RESUMO
Abstract We report a 74-year-old male presented to an outpatient dermatology clinic in Manaus, Amazonas, with a one-year history of pruritic, keloidal lesions on his left lower extremity. Histopathology showed round structures in reticular dermis. Grocott methenamine silver stain revealed numerous round yeasts with thick double walls, occurring singly or in chains connected by tubular projections. The diagnosis was lobomycosis. Although the keloidal lesions presented by this patient are typical of lobomycosis, their linear distribution along the left lower limb is unusual.
Assuntos
Humanos , Masculino , Idoso , Lobomicose/diagnóstico , Lobomicose/patologia , Queloide/diagnóstico , Queloide/patologia , Dermatoses da Perna/diagnóstico , Dermatoses da Perna/patologia , Biópsia , Derme/microbiologia , Derme/patologiaRESUMO
We report a 74-year-old male presented to an outpatient dermatology clinic in Manaus, Amazonas, with a one-year history of pruritic, keloidal lesions on his left lower extremity. Histopathology showed round structures in reticular dermis. Grocott methenamine silver stain revealed numerous round yeasts with thick double walls, occurring singly or in chains connected by tubular projections. The diagnosis was lobomycosis. Although the keloidal lesions presented by this patient are typical of lobomycosis, their linear distribution along the left lower limb is unusual.
Assuntos
Queloide/diagnóstico , Queloide/patologia , Dermatoses da Perna/diagnóstico , Dermatoses da Perna/patologia , Lobomicose/diagnóstico , Lobomicose/patologia , Idoso , Biópsia , Derme/microbiologia , Derme/patologia , Humanos , MasculinoRESUMO
We present a woman with a history of years of evolution of confluent hyperkeratotic papules and plaques with a generalized linear and reticulate pattern. Histopathological characteristics concordant with keratosis lichenoides chronica were finally evidenced after several non-specific biopsies. The cutaneous manifestations, chronicity. histopathology findings, and refractoriness to therapies are typical of this rare dermatosis.
Assuntos
Ceratose/patologia , Erupções Liquenoides/patologia , Idoso , Braço , Chile , Doença Crônica , Dermoscopia , Dermatoses Faciais/diagnóstico , Dermatoses Faciais/patologia , Feminino , Humanos , Ceratose/diagnóstico , Dermatoses da Perna/diagnóstico , Dermatoses da Perna/patologia , Erupções Liquenoides/diagnósticoAssuntos
Neoplasias da Mama/patologia , Linfoma de Células B/patologia , Neoplasias Cutâneas/secundário , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica , Biópsia por Agulha , Neoplasias da Mama/cirurgia , Eritema/diagnóstico , Eritema/etiologia , Feminino , Humanos , Imuno-Histoquímica , Dermatoses da Perna/diagnóstico , Dermatoses da Perna/etiologia , Linfoma de Células B/tratamento farmacológico , Mastectomia/métodos , Prognóstico , Medição de Risco , Neoplasias Cutâneas/tratamento farmacológico , Resultado do TratamentoAssuntos
Neoplasias da Mama/patologia , Linfoma de Células B/tratamento farmacológico , Linfoma de Células B/patologia , Neoplasias Cutâneas/tratamento farmacológico , Neoplasias Cutâneas/secundário , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Biópsia por Agulha , Neoplasias da Mama/radioterapia , Neoplasias da Mama/cirurgia , Eritema/diagnóstico , Eritema/etiologia , Feminino , Humanos , Imuno-Histoquímica , Dermatoses da Perna/diagnóstico , Dermatoses da Perna/etiologia , Mastectomia/métodos , Pessoa de Meia-Idade , Prognóstico , Radioterapia Adjuvante , Medição de Risco , Neoplasias Cutâneas/patologia , Resultado do TratamentoAssuntos
Dermatoses da Perna/diagnóstico , Granulomatose Linfomatoide/diagnóstico , Artrite Reumatoide/complicações , Eritema/complicações , Feminino , Humanos , Dermatoses da Perna/complicações , Dermatoses da Perna/patologia , Granulomatose Linfomatoide/complicações , Granulomatose Linfomatoide/patologia , Pessoa de Meia-IdadeRESUMO
Nail involvement in Langerhans cell histiocytosis is uncommon and is said to indicate a poor prognosis. We describe a 2-year-old boy with onycholysis, subungual hyperkeratosis, and hemorrhages on his fingernails. He also had hepatosplenomegaly and pulmonary involvement. The diagnosis of Langerhans cell histiocytosis was made by histopathologic examination of skin and liver.The role of nail involvement as an unfavorable prognostic sign is still unclear and this paper concludes that nail involvement in Langerhans cell histiocytosis is a possible sign of multisystemic involvement.
Assuntos
Hemorragia/diagnóstico , Histiocitose de Células de Langerhans/diagnóstico , Ceratose/diagnóstico , Onicólise/diagnóstico , Pré-Escolar , Dermatoses do Pé/diagnóstico , Dermatoses do Pé/patologia , Dermatoses da Mão/diagnóstico , Dermatoses da Mão/patologia , Histiocitose de Células de Langerhans/patologia , Humanos , Dermatoses da Perna/diagnóstico , Dermatoses da Perna/patologia , Masculino , Doenças da Unha/diagnóstico , Dermatoses do Couro Cabeludo/diagnóstico , Dermatoses do Couro Cabeludo/patologia , Pele/patologiaRESUMO
Although pretibial myxedema (PTM) occurs in 4.3% of patients with Graves's disease, the most severe variant, elephantiasis nostras verrucosa, is found in less than 1% of cases. The most frequent location of infiltration is the lower extremities, especially the pretibial areas and on the dorsum of the foot. The authors report one of the most severe cases of elephantiasis nostras verrucosa, following radioactive iodine therapy.
Assuntos
Elefantíase/patologia , Dermatoses da Perna/patologia , Mixedema/patologia , Tíbia/patologia , Elefantíase/diagnóstico , Feminino , Humanos , Dermatoses da Perna/diagnóstico , Pessoa de Meia-Idade , Mixedema/diagnósticoRESUMO
Presentamos cinco pacientes adolescentes cuyo motivo de consulta fue la presencia de máculas hiperpigmentadas, parduscas, con lesiones puntiformes rojas que no desaparecían a la vitropresión, distribuidas simétricamente en los miembros inferiores. Los exámenes de laboratorio fueron normales, exceptuando el hallazgo de serología positiva para parvovirus B19 en uno de los pacientes, que presentaba además artralgias. El cuadro se observó también en un paciente con hipercalcemia idiopática y en otro con síndrome de McCune-Albright. La histopatología confirmó el diagnóstico de sospecha: púrpura de Schamberg. El tratamiento fue sintomático, con resolución completa de las lesiones en el transcurso de los meses sucesivos en dos de ellos. La púrpura de Schamberg es la dermatosis purpúrica pigmentaria más frecuente en los niños.
We report five adolescent patients whose reason for consulting was the presence of hyperpigmentedbrownish macules with red pointed injuries distributed symmetrically in lower limbs that didn´tdisappear at finger pressing. Laboratory test were normal except for the discovery of positiveimmunoglobulin M for parvovirus B19 in the patient who presented arthralgias. The symptomswere observed in a case with idiopathic hypercalcemia and in another one with Mc Cune Albrightsyndrome.The histopathology confirmed the diagnosis suspected: Schamberg´s disease. The treatmentwas symptomatic with complete resolution of the injuries in two of the cases in the course of thefollowing months. Schambergs purpura is the most frequent pigmented purpuric dermatoses in children.
Assuntos
Humanos , Adolescente , Criança , Pele/patologia , Transtornos da Pigmentação/diagnóstico , Transtornos da Pigmentação/patologia , Diagnóstico Diferencial , Dermatoses da Perna/diagnóstico , Dermatoses da Perna/patologiaRESUMO
Se presenta caso de mujer adulta con múltiples lesiones ampollosas de 1 semana de evolución, acompañada de fiebre. Presentaba antecedentes de rectorragias ocasionales desde hace varios años. La colonoscopía detectó la presencia de Enfermedad inflamatoria intestinal, que se confirmó con la anatomía patológica. La biopsia de piel fue compatible con pioderma gangrenoso. La paciente mejoró con prednisona y aziatropina.
A case report of adult female with multiple bullous lesions of 1 week duration, accompanied by fever. She had a history of occasional rectal bleeding for several years. The colonoscopy detected the presence of inflammatory bowel disease, which was confirmed by pathology. Skin biopsy was consistent with pyoderma gangrenosum. The patient improved with prednisone and aziatropina.
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Pioderma Gangrenoso/diagnóstico , Dermatoses da Perna/diagnóstico , Doenças Retais/patologia , Azatioprina/uso terapêutico , Prednisona/uso terapêutico , Pioderma Gangrenoso/patologia , Pioderma Gangrenoso/tratamento farmacológico , Glucocorticoides/uso terapêutico , Imunossupressores/uso terapêutico , Dermatoses da Perna/patologia , Dermatoses da Perna/tratamento farmacológicoRESUMO
Cutaneous myiasis is usually a harmless tropical disease caused by infestation with larvae from a variety of flies. Because of its rare occurrence in Europe, it is often misdiagnosed. Increased travel to tropical regions has correspondingly increased the number of cases observed in Europe. The furuncular type of cutaneous myiasis in a 31-year-old biology student was diagnosed upon his return from French Guiana. The student cultured one of the larvae to obtain a botfly. This case is discussed in the light of the current literature on pathogenesis, incidence and therapy of cutaneous myiasis.
Assuntos
Antebraço , Dermatoses da Perna/diagnóstico , Miíase/diagnóstico , Viagem , Clima Tropical , Adulto , Animais , Dípteros/crescimento & desenvolvimento , Guiana Francesa , Humanos , Larva/crescimento & desenvolvimento , Dermatoses da Perna/terapia , Masculino , Miíase/parasitologia , Curativos OclusivosRESUMO
We report a case of lobomycosis in the left leg of a patient that had traveled to the endemic Brazilian Amazon region. After surgical resection of the lesion, there was relapse with local dissemination of the disease and the treatment was successfully performed by oral itraconazole and cryosurgery.
Assuntos
Dermatomicoses/tratamento farmacológico , Dermatomicoses/cirurgia , Dermatoses da Perna/tratamento farmacológico , Dermatoses da Perna/cirurgia , Antifúngicos/uso terapêutico , Brasil , Criocirurgia , Dermatomicoses/diagnóstico , Humanos , Itraconazol/uso terapêutico , Dermatoses da Perna/diagnóstico , Masculino , Pessoa de Meia-Idade , Pele/patologiaRESUMO
Most black fungi that are repeatedly involved in human infection belong to the order Chaetothyriales. Capnodialean melanized fungi often thrive in extreme environments like rock surfaces and hypersaline microhabitats. They are able to grow meristematically with very thick cellular walls, resembling muriform cells of agents of chromoblastomycosis. In this report we describe a member of the order Capnodiales causing a chromoblastomycosis-like infection in human skin. However, in tissue the fungus presented with toruloid hyphae and intercalary, chlamydospore-like conidia with transversal septa, rather than with muriform cells. Judging from ITS rRNA sequences, the fungus is related to, but clearly different from, the genera Catenulostroma and Pseudotaeniolina; members of these genera are environmental and only rarely occur on human hosts.
Assuntos
Ascomicetos/isolamento & purificação , Cromoblastomicose/microbiologia , Dermatomicoses , Diagnóstico Diferencial , Dermatoses da Perna , Ascomicetos/classificação , Ascomicetos/crescimento & desenvolvimento , Cromoblastomicose/diagnóstico , Dermatomicoses/diagnóstico , Dermatomicoses/microbiologia , Humanos , Dermatoses da Perna/diagnóstico , Dermatoses da Perna/microbiologia , Masculino , Pessoa de Meia-Idade , Pele/microbiologiaRESUMO
Lobomycosis is a common subcutaneous mycosis in South America. It is caused by Lacazia loboi. We report two cases of lobomycosis which were diagnosed by exfoliative cytology without any special staining. We highlight this diagnostic tool as a simple, low-cost, painless, non-invasive and fast method for the diagnosis of lobomycosis.
Assuntos
Citodiagnóstico , Dermatomicoses/diagnóstico , Dermatoses da Perna/diagnóstico , Onygenales/isolamento & purificação , Pele/microbiologia , Adulto , Brasil , Dermatomicoses/microbiologia , Dermatomicoses/patologia , Humanos , Dermatoses da Perna/microbiologia , Dermatoses da Perna/patologia , Masculino , Pessoa de Meia-Idade , Onygenales/classificação , Fatores de TempoRESUMO
Chromoblastomycosis is one of the most frequent infections caused by melanized fungi. It is a subcutaneous fungal infection, usually an occupational related disease, mainly affecting individuals in tropical and temperate regions. Although several species are etiologic agents, Fonsecaea pedrosoi and Cladophialophora carrionii are prevalent in the endemic areas. Chromoblastomycosis lesions are polymorphic and must be differentiated from those associated with many clinical conditions. Diagnosis is confirmed by the observation of muriform cells in tissue and the isolation and the identification of the causal agent in culture. Chromoblastomycosis still is a therapeutic challenge for clinicians due to the recalcitrant nature of the disease, especially in the severe clinical forms. There are three treatment modalities, i.e., physical treatment, chemotherapy and combination therapy but their success is related to the causative agent, the clinical form and severity of the chromoblastomycosis lesions. There is no treatment of choice for this neglected mycosis, but rather several treatment options. Most of the patients can be treated with itraconazole, terbinafine or a combination of both. It is also important to evaluate the patient's individual tolerance of the drugs and whether the antifungal will be provided for free or purchased, since antifungal therapy must be maintained in long-term regimens. In general, treatment should be guided according to clinical, mycological and histopathological criteria.