RESUMO
Sydenham's chorea (SC) is thought to result from the action of streptococcus-induced antibodies that cross react with basal ganglia antigens. Much less is known, however, about the involvement of cellular mechanisms in its pathogenesis. Since chemokines seem to play a role in several CNS inflammatory disorders, we sought to investigate the chemokine profile of patients with SC. Increased serum levels of CXCL9, formerly monokine induced by interferon-gamma (Mig), and CXCL10, formerly interferon-gamma-inducible protein of 10 kDa (IP-10) were demonstrated in acute SC patients, suggesting that a particular group of chemokines may be involved in SC pathogenesis.
Assuntos
Quimiocinas CXC/sangue , Coreia/imunologia , Peptídeos e Proteínas de Sinalização Intercelular/sangue , Doença Aguda , Adolescente , Adulto , Quimiocina CXCL10 , Quimiocina CXCL9 , Quimiocinas CXC/líquido cefalorraquidiano , Criança , Coreia/sangue , Coreia/líquido cefalorraquidiano , Feminino , Humanos , Mediadores da Inflamação/sangue , Mediadores da Inflamação/líquido cefalorraquidiano , Peptídeos e Proteínas de Sinalização Intercelular/líquido cefalorraquidiano , Masculino , Pessoa de Meia-Idade , Regulação para Cima/imunologiaRESUMO
Movement disorders are not common in acquired immunodeficiency syndrome. Hemichorea-hemiballism (HC-HB) is the most common of them all, and it is usually related to oportunistic toxoplasmosis of the basal ganglia. We present a 28-year-old man, HIV positive with HC-HB caused by a right subthalamic granuloma, which did not respond to treatment for toxoplasmosis. Cryptoccococic antigen was positive in the cerebrospinal fluid and antifungic therapy led to clinical and radiologic improvement, thus the diagnosis of a granulomatous lesion by Cryptococcus neoformans was established. Current literature on HC-HB and its relationship with AIDS is subsequently reviewed.
Assuntos
Infecções Oportunistas Relacionadas com a AIDS/microbiologia , Coreia/microbiologia , Criptococose/complicações , Discinesias/microbiologia , Infecções Oportunistas Relacionadas com a AIDS/líquido cefalorraquidiano , Adulto , Coreia/líquido cefalorraquidiano , Criptococose/líquido cefalorraquidiano , Discinesias/líquido cefalorraquidiano , Humanos , Masculino , Tomografia Computadorizada por Raios XRESUMO
Se hace una revisión de 15 niños, 6 hembras y 9 varones con corea Sydenham, analizando las características de los pacientes, formas de presentación, duración del proceso, correlación con pruebas biológicas reumáticas, alteraciones electroencefalográficas, sintomatología neurológica asociada y la respuesta terapeútica. Los autores enfatizan el valor del examen neurológico detallado para el diagnóstico del proceso y la buena respuesta terapéutica con el Haloperidol