RESUMO
BACKGROUND: Selective IgE deficiency is a profound deficiency (< 5 UI/mL) or absence of serum IgE levels without other immunologic abnormalities. It is usually asymptomatic, but may be associated with recurrent respiratory infections, chronic fatigue, and musculoskeletal complaints. OBJECTIVE: To describe the evolution and treatment in patients with selective IgE deficiency. PATIENTS AND METHOD: In selective IgE's deficiency patients identification note, atopy history, concurrent diseases, clinic of allergic diseases, Prick test and prior response to treatment were analyzed. RESULTS: Eleven patients were included, five women and six men within 16 months to 10 years old. The patients had serum IgE levels < 5 UI with other immunoglobulins and sub-classes in normal levels; except a patient with concomitant IgA and IgE deficiency. The treatment administered was since prophylactic antibiotic to intravenous gammaglobulin. DISCUSSION: We established the diagnosis of selective IgE deficiency in patient with serum IgE levels < 5 UI/mL associated with recurrent respiratory infections. CONCLUSIONS: We need more clinic studies to document with precision the selective IgE deficiency.
Assuntos
Disgamaglobulinemia/epidemiologia , Imunoglobulina E/deficiência , Antibioticoprofilaxia , Criança , Pré-Escolar , Comorbidade , Suscetibilidade a Doenças , Disgamaglobulinemia/terapia , Feminino , Humanos , Deficiência de IgA/epidemiologia , Hospedeiro Imunocomprometido , Imunoglobulinas Intravenosas/uso terapêutico , Masculino , México/epidemiologia , Infecções Respiratórias/epidemiologia , Infecções Respiratórias/etiologia , Infecções Respiratórias/prevenção & controleAssuntos
Asma/terapia , Disgamaglobulinemia/imunologia , Deficiência de IgG , Adolescente , Adulto , Asma/imunologia , Asma/fisiopatologia , Disgamaglobulinemia/fisiopatologia , Disgamaglobulinemia/terapia , Humanos , Imunização Passiva , Imunoglobulina G/classificação , Imunoglobulina G/uso terapêutico , Lactente , Testes de Função RespiratóriaRESUMO
Defects in regulation of the humoral immune system were examined in a family with selective IgA deficiency. Two patients (mother and son) were clinically well and had selective abnormalities of B lymphocytes that can differentiate into IgA plasma cells plus specific T cell suppression of IgA production. One patient (daughter) had several clinical problems and received nine monthly transfusions of normal plasma. Prior to therapy, this patient had abnormal immunoregulation of both B and T lymphocyte population that cooperated in the formation of all cases of immunoglobulin-producing cells. After treatment, her clinical problems were resolved and her cellular abnormalities appeared identical in those in her mother and brother.