RESUMO
Iodine solutions are widely used as antiseptic for treating and preventing wound infections. Povidone iodine, one of the most common topical iodine solutions in emergency kits, can lead to several abnormalities as thyroid dysfunction. Povidone iodine poisoning is unusual and previously reported effects are mainly complications of topical usage during surgical procedures. Here we present the case of a newborn that was accidentally given oral povidone iodine, showing no signs or symptoms of toxicity after ingestion.
Las soluciones yodadas se utilizan ampliamente como antiséptico para el tratamiento y la prevención de infecciones en las heridas. La povidona yodada, una de las soluciones yodadas de aplicación tópica que más se encuentra en los botiquines de emergencia, podría producir anomalías graves, como disfunción tiroidea. La intoxicación por povidona yodada es poco frecuente; entre los efectos notificados previamente se incluyen complicaciones del uso tópico durante procedimientos quirúrgicos. Se describe el caso de un neonato que recibió povidona yodada por vía oral accidentalmente, sin signos ni síntomas de toxicidad después de la ingesta.
Assuntos
Povidona-Iodo/administração & dosagem , Povidona-Iodo/intoxicação , Acidentes , Administração Oral , Anti-Infecciosos Locais/administração & dosagem , Anti-Infecciosos Locais/intoxicação , Humanos , Recém-NascidoRESUMO
Las soluciones yodadas se utilizan ampliamente como antiséptico para el tratamiento y la prevención de infecciones en las heridas. La povidona yodada, una de las soluciones yodadas de aplicación tópica que más se encuentra en los botiquines de emergencia, podría producir anomalías graves, como disfunción tiroidea. La intoxicación por povidona yodada es poco frecuente; entre los efectos notificados previamente se incluyen complicaciones del uso tópico durante procedimientos quirúrgicos. Se describe el caso de un neonato que recibió povidona yodada por vía oral accidentalmente, sin signos ni síntomas de toxicidad después de la ingesta.
Iodine solutions are widely used as antiseptic for treating and preventing wound infections. Povidone iodine, one of the most common topical iodine solutions in emergency kits, can lead to several abnormalities as thyroid dysfunction. Povidone iodine poisoning is unusual and previously reported effects are mainly complications of topical usage during surgical procedures. Here we present the case of a newborn that was accidentally given oral povidone iodine, showing no signs or symptoms of toxicity after ingestion.
Assuntos
Humanos , Feminino , Recém-Nascido , Povidona-Iodo/administração & dosagem , Povidona-Iodo/intoxicação , Acidentes , Administração Oral , Anti-Infecciosos Locais/administração & dosagem , Anti-Infecciosos Locais/intoxicaçãoRESUMO
BACKGROUND: Retrospective analysis of human toxicity files involving topical medicines for treatment of upper airways diseases (eardrops, topical nasal medicines, lozenges, drops and sprays for oropharyngeal affections). METHODS: Thirty-four brands of eardrops, 48 of topical nasal medicines and 22 of tablets, lozenges and sprays for oropharyngeal affections were selected, from a total of 104 products available in Brazil. We analyzed the registries in the electronic database from the Poison Control Centre of São Paulo (CCI-Jabaquara), Brazil, for the period from January 1996 through December 2000. The cases related to selected pharmaceuticals were collected. RESULTS: 10,823 cases of human toxicity caused by medicines were voluntarily reported to CCI-Jabaquara. Topical medicines for treatment of upper airways diseases accounted for 291 cases (2.68%), from which 240 (82.5%) represented poisoning; 12 (4.1%) involved ear drops, 268 (92%), topical nasal medicines and 11 (3.9%), topical medicines for oropharyngeal affections. Among topical nasal medicines, vasoconstrictors predominated (233 cases), and among medicines for oropharyngeal affections, it was tetracaine (four cases). Considering age distribution, toxicity predominated significantly in children aged from 1 to 4 years (p=0.0003). The main causes of toxicity were: accidental intake of medicines (43%) and error in drug administration (14.8%). Hypereflexia and vomiting were the most frequent symptoms related to toxicity. CONCLUSIONS: There was significant incidence of systemic toxicity due to eardrops, topical nasal and oropharyngeal medicines in children 1 to 4 years-old, whose main cause was accidental intake of these medicines.