Assuntos
Diatrizoato de Meglumina/efeitos adversos , Atresia Esofágica/diagnóstico por imagem , Pneumonia Aspirativa/etiologia , Fístula Traqueoesofágica/diagnóstico por imagem , Atresia Esofágica/complicações , Humanos , Recém-Nascido , Masculino , Radiografia , Fístula Traqueoesofágica/complicaçõesRESUMO
Los medios de contraste iónicos monómeros son los de uso más frecuente en estudios contrastados intravenosos en tomografía computada. Se describen las reacciones adversas de dos productos comerciales en los cuales el átomo de hidrógeno se reemplazó exclusivamente por meglumina (sin sodio) y que se diferencian sólo en la molécula R3 (diatrizoato en uno y ioxitalamato en el otro). Del registro y análisis de dos series, de más de 600 pacientes cada una, se concluye que ambos productos son igualmente seguros (reacciones graves y medianas) pero estadísticamente diferentes (p<0.05) en la frecuencia de reacciones leves
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Meios de Contraste , Diatrizoato de Meglumina/efeitos adversos , Diatrizoato de Meglumina/farmacologia , Relação Dose-Resposta a Droga , Injeções Intravenosas , Tomografia Computadorizada por Raios X/métodosRESUMO
Six patients died suddenly following the administration of radio contrast media. All had received the so-called older agents which are being replaced by newer contrast agents, which are characterized by reduced osmolality. Five of the six patients experienced almost immediate difficulty in breathing followed by death.
Assuntos
Meios de Contraste/efeitos adversos , Morte Súbita/etiologia , Adulto , Idoso , Diatrizoato/efeitos adversos , Diatrizoato de Meglumina/efeitos adversos , Combinação de Medicamentos/efeitos adversos , Feminino , Fluoresceína , Fluoresceínas/efeitos adversos , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Four children with brain tumors had marked alterations in levels of consciousness and vital signs after contrast-enhanced cranial computed tomography (CT). Each had clinical evidence of increased intracranial pressure but was alert and coherent before CT. During the procedure, 2 to 2.5 mL/kg 60% diatrizoate meglumine was administered intravenously, and within hours the patients became progressively lethargic and disoriented and bradycardia and hypertension developed; two had generalized seizures. Two children died immediately after the CT procedure. Contrast-enhanced CT may produce grave neurologic complications in children with brain tumors, and this study should be reserved for those patients in whom the probability of obtaining additional information is high. Use of low-osmolality agents or nonionic contrast agents may decrease the morbidity and mortality associated with the procedure.