RESUMO
Background: Kidney damage can be caused by many factors, such as using certain drugs in high doses or over the long term. The use of one such group of drugs, aminoglycosides, which act as Gram-negative antibacterial therapeutic agents, can lead to nephrotoxicity. It has been hypothesized that aminoglycoside-induced nephrotoxicity might be prevented by using pentoxifylline, which has antioxidant and anti-inflammatory effects and improves microcirculation. The objective of this present research was to determine the protective effects of pentoxifylline on kanamycin-induced kidney damage.Materials, Methods & Results: Thirty-two male Wistar rats were divided into four groups as follows: control, pentoxifylline, kanamycin, and kanamycin + pentoxifylline. The control group received intraperitoneal (IP) injections of 0.5 mL normal saline solution once a day (d) (SID) for 20 d; the pentoxifylline group received IP injections of 50 mg/kg pentoxifylline twice a day (BID) for 20 d, the kanamycin group received subcutaneous (SC) injections of 500 mg/kg kanamycin SID for 20 d, and the kanamycin + pentoxifylline group received both SC injections of 500 mg/kg kanamycin SID and IP injections of 50 mg/kg pentoxifylline BID for 20 d. At the end of 20 d, blood samples were taken from the heart by cardiac puncture under general anesthesia. After euthanizing the rats by cervical dislocation under anesthesia, the kidneys were immediately removed, relative kidney weights were calculated, and routine pathologic evaluations were conducted. Hemogram parameters were measured using a blood cell count apparatus and serum biochemical parameters were measured using an autoanalyzer. Kanamycin also caused (P < 0.05) tubular degeneration and tubular dilatation. Although pentoxifylline significantly reduced the level of kanamycin-induced tubular degeneration (P < 0.05), it did not significantly reduce tubular dilatation.[...]
Assuntos
Masculino , Animais , Ratos , Canamicina/efeitos adversos , Nefropatias/induzido quimicamente , Nefropatias/veterinária , Pentoxifilina/farmacologia , Pentoxifilina/uso terapêutico , Ratos WistarRESUMO
Background: Kidney damage can be caused by many factors, such as using certain drugs in high doses or over the long term. The use of one such group of drugs, aminoglycosides, which act as Gram-negative antibacterial therapeutic agents, can lead to nephrotoxicity. It has been hypothesized that aminoglycoside-induced nephrotoxicity might be prevented by using pentoxifylline, which has antioxidant and anti-inflammatory effects and improves microcirculation. The objective of this present research was to determine the protective effects of pentoxifylline on kanamycin-induced kidney damage.Materials, Methods & Results: Thirty-two male Wistar rats were divided into four groups as follows: control, pentoxifylline, kanamycin, and kanamycin + pentoxifylline. The control group received intraperitoneal (IP) injections of 0.5 mL normal saline solution once a day (d) (SID) for 20 d; the pentoxifylline group received IP injections of 50 mg/kg pentoxifylline twice a day (BID) for 20 d, the kanamycin group received subcutaneous (SC) injections of 500 mg/kg kanamycin SID for 20 d, and the kanamycin + pentoxifylline group received both SC injections of 500 mg/kg kanamycin SID and IP injections of 50 mg/kg pentoxifylline BID for 20 d. At the end of 20 d, blood samples were taken from the heart by cardiac puncture under general anesthesia. After euthanizing the rats by cervical dislocation under anesthesia, the kidneys were immediately removed, relative kidney weights were calculated, and routine pathologic evaluations were conducted. Hemogram parameters were measured using a blood cell count apparatus and serum biochemical parameters were measured using an autoanalyzer. Kanamycin also caused (P < 0.05) tubular degeneration and tubular dilatation. Although pentoxifylline significantly reduced the level of kanamycin-induced tubular degeneration (P < 0.05), it did not significantly reduce tubular dilatation.[...](AU)
Assuntos
Animais , Masculino , Ratos , Pentoxifilina/farmacologia , Pentoxifilina/uso terapêutico , Canamicina/efeitos adversos , Nefropatias/induzido quimicamente , Nefropatias/veterinária , Ratos WistarRESUMO
Se revisaron las historias clínicas de un grupo de pacientes con insuficiencia renal aguda y de ellos, en 51, el factor principal de esta afecciòn fue el empleo de ceporán más gentamicina y la mezcla de los tres antibióticos (con la inclusión de la kanamicina). Se analizan el uso indiscriminado y la dosis que puedan provocar estos efectos indeseables. Se debe tener en cuenta que la evolución no satisfactoria de estos pacientes (19 de 34) se entiende que no se debe a la mezcla en sí, sino a la mayor gravedad (sepsis más serias) que obligaron a su empleo
Assuntos
Adulto , Pessoa de Meia-Idade , Humanos , Masculino , Feminino , Cefalosporinas/efeitos adversos , Gentamicinas/efeitos adversos , Insuficiência Renal Crônica/induzido quimicamente , Canamicina/efeitos adversosAssuntos
Canamicina/administração & dosagem , Adolescente , Audiometria , Bacillus subtilis , Infecções Bacterianas/tratamento farmacológico , Bioensaio , Criança , Pré-Escolar , Feminino , Audição/efeitos dos fármacos , Humanos , Lactente , Canamicina/efeitos adversos , Canamicina/sangue , Rim/efeitos dos fármacos , Testes de Função Renal , MasculinoRESUMO
A retrospective study of ten patients with infant botulism who received gentamicin or kanamycin suggests that aminoglycoside antibiotics potentiate muscular weakness and precipitate respiratory failure as late as 27 days after onset of the disease. Although it is difficult to separate progression of the disease from the effects of antibiotics, the rapidity of deterioration following aminoglycoside treatment and the rapidity of recovery following cessation of aminoglycoside therapy is highly suggestive. A review of five patients who received only penicillin or a semisynthetic derivative of penicillin did not reveal any temporal deterioration with onset of penicillin therapy or improvement with cessation of penicillin therapy.