Assuntos
Animais , Gatos , Colesteatoma/etiologia , Otite Média/complicações , Chinchila , Colesteatoma/fisiopatologiaRESUMO
A cytomorphodensitometric study was made by analysis of the computerised image of the germinative and intermediate epithelial layers in a sample of five specimens of cholesteatoma and the corresponding skin from the external auditory canal. A morphometric variable corresponding to the nuclear area was determined and densitometric variables equivalent to the relative quantity of nuclear DNA were determined. Within the germinative layers of the cholesteatoma epithelium, we observed larger nuclei and more relative DNA per nucleus. The average densitometric values were in the range of 2C-4C, which is indicative of a greater cellular population in S phase in the cholesteatoma than in the skin.
Assuntos
Colesteatoma/diagnóstico , Colesteatoma/fisiopatologia , Densitometria/métodos , Orelha Média/citologia , Orelha Média/fisiopatologia , Otite Média/fisiopatologia , Adulto , Contagem de Células , Colesteatoma/complicações , Técnicas de Cultura , DNA/análise , Orelha Externa/citologia , Células Epiteliais , Epitélio/fisiopatologia , Feminino , Humanos , Interpretação de Imagem Assistida por Computador , Masculino , Pessoa de Meia-Idade , Otite Média/complicações , Fase S , Pele/citologiaRESUMO
Epithelial proliferation in colesteatoma and its influence on the subepithelial inflammatory reaction was studied using morphometry and nuclear photometry of specimens. Twenty specimens of colesteatoma and 15 specimens of skin from the external auditory canal were examined. Nuclear content was greater in the basal cells of colesteatoma epithelium than in the basal cells of external auditory canal epithelium, suggesting increased proliferative activity. This activity was found to be reted to the inflammatory infiltrate of the conjunctive tissue and varied in different specimens.
Assuntos
Movimento Celular , Colesteatoma/fisiopatologia , Orelha Média/fisiopatologia , Adolescente , Adulto , Criança , Tecido Conjuntivo , Orelha Externa/fisiopatologia , Epitélio/fisiopatologia , Feminino , Humanos , Linfócitos , MasculinoRESUMO
In 1988, the authors reported their experience in medical treatment of 66 children who had chronic suppurative otitis media, including the administration of intravenous antimicrobial agents. At the time of their initial treatment, 89 percent were successfully treated with medical treatment only, and the remaining 11 percent required surgical intervention. This report presents the long-term follow-up of 51 of those children who were available for study. Of these 51 patients, 40 (78%) had resolution of their initial or recurrent otorrhea, whereas 11 (22%) had surgery either initially or at the time of a recurrence. Medical management is successful in most children who have chronic suppurative otitis media, but surgical intervention should be considered if a cholesteatoma is suspected, if medical treatment is not effective in rapidly improving the chronic infection, or if the patient has recurrent disease over a relatively short period.
Assuntos
Antibacterianos/uso terapêutico , Colesteatoma/diagnóstico , Otite Média com Derrame/tratamento farmacológico , Adolescente , Antibacterianos/administração & dosagem , Otorreia de Líquido Cefalorraquidiano/etiologia , Criança , Pré-Escolar , Colesteatoma/fisiopatologia , Doença Crônica , Orelha Média/microbiologia , Orelha Média/fisiopatologia , Orelha Média/cirurgia , Feminino , Seguimentos , Humanos , Lactente , Injeções Intravenosas , Masculino , Otite Média com Derrame/microbiologia , Otite Média com Derrame/cirurgia , Pseudomonas aeruginosa/isolamento & purificação , Staphylococcus aureus/isolamento & purificaçãoRESUMO
Após fazerem consideraçöes sobre o conceito de colesteatoma, os autores dissertam sobre seu mecanismo de formaçäo e várias teorias existentes, ao mesmo tempo que o classifica. Descrevem seu padräo histólogico o relacionado com sua agressividade ao osso temporal. Comentam sobre as principais técnicas operatórias, discutindo as vantagens e desvantagens dos vários procedimentos cirúrgicos