RESUMO
Impairment of natural cytotoxicity mediated by natural killer (NK) cells may play a role in the pathogenesis of penile carcinoma. The aim of this study was to examine the NK activity profile and its prognostic significance in patients with squamous cell carcinoma of the penis. The NK activity was measured in peripheral blood mononuclear cells (PBMCs) from 39 patients diagnosed histologically as having invasive squamous cell penile carcinoma and 4 patients with verrucous carcinoma of the penis. Of 39 patients with invasive squamous cell carcinoma, 4 had undergone previous penile amputation. According to the prognosis, the patients with invasive squamous cell carcinoma were divided into two groups: with metastasis and without metastasis. The patients were evaluated in relation to clinicopathologic variables using univariate analyses. NK cell activity was significantly decreased in all patients with penile carcinoma when compared with the control groups (p < 0.0001). There was no statistically significant difference between the groups with and without metastasis. We conclude that there is a decrease in NK activity in PBMCs from patients with penile carcinoma and that the presence of advanced disease or metastatic involvement is not responsible for this reduction.
Assuntos
Carcinoma de Células Escamosas/imunologia , Citotoxicidade Imunológica , Células Matadoras Naturais/imunologia , Neoplasias Penianas/imunologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma de Células Escamosas/secundário , Carcinoma Verrucoso/imunologia , Carcinoma Verrucoso/secundário , Estudos de Casos e Controles , Humanos , Técnicas In Vitro , Células K562 , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica/imunologia , Estadiamento de Neoplasias , PrognósticoRESUMO
El carcinoma verrugoso o tumor de Ackerman es considerado una variedad especial del carcinoma espinocelular bien diferenciado que se caracteriza por su bajo grado de malignidad, comportamiento clínico específico y un pronóstico favorable. Este tumor, asociado desde siempre con el consumo de tabaco masticable, higiene bucal deficiente y prótesis mal adpatadas, se ha visto relacionado últimamente con la infección por el virus de papiloma humano. Presentamos un caso de carcinoma verrugoso en mucosa de cavidad bucal con historia de prótesis mal adaptadas y consumo de tabaco masticado en una mujer blanca de 60 años. Puesto que el diagnóstico de esta lesión suele ser confundido, el examen clínico e histopatológico del carcinoma verrugoso son indispensables, ya que de ellos depende la identificación del tumor y posterior planificación del tratamiento