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Mem Inst Oswaldo Cruz ; 95 Suppl 1: 171-3, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-11142709

RESUMO

Mucosal surfaces have a fundamental participation in many aspects of the human immunodeficiency virus (HIV) infection pathogenesis. In Brazilian HIV-1 infected subjects, loss of weight and appetite are among the most debilitating symptoms. In this review we describe a defined mucosal immunogen that has profound but transient effects on HIV viral load, and we suggest that gut associated lymphoid tissue under constant immunostimulation is likely to provide a major contribution to the total levels of HIV. We also show that hypermetabolism appears to play a role in the wasting process in Brazilian patients coinfected with HIV and tuberculosis.


Assuntos
Infecções por HIV/imunologia , HIV-1/imunologia , Distúrbios Nutricionais/imunologia , Infecções por HIV/complicações , Humanos , Imunidade nas Mucosas , Distúrbios Nutricionais/virologia , Carga Viral , Redução de Peso
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