RESUMO
The ultrastructural study of adrenal gland from mice experimentally infected with Trypanosoma evansi, in addition to intravascular and intracellular trypanosomes, showed different degrees of cortical cell alterations and capillary wall modifications. Beside its biological scope, these results suggest a role for the adrenal cortex to partake in Surra's etiopathogenesis and describe for the very first time a T. evansi intracellular stage.
Assuntos
Córtex Suprarrenal/ultraestrutura , Tripanossomíase/patologia , Córtex Suprarrenal/parasitologia , Animais , Feminino , Cavalos/parasitologia , Camundongos , Camundongos Endogâmicos BALB C , Microscopia Eletrônica , Trypanosoma/isolamento & purificação , Trypanosoma/ultraestrutura , Tripanossomíase/etiologia , Tripanossomíase/parasitologia , VenezuelaRESUMO
The ultrastructural study of adrenal cortex from Plasmodium berghei infected mice showed different degrees of capillary wall alterations including disruption and widening of the fenestrae, capillaries packed with parasitized erythrocytes, necrosis of cortical cells, parasitized erythrocytes outside capillaries and in some instances inside cortical cell cytoplasm. Lymphocytes were also observed in degenerated cortical cells. Our results suggest that adrenal cortex lesions may be relevant in the etiopathogenesis of severe malaria.
Assuntos
Córtex Suprarrenal/parasitologia , Córtex Suprarrenal/ultraestrutura , Malária/patologia , Plasmodium berghei/ultraestrutura , Córtex Suprarrenal/patologia , Animais , Eritrócitos/parasitologia , Malária/sangue , Malária/parasitologia , Masculino , CamundongosRESUMO
The rat adrenal gland is poorly parasitized during the experimental infection with Y strain of Trypanosoma cruzi. In both cortical and medullary regions, the parasitism peaked at day 10 and was characterized by the predominance of single amastigotes over nests containing 2 or more parasites. After day 10 of infection, the tissue parasitism dropped rapidly to become practically null at day 32 of infection. In cortical tissue, the amastigotes occurred mainly inside the endocrine cells. In the medulla, they found mainly in glial cells and non-identified stromal cells. In both cortex and medulla, inflammatory processes were found till day 20 of infection. Our data do not support the hypothesis that a corticoid rich environment would favor T. cruzi parasitism in adrenal medulla.