RESUMO
Contrast media (CM) are frequently used in diagnostic radiology and in radiotherapy as a diagnostic tool and in treatment planning. Previous studies have demonstrated that these compounds induce chromosomal aberrations. This study evaluates the mutagenic effects induced by the contrast medium Urografina® 292 (meglumine amidotrizoate and sodium-ionic dimmer) in bone marrow cells (BMC) of mice in vivo. Micronuclei assay was performed in BMC of CF-1 mice injected with CM 1.5 and 3.0 mL/kg intravenous doses and 1.0, 2.0, 3.0 mL/kg intraperitoneal doses. The animals were beheaded 24 h after treatment by cervical dislocation, and femur BMC from each animal were used in the micronucleus test. The group treated with the highest intravenous injection of Urografina® 292 (3.0 mL/kg) presented an increase in the frequency of micronucleated polychromatic erythrocytes (MNPCEs) in relation at the control group (P<0.05). The results obtained after intraperitoneal administration of CM showed that all doses (1.0 mL/kg, 2.0 mL/kg and 3.0 mL/kg) increased the frequency of MNPCEs, being significantly different from the negative control (P< 0.01). The present results suggest that iodinated contrast media Urografina® 292 may cause a significant increase of cytogenetic damage in bone marrow cells of mice.
Assuntos
Células da Medula Óssea/efeitos dos fármacos , Aberrações Cromossômicas/induzido quimicamente , Meios de Contraste/toxicidade , Diatrizoato de Meglumina/toxicidade , Animais , Meios de Contraste/administração & dosagem , Diatrizoato de Meglumina/administração & dosagem , Relação Dose-Resposta a Droga , Masculino , Camundongos , Camundongos Endogâmicos , Testes para Micronúcleos/métodosRESUMO
Various methods of regional chemotherapy have been used in patients with non resectable heptic carcinoma. We report our preliminary experience with embolization using adriamycin-urographin-lipiodol in 2 patients with this cancer in whom a considerable reduction of tumoral mass was observed. The pertinent literature is briefly commented.