RESUMO
Serum and urine analytes were compared between adult wild-caught owl monkeys (Aotus nancymae) and adult wild-caught squirrel monkeys (Saimiri peruviensis) to determine if normative clinical pathology data were similar. An objective of the study was to confirm that species of neotropical primates are distinct with regard to physiologic parameters, and should not be considered interchangeable in biomedical research. Significant differences (P < 0.05) were noted in many serum and urine analytes between the two groups. The results suggest that reference data for wild-caught owl monkeys are not applicable to squirrel monkeys, and the differences are sufficiently large to be of clinical significance. These findings illuminate the diversity among species of neotropical primates.
Assuntos
Aotus trivirgatus/sangue , Saimiri/sangue , Animais , Animais Selvagens , Aotus trivirgatus/urina , Análise Química do Sangue/veterinária , Proteínas Sanguíneas/análise , Eletrólitos/sangue , Eletrólitos/urina , Peru , Proteinúria , Saimiri/urina , Especificidade da Espécie , Manejo de Espécimes/instrumentação , Manejo de Espécimes/métodos , Manejo de Espécimes/veterinária , Urinálise/veterináriaRESUMO
South American Aotus and Saimiri monkeys, which are susceptible to infection with human malarias, have been used to develop models for the testing of human malaria vaccines. Studies indicate that blood-stage and sporozoite vaccines can be tested in these monkeys using appropriate strains of parasites.
Assuntos
Aotus trivirgatus/parasitologia , Vacinas Antimaláricas , Malária Falciparum/prevenção & controle , Malária Vivax/prevenção & controle , Plasmodium falciparum/patogenicidade , Plasmodium vivax/patogenicidade , Saimiri/parasitologia , Animais , Aotus trivirgatus/sangue , Aotus trivirgatus/imunologia , Sangue/parasitologia , Culicidae , Suscetibilidade a Doenças , Estudos de Avaliação como Assunto , Humanos , Mordeduras e Picadas de Insetos , Insetos Vetores , Vacinas Antimaláricas/imunologia , Malária Falciparum/parasitologia , Malária Falciparum/transmissão , Malária Vivax/parasitologia , Malária Vivax/transmissão , Plasmodium falciparum/crescimento & desenvolvimento , Plasmodium falciparum/imunologia , Plasmodium vivax/crescimento & desenvolvimento , Plasmodium vivax/imunologia , Saimiri/sangue , Saimiri/imunologia , Especificidade da Espécie , EsplenectomiaRESUMO
Chronic quartan malarial infection has been established in the common marmoset (Callithrix jacchus). Plasmodium brasilianum from a douroucouli monkey (Aotus trivirgatus) was used to infect splenectomized twin animals, passed to an intact animal, and then to 4 other intact adults, 2 pairs of twins. In 2 of the 4 latter animals there was continuing patency with parasitaemias of less than or equal to 0.5% parasitized erythrocytes for 30 weeks. The other 2 had lower initial levels of parasitaemia; in 1 of these parasitaemias remained low or subpatent. All marmosets developed lymphocytosis. One animal became ill 30 weeks after infection with anaemia, weight loss and mild proteinurea, the other 3 remained well. Histological examination showed minor changes in the kidneys; spleens of infected animals showed marked follicular hyperplasia and phagocytosis of pigment. The livers showed sinusoidal hypercellularity and pigment deposition and in splenectomized animals, a marked lymphoid follicular hyperplasia in the portal tracts.