RESUMO
OBJECTIVE: To describe the frequency, clinical, and demographic features of minor salivary gland tumors and possible associated factors. MATERIALS AND METHODS: A cross-sectional study was conducted. Clinical and demographic data were collected from biopsy records of two oral pathology services. Chi-square test, Fisher's exact test, and descriptive statistical analysis were performed. RESULTS: A total of 480 (0.89%) minor salivary gland tumors were retrieved, 272 (56.7%) benign and 147 (30.7%) malignant. Sixty-one (12.6%) had no subtype specification. Most patients were women (307/64.0%), in sixth decade of life (80/16.7%), with a mean age of 45.32 years. Palate was the most common site (336/70.1%). Pleomorphic adenoma (PA; 245/51.1%), mucoepidermoid carcinoma (MEC; 70/14.6%), and adenoid cystic carcinoma (ACC; 43/8.9%) were the most frequent tumors. Symptomatic case, recurrence, and tobacco use were associated with malignancy (p < 0.05). PA and MEC were more frequent in palate (p < 0.05). No association between the three most frequent histological types and gender or age group was observed (p > 0.05). CONCLUSIONS: This represents one of the largest exclusive series of minor salivary gland tumors in Brazil and worldwide. PA, MEC, and ACC were the most frequent tumors. Clinical and demographic data are similar from Brazilian studies or from other countries.
Assuntos
Adenoma Pleomorfo , Carcinoma Adenoide Cístico , Neoplasias das Glândulas Salivares , Humanos , Feminino , Pessoa de Meia-Idade , Masculino , Estudos Transversais , Glândulas Salivares Menores , Neoplasias das Glândulas Salivares/epidemiologia , Neoplasias das Glândulas Salivares/patologia , Adenoma Pleomorfo/epidemiologia , Adenoma Pleomorfo/patologia , Carcinoma Adenoide Cístico/epidemiologia , Carcinoma Adenoide Cístico/patologia , Demografia , Estudos RetrospectivosRESUMO
BACKGROUND: Sinonasal adenoid cystic carcinoma (SNACC) is a rare malignancy with a propensity for distant metastasis. In this study we describe the incidence and determinants of survival among patients with SNACC between the years 2004 and 2012 using the National Cancer Database (NCDB). METHODS: This was a retrospective, population-based cohort study performed at a tertiary academic medical center. All participants were diagnosed with SNACC between 2004 and 2012 within the NCDB. The main outcome was overall survival (OS). RESULTS: A total of 793 patients were identified. The cohort was composed of 46.9% males. Mean age at diagnosis was 59.6 years. The maxillary sinus was the most common primary site (49.7%). Nodal disease was seen in 3.6% of the patients, whereas 3.7% had distant metastases. Stage IV disease was seen in 49.1% of cases. In total, 77.4% of patients underwent surgery, 68.2% received radiation therapy, and 16.4% had chemotherapy. Median OS was 78.5 months; OS at 1, 2, and 5 years was 91%, 83%, and 61%, respectively. On multivariate analysis, advanced age (p = 0.001), frontal sinus primary site (p < 0.001), positive margins (p < 0.001), Charlson comorbidity index >0 (p = 0.01), residing in an urban setting (p = 0.04), poorly differentiated or undifferentiated tumor grade (p = 0.003), and advanced tumor stage (p = 0.01) were associated with worse OS, whereas surgery (p < 0.001), but not radiation therapy (p = 0.52) or chemotherapy (p = 0.57), predicted improved OS. CONCLUSION: Predictors of survival in SNACC include age, comorbidity status, grade, and stage. Surgery is associated with improved survival and remains the mainstay of therapy, whereas the roles of radiation therapy and chemotherapy require future investigation.
Assuntos
Carcinoma Adenoide Cístico/epidemiologia , Neoplasias dos Seios Paranasais/epidemiologia , Idoso , Carcinoma Adenoide Cístico/terapia , Bases de Dados Factuais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias dos Seios Paranasais/terapia , Estudos RetrospectivosRESUMO
Tumours of the minor salivary glands are relatively uncommon, and publications from around the world normally include tumours of both the minor and major salivary glands, making it difficult to assess their prevalence and distribution. Our aim was to evaluate retrospectively the clinicopathological features of a series of tumours of the intraoral minor salivary glands from two universities in Rio de Janeiro, Brazil, and to compare the data with those from other epidemiological studies. A total of 170 such tumours were diagnosed from 1942 to 2012, and were selected from two university departments of oral pathology. Eighty-nine of the tumours were benign (52%). Pleomorphic adenoma (n=75) and mucoepidermoid carcinoma (n=23) were the most common benign (44%) and malignant tumours (14%), respectively. There were 104 female patients (61%) and both benign and malignant tumours affected more women than men. Significantly more tumours were in the palate (n=95, 56%; p=0.001). We conclude that these tumours had features similar to those from other studies from North and Latin America, but differ from the results presented from Asia. Further studies should be designed to highlight possible geographical and population-specific characteristics of these tumours.
Assuntos
Neoplasias das Glândulas Salivares , Glândulas Salivares Menores , Adenoma Pleomorfo/epidemiologia , Brasil , Carcinoma Adenoide Cístico/epidemiologia , Carcinoma Mucoepidermoide/epidemiologia , Feminino , Humanos , Masculino , Estudos Retrospectivos , Neoplasias das Glândulas Salivares/epidemiologiaRESUMO
INTRODUCTION: Salivary gland tumors comprise three to ten percent of all head and neck tumors. The parotid gland is affected most often (64-80%). Malignant tumors constitute a minority, occurring in 15-32% of cases. Pleomorphic adenoma is the most common benign tumor, while mucoepidermoid carcinoma is a malignant neoplasm characterized by the highest incidence. OBJECTIVES: The objective of this study was to conduct a cross-sectional study of all salivary gland tumors diagnosed in a tertiary hospital in the period between 1995 and 2013. METHODS: We reviewed all salivary gland histopathological reports completed at a single institution. Patient demographics and clinical data were analyzed. We used Pearson's chi-square test (χ2) to determine statistical significance for the variables. RESULTS: Neoplastic lesions amounted to 271 cases (37,27%). Pleomorphic adenoma was the most frequent benign tumor, while mucoepidermoid carcinoma was the most commonly found malignant tumor. Parotid gland showed a clear, statistically significant (p=0.045) preponderance of benign tumors. Age was the only predictor of malignancy (OR 1.03). CONCLUSION: The present study is in agreement with the current literature regarding the most frequent types of tumors, incidence according to a type of gland and gender.
Assuntos
Adenoma Pleomorfo/epidemiologia , Carcinoma Mucoepidermoide/epidemiologia , Neoplasias das Glândulas Salivares/epidemiologia , Adenocarcinoma/epidemiologia , Adenoma Pleomorfo/patologia , Carcinoma Adenoide Cístico/epidemiologia , Carcinoma Mucoepidermoide/patologia , Estudos Transversais , Feminino , Humanos , Masculino , Neoplasias das Glândulas Salivares/cirurgiaRESUMO
O adenoma pleomórfico (AP), o carcinoma mucoepidermóide (CME) e o carcinoma adenóide cístico (CAC) representam tumores frequentes em glândula salivar. A via de sinalização Sonic Hedgehog (Hh) e o Transdutor de sinal e ativador da transcrição 3 (STAT3) desempenham funções importantes na proliferação celular, favorecendo o desenvolvimento tumoral e a proteína MCM3 tem sido considerada uma nova classe de marcadores de proliferação celular. Portanto, o presente trabalho propõe-se a estudar componentes da via Hh, bem como o STAT3 e o MCM3 em neoplasias de glândula salivar, na tentativa de adicionar informações sobre as características biológicas dessas neoplasias. Foram utilizados 9 casos de AP, 17 casos de CAC e 20 casos de CME e, por meio da técnica imunoistoquímica, realizou-se a detecção das seguintes proteínas: SHH, GLI1, SUFU, HHIP, STAT3 e MCM3. No AP, observou-se alta expressão citoplasmática de SHH e SUFU, e baixa expressão de STAT3 e MCM3. No CAC, observou-se alta expressão de GLI1, HHIP e STAT3 e baixa expressão de SHH, SUFU e MCM3. No CME, observou-se alta expressão de SHH, GLI1, SUFU e HHIP e baixa expressão de STAT3 e MCM3. Quando comparado entre os tipos tumorais, observou-se diferença estatisticamente significante para expressão de SHH (p=0.0064), STAT3 (p=0.0003) e MCM3 (p=0.0257)...
The pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC) and the adenoid cystic carcinoma (ACC) are common tumors arising from salivary glands. The Sonic Hedgehog signaling pathway (Hh) and signal transducer and activator of transcription 3 (STAT3) play important roles in cell proliferation, favoring tumor growth. The MCM3 protein has been considered as a novel class of cell proliferation markers. The aim of this investigation was to study components of the Hh pathway, as well as STAT3 and MCM3 in salivary gland neoplasms in an attempt to add information about the biological characteristics of these neoplasms. We used 9 cases of PA, 17 cases of ACC and 20 cases of MEC. Using immunohistochemistry, were investigated: SHH, GLI1, Sufu, HHIP, STAT3 and MCM3. In PA, there was high expression of cytoplasmic SHH and Sufu, and low expression of STAT3 and MCM3. In the ACC, there was high expression of GLI1, HHIP and STAT3 and low expression of SHH, SUFU and MCM3. In the MEC, we observed high expression of SHH, GLI1, SUFU and HHIP and low expression of STAT3 and MCM3. There was a statistically significant difference between SHH (p=0.0064), STAT3 (p=0.0003) and MCM3 (p=0.0257) when all tumors were compared...
Assuntos
Humanos , Adenoma/imunologia , Carcinoma Adenoide Cístico/diagnóstico , Carcinoma Adenoide Cístico/epidemiologia , Carcinoma Adenoide Cístico/imunologia , Carcinoma Adenoide Cístico/prevenção & controle , Carcinoma Adenoide Cístico/sangue , Carcinoma Mucoepidermoide/complicações , Carcinoma Mucoepidermoide/patologiaRESUMO
OBJECTIVE: The aim of this study was to determine the distribution and demographic features of salivary gland tumors (SGTs) in a large Brazilian population. STUDY DESIGN: A total of 493 cases of SGTs diagnosed between 2001 and 2011 from a general pathology laboratory and an oral pathology service were reviewed with respect to their clinicopathologic features. RESULTS: A total of 369 tumors were benign and 124 were malignant. The mean age of patients with benign tumors was 46.3 years and that of patients with malignancies was 54.0 years. The parotid gland was the most common location (42.3%). Pleomorphic adenoma (PA) and Warthin's tumor were the most common benign neoplasias, whereas mucoepidermoid carcinoma (MEC) and adenocarcinoma, not otherwise specified, were the most frequent malignancies. CONCLUSIONS: The present data confirm that PA and MEC are the most common benign and malignant SGTs. However, it is important to consider that differences in tumor types may be influenced by whether a tumor derives from a medical or a dental service.
Assuntos
Adenocarcinoma/patologia , Adenolinfoma/patologia , Adenoma Pleomorfo/patologia , Carcinoma Mucoepidermoide/patologia , Neoplasias das Glândulas Salivares/patologia , Adenocarcinoma/epidemiologia , Adenolinfoma/epidemiologia , Adenoma Pleomorfo/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Brasil/epidemiologia , Carcinoma Adenoide Cístico/epidemiologia , Carcinoma Adenoide Cístico/patologia , Carcinoma Mucoepidermoide/epidemiologia , Criança , Clínicas Odontológicas , Feminino , Hospitais Gerais , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Parotídeas/epidemiologia , Neoplasias Parotídeas/patologia , Estudos Retrospectivos , Neoplasias das Glândulas Salivares/epidemiologia , Adulto JovemRESUMO
INTRODUCTION: Primary carcinomas of the trachea are rare tumors, occurring at a rate of 2.6 new cases per 1,000,000 people per year. This study investigates the large observational cohort of patients recorded in the NCI Surveillance, Epidemiology, and End Results (SEER) 1973-2004 database, and provides information regarding epidemiology, treatment, and prognosis. METHODS: The SEER database was investigated, and all patients for whom primary tracheal carcinoma was the first and only cancer were investigated. Demographic information was investigated. The cohort was analyzed for variables effecting survival, including age, gender, race, histology, extent of disease, extent of surgery, use of radiation, and year of diagnosis. RESULTS: Between 1973 and 2004, 578 cases of primary tracheal carcinomas were reported in the SEER database. There were 322 men (55.7%) and 256 women (44.3%). Squamous cell carcinoma was the predominant histology, representing 259 tumors (44.8%). Adenoid cystic carcinoma (ACC) was the second most common tumor (16.3%). Localized, regional and distant disease was found in 140 (24.2%), 212 (36.7%), and 108 (18.7%), respectively. Twenty percent of the patients did not undergo staging. Patients with localized disease had a better prognosis than those with regional (P = 0.001) or distant disease (P = <0.001).A significant fraction of patients did not receive cancer directed local therapy; 34.3% did not undergo surgery and 29.1% did not receive any kind of radiation therapy. There was a statistically significant improved survival for patients who underwent any type of surgery in comparison with patients who did not undergo cancer directed surgery. There was no statistical benefit for patients who underwent radiation therapy.General overall 5-year survival for all patients was 27.1% (95% CI: 23.1-33.3%). Patients with localized disease had a better outcome than patients with regional or distant disease with an overall 5-year survival of 46% (95% CI: 37.3%-55.8%). Squamous cell carcinoma tumors had worse outcomes than any other histologic type, with a 5 year overall survival of 12.6% (95% CI: 8.4-17.6%). In contrast, 5-year overall survival for AACs was relatively good at 74.3% (95% CI: 63.1-82.5). For localized disease, 5-year survival was 24.7% (95% CI: 12.8-38.7%) for squamous cell carcinoma versus 90.5% (95% CI: 73.3-96.8%) for ACCs (P < 0.001). CONCLUSION: Primary tracheal tumors are very uncommon; squamous cell carcinoma is the most common histologic type, followed by ACCs. General 5-year overall survival is poor, though localized disease has better survival when compared with regional or distant disease. There is a remarkable difference in survival between squamous cell carcinoma and ACC.
Assuntos
Carcinoma Adenoide Cístico/epidemiologia , Carcinoma de Células Escamosas/epidemiologia , Neoplasias da Traqueia/epidemiologia , Adolescente , Adulto , Idoso , Carcinoma Adenoide Cístico/patologia , Carcinoma Adenoide Cístico/terapia , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/terapia , Criança , Pré-Escolar , Estudos de Coortes , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Prognóstico , Sistema de Registros , Programa de SEER , Neoplasias da Traqueia/patologia , Neoplasias da Traqueia/terapia , Estados Unidos/epidemiologia , Adulto JovemRESUMO
Introducción: El cáncer laríngeo en 95 por ciento de los casos corresponde a carcinomas escamosos, siendo el porcentaje restante de diversos tipos histológicos. Objetivo: Determinar la frecuencia de cáncer laríngeo de histología inhabitual en nuestro centro. Material y método: Estudio retrospectivo, revisión de fichas clínicas de pacientes con diagnóstico histopatológico de cáncer laríngeo evaluados en el Servicio Otorrinolaringología Hospital San Juan de Dios, entre años 2000-2008. Se describen sexo, edad, tipo histológico, hábito tabáquico y localización tumoral, realizándose un análisis descriptivo de los datos. Resultados: Se incluyeron 85 pacientes; 74 casos (87,1 por ciento) de sexo masculino; promedio edad 64 años; se encontraron 5 casos de tumores de histología inhabitual (5,9 por ciento); un caso respectivamente de: condrosarcoma, tumor carcinoide, carcinoma adenoideo-quístico, carcinoma sarcomatoide y carcinoma verrucoso. Discusión: Se podría sospechar histología inhabitual con base estadística ante un paciente menor de 60 años y con un tumor de localización subglótica. Además, sexo femenino, no fumador y más de una toma de muestra para biopsia. Conclusión: Los tumores de histología inhabitual se encontraron en 5,9 por ciento de los casos, similar a lo reportado en la literatura.
Introduction: The laryngeal cancer in 95 percent of the cases corresponds to squamous cell carcinomas, being the remaining percentage several histological different types. Aim: To determine the frequency of laryngeal cancer of unusual histology in our center. Material and method: Retrospective study review of clinical data of patients with histophatological diagnosis of laryngeal cancer evaluated in Otolaryngology Department ofSan Juan de Dios's Hospital between years 2000-2008. Sex, age, histological type, tobacco smoking and tumor location are described, being carried outa descriptive analysis ofthe data. Results: 85 patients were included; 74 cases (87,1 percent) ofmasculine sex; mean age 64 years; there were 5 cases of unusual histology tumors (5,9 percent); a case respectively of: chondrosarcoma, carcinoid tumor, adenoid-cystic carcinoma, sarcomatoid carcinoma and verrucous carcinoma. Discussion: It might suspect unusual histology with statistical base in patient younger than 60 years and tumor of subglotic location. Also, in feminine patient, not smoking and more than one capture ofsample forbiopsy Conclusion: The tumors of unusual histology viere found in a 5.9 percent of the cases, similar to the reponed in the literature.
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Neoplasias Laríngeas/epidemiologia , Neoplasias Laríngeas/patologia , Carcinoma Adenoide Cístico/epidemiologia , Carcinoma Verrucoso/epidemiologia , Carcinoma de Células Escamosas/epidemiologia , Condrossarcoma/epidemiologia , Distribuição por Idade e Sexo , Estudos Retrospectivos , Sarcoma/epidemiologia , Tabagismo/efeitos adversos , Tabagismo/epidemiologia , Tumor Carcinoide/epidemiologiaRESUMO
Los tumores de la tráquea son poco frecuentes y entre ellos el carcinoma adenoideo quístico es una neoplasia muy rara. La incidencia no difiere según el sexo y es más frecuente entre la tercera y quinta décadas de la vida. El tratamiento de elección es el quirúrgico, siempre que se trate de tumores resecables. Con este trabajo presentamos un caso intervenido por un tumor traqueal infrecuente, en una mujer con un carcinoma adenoideo quístico del tercio superior de la tráquea, con bordes de sección libres de tumor, que no recibió tratamiento oncológico(AU)
The tumors of the windpipe are not very frequent and among them the cystic adenoid carcinoma is a very strange neoplasia. The incidence doesn't differ according to the sex and it is more frequent between the third and fifth decades of the life. The election treatment is the surgical one, whenever it is tumors resecables. With this work we present a case intervened by an uncommon tracheal tumor, in a woman with a cystic adenoid carcinoma of the superior third of the windpipe, with section borders free of tumor that didn't receive treatment oncológico(AU)
Assuntos
Humanos , Feminino , Adulto , Neoplasias da Traqueia/cirurgia , Carcinoma Adenoide Cístico/epidemiologiaRESUMO
El carcinoma adenoide quístico (CAQ) o cilindroma es una rara entidad clasificada por la OMS dentro de los carcinomas de glándulas salivales. Representa sólo el 1 por ciento de todos los tumores malignos de la región bucal y maxilofacial, aunque al hacer referencia a las glándulas salivales, constituye el 5 por ciento de los carcinomas de parótida, submaxilar y sublingual, y aproximadamente el 50 por ciento de las menores. La ubicación más frecuente es en las glándulas palatinas y sus características principales son: crecimiento lento pero persistente, altas tasas de recidiva local y metástasis a distancia, originando la muerte dentro de los 5 a 10 primeros años en aproximadamente el 50-70 por ciento de los casos. Se presenta un caso de localización en glándula sublingual, el cual fue tratado quirúgicamente con posterior radioterapia, obteniendo buenos resultados
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Biópsia , Carcinoma Adenoide Cístico/epidemiologia , Neoplasias da Glândula Sublingual , Tomografia Computadorizada por Raios XRESUMO
El carcinoma adenoide quístico (CAQ) o cilindroma es una rara entidad clasificada por la OMS dentro de los carcinomas de glándulas salivales. Representa sólo el 1 por ciento de todos los tumores malignos de la región bucal y maxilofacial, aunque al hacer referencia a las glándulas salivales, constituye el 5 por ciento de los carcinomas de parótida, submaxilar y sublingual, y aproximadamente el 50 por ciento de las menores. La ubicación más frecuente es en las glándulas palatinas y sus características principales son: crecimiento lento pero persistente, altas tasas de recidiva local y metástasis a distancia, originando la muerte dentro de los 5 a 10 primeros años en aproximadamente el 50-70 por ciento de los casos. Se presenta un caso de localización en glándula sublingual, el cual fue tratado quirúgicamente con posterior radioterapia, obteniendo buenos resultados (AU)
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Neoplasias da Glândula Sublingual/radioterapia , Carcinoma Adenoide Cístico/epidemiologia , Biópsia/métodos , Tomografia Computadorizada por Raios XRESUMO
Salivary gland tumors are uncommon and the microscopical features can be complex. Epidemiological data of these tumors in the various parts of the world can be helpful for a better understanding of its biology and clinical characteristics. In this study, 496 epithelial and mesenchymal tumors of major and minor salivary glands diagnosed at Londrina Cancer Institute during the period from 1972 to 2001 were reviewed. Out of all cases, 335 (67.5%) were classified as benign and 161 (32.5%) as malignant. The majority of the cases occurred in the parotid gland (67.7%), followed by the minor salivary glands (22.8%) and submandibular gland (9.5%). Among the minor salivary gland tumors, the palate was the most frequent location (67%). The tumors affected more commonly adult patients with peak incidence between 40 and 50 years of age and with a slightly predominance in females. Pleomorphic adenoma was the most frequent tumor representing 54.2% of all cases, followed by mucoepidermoid carcinoma (13.5%), Warthin's tumor (8.5%) and adenoid cystic carcinoma (7.9%).
Assuntos
Neoplasias das Glândulas Salivares/epidemiologia , Adenolinfoma/epidemiologia , Adenoma Pleomorfo/epidemiologia , Adolescente , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Brasil/epidemiologia , Carcinoma Adenoide Cístico/epidemiologia , Carcinoma Mucoepidermoide/epidemiologia , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Epiteliais e Glandulares/epidemiologia , Palato/patologia , Neoplasias Parotídeas/epidemiologia , Estudos Retrospectivos , Glândulas Salivares Menores/patologia , Fatores Sexuais , Neoplasias da Glândula Submandibular/epidemiologiaRESUMO
OBJETIVO: este trabalho tem por objetivo determinar a freqüência relativa e a distribuição das neoplasias epiteliais benignas e malignas de glândulas salivares. FORMA DE ESTUDO: Coorte histórica. MATERIAL E MÉTODO: registradas no Laboratório de Patologia e Citologia, em Aracaju-SE, no período de janeiro de 1980 a dezembro de 1999, considerando-se as variáveis sexo, idade, tipo racial, localização anatômica e diagnóstico histopatológico. RESULTADO: Dos 162.312 casos registrados, 245 (0,15 por cento) foram de neoplasias epiteliais de glândulas salivares, sendo 187 de natureza benigna (76,33 por cento) e 58 (23,67 por cento) malignas. O adenoma pleomórfico foi o tumor benigno mais identificado (89,94 por cento) e o carcinoma adenóide cístico foi o representante maligno mais prevalente (22,41 por cento). As neoplasias benignas ocorreram principalmente entre as 2° e 3° décadas de vida, exibindo predileção pelo sexo feminino, enquanto as malignas foram diagnosticadas entre as 6° e 7° décadas de vida, sendo as mulheres o principal alvo. CONCLUSÃO: Constatou-se que o padrão epidemiológico das neoplasias estudadas está em consonância com a maioria da literatura pesquisada.
Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Adenoma Pleomorfo/epidemiologia , Carcinoma Adenoide Cístico/epidemiologia , Neoplasias das Glândulas Salivares/epidemiologia , Distribuição por Idade , Fatores Etários , Adenoma Pleomorfo/patologia , Brasil/epidemiologia , Estudos de Coortes , Grupos Raciais , Carcinoma Adenoide Cístico/patologia , Incidência , Prevalência , Distribuição por Sexo , Fatores Sexuais , Neoplasias das Glândulas Salivares/patologiaRESUMO
AIM: The aim of the present study is to establish the relative frequency and distribution of benign and malignant epithelial neoplasms of salivary glands in the Pathology and Cytology Laboratory, STUDY DESIGN: Historic cohort. MATERIAL AND METHOD: in the state of Sergipe, during the period 1980-1999. The neoplasms were individualized by gender, age, race of the patients, anatomic localization of the lesions and histopathological diagnosis. RESULTS: Out of 162,312 registered cases, 245 were salivary gland epithelial neoplasms and 187 (76.33%) were benign and 58 (23.67%) were malignant. Pleomorphic adenoma was the most frequent benign neoplasm (89.94%) and adenoid cystic carcinoma represented the most prevalent malignant neoplasm (22.41%). The benign neoplasms occurred mainly between the second and third decades of life and showed preference for female, while malignant neoplasms were diagnosed between the sixth and seventh decades of life and in women. CONCLUSION: The data demonstrate that epidemiology profile of studied neoplasms corroborated the majority researched literature.
Assuntos
Adenoma Pleomorfo/epidemiologia , Carcinoma Adenoide Cístico/epidemiologia , Neoplasias das Glândulas Salivares/epidemiologia , Adenoma Pleomorfo/patologia , Adolescente , Adulto , Distribuição por Idade , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Brasil/epidemiologia , Carcinoma Adenoide Cístico/patologia , Criança , Pré-Escolar , Estudos de Coortes , Feminino , Humanos , Incidência , Lactente , Masculino , Pessoa de Meia-Idade , Prevalência , Grupos Raciais , Neoplasias das Glândulas Salivares/patologia , Distribuição por Sexo , Fatores SexuaisRESUMO
OBJECTIVES: Malignant salivary gland tumors (MSGT) are uncommon. Age-standardized incidence rates are 0.5 and 0.3 per 100,000 in Quito, Ecuador; and 1.0 and 0.7 per 100,000 in the USA (SEER Program), for males and females, respectively. The goal of this study was to review a 16-year experience of a major general hospital in the treatment of these lesions. PATIENTS AND METHODS: From 1982 to 1998, 308 salivary gland tumors were surgically treated at the Hospital 'Carlos Andrade Marin' of the Ecuadorian Institute of Social Security in Quito, Ecuador, an Andean city of approximately 2 million inhabitants. Malignant lesions were found in 58 cases (19%): 37 out of 194 parotid gland tumors (19%), 7 out of 86 submandibular tumors (8%) and 14 out of 28 minor salivary gland tumors (50%). Adenoid cystic carcinoma and mucoepidermoid carcinoma were the most common histologic types. Twenty-two cases were classified as stage I, 13 as stage II, 1 as stage III and 20 as stage IV (UICC TNM staging classification). Thirty-one (53%) patients were treated by surgery alone; postoperative radiation therapy was additionally given to 22 (38%), and surgery, radiotherapy and chemotherapy were applied in 5 cases (9%). RESULTS: Local (LR) and/or regional recurrences were detected in 13 patients (22%). Twelve patients (21%) developed distant metastasis (DM; 2 in more than one site): 7 in the lungs, 2 in the brain, 2 in the bone and 1 each in the liver, subcutaneous tissue and pleura. Thirty-five patients are alive, 33 disease free. Twenty-three patients are deceased: 6 with LR, 7 with DM, 3 with both LR and DM, 1 with locoregional recurrence and DM, 2 with a second neoplasm, 3 with intercurrent disease and 1 from unknown causes. Five- and 10-year overall survival rates were 75 and 68%, respectively. There were no significant differences in mortality according to the site of the primary tumor or histologic type, but stage and involved surgical margins were important prognostic factors (p = 0.006 and 0.003). CONCLUSIONS: The surgical or multimodality treatment of MSGT has provided a good locoregional control (78%) and 68% 10-year survival in a series of patients treated at the oncology department of a general hospital in Quito, Ecuador. Stage and involved surgical margins were significant prognostic factors.
Assuntos
Carcinoma Adenoide Cístico/terapia , Carcinoma Mucoepidermoide/terapia , Neoplasias das Glândulas Salivares/terapia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Carcinoma Adenoide Cístico/diagnóstico , Carcinoma Adenoide Cístico/epidemiologia , Carcinoma Mucoepidermoide/diagnóstico , Carcinoma Mucoepidermoide/epidemiologia , Terapia Combinada , Equador/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Prognóstico , Neoplasias das Glândulas Salivares/diagnóstico , Neoplasias das Glândulas Salivares/epidemiologia , Glândulas Salivares/patologia , Análise de SobrevidaRESUMO
El objetivo de este trabajo fue conocer la frecuencia relativa de los tumores malignos de glándulas salivales en una población mexicana y compararla con datos previamente publicados de poblaciones latinoamericanas y no latinoamericanas. Se revisaron los archivos del Servicio de Diagnóstico en Patología Bucal y Maxilo-Facial de la Facultad de Odontología, UNAM de 1962 a 1997. Durante ese lapso se procesaron 9,639 biopsias de las cuales el 6.1 por ciento fueron lesiones o tumores de glándulas salivales, de éstas, 75 casos fueron neoplasias y de ellas, 26 casos correspondieron a carcinomas. De los 26 casos, el 50 por ciento fueron carcinomas mucoepidermoides, el 31 por ciento carcinomas adenoideos quísticos, 7.7 por ciento fueron adenocarcinomas NOS y 11.3 por ciento de otros carcinomas. Estos carcinomas fueron más frecuentes entre la 5º y 7º décadas de la vida y aparecieron con mayor frecuencia en el paladar, seguido por el área retromolar y el piso de la boca. El promedio de edad fue de 44.3 años y no se observó diferencia significativa por sexo (relación hombre:mujer de 1.1:1). Se observaron algunas diferencias con reportes previos. Nuestros resultados junto con otros de países latinoamericanos, sugieren que las diferencias con poblaciones no Latinoamericanas se deben a factores genéticos o étnicos.
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Carcinoma Adenoide Cístico/epidemiologia , Carcinoma Mucoepidermoide , Neoplasias das Glândulas SalivaresRESUMO
We present a retrospective study of 196 patients with intraoral minor salivary gland tumours, 128 malignant and 68 benign, diagnosed from 1954 to 1993 in the A. C. Camargo Hospital, São Paulo, Brazil. Sixty-five percent of the cases occurred in the palate, followed by tongue (9.7%) and retromolar area (6.1%). Pleomorphic adenoma was the most common benign tumour, and mucoepidermoid carcinoma was predominant among the malignant tumours. Surgery was the main treatment method and postoperative radiotherapy and radiotherapy alone were used in 40 and 15 patients, respectively. Local recurrence was observed in two patients with pleomorphic adenoma and in eight patients with malignant tumours. Regional lymph node metastases occurred in four cases and distant metastases in five. Forty-six of 47 patients with benign tumours who were followed up from 1 to 7 years were alive without disease. Twenty-four of 79 patients with malignant tumours who were followed up for at least 5 years died due the tumour and 47 were alive without disease.
Assuntos
Neoplasias das Glândulas Salivares/patologia , Glândulas Salivares Menores/patologia , Adenoma Pleomorfo/epidemiologia , Adenoma Pleomorfo/mortalidade , Adenoma Pleomorfo/patologia , Adulto , Carcinoma Adenoide Cístico/epidemiologia , Carcinoma Adenoide Cístico/mortalidade , Carcinoma Adenoide Cístico/patologia , Carcinoma Mucoepidermoide/epidemiologia , Carcinoma Mucoepidermoide/mortalidade , Carcinoma Mucoepidermoide/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva , Estudos Retrospectivos , Neoplasias das Glândulas Salivares/epidemiologia , Neoplasias das Glândulas Salivares/mortalidade , Taxa de SobrevidaRESUMO
A proposta deste trabalho é fornecer uma revisäo e informaçöes atualizadas sobre a síndrome conhecida como cilindromatose ou tumor em turbante. A cilindromatose é uma desordem genética autossômica dominante que possui duas formas de manifestaçäo, uma de origem hereditária e a outra esporádica. A clínica se baseia no surgimento de tumores oriundos das glândulas sudoríparas écrinas que tendem a se concentrar na cabeça, principalmente, couro cabeludo e pescoço.