RESUMO
ABSTRACT CONTEXT: Various skin manifestations have been reported in coronavirus disease. It may be difficult to determine the etiology of these lesions in view of the increased frequency of handwashing during the pandemic, along with occurrences of irritant contact dermatitis and allergic contact dermatitis due to disinfectant use; usage of herbal medicine and supplements to strengthen the immune system; and urticarial or maculopapular drug eruptions due to COVID-19 treatment. The variety of associated skin manifestations seen with COVID-19 makes it challenging to identify virus-specific skin manifestations. Petechiae, purpura, acrocyanosis and necrotic and non-necrotic purpura, which can be considered as manifestations of vascular involvement on the skin, have been reported. CASE REPORT: Here, we report a case of eruptive cherry angiomas, which was thought to have developed due to COVID-19, with a papulovesicular rash on distal extremities that progressed over time to reticular purpura. CONCLUSION: The case presented had a papulovesicular rash at the onset, which evolved to retiform purpura, and eruptive cherry angiomas were observed. It should be kept in mind that dermatological signs may vary in patients with COVID-19.
Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Púrpura/virologia , Pele/virologia , Dermatopatias Virais/virologia , Exantema/virologia , COVID-19/complicações , COVID-19/virologia , Hemangioma/virologia , Pele/efeitos dos fármacos , Pele/patologia , Resultado do Tratamento , Dermatopatias Virais/diagnóstico , Dermatopatias Virais/terapia , Teste para COVID-19 , SARS-CoV-2 , COVID-19/tratamento farmacológico , COVID-19/terapiaRESUMO
CONTEXT: Various skin manifestations have been reported in coronavirus disease. It may be difficult to determine the etiology of these lesions in view of the increased frequency of handwashing during the pandemic, along with occurrences of irritant contact dermatitis and allergic contact dermatitis due to disinfectant use; usage of herbal medicine and supplements to strengthen the immune system; and urticarial or maculopapular drug eruptions due to COVID-19 treatment. The variety of associated skin manifestations seen with COVID-19 makes it challenging to identify virus-specific skin manifestations. Petechiae, purpura, acrocyanosis and necrotic and non-necrotic purpura, which can be considered as manifestations of vascular involvement on the skin, have been reported. CASE REPORT: Here, we report a case of eruptive cherry angiomas, which was thought to have developed due to COVID-19, with a papulovesicular rash on distal extremities that progressed over time to reticular purpura. CONCLUSION: The case presented had a papulovesicular rash at the onset, which evolved to retiform purpura, and eruptive cherry angiomas were observed. It should be kept in mind that dermatological signs may vary in patients with COVID-19.
Assuntos
COVID-19/complicações , COVID-19/virologia , Exantema/virologia , Hemangioma/virologia , Púrpura/virologia , Dermatopatias Virais/virologia , Pele/virologia , COVID-19/terapia , Teste para COVID-19 , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , SARS-CoV-2 , Pele/efeitos dos fármacos , Pele/patologia , Dermatopatias Virais/diagnóstico , Dermatopatias Virais/terapia , Resultado do Tratamento , Tratamento Farmacológico da COVID-19RESUMO
INTRODUCTION: Reports of dermatological manifestations in patients with COVID-19 suggest a possible cutaneous tropism of SARS-CoV-2; however, the capacity of this virus to infect the skin is unknown. OBJECTIVE: To determine the susceptibility of the skin to SARS-CoV-2 infection based on the expression of viral entry factors ACE2 and TMPRSS2 in this organ. METHOD: A comprehensive analysis of human tissue gene expression databases was carried out looking for the presence of the ACE2 and TMPRSS2 genes in the skin. mRNA expression of these genes in skin-derived human cell lines was also assessed. RESULTS: The analyses showed high co-expression of ACE2 and TMPRSS2 in the gastrointestinal tract and kidney, but not in the skin. Only the human immortalized keratinocyte HaCaT cell line expressed detectable levels of ACE2, and no cell line originating in the skin expressed TMPRSS2. CONCLUSIONS: Our results suggest that cutaneous manifestations in patients with COVID-19 cannot be directly attributed to the virus. It is possible that cutaneous blood vessels endothelial damage, as well as the effect of circulating inflammatory mediators produced in response to the virus, are the cause of skin involvement.
INTRODUCCIÓN: Reportes de manifestaciones dermatológicas en pacientes con COVID-19 sugieren un posible tropismo cutáneo del virus SARS-CoV-2; sin embargo, se desconoce la capacidad de este virus para infectar la piel. OBJETIVO: Determinar la susceptibilidad de la piel a la infección por SARS-CoV-2 con base en la expresión de los factores de entrada viral ACE2 y TMPRSS2 en dicho órgano. MÉTODO: Se buscaron los genes ACE2 y TMPRSS2 en la piel, para lo cual se realizó un análisis extenso de las bases de datos de expresión genética en tejidos humanos. Asimismo, se evaluó la expresión de dichos genes en líneas celulares humanas derivadas de la piel. RESULTADOS: Los análisis mostraron alta expresión conjunta de ACE2 y TMPRSS2 en el tracto gastrointestinal y en los riñones, pero no en la piel. Solo la línea celular de queratinocitos humanos inmortalizados HaCaT expresó niveles detectables de ACE2 y ninguna línea celular de origen cutáneo expresó TMPRSS2. CONCLUSIONES: Los resultados sugieren que las manifestaciones dermatológicas en pacientes con COVID-19 no pueden ser atribuidas directamente al virus; es posible que sean originadas por el daño endotelial a los vasos sanguíneos cutáneos y el efecto de los mediadores inflamatorios circulantes producidos en respuesta al virus.
Assuntos
Infecções por Coronavirus/complicações , Peptidil Dipeptidase A/genética , Pneumonia Viral/complicações , Serina Endopeptidases/genética , Dermatopatias Virais/virologia , Enzima de Conversão de Angiotensina 2 , Betacoronavirus/isolamento & purificação , COVID-19 , Linhagem Celular , Infecções por Coronavirus/genética , Regulação da Expressão Gênica , Predisposição Genética para Doença , Humanos , Pandemias , Pneumonia Viral/genética , SARS-CoV-2 , Pele/virologia , Dermatopatias Virais/genética , Tropismo Viral/fisiologia , Internalização do VírusRESUMO
Coronavirus disease (COVID-19) became pandemic since this is a disease with a high infection rate. The study's object is to identify clinical and histopathological findings of cutaneous manifestations of COVID-19 patients. The evidence was analyzed in PubMed, CINAHL, Cochrane, Web of Science, and Scopus, with the search strategy (covid 19 OR covid-19 OR corona OR coronavirus OR sars-cov-2) AND (cutaneous or cutaneous manifestations OR), and 17 studies were included, involving 351 cases with COVID19 and skin manifestations. The lesions were classified mainly as maculopapular, erythematous, vesicular, and urticarial. Histopathological analyses suggest a predominance of spongiosis, perivascular infiltrate of lymphocytes, and thrombogenic vasculopathy.
Assuntos
COVID-19/complicações , Dermatopatias Virais/epidemiologia , Humanos , Dermatopatias Virais/patologia , Dermatopatias Virais/virologiaRESUMO
Abstract Introduction: Reports of dermatological manifestations in patients with COVID-19 suggest a possible cutaneous tropism of SARS-CoV-2; however, the capacity of this virus to infect the skin is unknown. Objective: To determine the susceptibility of the skin to SARS-CoV-2 infection based on the expression of viral entry factors ACE2 and TMPRSS2 in this organ. Method: A comprehensive analysis of human tissue gene expression databases was carried out looking for the presence of the ACE2 and TMPRSS2 genes in the skin. mRNA expression of these genes in skin-derived human cell lines was also assessed. Results: The analyses showed high co-expression of ACE2 and TMPRSS2 in the gastrointestinal tract and kidney, but not in the skin. Only the human immortalized keratinocyte HaCaT cell line expressed detectable levels of ACE2, and no cell line originating in the skin expressed TMPRSS2. Conclusions: Our results suggest that cutaneous manifestations in patients with COVID-19 cannot be directly attributed to the virus. It is possible that cutaneous blood vessels endothelial damage, as well as the effect of circulating inflammatory mediators produced in response to the virus, are the cause of skin involvement.
Resumen Introducción: Reportes de manifestaciones dermatológicas en pacientes con COVID-19 sugieren un posible tropismo cutáneo del virus SARS-CoV-2; sin embargo, se desconoce la capacidad de este virus para infectar la piel. Objetivo: Determinar la susceptibilidad de la piel a la infección por SARS-CoV-2 con base en la expresión de los factores de entrada viral ACE2 y TMPRSS2 en dicho órgano. Método: Se buscaron los genes ACE2 y TMPRSS2 en la piel, para lo cual se realizó un análisis extenso de las bases de datos de expresión genética en tejidos humanos. Asimismo, se evaluó la expresión de dichos genes en líneas celulares humanas derivadas de la piel. Resultados: Los análisis mostraron alta expresión conjunta de ACE2 y TMPRSS2 en el tracto gastrointestinal y en los riñones, pero no en la piel. Solo la línea celular de queratinocitos humanos inmortalizados HaCaT expresó niveles detectables de ACE2 y ninguna línea celular de origen cutáneo expresó TMPRSS2. Conclusiones: Los resultados sugieren que las manifestaciones dermatológicas en pacientes con COVID-19 no pueden ser atribuidas directamente al virus; es posible que sean originadas por el daño endotelial a los vasos sanguíneos cutáneos y el efecto de los mediadores inflamatorios circulantes producidos en respuesta al virus.
Assuntos
Humanos , Pneumonia Viral/complicações , Serina Endopeptidases/genética , Dermatopatias Virais/virologia , Infecções por Coronavirus/complicações , Peptidil Dipeptidase A/genética , Pneumonia Viral/genética , Pele/virologia , Linhagem Celular , Regulação da Expressão Gênica , Infecções por Coronavirus/genética , Predisposição Genética para Doença , Internalização do Vírus , Tropismo Viral/fisiologia , Pandemias , Betacoronavirus/isolamento & purificação , Enzima de Conversão de Angiotensina 2 , SARS-CoV-2 , COVID-19RESUMO
Currently, bovine papillomavirus types are divided into five genera, namely, Deltapapillomavirus, Epsilonpapillomavirus, Xipapillomavirus, Dyoxipapillomavirus, and Dyokappapapillomavirus. In the recent decades, the characterization of numerous putative and novel bovine papillomavirus types from cattle in several geographic regions, has revealed the occurrence of a high viral diversity. In this study, we describe the identification and characterization of a putative new bovine papillomavirus type within species Xipapillomavirus 1 of Xipapillomavirus genus. The detection of the viral types identified in the skin warts was obtained by polymerase chain reaction assays targeting the L1 gene, followed by direct sequencing of the generated amplicons. The partial L1 sequences revealed that bovine papillomavirus types 6, 10, and 11, the putative new bovine papillomavirus type designated BPV/CHI-SW2, and an unreported putative new bovine papillomavirus type (named BPV/BR-UEL08) were associated with cutaneous papillomatosis in the cows from the dairy herd investigated. Phylogenetic reconstruction based on the L1 gene revealed that the BPV/BR-UEL08 isolate clustered with other bovine papillomaviruses classified in the Xipapillomavirus genus, being closely related to representatives of the species Xipapillomavirus 1. Investigations focusing on the molecular epidemiology of bovine papillomaviruses related to clinical outcomes in cattle are of fundamental importance to determine the actual genetic diversity and prevalent viral types to be included in vaccines for cattle.
Assuntos
Doenças dos Bovinos/virologia , Infecções por Papillomavirus/veterinária , Dermatopatias Virais/veterinária , Verrugas/veterinária , Xipapillomavirus/classificação , Xipapillomavirus/genética , Animais , Brasil , Bovinos , Análise por Conglomerados , DNA Viral/química , DNA Viral/genética , Infecções por Papillomavirus/virologia , Filogenia , Reação em Cadeia da Polimerase , Análise de Sequência de DNA , Dermatopatias Virais/virologia , Verrugas/virologia , Xipapillomavirus/isolamento & purificaçãoRESUMO
Abstract: Epstein-Barr virus is a DNA virus infecting human beings and could affect 90% of human population. It is crucial to take in account that in Latin America, unlike what happens in developed countries, the exposure to the virus is very early and therefore people have a much longer interaction with the virus. The virus is related to many diseases, mainly the oncological ones, and when the onset is in cutaneous tissue, it can present many clinical variants, as well acute as chronic ones. Among the acute ones are infectious mononucleosis rash and Lipschutz ulcers; the chronic presentations are hypersensivity to mosquito bites, hydroa vacciniforme, hydroa vacciniforme-like lymphoma, its atypical variants and finally nasal and extra-nasal NK/T-cell lymphoma. Although they are not frequent conditions, it is crucial for the dermatologist to know them in order to achieve a correct diagnosis.
Assuntos
Humanos , Dermatopatias Virais/virologia , Herpesvirus Humano 4 , Infecções por Vírus Epstein-Barr/diagnóstico , Dermatopatias Virais/classificação , Dermatopatias Virais/diagnóstico , Dermatopatias Virais/patologia , Infecções por Vírus Epstein-Barr/classificação , Infecções por Vírus Epstein-Barr/patologiaRESUMO
Epstein-Barr virus is a DNA virus infecting human beings and could affect 90% of human population. It is crucial to take in account that in Latin America, unlike what happens in developed countries, the exposure to the virus is very early and therefore people have a much longer interaction with the virus. The virus is related to many diseases, mainly the oncological ones, and when the onset is in cutaneous tissue, it can present many clinical variants, as well acute as chronic ones. Among the acute ones are infectious mononucleosis rash and Lipschutz ulcers; the chronic presentations are hypersensivity to mosquito bites, hydroa vacciniforme, hydroa vacciniforme-like lymphoma, its atypical variants and finally nasal and extra-nasal NK/T-cell lymphoma. Although they are not frequent conditions, it is crucial for the dermatologist to know them in order to achieve a correct diagnosis.
Assuntos
Infecções por Vírus Epstein-Barr/diagnóstico , Herpesvirus Humano 4 , Dermatopatias Virais/virologia , Infecções por Vírus Epstein-Barr/classificação , Infecções por Vírus Epstein-Barr/patologia , Humanos , Dermatopatias Virais/classificação , Dermatopatias Virais/diagnóstico , Dermatopatias Virais/patologiaRESUMO
There are few studies on pathogens affecting free-ranging pinnipeds from South America. We employed molecular techniques to identify a gammaherpesvirus infection by two putative novel herpesvirus species: Otariid herpesvirus 5 (OtHV-5), possibly associated with ulcerative cutaneous lesions, and Otariid herpesvirus 6 (OtHV-6) in a wild South American fur seal ( Arctocephalus australis) that stranded alive in Santa Catarina state, southern Brazil. Here we provide new information regarding pinniped herpesviruses, important for the design of future disease surveillance studies.
Assuntos
Otárias , Gammaherpesvirinae/isolamento & purificação , Dermatopatias Virais/veterinária , Úlcera Cutânea/veterinária , Animais , Evolução Fatal , Gammaherpesvirinae/genética , Masculino , Filogenia , Dermatopatias Virais/patologia , Dermatopatias Virais/virologia , Úlcera Cutânea/patologia , Úlcera Cutânea/virologiaRESUMO
Cutaneous human papillomaviruses (HPVs) comprise a large and highly heterogeneous virus group. Some of the cutaneous HPVs of the genus Beta have been suggested as a co-factor in the development of non-melanoma skin cancer (NMSC). The aim of this study was to determine cutaneous HPV prevalence and type-specific distribution in different kinds of skin lesions from Argentine patients visiting Dermatology Departments of three hospitals from Buenos Aires. A cross-sectional analysis was performed. HPV DNA was analyzed in (i) 3 patients with Epidermodysplasia verruciformis (EV) harboring benign lesions (BL) (n = 1) and squamous cell carcinoma (SCC) (n = 4); (ii) 240 non-EV patients harboring: (a) BL (n = 38), (b) Actinic Keratosis (AK) (n = 83), (c) SCC (n = 74), and (d) basal cell carcinoma (BCC) (n = 96). Detection and genotyping of 35 cutaneous HPV DNA was carried out by BGC-PCR and GP5+/6 + PCR followed by reverse line blot assay. In EV patients, Beta types were found in all lesions (5/5), including the potentially high-risk HPV types 5 and 8, mostly in multiple infections. In non-EV patients, cutaneous types were found in 50.0% of BL, 43.4% of AK, 31.1% of SCC, and 16.7% of BCC. Beta HPVs were the most frequently found in all lesions, being present in all AK and SCC cases that were positive for HPV. No type-specific correlation with lesion severity was found. In our series, a wide spectrum of cutaneous HPV types was detected in different skin lesions. A possible role for these HPVs in skin carcinogenesis deserves further study. J. Med. Virol. 89:352-357, 2017. © 2016 Wiley Periodicals, Inc.
Assuntos
Genótipo , Papillomaviridae/classificação , Papillomaviridae/genética , Infecções por Papillomavirus/epidemiologia , Infecções por Papillomavirus/virologia , Dermatopatias Virais/epidemiologia , Dermatopatias Virais/virologia , Idoso , Argentina/epidemiologia , Estudos Transversais , Feminino , Técnicas de Genotipagem , Humanos , Masculino , Pessoa de Meia-Idade , Epidemiologia Molecular , Hibridização de Ácido Nucleico , Papillomaviridae/isolamento & purificação , Reação em Cadeia da Polimerase , PrevalênciaRESUMO
Human T cell lymphotropic virus type 1 (HTLV-1)-associated infective dermatitis (ID) is a chronic, severe and recurrent eczema occurring during childhood in patients vertically infected with HTLV-1. HTLV-1-associated myelopathy/tropical spastic paraparesia (HAM/ TSP) is slow and progressive. We report the case of an adolescent female from a non-endemic area for HTLV-1 who presents ID and, most likely, associated HAM/TSP.
Assuntos
Dermatite/virologia , Infecções por HTLV-I/complicações , Paraparesia Espástica Tropical/virologia , Dermatopatias Virais/virologia , Adolescente , Dermatite/patologia , Progressão da Doença , Feminino , Infecções por HTLV-I/patologia , Humanos , Imuno-Histoquímica , Paraparesia Espástica Tropical/patologia , Dermatoses do Couro Cabeludo/patologia , Dermatoses do Couro Cabeludo/virologia , Dermatopatias Virais/patologiaRESUMO
Human T cell lymphotropic virus type 1 (HTLV-1)-associated infective dermatitis (ID) is a chronic, severe and recurrent eczema occurring during childhood in patients vertically infected with HTLV-1. HTLV-1-associated myelopathy/tropical spastic paraparesia (HAM/ TSP) is slow and progressive. We report the case of an adolescent female from a non-endemic area for HTLV-1 who presents ID and, most likely, associated HAM/TSP.
.Assuntos
Adolescente , Feminino , Humanos , Dermatite/virologia , Infecções por HTLV-I/complicações , Paraparesia Espástica Tropical/virologia , Dermatopatias Virais/virologia , Progressão da Doença , Dermatite/patologia , Infecções por HTLV-I/patologia , Imuno-Histoquímica , Paraparesia Espástica Tropical/patologia , Dermatoses do Couro Cabeludo/patologia , Dermatoses do Couro Cabeludo/virologia , Dermatopatias Virais/patologiaRESUMO
Human dialyzable leukocyte extracts (DLEs) are heterogeneous mixtures of low-molecular-weight peptides that are released on disruption of peripheral blood leukocytes from healthy donors. DLEs improve clinical responses in infections, allergies, cancer, and immunodeficiencies. Transferon is a human DLE that has been registered as a hemoderivate by Mexican health authorities and commercialized nationally. To develop an animal model that could be used routinely as a quality control assay for Transferon, we standardized and validated a murine model of cutaneous HSV-1 infection. Using this model, we evaluated the activity of 27 Transferon batches. All batches improved the survival of HSV-1-infected mice, wherein average survival rose from 20.9% in control mice to 59.6% in Transferon-treated mice. The activity of Transferon correlated with increased serum levels of IFN-γ and reduced IL-6 and TNF-α concentrations. Our results demonstrate that (i) this mouse model of cutaneous herpes can be used to examine the activity of DLEs, such as Transferon; (ii) the assay can be used as a routine test for batch release; (iii) Transferon is produced with high homogeneity between batches; (iv) Transferon does not have direct virucidal, cytoprotective, or antireplicative effects; and (v) the protective effect of Transferon in vivo correlates with changes in serum cytokines.
Assuntos
Extratos Celulares/farmacologia , Herpes Simples/tratamento farmacológico , Herpesvirus Humano 1/efeitos dos fármacos , Leucócitos/metabolismo , Dermatopatias Virais/tratamento farmacológico , Animais , Bioensaio , Linhagem Celular , Chlorocebus aethiops , Modelos Animais de Doenças , Herpes Simples/virologia , Interferon gama/sangue , Interleucina-6/sangue , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Dermatopatias Virais/virologia , Fator de Necrose Tumoral alfa/sangue , Células VeroRESUMO
The aim of this study was to evaluate the use of RNA interference to inhibit herpes simplex virus type-1 replication in vitro. For herpes simplex virus type-1 gene silencing, three different small interfering RNAs (siRNAs) targeting the herpes simplex virus type-1 UL39 gene (sequence si-UL 39-1, si-UL 39-2, and si-UL 39-3) were used, which encode the large subunit of ribonucleotide reductase, an essential enzyme for DNA synthesis. Herpes simplex virus type-1 was isolated from saliva samples and mucocutaneous lesions from infected patients. All mucocutaneous lesions' samples were positive for herpes simplex virus type-1 by real-time PCR and by virus isolation; all herpes simplex virus type-1 from saliva samples were positive by real-time PCR and 50% were positive by virus isolation. The levels of herpes simplex virus type-1 DNA remaining after siRNA treatment were assessed by real-time PCR, whose results demonstrated that the effect of siRNAs on gene expression depends on siRNA concentration. The three siRNA sequences used were able to inhibit viral replication, assessed by real-time PCR and plaque assays and among them, the sequence si-UL 39-1 was the most effective. This sequence inhibited 99% of herpes simplex virus type-1 replication. The results demonstrate that silencing herpes simplex virus type-1 UL39 expression by siRNAs effectively inhibits herpes simplex virus type-1 replication, suggesting that siRNA based antiviral strategy may be a potential therapeutic alternative.
Assuntos
Herpesvirus Humano 1/fisiologia , RNA Interferente Pequeno/farmacologia , Saliva/virologia , Dermatopatias Virais/virologia , Replicação Viral/efeitos dos fármacos , Animais , Chlorocebus aethiops , Herpesvirus Humano 1/genética , Humanos , Reação em Cadeia da Polimerase em Tempo Real , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Células Vero , Ensaio de Placa Viral , Replicação Viral/genética , Replicação Viral/fisiologiaRESUMO
Vaccinia virus (VACV) is the etiological agent of bovine vaccinia (BV), an important zoonosis that affects dairy cattle. There are many aspects of the disease that remain unknown, and aiming to answer some of these questions, the clinical, hematological, and biochemical parameters of VACV experimentally infected cows were evaluated. In the first part of the study, lactating cows were infected with VACV-GP2 strain. In the second part, animals previously infected with VACV-GP2 were divided into two treatment groups: Group 1, immunosuppressed cows; and Group 2, re-infected cows. In this study, BV could be experimentally reproduced, with similar lesions as observed in natural infections. Moreover, a short incubation period and local lymphadenopathy were also observed. VACV could be detected by PCR and isolated from scabs taken from teat lesions of all inoculated and re-inoculated animals. Lymphocytosis and neutrophilia were observed in all animals from the first part of the experiment, and lymphopenia and relative neutrophilia were observed in the immunosuppressed animals. Detection of viral DNA in oral mucosa lesions suggests that viral reactivation might occur in immunosuppressed animals. Moreover, clinical disease with teat lesions may occur in previously VACV-infected cows under the experimental conditions of the present study.
Assuntos
Mastite Bovina/virologia , Dermatopatias Virais/veterinária , Vaccinia virus/fisiologia , Vacínia/veterinária , Animais , Anticorpos Antivirais , Bovinos , Indústria de Laticínios , Feminino , Glândulas Mamárias Animais/patologia , Glândulas Mamárias Animais/virologia , Mastite Bovina/patologia , Leite/citologia , Úlceras Orais/patologia , Úlceras Orais/veterinária , Úlceras Orais/virologia , Dermatopatias Virais/patologia , Dermatopatias Virais/virologia , Vacínia/virologiaRESUMO
Standard treatment of leishmaniasis consists of n-metilglucamine, meglumine antimoniate, which can trigger side effects such as general malaise, renal and hepatic impairment, and cardiac arrhythmias. Infrequently, reactivations of varicella-zoster virus infections have been reported. This paper describes a patient with cutaneous leishmaniasis in treatment with meglumine and herpes zoster multiplex. After ruling out other possible causes of immunosuppression, an acyclovir therapy was initiated.
Assuntos
Antiprotozoários/efeitos adversos , Herpes Zoster/induzido quimicamente , Leishmaniose Cutânea/tratamento farmacológico , Meglumina/efeitos adversos , Compostos Organometálicos/efeitos adversos , Dermatopatias Virais/induzido quimicamente , Adulto , Feminino , Humanos , Antimoniato de Meglumina , Dermatopatias Virais/virologiaRESUMO
Papular-purpuric gloves and socks syndrome is a rare, highly contagious dermatosis caused by parvovirus B19, which may result in the abrupt cessation of red blood cell production in patients with preexisting hematological diseases. It affects predominantly children and young adults and has an unusual presentation.
Assuntos
Dermatoses do Pé/virologia , Dermatoses da Mão/virologia , Infecções por Parvoviridae/complicações , Parvovirus B19 Humano , Púrpura/virologia , Dermatopatias Virais/virologia , Adulto , Feminino , Humanos , Púrpura/diagnóstico , SíndromeRESUMO
Papular-purpuric gloves and socks syndrome is a rare, highly contagious dermatosis caused by parvovirus B19, which may result in the abrupt cessation of red blood cell production in patients with preexisting hematological diseases. It affects predominantly children and young adults and has an unusual presentation.
A síndrome "gloves and socks" pápulo-purpúrica é uma dermatose incomum, altamente contagiosa, causada pelo parvovírus B19, que pode provocar interrupção aguda da produção de glóbulos vermelhos em pacientes com doenças hematológicas preexistentes. Acomete, principalmente, crianças e jovens, e tem uma apresentaçao nao-usual.
Assuntos
Humanos , Feminino , Adulto , Púrpura/virologia , Parvovirus B19 Humano , Dermatopatias Virais/virologia , Infecções por Parvoviridae/complicações , Dermatoses do Pé/virologia , Dermatoses da Mão/virologia , Púrpura/diagnóstico , SíndromeRESUMO
The susceptibility of rabbits to two isolates of Vaccinia virus (VACV) recovered from cutaneous disease in horses in Southern Brazil was investigated. Rabbits were inoculated in the ear skin with both VACV isolates, either in single or mixed infection. All inoculated animals presented local skin lesions characterized by hyperaemia, papules, vesicles, pustules and ulcers. Infectious virus was detected in the lungs and intestine of rabbits that died during acute disease. Histological examination of the skin revealed changes characteristic of those associated with members of the genus Orthopoxvirus. These results demonstrate that rabbits develop skin disease accompanied by systemic signs upon intradermal inoculation of these two equine VACV isolates, either alone or in combination, opening the way for using rabbits to study selected aspects of the biology and pathogenesis of VACV infection.
Assuntos
Doenças dos Cavalos/virologia , Orthopoxvirus/isolamento & purificação , Infecções por Poxviridae/veterinária , Dermatopatias Virais/veterinária , Vaccinia virus/classificação , Animais , Brasil/epidemiologia , Chlorocebus aethiops , DNA Viral , Doenças dos Cavalos/epidemiologia , Cavalos , Pneumopatias/patologia , Pneumopatias/veterinária , Pneumopatias/virologia , Orthopoxvirus/classificação , Orthopoxvirus/patogenicidade , Reação em Cadeia da Polimerase/veterinária , Infecções por Poxviridae/epidemiologia , Infecções por Poxviridae/virologia , Coelhos , Dermatopatias Virais/epidemiologia , Dermatopatias Virais/virologia , Células Vero , Viremia , Eliminação de Partículas ViraisRESUMO
The diversity of papillomavirus (PV) found in bovine cutaneous warts from Brazilian cattle was evaluated using the PCR technique with the utilization of consensus primers MY09/11 and by PCR using Bovine Papillomavirus (BPV) type-specific primers followed by sequencing. Eleven cutaneous warts from 6 cattle herds were selected. Six warts were positive for the presence of PV. The presence of BPV types 1, 2, 3, 6 and feline sarcoid-associated PV (FeSarPV) in cutaneous wart lesions, as well as the presence of co-infections, was found. To the best of our knowledge, this is the first time that FeSarPV is described co-infecting a cutaneous wart in Brazil. The present study confirms the previous finding of FeSarPV infecting cattle. These results show the necessity of more studies to investigate the diversity of PV in cattle, its diversity and the possibility of co-infection in cattle and other animals.