RESUMO
Here we report a case of ulcerative caseous gastroesophagitis associated with Rameshwarotrema uterocrescens, Rao, 1975 (Digenea: Pronocephalidae), in a juvenile green turtle ( Chelonia mydas ) from southern Brazil. Similar pathologies have been reported only in adult green turtles from Costa Rica. This paper presents the second report of parasitic esophagitis due to R. uterocrescens and the first occurrence in juvenile green turtles along coastal Brazil.
Assuntos
Esofagite/veterinária , Gastrite/veterinária , Infecções por Trematódeos/veterinária , Tartarugas/parasitologia , Aminoácidos/administração & dosagem , Animais , Antibacterianos/administração & dosagem , Anti-Inflamatórios/administração & dosagem , Autopsia/veterinária , Brasil , Ceftazidima/administração & dosagem , Dexametasona/administração & dosagem , Esofagite/parasitologia , Esofagite/patologia , Esôfago/parasitologia , Esôfago/patologia , Evolução Fatal , Feminino , Hidratação/veterinária , Gastrite/parasitologia , Gastrite/patologia , Infusões Intravenosas/veterinária , Lipídeos/administração & dosagem , Trematódeos/classificação , Trematódeos/isolamento & purificação , Trematódeos/ultraestrutura , Infecções por Trematódeos/patologia , Infecções por Trematódeos/terapiaRESUMO
Chagasic megaoesophagus and megacolon are characterised by motor abnormalities related to enteric nervous system lesions and their development seems to be related to geographic distribution of distinct Trypanosoma cruzi subpopulations. Beagle dogs were infected with Y or Berenice-78 (Be-78) T. cruzi strains and necropsied during the acute or chronic phase of experimental disease for post mortem histopathological evaluation of the oesophagus and colon. Both strains infected the oesophagus and colon and caused an inflammatory response during the acute phase. In the chronic phase, inflammatory process was observed exclusively in the Be-78 infected animals, possibly due to a parasitism persistent only in this group. Myenteric denervation occurred during the acute phase of infection for both strains, but persisted chronically only in Be-78 infected animals. Glial cell involvement occurred earlier in animals infected with the Y strain, while animals infected with the Be-78 strain showed reduced glial fibrillary acidic protein immunoreactive area of enteric glial cells in the chronic phase. These results suggest that although both strains cause lesions in the digestive tract, the Y strain is associated with early control of the lesion, while the Be-78 strain results in progressive gut lesions in this model.
Assuntos
Animais , Cães , Doença de Chagas/parasitologia , Colo/parasitologia , Modelos Animais de Doenças , Esôfago/parasitologia , Plexo Mientérico/parasitologia , Trypanosoma cruzi/classificação , Autopsia , Reação de Fase Aguda/parasitologia , Doença Crônica , Doença de Chagas/patologia , Colite/parasitologia , Colo/patologia , Progressão da Doença , Acalasia Esofágica/parasitologia , Esofagite/parasitologia , Esôfago/patologia , Megacolo/parasitologia , Especificidade da EspécieRESUMO
Chagasic megaoesophagus and megacolon are characterised by motor abnormalities related to enteric nervous system lesions and their development seems to be related to geographic distribution of distinct Trypanosoma cruzi subpopulations. Beagle dogs were infected with Y or Berenice-78 (Be-78) T. cruzi strains and necropsied during the acute or chronic phase of experimental disease for post mortem histopathological evaluation of the oesophagus and colon. Both strains infected the oesophagus and colon and caused an inflammatory response during the acute phase. In the chronic phase, inflammatory process was observed exclusively in the Be-78 infected animals, possibly due to a parasitism persistent only in this group. Myenteric denervation occurred during the acute phase of infection for both strains, but persisted chronically only in Be-78 infected animals. Glial cell involvement occurred earlier in animals infected with the Y strain, while animals infected with the Be-78 strain showed reduced glial fibrillary acidic protein immunoreactive area of enteric glial cells in the chronic phase. These results suggest that although both strains cause lesions in the digestive tract, the Y strain is associated with early control of the lesion, while the Be-78 strain results in progressive gut lesions in this model.
Assuntos
Doença de Chagas/parasitologia , Colo/parasitologia , Modelos Animais de Doenças , Esôfago/parasitologia , Plexo Mientérico/parasitologia , Trypanosoma cruzi/classificação , Reação de Fase Aguda/parasitologia , Animais , Autopsia , Doença de Chagas/patologia , Doença Crônica , Colite/parasitologia , Colo/patologia , Progressão da Doença , Cães , Acalasia Esofágica/parasitologia , Esofagite/parasitologia , Esôfago/patologia , Megacolo/parasitologia , Especificidade da EspécieRESUMO
Patients diagnosed as having chronic chagasic esophagopathy were divided into three groups on the basis of radiologic findings: group I, no dilation; group II, moderate dilation, and group III, extensive dilation. Stasis esophagitis was more frequent in group III, with a significant increase in basal layer thickness when compared with groups I and II. The pathogenesis of basal layer hyperplasia may have been due to stasis of ingested food and to myenteric denervation of the viscera. This hyperplasia may be an intermediate condition explaining the higher frequency of cancer among patients with chagasic megaesophagus.