were involved in this study. The best-performing ML models, which included logistic regression (LR) (AUC: 0.796) and XGBoost (AUC: 0.789), were selected. The DALEX package revealed that age, total mercury in blood, poverty-to-income ratio (PIR), and cadmium were the most significant contributors to IS in the logistic regression and XGBoost models. Conclusion: The logistic regression and XGBoost models showed high efficiency, accuracy, and robustness in identifying associations between heavy metal exposure and IS in NHANES 2003-2018 participants.
Assuntos
AVC Isquêmico , Aprendizado de Máquina , Metais Pesados , Inquéritos Nutricionais , Humanos , Feminino , Masculino , Pessoa de Meia-Idade , Estados Unidos , Idoso , Adulto , Exposição Ambiental/efeitos adversos , Exposição Ambiental/estatística & dados numéricosRESUMO
Objectives: To construct an improved air health index (AHI) based on cardiovascular years of life lost (YLL) in Tianjin and assess its utility. Methods: We derived the exposure-response coefficients from time-series models and calculated the excess YLL (EYLL) for simultaneous exposure to air pollution and non-optimum temperature. The AHI was developed using the EYLL at the WHO 2021 Air Quality Guideline annual mean values and optimum temperature as a reference. We assessed the validity of AHI by comparing the correlations and model fit between the AHI, air quality health index (AQHI), and air quality index (AQI) with cause-specific YLLs. Results: Each inter quartile range (IQR) increase in AHI was associated with 256.31 (95%CI: 183.05, 329.57), 150.34 (95%CI: 108.23, 192.46), 90.41 (95%CI: 64.80, 116.02) and 60.80 (95%CI:33.41, 88.18) person-year increments for non-accidental, cardiovascular, ischaemic, and cerebrovascular YLL, respectively. The AHI, in contrast to the AQHI and AQI, showed the strongest correlations with the risks of cause-specific YLLs, both in the total population and subpopulations. Conclusion: The AHI based on cardiovascular YLL has a greater predictive ability for health risks.
Assuntos
Poluição do Ar , Doenças Cardiovasculares , Humanos , China , Doenças Cardiovasculares/epidemiologia , Poluição do Ar/análise , Masculino , Exposição Ambiental , Feminino , Pessoa de Meia-Idade , Idoso , Poluentes Atmosféricos/análiseRESUMO
Background: Environmental lipopolysaccharide (LPS) and microbial component-enriched organic dusts cause significant lung disease. These environmental exposures induce the recruitment and activation of distinct lung monocyte/macrophage subpopulations involved in disease pathogenesis. Aconitate decarboxylase 1 (Acod1) was one of the most upregulated genes following LPS (vs. saline) exposure of murine whole lungs with transcriptomic profiling of sorted lung monocyte/macrophage subpopulations also highlighting its significance. Given monocyte/macrophage activation can be tightly linked to metabolism, the objective of these studies was to determine the role of the immunometabolic regulator ACOD1 in environmental exposure-induced lung inflammation. Methods: Wild-type (WT) mice were intratracheally (i.t.) instilled with 10 µg of LPS or saline. Whole lungs were profiled using bulk RNA sequencing or sorted to isolate monocyte/macrophage subpopulations. Sorted subpopulations were then characterized transcriptomically using a NanoString innate immunity multiplex array 48 h post-exposure. Next, WT and Acod1-/- mice were instilled with LPS, 25% organic dust extract (ODE), or saline, whereupon serum, bronchoalveolar lavage fluid (BALF), and lung tissues were collected. BALF metabolites of the tricarboxylic acid (TCA) cycle were quantified by mass spectrometry. Cytokines/chemokines and tissue remodeling mediators were quantitated by ELISA. Lung immune cells were characterized by flow cytometry. Invasive lung function testing was performed 3 h post-LPS with WT and Acod1-/- mice. Results: Acod1-/- mice treated with LPS demonstrated decreased BALF levels of itaconate, TCA cycle reprogramming, decreased BALF neutrophils, increased lung CD4+ T cells, decreased BALF and lung levels of TNF-α, and decreased BALF CXCL1 compared to WT animals. In comparison, Acod1-/- mice treated with ODE demonstrated decreased serum pentraxin-2, BALF levels of itaconate, lung total cell, neutrophil, monocyte, and B-cell infiltrates with decreased BALF levels of TNF-α and IL-6 and decreased lung CXCL1 vs. WT animals. Mediators of tissue remodeling (TIMP1, MMP-8, MMP-9) were also decreased in the LPS-exposed Acod1-/- mice, with MMP-9 also reduced in ODE-exposed Acod1-/- mice. Lung function assessments demonstrated a blunted response to LPS-induced airway hyperresponsiveness in Acod1-/- animals. Conclusion: Acod1 is robustly upregulated in the lungs following LPS exposure and encodes a key immunometabolic regulator. ACOD1 mediates the proinflammatory response to acute inhaled environmental LPS and organic dust exposure-induced lung inflammation.
Assuntos
Carboxiliases , Lipopolissacarídeos , Camundongos Knockout , Animais , Camundongos , Carboxiliases/metabolismo , Carboxiliases/genética , Lipopolissacarídeos/imunologia , Líquido da Lavagem Broncoalveolar/imunologia , Líquido da Lavagem Broncoalveolar/citologia , Camundongos Endogâmicos C57BL , Pulmão/imunologia , Pulmão/metabolismo , Pulmão/patologia , Exposição Ambiental/efeitos adversos , Pneumonia/imunologia , Pneumonia/induzido quimicamente , Pneumonia/metabolismo , Monócitos/imunologia , Monócitos/metabolismo , Citocinas/metabolismo , Masculino , HidroliasesAssuntos
Poluição do Ar , Exposição Ambiental , Neoplasias Ovarianas , Humanos , Feminino , Neoplasias Ovarianas/epidemiologia , Estados Unidos/epidemiologia , Estudos Prospectivos , Exposição Ambiental/estatística & dados numéricos , Incidência , Poluição do Ar/estatística & dados numéricos , Poluição do Ar/efeitos adversos , Poluentes Atmosféricos/análise , Pessoa de Meia-IdadeRESUMO
Dust particles and their associated compounds can adversely affect human health and ecosystems. The aim of this study was to investigate the concentration, health, and ecological risks of selected potentially toxic elements (e.g. Pb, Cd, Cr, Co, Cu, Zn, V, Ni, and As) bound to air particles generated by dust storms in the Sejzi plain desert area within the industrial district of Isfahan metropolitan, Iran. The enrichment factor revealed the highest values for Zn, Pb, and Cd which among them Zn showed the highest value (8.1) with the potential source of industrial activities confirmed by the integrated pollution index, accumulation coefficient, and ecological risk index. Regarding health risk analysis (non-cancer and cancer risks) the elements including Co, As, and Cr showed a significant risk for adults and children across all seasons. It's concluded that mitigation of air particles originated from both natural and industrial activities is necessary to reduce their relevant risks to human being and ecosystems in the region.
Assuntos
Poluentes Atmosféricos , Poeira , Irã (Geográfico) , Poeira/análise , Humanos , Medição de Risco , Poluentes Atmosféricos/análise , Poluentes Atmosféricos/efeitos adversos , Monitoramento Ambiental/métodos , Metais Pesados/análise , Metais Pesados/toxicidade , Clima Desértico , Exposição Ambiental/efeitos adversos , Material Particulado/análise , Material Particulado/efeitos adversos , Indústrias , Criança , AdultoRESUMO
PURPOSE: To determine the effect of electromagnetic waves of mobile phone stations on several sperm parameters and the male reproductive system. METHODS: This observational study was performed on 216 subjects, aged 18-60 years. Two equal groups of subjects were assigned to group A (study group) if they were living close to cell phone tower stations for at least 6 months and group B (control group) formed from individuals living 100 meters away from cell phone tower stations. Every subject underwent a comprehensive history taking, a clinical assessment, and laboratory testing. RESULTS: Regarding morphology index in the studied groups, the exposed group exhibited a trend of reduced percentage of normal morphology compared to the non-exposed group, with no statistical difference between the two groups. Regarding the total sperm motility (A+B+C) and progressive sperm motility (A+B) in the studied groups, the exposed group showed a trend of decreased total sperm motility and of progressive sperm motility in contrast to the non-exposed group, with no statistical difference between the two groups. CONCLUSIONS: Personal wrong lifestyles with exposure to electromagnetic waves have shown a trend towards a reduced percentage of normal morphology and reduced motility although nonstatistically significant compared with non-exposed populations.
Assuntos
Telefone Celular , Ondas de Rádio , Motilidade dos Espermatozoides , Humanos , Masculino , Adulto , Adolescente , Adulto Jovem , Motilidade dos Espermatozoides/efeitos da radiação , Ondas de Rádio/efeitos adversos , Pessoa de Meia-Idade , Radiação Eletromagnética , Fertilidade/efeitos da radiação , Espermatozoides/efeitos da radiação , Infertilidade Masculina/etiologia , Exposição Ambiental/efeitos adversosRESUMO
OBJECTIVES: We aimed to describe the characteristics of traditional eye cosmetics and cultural powders, including the types, lead concentrations, origin, and regional variation in product names, and assess the differences in blood lead levels (BLLs) between product users and non-users. METHODS: We analyzed 220 samples of traditional eye cosmetics and cultural powders collected in New York City between 2013 and 2022 during lead poisoning investigations and store surveys. We compared the BLLs of children who used these products with those of non-users. RESULTS: Lead levels in traditional eye cosmetics surma and kohl were much higher than levels in kajal and other cultural powders. Although the terminologies surma, kohl, and kajal are often used interchangeably, findings suggest regional variations in the product names. The majority of the surma in this study were from Pakistan, kohl was from Morocco, and kajal was from India. The results also show that these products can contribute to elevated BLLs in children. CONCLUSIONS: Our study reveals that traditional eye cosmetics and cultural powders are used among children as young as newborns, and exposure to these products can significantly add to their lead body burden. The study findings also reveal that lead concentrations in these products can vary by product type and product names can vary by region. Public health officials must be cognizant of these unique variations and use culturally appropriate terminologies for these types of products because such distinctions can be critical when conducting risk assessments, risk communication, and risk reduction activities.
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Cosméticos , Intoxicação por Chumbo , Chumbo , Pós , Humanos , Cosméticos/química , Chumbo/sangue , Chumbo/análise , Intoxicação por Chumbo/sangue , Intoxicação por Chumbo/epidemiologia , Intoxicação por Chumbo/prevenção & controle , Criança , Cidade de Nova Iorque , Pré-Escolar , Feminino , Exposição Ambiental/efeitos adversos , Masculino , Lactente , Índia , Recém-Nascido , PaquistãoAssuntos
Asma , Exposição Ambiental , Material Particulado , Humanos , Asma/epidemiologia , Material Particulado/efeitos adversos , Material Particulado/análise , Criança , Incidência , Exposição Ambiental/efeitos adversos , Pré-Escolar , Poluição do Ar/efeitos adversos , Poluentes Atmosféricos/efeitos adversosRESUMO
Importance: Schizophrenia episodes may be triggered by short-term environmental stimuli. Short-term increases in ambient air pollution levels may elevate the risk of schizophrenia episodes, yet few epidemiologic studies have examined this association. Objective: To investigate whether short-term increases in air pollution levels are associated with an additional risk of schizophrenia episodes, independent of absolute air pollution concentrations, and whether sustained increases in air pollution levels for several days are associated with more pronounced risks of schizophrenia episodes. Design, Setting, and Participants: This nationwide, population-based, time-stratified case-crossover study was performed based on hospitalization records for schizophrenia across 295 administrative divisions of prefecture-level or above cities in China. Records were extracted from 2 major health insurance systems from January 1, 2013, to December 31, 2017. Thirty-six cities with a small number of schizophrenia hospitalizations (n < 50) were excluded. Data analysis for this study was performed from January to March 2024. Exposure: Daily absolute concentrations of fine particulate matter (PM2.5), inhalable particulate matter (PM10), nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide were collected. Air pollution increases between neighboring days (APINs) were generated as the differences in absolute air pollution concentrations on the current day minus that on the previous day. Sustained increases (APIN ≥5 µg/m3 for PM2.5 and PM10, APIN ≥1 µg/m3 for nitrogen dioxide and sulfur dioxide, and APIN ≥0.05 mg/m3 for carbon monoxide) lasting for 1 or more to 4 or more days were defined for different air pollutants. Main Outcome and Measure: Patients with schizophrenia episodes were identified by principal discharge diagnoses of schizophrenia. A conditional logistic regression model was used to capture the associations of absolute concentrations, APINs, and sustained increase events for different air pollutants with risks of schizophrenia hospitalizations. Results: The study included 817â¯296 hospitalization records for schizophrenia across 259 Chinese cities (30.6% aged 0-39 years, 56.4% aged 40-64 years, and 13.0% aged ≥65 years; 55.04% male). After adjusting for the absolute concentrations of respective air pollutants, per-IQR increases in 6-day moving average (lag0-5) APINs of PM2.5, PM10, nitrogen dioxide, sulfur dioxide, and carbon monoxide were associated with increases of 2.37% (95% CI, 0.88%-3.88%), 2.95% (95% CI, 1.46%-4.47%), 4.61% (95% CI, 2.93%-6.32%), 2.16% (95% CI, 0.59%-3.76%), and 2.02% (95% CI, 0.39%-3.68%) in schizophrenia hospitalizations, respectively. Greater risks of schizophrenia hospitalizations were associated with sustained increases in air pollutants lasting for longer durations up to 4 or more days. Conclusions and Relevance: This case-crossover study of the association between ambient air pollution increases and schizophrenia hospitalizations provides novel evidence that short-term increases in ambient air pollution levels were positively associated with an elevated risk of schizophrenia episodes. Future schizophrenia prevention practices should pay additional attention to APINs, especially sustained increases in air pollution levels for longer durations, besides the absolute air pollution concentrations.