RESUMO
Animals in human care often exceed the life expectancy of animals in the wild when they have veterinarian follow-ups, no competition for space or food, and continuous care. Advanced age favors the development of mutations that often trigger cancer, which sometimes causes death. There are reports in the literature on neoplasms in lions in the liver, which are one of the main organs affected. A 20-year-old lion specimen was received for necropsy at the Federal University of Paraná, Curitiba, Brazil. Multiple cystic dilations were observed in the liver. Histologically, they were internally covered by a simple cuboidal epithelium, similar to that observed in the bile ducts, without cellular atypia. The adjacent liver parenchyma presented with mild disorganization of the hepatocyte cords. Biliary cystadenomas are benign growths formed by a thin opaque capsule filled with a slightly yellowish translucent fluid compressing the adjacent liver parenchyma, as highlighted in this case. The epithelium of the cysts was positive for anti-cytokeratin (CK) (EIA/A3E) and anti-CK7, confirming histogenesis in the bile ducts. This study reports a case of biliary cystadenoma in a Panthera leo specimen.(AU)
Assuntos
Animais , Expectativa de Vida , Cistadenoma/fisiopatologia , Leões/lesões , Fígado , Neoplasias/diagnóstico , Relatório de PesquisaRESUMO
Biliary cystadenoma (BCA) and biliary cystadenocarcinoma (BCAC) are rare biliary duct neoplasms. This study investigated reasonable management strategies of cystic neoplasms in the liver. Charts of 39 BCA/BCAC patients (9 males, 30 female; median age 53.74 ± 14.50 years) who underwent surgery from January 1999 to December 2009 were reviewed retrospectively. Cyst fluid samples of 32 BCA/BCAC patients and 40 simple hepatic cyst patients were examined for the tumor markers carbohydrate associated antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA). The most frequent symptoms were abdominal pain (N = 10), abdominal mass (N = 7), abdominal distension (N = 4), jaundice (N = 2), and fever (N = 3); the remaining patients showed no clinical symptoms. Liver resection (N = 17) or enucleation (N = 22) was performed in the 39 patients. Ultimately, 35 patients were diagnosed with intrahepatic BCA and four patients were diagnosed with BCAC. The median CA19-9 level was significantly higher in BCA/BCAC patients than in simple hepatic cyst patients. The median CEA levels in BCA/BCAC patients and controls were 6.83 ± 2.43 and 4.21 ± 2.91 mg/L, respectively. All symptoms were resolved after surgery, and only one BCAC patient showed recurrence. The incidence of intrahepatic cystic lesions was 1.7%. Increased CA19-9 levels in the cyst fluid is a helpful marker for distinguishing BCA/BCAC from common simple cysts. The presence of coarse calcifications is suggestive of BCAC. Complete surgical removal of these lesions yielded satisfying long-term outcomes with a very low recurrence rate.
Assuntos
Ductos Biliares/cirurgia , Neoplasias do Sistema Biliar/cirurgia , Biomarcadores Tumorais/genética , Cistadenocarcinoma/cirurgia , Cistadenoma/cirurgia , Fígado/cirurgia , Adulto , Idoso , Antígenos Glicosídicos Associados a Tumores/genética , Ductos Biliares/metabolismo , Ductos Biliares/patologia , Ductos Biliares/fisiopatologia , Neoplasias do Sistema Biliar/metabolismo , Neoplasias do Sistema Biliar/patologia , Neoplasias do Sistema Biliar/fisiopatologia , Antígeno Carcinoembrionário/genética , Cistadenocarcinoma/metabolismo , Cistadenocarcinoma/patologia , Cistadenocarcinoma/fisiopatologia , Cistadenoma/metabolismo , Cistadenoma/patologia , Cistadenoma/fisiopatologia , Feminino , Expressão Gênica , Humanos , Fígado/metabolismo , Fígado/patologia , Fígado/fisiopatologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do TratamentoAssuntos
Humanos , Masculino , Adulto , Ductos Biliares/patologia , Cistadenoma/patologia , Cistadenoma/fisiopatologiaRESUMO
Os autores apresentam dois casos de cistadenomas de pâncreas, considerados tumores raros, discutindo seus aspectos clínicos, diagnósticos e terapêuticos