Assuntos
Glomerulonefrite/microbiologia , Streptococcus/classificação , Doença Aguda , Adulto , Anticorpos/análise , Antígenos/análise , Bacteriófagos/análise , Criança , Surtos de Doenças , Feminino , Glomerulonefrite/epidemiologia , Humanos , Masculino , Nefrite/microbiologia , Serviços de Saúde Escolar , Streptococcus/análise , Streptococcus/isolamento & purificação , Trinidad e TobagoRESUMO
Twenty-seven strains of beta hemolytic streptococci from patients with acute glomerulonephritis and 212 strains from school children were isolated in Trinidad during an epidemic of nephritis involving over 1,000 patients. Sixty-two per cent of the 27 strains from nephritic patients and 3 strains from school children belonged to an apparently new serotype referred to here as Trinidad type A. Type-specific antibodies against this type were found in 50 per cent of 56 patients 1 to 3 months after acute glomerulonephritis. Six of the 10 remaining strains from patients with nephritis and 34 strains from school children were characterized as a second new type B. This strain contained M protein of provisional type Schoenborn isolated from pyoderma in Red Lake, Minnesota. It also contained a second antigen found in some type 41 strains of streptococci. Studies of temperate bacteriophage related to these strains suggested a possible association with nephritis in a negative way. With one exception, streptococci strains from nephritic patients were not lysogenic, while antiphage activity was observed in sera from 72 per cent of 50 patients. Moreover, 33 per cent of 86 strains from school children in areas where nephritis was occurring were lysogenic, while only 3 of 46 strains from areas without nephritis contained bacteriophage.(AU)