RESUMO
OBJECTIVE: To determine the efficacy of Uterine Artery Embolization in patients with bleeding acquired uterine arteriovenous malformations (AVMs). METHODS: A prospective review of all patients who underwent Uterine Artery Embolization at our institution between July 2015 and April 2022 was performed. 225 patients were diagnosed with a uterine vascular malformation on doppler and corresponding MRI imaging. All patients underwent transcatheter embolization of the uterine arteries. Embolic agents in the 375 procedures included Histoacryl glue only (n = 326), polyvinyl alcohol (PVA) particles and Histoacryl glue (n = 29), PVA particles (n = 5), Gelfoam (n = 5), coils (n = 4), PVA particles and coils (n = 3), Histoacryl glue and Gelfoam (n = 2), and Histoacryl glue and coils (n = 1). RESULTS: A total of 375 embolization procedures were performed in 225 patients. 90 patients required repeat embolization for recurrence of bleeding. The technical success rate of embolization was 100%. The clinical success rate was 92%: bleeding was controlled in 222 of 225 patients and three patients underwent a hysterectomy. 60 of the 225 patients had uneventful intrauterine pregnancies carried to term. The 210 patients who underwent successful embolization had no recurrence of bleeding at a median follow-up of 53 months (range, 5-122 months) after treatment. 15 patients were eventually lost to follow-up. One minor complication (0.4%) of non-flow-limiting dissection of the internal iliac artery occurred. CONCLUSION: Uterine Artery Embolization is a safe, effective, minimally invasive method to treat uterine AVMs with long-term efficacy, which can provide the preservation of fertility.
Assuntos
Malformações Arteriovenosas , Embucrilato , Embolização da Artéria Uterina , Malformações Vasculares , Gravidez , Feminino , Humanos , Hemorragia Uterina/etiologia , Estudos Prospectivos , Centros de Atenção Terciária , Malformações Arteriovenosas/diagnóstico por imagem , Malformações Arteriovenosas/terapia , Malformações Arteriovenosas/complicações , Embolização da Artéria Uterina/efeitos adversos , Malformações Vasculares/complicações , Malformações Vasculares/terapia , Estudos Retrospectivos , Resultado do TratamentoRESUMO
Since the introduction of uterine artery embolization as a treatment option for symptomatic leiomyomas, there has been a growing interest in expanding the role of interventional radiology (IR) in the evaluation and treatment of obstetrics and gynecology (OBGYN) patients. This review provides an overview of opportunities for collaboration between IR and OBGYN. This can include medically and/or surgically complex patients, efforts to reduce quantitative blood loss, obstetrical emergencies, and consideration of fertility or uterine preservation. Increased collaborative efforts between IR and OBGYN would allow for patients to be fully informed regarding the complete spectrum of surgical and nonsurgical treatment options available to them. The purpose of this review is to foster opportunities to improve outcomes and respect patient values.
Assuntos
Leiomioma/terapia , Equipe de Assistência ao Paciente , Hemorragia Pós-Parto/terapia , Radiografia Intervencionista , Embolização da Artéria Uterina , Neoplasias Uterinas/terapia , Adulto , Comportamento Cooperativo , Feminino , Preservação da Fertilidade , Humanos , Comunicação Interdisciplinar , Leiomioma/diagnóstico por imagem , Leiomioma/patologia , Hemorragia Pós-Parto/diagnóstico por imagem , Radiografia Intervencionista/efeitos adversos , Resultado do Tratamento , Embolização da Artéria Uterina/efeitos adversos , Neoplasias Uterinas/diagnóstico por imagem , Neoplasias Uterinas/patologiaRESUMO
Resumo A embolização da artéria uterina (EAU) é um tratamento pouco invasivo e alternativo à cirurgia aberta no tratamento de miomatose uterina. Este estudo visa analisar a eficácia e a segurança da EAU nesses casos. Para isso, foi realizada uma revisão sistemática a partir de estudos disponíveis nas bases de dados MEDLINE/PubMed, LILACS e PEDro, via Biblioteca Virtual em Saúde. Foram encontrados 817 trabalhos; destes, 7 foram selecionados pelos critérios de elegibilidade (estudos analíticos, de corte longitudinal, retrospectivos ou prospectivos), totalizando 367 pacientes no estudo. As variáveis estudadas, bem como as características dos estudos incluídos, foram coletadas e armazenadas em um banco de dados. As taxas de redução do volume uterino e do mioma dominante foram 44,1% e 56,3%, respectivamente. A média do infarto completo do mioma dominante foi de 88,6% (82-100%). Quanto às complicações, a média obtida foi de 15±8,6 casos, sendo a maioria destas classificadas como menores, e nenhum óbito foi registrado. A média de reabordagem em valores absolutos foi de 12,2±15,5 casos. Portanto, a embolização da artéria uterina é um procedimento eficaz e com baixa taxa de complicações para o tratamento da leiomiomatose uterina na literatura analisada.
Abstract Uterine Artery Embolization (UAE) is a noninvasive alternative to open surgery for treatment of uterine myomatosis. This study aims to analyze the efficacy and safety of UAE in these cases. A systematic review was carried out of studies available on the Medline (via PubMed) and the LILACS and PEDro (via the Biblioteca Virtual em Saúde) databases. The searches found 817 studies, 7 of which were selected according to the eligibility criteria (analytical, longitudinal, retrospective, or prospective studies), with a total of 367 patients studied. The variables analyzed and the characteristics of the studies included were collated and input to a database. Rates of volume reduction of the uterus and the dominant myoma were 44.1% and 56.3%, respectively. Mean rate of complete infarction of the dominant myoma was 88.6% (82-100%). The mean number of complications observed was 15±8.6 cases, most of which were classified as minor, and no deaths were recorded. The mean number of re-interventions in absolute values was 12.2±15.5 cases. Therefore, in the literature analyzed, uterine artery embolization is an effective procedure with a low rate of complications for treatment of uterine leiomyomatosis.
Assuntos
Humanos , Feminino , Neoplasias Uterinas , Embolização da Artéria Uterina/efeitos adversos , Leiomioma , Eficácia , Procedimentos EndovascularesRESUMO
Intra-uterine growth restriction (IUGR) is associated with short and long-term metabolic and cardiovascular alterations. Mice and rats have been extensively used to study the effects of IUGR, but there are notable differences in fetal and placental physiology relative to those of humans that argue for alternative animal models. This study proposes that gradual occlusion of uterine arteries from mid-gestation in pregnant guinea pigs produces a novel model to better assess human IUGR. Fetal biometry and in vivo placental vascular function were followed by sonography and Doppler of control pregnant guinea pigs and sows submitted to surgical placement of ameroid constrictors in both uterine arteries (IUGR) at mid-gestation (35 days). The ameroid constrictors induced a reduction in the fetal abdominal circumference growth rate (0.205 cm day(-1) ) compared to control (0.241 cm day(-1) , P < 0.001) without affecting biparietal diameter growth. Umbilical artery pulsatility and resistance indexes at 10 and 20 days after surgery were significantly higher in IUGR animals than controls (P < 0.01). These effects were associated with a decrease in the relative luminal area of placental chorionic arteries (21.3 ± 2.2% vs. 33.2 ± 2.7%, P < 0.01) in IUGR sows at near term. Uterine artery intervention reduced fetal (â¼30%), placental (â¼20%) and liver (â¼50%) weights (P < 0.05), with an increased brain to liver ratio (P < 0.001) relative to the control group. These data demonstrate that the ameroid constrictor implantations in uterine arteries in pregnant guinea pigs lead to placental vascular dysfunction and altered fetal growth that induces asymmetric IUGR.
Assuntos
Retardo do Crescimento Fetal/fisiopatologia , Circulação Placentária , Embolização da Artéria Uterina/métodos , Artéria Uterina/cirurgia , Animais , Modelos Animais de Doenças , Feminino , Retardo do Crescimento Fetal/etiologia , Cobaias , Gravidez , Artéria Uterina/patologia , Embolização da Artéria Uterina/efeitos adversosRESUMO
PURPOSE: To evaluate the feasibility and safety of prophylactic uterine artery catheterization and embolization in the management of placenta accreta (PA). MATERIALS AND METHODS: Retrospective chart review was performed of 95 consecutive patients with prenatal suspicion of PA managed in a 10-year period with a strategy that included prophylactic bilateral uterine artery catheterization, delivery of the baby, uterine artery embolization if indicated, and subsequent surgery. Feasibility was defined as catheterization being possible to perform, technical success as embolization being possible when indicated and complete stasis of the vessels achieved, and clinical success as no maternal death or major blood loss. Median gestational age at delivery was 36 weeks (interquartile range, 24-39 wk). RESULTS: PA was confirmed in 79 patients (83%). Feasibility was 97% (92 of 95); in three cases (3%), acute early massive hemorrhage forced emergency delivery without catheterization. Embolization was performed in 83 of 92 patients (87%) to the extent of complete stasis; in the remaining nine, it was unnecessary because spontaneous placental detachment was visualized after fetal delivery (technical success rate, 100%). There were several complications, including bleeding requiring blood transfusion (49%) and bladder surgery (37%), but there were no major complications attributable to the endovascular procedures. There was one minor complication presumably related to embolization (transient paresthesia and decreased temperature of lower limb), with uneventful follow-up. Clinical success rate was 86%, with no maternal deaths, but 14% of patients received large-volume blood transfusion. CONCLUSIONS: Prophylactic uterine artery catheterization and embolization in the management of PA appeared to be feasible and safe in this consecutive series of patients.
Assuntos
Cateterismo Periférico/efeitos adversos , Cateterismo Periférico/métodos , Placenta Acreta/terapia , Hemorragia Pós-Parto/prevenção & controle , Tromboembolia/etiologia , Embolização da Artéria Uterina/métodos , Adulto , Estudos de Viabilidade , Feminino , Humanos , Placenta Acreta/diagnóstico por imagem , Hemorragia Pós-Parto/diagnóstico por imagem , Hemorragia Pós-Parto/etiologia , Gravidez , Resultado da Gravidez , Radiografia Intervencionista/métodos , Fatores de Risco , Tromboembolia/diagnóstico , Resultado do Tratamento , Embolização da Artéria Uterina/efeitos adversosRESUMO
Objetivo: Evaluar las complicaciones asociadas a la miomectomía laparotómica y a la embolización de las arterias uterinas en mujeres con miomas sintomáticos. Métodos: Estudio descriptivo restrospectivo efectuado en el Complejo Hospitalario Universitario de Vigo desde el año 2008 al 2010. La población en estudio la conformaron aquellas mujeres sometidas a una miomectomía laparotómica o a una embolización de las arterias uterinas. Se recopilaron las complicaciones registradas en las historias clínicas de las pacientes tras las técnicas. Resultados: La tasa de complicaciones en el grupo de las pacientes sometidas a miomectomía fue de 15,2 por ciento; las más frecuentes fueron fiebre, anemia, necesidad de trasfusión y hematoma subcutáneo. La tasa de complicaciones en el grupo de embolización fue de 4,5 por ciento recogiéndose casos de síndrome postembolización, mioma parido y un caso de histerectomía. Conclusión: La adecuada indicación de cada técnica es fundamental para tener una baja tasa de complicaciones. Se debe tener en cuenta la sintomatología, tipo y número de miomas, edad y deseo genésico de cada paciente.
Objective: This study was undertaken to evaluate the complications after laparotomy myomectomy and uterine artery embolization in women with symptomatic uterine leiomyoma. Methods: This was a descriptive and retrospective study of patients who were treated with embolization and myomectomy for leiomyomas from 2008-2010. Complications were measured. Results: The rate of complications collected in the myo-mectomy group was 15.2 percent; there were cases of fever, anemia, need for transfusion and subcutaneous hematoma. The rate of complications collected in the embolization group was 4.5 percent; there were cases of embolization syndrome, transcervical fibroid expulsion and a case of hysterectomy. Conclusion: The suitable indication of every tecnic is fundamental to have a low rate of complications. It is necessary to bear in mind the symptomatology, type and number of myomas and age and reproductive desire of each patient.
Assuntos
Pessoa de Meia-Idade , Embolização da Artéria Uterina/métodos , Leiomioma/terapia , Neoplasias Uterinas/terapia , Evolução Clínica , Embolização da Artéria Uterina/efeitos adversos , Fertilidade , Tempo de Internação , Leiomioma/cirurgia , Neoplasias Uterinas/cirurgia , Complicações Pós-Operatórias , Reoperação , Estudos Retrospectivos , Resultado do TratamentoRESUMO
PURPOSE: To determine the feasibility, efficacy, and safety of a mobile uterine artery embolization (UAE) program for patients in medically underserved, socioeconomically deprived areas. MATERIALS AND METHODS: One hundred women with symptomatic uterine leiomyomas were treated with UAE. A small truck containing a mobile c-arm and all needed supplies visited one hospital per week during a 6-month period. Four public hospitals were visited in rotation. Pre- and postprocedural magnetic resonance (MR) imaging and validated quality of life (QOL) questionnaires were obtained, and procedural details and complications were recorded. RESULTS: Technical success was achieved in 97 of 100 women. Mean procedure time was 41 minutes (range, 15-140 min) and mean fluoroscopy time was 17 minutes (range, 6-45 min). Mean hospital stay was 1.03 days (range, 1-3 d) and mean time to resumption of normal activities was 8.2 days (range, 2-20 d). At 12 weeks, 88% of patients noted symptomatic improvement and 98% stated they would recommend the procedure to other women. Complete tumor ischemia was seen on postprocedural MR imaging in 92% of women, with a mean uterine volume reduction of 36.3% (range, -4.3% to 65%) and a mean tumor volume reduction of 57.1% (range, -23.4% to 95.8%). Health-related QOL scores increased from 41.4 points before UAE to 81.2 points at 12 weeks and 85.3 points at 1 year after UAE. Complications were recorded in seven women (7%): three puncture site hematomas, three readmissions for pain control, and one case of leiomyoma passage. CONCLUSIONS: A mobile interventional radiology unit is a feasible, efficient, and safe method to provide UAE to an underserved patient community. Outcomes and complications are similar to published results from centers with conventional angiographic facilities.