RESUMO
El ALTE no es una enfermedad específica en sí misma, sino una forma de presentación clínica de diversas enfermedades, su incidencia se estima en 6 por 1 000 en aquellos lactantes nacidos a término, y asciende a un 86 por 1 000 en los nacidos pretérmino. Su etiología es multifactorial, el diagnóstico es difícil y precisa de experiencia, y la conducta depende de las causas que lo originen. Esta afección poco reconocida en la práctica médica actual, genera una enorme ansiedad en la familia, y constituye un desafío en cuanto al diagnóstico, manejo y consejos por parte del pediatra(AU)
Apparent life-threatening event (ALTE) is not a specific disease, rather a form of clinical presentation of several diseases. Its incidence rate is estimated to be 6 per 1000 in the term infants and 86 per 1000 in preterm infants. The etiology of the event is multifactoral, the diagnosis is difficult and requires experience, and the behavior to be adopted depends on the causes that bring it about. This poorly recognized illness in the present medical practice gives rise to a lot of anxiety for the family and represents a true challenge in terms of diagnosis, management and counseling by the pediatrician(AU)
Assuntos
Humanos , Recém-Nascido , Lactente , Evento Inexplicável Breve Resolvido/complicações , Evento Inexplicável Breve Resolvido/diagnóstico , Evento Inexplicável Breve Resolvido/epidemiologia , Evento Inexplicável Breve Resolvido/prevenção & controleRESUMO
OBJECTIVE: To detect factors associated with greater risk of death in infants after an apparent life-threatening event (ALTE). METHODS: This cross-sectional, retrospective, descriptive and analytic study evaluated infants younger than 12 months who had a sudden event of cyanosis, pallor, hypotonia or apnea and were seen in the emergency department of a tertiary university hospital. Forward stepwise logistic regression (Wald) was used to calculate and adjust odds ratios to evaluate associations. RESULTS: Mean age of the 145 patients included in the study was 105 days (median = 65 days). Eleven (7.6%) died, and their mean age was 189 days (median = 218 days). Mean age of survivors was 98 days (median = 62 days) (p = 0.003). Activity before the event, prematurity and number of events were not associated with death. A significant association was found with pallor. Of the 11 infants, 3 had spontaneous resolution of ALTE, whereas 8 patients [27.6%; p < 0.001; OR = 14.3 (95%CI 3.51-58.3)] did not. The associations with respiratory or cardiovascular disease were also significant. In multivariate analysis, immediate spontaneous resolution [p = 0.015; OR = 6.06 (95%CI 1.02-35.94)] and diagnosis of cardiovascular disease [p = 0.047; OR = 164.27 (95%CI 7.34-3.673.78)] remained statistically significant. CONCLUSION: Infants who experienced an ALTE had a higher risk of subsequent death when their age was greater than 6 months and the event had a long duration, particularly when ALTE was associated with cardiovascular disease.
Assuntos
Evento Inexplicável Breve Resolvido/mortalidade , Doenças Cardiovasculares/complicações , Doenças Respiratórias/complicações , Evento Inexplicável Breve Resolvido/complicações , Métodos Epidemiológicos , Feminino , Humanos , Lactente , MasculinoRESUMO
OBJETIVO: Identificar, na admissão dos lactentes com após eventos com aparente risco de morte (apparent life-threatening event, ALTE), fatores que possam indicar maior risco de evolução para o óbito. MÉTODOS: Estudo transversal retrospectivo, descritivo e analítico com lactentes menores de 12 meses, com evento súbito de cianose, palidez, hipotonia e/ou apneia, atendidos na unidade de emergência de hospital universitário de nível terciário. Para avaliação da associação, determinaram-se os valores de odds ratio bruto e ajustado por regressão logística (método stepwise forward Wald). RESULTADOS: Foram avaliados 145 pacientes com idade média de 105 dias (mediana = 65 dias). Onze (7,6 por cento) evoluíram para óbito, com idade média de 189 dias (mediana = 218 dias), enquanto que a idade média dos sobreviventes foi de 98 dias (mediana = 62 dias) (p = 0,003). Atividades que precederam o evento, antecedente de prematuridade e número de episódios não apresentaram associação com o óbito. Apresentou relação significativa o relato de palidez pelos observadores. Entre os 11 lactentes, 3 apresentaram melhora imediata e espontânea; já 8 pacientes [27,6 por cento; p < 0,001; OR = 14,3 (IC95 por cento 3,51-58,3)] não tiveram melhora espontânea. Os diagnósticos de doença do trato respiratório e do sistema cardiocirculatório também foram significantes. Na análise multivariada, mostraram significância estatística: não melhora imediata e espontânea [p = 0,015; OR = 6,06 (IC95 por cento 1,02-35,94)] e diagnóstico de doença do sistema cardiocirculatório [p = 0,047; OR = 164,27 (IC95 por cento 7,34-3.673,78)]. CONCLUSÃO: Os lactentes que apresentaram ALTE tiveram maior risco de óbito quando presentes na faixa etária acima dos 6 meses e quando os eventos tiveram duração prolongada, principalmente quando ocorreram como manifestação de doenças do sistema cardiocirculatório.
OBJECTIVE: To detect factors associated with greater risk of death in infants after an apparent life-threatening event (ALTE). METHODS: This cross-sectional, retrospective, descriptive and analytic study evaluated infants younger than 12 months who had a sudden event of cyanosis, pallor, hypotonia or apnea and were seen in the emergency department of a tertiary university hospital. Forward stepwise logistic regression (Wald) was used to calculate and adjust odds ratios to evaluate associations. RESULTS: Mean age of the 145 patients included in the study was 105 days (median = 65 days). Eleven (7.6 percent) died, and their mean age was 189 days (median = 218 days). Mean age of survivors was 98 days (median = 62 days) (p = 0.003). Activity before the event, prematurity and number of events were not associated with death. A significant association was found with pallor. Of the 11 infants, 3 had spontaneous resolution of ALTE, whereas 8 patients [27.6 percent; p < 0.001; OR = 14.3 (95 percentCI 3.51-58.3)] did not. The associations with respiratory or cardiovascular disease were also significant. In multivariate analysis, immediate spontaneous resolution [p = 0.015; OR = 6.06 (95 percentCI 1.02-35.94)] and diagnosis of cardiovascular disease [p = 0.047; OR = 164.27 (95 percentCI 7.34-3.673.78)] remained statistically significant. CONCLUSION: Infants who experienced an ALTE had a higher risk of subsequent death when their age was greater than 6 months and the event had a long duration, particularly when ALTE was associated with cardiovascular disease.