RESUMO
OBJECTIVE: To compare Doppler ultrasonographic measurements of the fetal middle cerebral artery peak systolic velocity (MCA PSV) among women with or without gestational diabetes mellitus (GDM). METHODS: A cross-sectional study was conducted among pregnant women who presented for prenatal care at a single hospital in Brazil between September 11, 2015, and January 6, 2017. Patients were stratified into a group with GDM and a control group without GDM. One Doppler ultrasonographic assessment was performed per participant. This measurement was made after diagnosis but before the start of treatment among women in the GDM group. Fetal ultrasonographic and biometric variables assessed included MCA PSV, MCA pulsatility index, umbilical artery pulsatility index, the MCA-to-umbilical artery ratio, abdominal circumference, and weight. RESULTS: The study included 238 women: 115 in the GDM group and 123 in the control group. The median MCA PSV was 1.02 in the GDM group and 1.08 in the control group (P=0.036). No statistically significant between-group differences were found for the other fetal ultrasonographic variables or for the fetal biometric variables assessed. None of the maternal or fetal parameters assessed displayed a linear correlation with MCA PSV. CONCLUSION: Doppler ultrasonographic measurements of MCA PSV were lowered among the fetuses of women diagnosed with GDM.
Assuntos
Diabetes Gestacional/fisiopatologia , Artéria Cerebral Média/diagnóstico por imagem , Artérias Umbilicais/diagnóstico por imagem , Adulto , Velocidade do Fluxo Sanguíneo , Brasil , Estudos de Casos e Controles , Estudos Transversais , Feminino , Feto/irrigação sanguínea , Humanos , Artéria Cerebral Média/embriologia , Artéria Cerebral Média/fisiopatologia , Gravidez , Cuidado Pré-Natal , Ultrassonografia Doppler , Ultrassonografia Pré-Natal , Artérias Umbilicais/irrigação sanguínea , Artérias Umbilicais/fisiopatologiaRESUMO
Examining feto-maternal blood flow is extremely important for accurate prenatal control and predicting adverse conditions during puerperium. We aimed to analyze blood flow of uterine artery (UA) and umbilical artery (UMA) from and subsequent to mid-gestation, lambing and postpartum of 15 ewes, subjected to lambing induction with aglepristone. Hemodynamic variables, diameter and blood flow of UA and UMA were determined by Doppler and B-mode ultrasonography at 60, 90 and 120 days of pregnancy, at 12 h before, 12 h after first aglepristone injection and 12 h after induction and days 1, 3, 5, 7, 15 and 30 after lambing. The UMA peak systolic:diastolic velocity (S/D), resistance index (RI) and pulsatility index (PI) decreased from mid-pregnancy until 120 d, whereas peak systolic velocity (PSV), end diastolic velocity (EDV) and time average maximum velocity (TAMAX) increased towards 120 d. The UMA RI additionally decreased at 12 h after lambing induction. The UMA diameter and volume increased from mid-gestation until 12 h before lambing induction. UA PSV and TAMAX increased from 60 until 90 days of pregnancy, while EDV, PSV and TAMAX decreased soon after parturition, with a further reduction at 7 days. The UA diameter and volume decreased during postpartum, stabilizing by 15 days after parturition. In conclusion, pregnancy is marked by progressive increase in uterine and umbilical blood flow, while lambing acutely diminishes umbilical vascular resistance, suggesting lack of progesterone influence on vasodilation. Conversely, puerperium is characterized by reduction in uterine blood supply mostly within the first 2 weeks of postpartum in sheep.
Assuntos
Hemodinâmica , Parto/fisiologia , Período Pós-Parto/fisiologia , Ovinos/fisiologia , Artérias Umbilicais/irrigação sanguínea , Artéria Uterina/fisiologia , Animais , Animais Recém-Nascidos , Velocidade do Fluxo Sanguíneo , Feminino , Hemodinâmica/fisiologia , Gravidez , Fluxo Sanguíneo Regional/fisiologia , Ultrassonografia Pré-Natal/veterinária , Artérias Umbilicais/diagnóstico por imagem , Artérias Umbilicais/fisiologia , Artéria Uterina/diagnóstico por imagemRESUMO
ABSTRACT: CONTEXT: Umbilical cord thrombosis is related to greater fetal and perinatal morbidity and mortality. It is usually associated with umbilical cord abnormalities that lead to mechanical compression with consequent vascular ectasia. Its correct diagnosis and clinical management remains a challenge that has not yet been resolved. CASE REPORT: This study reports a case of umbilical artery thrombosis that occurred in the second half of a pregnancy. The umbilical cord was long, thin and overly twisted and the fetus presented severe intrauterine growth restriction. The clinical and histopathological findings from this case are described. CONCLUSIONS: This case report emphasizes the difficulty in diagnosing and clinically managing abnormalities of intrauterine life with a high chance of perinatal complications.
RESUMO: CONTEXTO: A trombose do cordão umbilical está relacionada com o aumento da morbimortalidade fetal e perinatal. É geralmente associada a alterações do cordão umbilical que levam à compressão mecânica com consequente ectasia vascular. Seu correto diagnóstico e manejo clínico é um desafio que não está ainda bem esclarecido. RELATO DE CASO: Neste relato se descreve caso de trombose da artéria umbilical de ocorrência na segunda metade da gravidez associada a cordão umbilical longo, fino, excessivamente retorcido, associado a feto com restrição de crescimento intrauterino grave. São descritos seus achados clínicos e histopatológicos correlacionados. CONCLUSÃO: Este relato de caso reforça a dificuldade diagnóstica e de manejo clínico em alteração da vida intrauterina com grande possibilidade de complicações perinatais.
Assuntos
Humanos , Feminino , Gravidez , Recém-Nascido , Adulto , Artérias Umbilicais/irrigação sanguínea , Artérias Umbilicais/patologia , Trombose Venosa/patologia , Feto/anormalidades , Terceiro Trimestre da Gravidez , Diagnóstico Pré-Natal , Artérias Umbilicais/diagnóstico por imagem , Resultado da Gravidez , Fatores de Risco , Trombose Venosa/complicações , Trombose Venosa/diagnóstico por imagem , Retardo do Crescimento Fetal/etiologia , Feto/diagnóstico por imagemRESUMO
CONTEXT: Umbilical cord thrombosis is related to greater fetal and perinatal morbidity and mortality. It is usually associated with umbilical cord abnormalities that lead to mechanical compression with consequent vascular ectasia. Its correct diagnosis and clinical management remains a challenge that has not yet been resolved. CASE REPORT: This study reports a case of umbilical artery thrombosis that occurred in the second half of a pregnancy. The umbilical cord was long, thin and overly twisted and the fetus presented severe intrauterine growth restriction. The clinical and histopathological findings from this case are described. CONCLUSIONS: This case report emphasizes the difficulty in diagnosing and clinically managing abnormalities of intrauterine life with a high chance of perinatal complications.
Assuntos
Feto/anormalidades , Artérias Umbilicais/irrigação sanguínea , Artérias Umbilicais/patologia , Trombose Venosa/patologia , Adulto , Feminino , Retardo do Crescimento Fetal/etiologia , Feto/diagnóstico por imagem , Humanos , Recém-Nascido , Masculino , Gravidez , Resultado da Gravidez , Terceiro Trimestre da Gravidez , Diagnóstico Pré-Natal , Fatores de Risco , Artérias Umbilicais/diagnóstico por imagem , Trombose Venosa/complicações , Trombose Venosa/diagnóstico por imagemRESUMO
OBJECTIVE: To study the umbilical artery (UA) half-peak systolic velocity deceleration time (hPSV-DT) in pregnancies complicated by fetal growth restriction (FGR). METHODS: The study included 266 singleton, high-risk pregnancies with an estimated fetal weight <10th percentile, which were examined between 24 and 40 weeks' gestation and delivered within a week from the last ultrasound evaluation. UA hPSV-DT was measured with Doppler ultrasound in the same wave used to measure the pulsatility index. UA hPSV-DT values were correlated with perinatal outcome. RESULTS: UA hPSV-DT <5th percentile was found in 87 and 98% of fetuses with moderate and severe FGR, respectively. 94% of fetuses with a UA hPSV-DT <90 ms had poor perinatal outcome including perinatal death or prolonged admission to the neonatal intensive care unit. None of the fetuses had a UA hPSV-DT <70 ms. Perinatal death occurred in 39 fetuses; UA hPSV-DT was abnormal in all of them, with 95% of these fetuses having values of ≤120 ms. In the group of fetuses with absent/reverse end-diastolic velocity in the UA, the perinatal mortality rate was 51% for those with a UA hPSV-DT ≤90 ms and only 23% for those having a UA hPSV-DT >90 ms (p < 0.01). CONCLUSIONS: UA hPSV-DT seems to be a useful technique in the evaluation of pregnancies at risk for FGR and perinatal death. Additionally, hPSV-DT was shown to be a good predictor of perinatal death, with values of <90 ms corresponding to imminent risk of intrauterine demise and values of <70 ms being likely to be incompatible with intrauterine life.
Assuntos
Velocidade do Fluxo Sanguíneo , Retardo do Crescimento Fetal/fisiopatologia , Artérias Umbilicais/irrigação sanguínea , Adulto , Feminino , Retardo do Crescimento Fetal/diagnóstico por imagem , Idade Gestacional , Humanos , Mortalidade Perinatal , Gravidez , Resultado da Gravidez , Prognóstico , Sístole , Ultrassonografia Pré-NatalRESUMO
OBJECTIVES: To investigate fetal venous Doppler measurements in monochorionic twin pregnancies complicated by placental insufficiency and the relationship between fetal venous flow and acidemia at birth or intrauterine fetal death. METHODS: This was a prospective study of 18 monochorionic twin pregnancies with placental insufficiency. Inclusion criteria were monochorionic-diamniotic twin pregnancy, abnormal umbilical artery (UA) Doppler indices, intact membranes and absence of fetal congenital abnormalities. Cases of twin-to-twin transfusion syndrome were excluded. The following Doppler measurements were studied: UA pulsatility index (PI), ductus venosus PI, middle cerebral artery PI and peak systolic velocity, intra-abdominal umbilical vein (UV) time-averaged maximum velocity (TAMXV) and left portal vein (LPV) TAMXV. Doppler parameters were transformed into Z-scores (SD values from the mean) or multiples of the median according to normative references. RESULTS: UA pH < 7.20 occurred in nine (25.0%) neonates, pH < 7.15 in four (11.1%) and intrauterine death in four (11.1%) fetuses. The UV-TAMXV and LPV-TAMXV Z-scores were significantly lower in the group with pH < 7.20 or intrauterine fetal death (-1.79 vs -1.22, P = 0.006 and -2.26 vs -1.13, P = 0.04, respectively). In cases with pH < 7.15 or intrauterine fetal death, UV pulsations were more frequent (50.0% vs 10.7%, P = 0.03) and UV-TAMXV Z-score was significantly lower (-1.89 vs -1.26, P = 0.003). Mixed effects logistic regression analysis, accounting for the paired nature of the outcomes for the two twins in each pregnancy, demonstrated that the UV-TAMXV Z-score significantly predicted UA pH at birth < 7.20 or intrauterine fetal death. The Doppler parameter that independently predicted pH < 7.15 or intrauterine fetal death was presence of pulsation in the UV. CONCLUSION: UV Doppler parameters may predict acidemia at birth or intrauterine fetal death in monochorionic twins complicated by placental insufficiency.
Assuntos
Acidose/fisiopatologia , Morte Fetal , Retardo do Crescimento Fetal/fisiopatologia , Feto/irrigação sanguínea , Artéria Cerebral Média/fisiopatologia , Insuficiência Placentária/fisiopatologia , Veia Porta/fisiopatologia , Artérias Umbilicais/irrigação sanguínea , Acidose/diagnóstico por imagem , Acidose/mortalidade , Velocidade do Fluxo Sanguíneo , Feminino , Retardo do Crescimento Fetal/diagnóstico por imagem , Humanos , Recém-Nascido , Masculino , Artéria Cerebral Média/diagnóstico por imagem , Insuficiência Placentária/diagnóstico por imagem , Insuficiência Placentária/mortalidade , Veia Porta/diagnóstico por imagem , Veia Porta/embriologia , Gravidez , Resultado da Gravidez , Gravidez de Gêmeos , Estudos Prospectivos , Fluxo Pulsátil , Sensibilidade e Especificidade , Ultrassonografia DopplerRESUMO
Se presenta el resultado perinatal de 15 embarazos de alto riesgo que mostraron flujo ausente o reverso al final del diástole en arteria umbilical o aorta descendente. Este hallazgo representa una situación fetal muy comprometida. Todos fueron retardos de crecimiento intrauterino severos y la mortalidad perinatal fue de 47%. El parámetro más importante para predecir el resultado perinatal fue el peso del recién nacido; 900 g o más se asoció con buen resultado. En menor medida lo fue la edad gestacional al nacimiento