RESUMO
Eight of 57 water buffalo (Bubalus bubalis) died after grazing 30 days on 38-hectare pasture contaminated with Baccharis coridifolia in the north of the Province of Corrientes (northeastern Argentina). Most were found dead, others showed depression, anorexia, diarrhea, incoordination of movements and collision against fences. The conditions that caused the poisoning were overgrazing, poor pasture and lack of aversion to the consumption of Baccharis coridifolia. Gross findings included necrotic rumenitis, necrotic-hemorrhagic abomasitis, necrotic-hemorrhagic enteritis and marked brain edema. The histopathological findings were necrosis of the epithelium of the mucosa of the forestomachs, necrosis and hemorrhage in mucosa of the small intestine, necrosis of lymphocytes in lymph follicles in spleen and thymus and vasogenic brain edema. The lesions, except for brain edema, are typically reported in cattle intoxicated by Baccharis coridifolia. Vasogenic brain edema is not described in any animal species naturally or experimentally intoxicated with this plant; this change may be due to direct toxic effect of Baccharis coridifolia that cause vascular injury or was a secondary injury.
Assuntos
Animais , Baccharis/toxicidade , Búfalos , Edema Encefálico/veterinária , Plantas Tóxicas , Argentina , Intoxicação por Plantas/veterináriaRESUMO
Eight of 57 water buffalo (Bubalus bubalis) died after grazing 30 days on 38-hectare pasture contaminated with Baccharis coridifolia in the north of the Province of Corrientes (northeastern Argentina). Most were found dead, others showed depression, anorexia, diarrhea, incoordination of movements and collision against fences. The conditions that caused the poisoning were overgrazing, poor pasture and lack of aversion to the consumption of Baccharis coridifolia. Gross findings included necrotic rumenitis, necrotic-hemorrhagic abomasitis, necrotic-hemorrhagic enteritis and marked brain edema. The histopathological findings were necrosis of the epithelium of the mucosa of the forestomachs, necrosis and hemorrhage in mucosa of the small intestine, necrosis of lymphocytes in lymph follicles in spleen and thymus and vasogenic brain edema. The lesions, except for brain edema, are typically reported in cattle intoxicated by Baccharis coridifolia. Vasogenic brain edema is not described in any animal species naturally or experimentally intoxicated with this plant; this change may be due to direct toxic effect of Baccharis coridifolia that cause vascular injury or was a secondary injury.(AU)
Assuntos
Animais , Búfalos , Baccharis/toxicidade , Plantas Tóxicas , Edema Encefálico/veterinária , Intoxicação por Plantas/veterinária , ArgentinaRESUMO
In cattle, a neurological lesion similar to that produced in sheep and goats by Clostridium perfringens type D enterotoxaemia has been reported. However, no causal relationship has been established between this disease and the lesion in cattle. The effects of single and multiple intravenous injections of epsilon toxin in three calves aged 6 months were studied. A further calf was inoculated intravenously with saline solution and used as a control. Epsilon toxin invariably produced neurological signs within 2-60 min of the end of the injection process. Clinical signs consisted of loss of consciousness, recumbency, convulsions, paddling, opisthotonus, hyperaesthesia and dyspnoea. Gross changes consisted of severe acute pulmonary oedema, which was particularly marked in the interlobular septa. The histological lesions consisted of intra-alveolar and interstitial oedema of the lung and variable degrees of perivascular proteinaceous oedema in the internal capsule, thalamus and cerebellar white matter. No clinical or post-mortem changes were observed in the control calf. These results show that calves are susceptible to the intravenous injection of epsilon toxin, and that they can show at least some of the histological lesions produced in sheep and goats by this toxin.
Assuntos
Toxinas Bacterianas/toxicidade , Doenças dos Bovinos/patologia , Doenças dos Bovinos/fisiopatologia , Infecções por Clostridium/veterinária , Clostridium perfringens , Doença Aguda , Animais , Toxinas Bacterianas/administração & dosagem , Edema Encefálico/induzido quimicamente , Edema Encefálico/patologia , Edema Encefálico/fisiopatologia , Edema Encefálico/veterinária , Bovinos , Doenças dos Bovinos/microbiologia , Infecções por Clostridium/microbiologia , Infecções por Clostridium/patologia , Infecções por Clostridium/fisiopatologia , Injeções Intravenosas , Masculino , Edema Pulmonar/induzido quimicamente , Edema Pulmonar/patologia , Edema Pulmonar/veterináriaRESUMO
Two ewes died after being fed rabbit ration and mineral salts designated for cows. This food is known to contain copper levels above that indicated for sheep. Blood counts revealed anemia, and serological tests showed high blood urea nitrogen, glutamic pyruvic transaminase and glutamic oxalacetic transaminase values. At necropsy, the animals had hepatopathy and nephropathy. Hepatic copper levels were 414 ppm. Histological examination revealed chronic active hepatitis with bile casts and tubular nephrosis. The liver, spleen and kidneys had hemosiderosis. This was attributed to the massive hemolysis caused by the copper. The liver failure and hemolytic anemia caused death in these sheep.