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1.
Ann N Y Acad Sci ; 1029: 371-3, 2004 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-15681784

RESUMO

In a model of immunodeficiency provoked by protein deficiency, cytosol fractions from gut IELS isolated from immunodeficient rats presenting oral tolerance to dextrin showed increased expression of TGF-beta to reduce the effect of higher levels of inflammatory cytokines.


Assuntos
Dextrinas/imunologia , Dieta , Tolerância Imunológica/fisiologia , Imunidade nas Mucosas , Síndromes de Imunodeficiência/imunologia , Mucosa Intestinal/imunologia , Fator de Crescimento Transformador beta/imunologia , Animais , Modelos Animais de Doenças , Tolerância Imunológica/imunologia , Interferon gama/imunologia , Ratos , Linfócitos T/imunologia , Fator de Crescimento Transformador alfa/imunologia
2.
Lymphology ; 36(1): 26-38, 2003 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-12755465

RESUMO

Antigens presented to the immune system through the oral route induce antigen specific secretory IgA and systemic unresponsiveness, termed oral tolerance (OT). We studied the induction of OT towards a diet antigen: dextrin (DEX) in rats that underwent protein deprivation and were further re-fed. Peyer's patches (PP), mesenteric lymph nodes (MLN) and spleen (Sp) cells from protein re-fed (R) rats mediated hyporesponsiveness after transfer into naïve recipient rats. Low numbers of MLN T cells transferred hyporesponsiveness while higher numbers transferred an enhancement of the delayed type hypersensitivity (DTH) reaction. MLN T cells were further separated based on their ability to bind Vicia villosa (VV). MLN VV- T cells, mainly CD8+, mediated hyporesponsiveness and MLN VV+ T cells (CD45RC+ CD4- CD8- cells) abrogated the hyporesponsiveness. Moreover, Sp DEX adherent T cells were mainly CD8+. Intestinal intraepithelial lymphocytes (iIELs) mainly CD8alpha+ gamma(delta)-TCR+ cells also inhibited the DTH response to DEX after transfer. The positive DTH response to another carbohydrate (levan) indicates the specificity of the suppression to dextrin. Therefore, our data indicate that after oral administration of DEX, two different populations of T cells were generated: one found only in the MLN that mediated DTH responses and the other one capable of migrating from the intestinal intraepithelium through PP and MLN to the Sp, mediating systemic tolerance.


Assuntos
Dextrinas/imunologia , Linfócitos T Reguladores/fisiologia , Administração Oral , Animais , Movimento Celular , Dieta , Intestinos/citologia , Linfonodos/citologia , Masculino , Deficiência de Proteína/imunologia , Deficiência de Proteína/fisiopatologia , Ratos , Ratos Wistar
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