RESUMO
BACKGROUND: We report a 15 year-old girl with sickle cell disease, who developed important cognitive impairment due to multiple strokes, and who had been diagnosed with PVS. Nonetheless, when she was later admitted to our Institute, according to the presence of inconsistent but clearly demonstrable behavioral evidence of consciousness awareness, we changed our diagnosis to MCS. METHODS: This patient was studied by T1 MRI images, co-registration of fractional anisotropy (FA), and SPECT with MRI. RESULTS: Brain structures were mainly preserved in posterior areas of both cerebral hemispheres, although small tissue islands were present in both frontal lobes, mainly preserved in the right one. SPECT showed CBF preservation in posterior brain regions and in the cerebellum, and in those frontal small islands of tissue lateralized to the right frontal lobe; meanwhile FA showed preservation of anatomical connectivity among posterior and frontal brain regions. These remaining cortical regions are also connected with the thalami. CONCLUSION: These results showing connectivity among posterior and frontal cortical and probably with other subcortical regions, and CBF preservation in these areas, might explain the recovery of minimum awareness despite huge anatomical brain lesions.
Assuntos
Encéfalo/patologia , Circulação Cerebrovascular/fisiologia , Estado de Consciência/fisiologia , Estado Vegetativo Persistente/etiologia , Estado Vegetativo Persistente/patologia , Adolescente , Anemia Falciforme/complicações , Encéfalo/diagnóstico por imagem , Feminino , Humanos , Imageamento por Ressonância Magnética/métodos , Estado Vegetativo Persistente/complicações , Recuperação de Função Fisiológica/fisiologia , Acidente Vascular Cerebral/complicações , Tomografia Computadorizada de Emissão de Fóton Único/métodosRESUMO
CONTEXT AND OBJECTIVE: Pressure ulcers are lesions caused by inadequate blood flow and tissue malnourishment secondary to prolonged pressure on skin, soft connective tissues, muscle and/or bones. The authors report two distinct clinical situations of severely compromised neurological patients who shared several predisposing factors for pressure ulcers, but with opposite outcomes regarding the development of pressure ulcers. CASE REPORTS: The first case was a young patient in a persistent vegetative state who developed pressure ulcers that resulted in secondary sepsis and death. The second case was a patient with a diagnosis of amyotrophic lateral sclerosis who, in spite of being bedridden for several months with severe immobility, never developed pressure ulcers. These intriguing contrary clinical situations had already been defined by Charcot in the nineteenth century, with his creation of the expression "decubitus ominosus". He indicated that patients with amyotrophic lateral sclerosis usually did not develop this form of complication, as was illustrated by the cases presented here.
Assuntos
Estado Vegetativo Persistente/complicações , Úlcera por Pressão/etiologia , Adulto , Esclerose Lateral Amiotrófica , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
CONTEXT AND OBJECTIVE: Pressure ulcers are lesions caused by inadequate blood flow and tissue malnourishment secondary to prolonged pressure on skin, soft connective tissues, muscle and/or bones. The authors report two distinct clinical situations of severely compromised neurological patients who shared several predisposing factors for pressure ulcers, but with opposite outcomes regarding the development of pressure ulcers. CASE REPORTS: The first case was a young patient in a persistent vegetative state who developed pressure ulcers that resulted in secondary sepsis and death. The second case was a patient with a diagnosis of amyotrophic lateral sclerosis who, in spite of being bedridden for several months with severe immobility, never developed pressure ulcers. These intriguing contrary clinical situations had already been defined by Charcot in the nineteenth century, with his creation of the expression "decubitus ominosus". He indicated that patients with amyotrophic lateral sclerosis usually did not develop this form of complication, as was illustrated by the cases presented here.
CONTEXTO E OBJETIVO: Escaras de decúbito (ED) são lesões decorrentes de fluxo sangüíneo inadequado, com desnutrição tecidual secundária à pressão prolongada da pele, tecido conjuntivo, músculos e/ou ossos. Os autores relatam dois casos de pacientes com grave comprometimento neurológico e com vários fatores predisponentes para o desenvolvimento de escaras de decúbito, porém com conseqüências opostas. RELATO DE CASOS: O primeiro caso, um jovem paciente em estado vegetativo persistente, desenvolveu extensas ED evoluindo para sepse e óbito. O segundo caso, o paciente com esclerose lateral amiotrófica (ELA), ficou longo período restrito ao leito com imobilidade acentuada, mas sem o aparecimento de ED. Estas duas situações clínicas já foram bem definidas por Charcot no século XIX, quando este criou o termo "decubitus ominosus" que se aplica ao primeiro caso, e quando definiu que pacientes com ELA raramente desenvolvem ED, fato observado no segundo caso.
Assuntos
Adulto , Humanos , Masculino , Pessoa de Meia-Idade , Estado Vegetativo Persistente/complicações , Úlcera por Pressão/etiologia , Esclerose Lateral AmiotróficaRESUMO
INTRODUCTION: The vegetative state is the current paradigm of discussions about the alterations of conscience. DEVELOPMENT: Although accepted by most investigators, it is still controversial. The dilemma starts with the denomination itself. In this paper we propose the denomination persistent vegetative state . We start with a historical review of the integration of consciousness. We also give epidemiological data and point out the clinical features, complementary tests and anatomical findings. The patients are classified into three grades for prognosis. Grade III includes those with the worst prognosis, who have no sleep waking cycles with or without opening their eyes. This section emphasises cases of prolonged survival and of late recovery who made almost complete recovery of their intellectual functions. We state that treatment is based on two aspects: treatment of the underlying disease and general measures and emphasise the need for a multidisciplinary team. From the bio ethical point of view, it should be remembered that the patients are alive and cannot be considered in the same group as the brain dead, in whom all encephalic function has been lost. CONCLUSIONS: It is not ethical to decide to suspend medical treatment when it is known that there is a possibility of recovery of the structural anatomy and function. We are morally obliged to maintain qualified medical attention. It has been shown scientifically that we not only should, but can, obtain the recovery of these patients, in spite of the serious damage suffered by their nervous system