RESUMO
Few studies have examined the genes related to risk fac-tors that may contribute to intracranial aneurysms (IAs). This study in Chinese patients aimed to explore the relationship between IA and 28 gene loci, proven to be associated with risk factors for IA. We recruited 119 patients with aneurysms and 257 controls. Single factor and logistic regression models were used to analyze the association of IA and IA rup-ture with risk factors. Twenty-eight single nucleotide polymorphisms (SNPs) in 22 genes were genotyped for the patient and control groups. SNP genotypes and allele frequencies were analyzed by the chi-square test. Logistic regression analysis identified hypertension as a factor that increased IA risk (P = 1.0 x 10(-4); OR, 2.500; 95%CI, 1.573-3.972); IA was associated with two SNPs in the TSLC2A9 gene: rs7660895 (P = 0.007; OR, 1.541; 95%CI, 1.126-2.110); and in the TOX gene: rs11777927 (P = 0.013; OR, 1.511; 95%CI, 1.088-2.098). Subsequent removal of the influence of family relationship identified between 12 of 119 patients enhanced the significant association of these SNPs with IA (P = 0.001; OR, 1.691; 95%CI, 1.226-2.332; and P = 0.006; OR, 1.587; 95%CI, 1.137-2.213 for rs7660895 and rs11777927, respectively). Fur-thermore, the minor allele of rs7660895 (A) was also associated with IA rupture (P = 0.007; OR, 2.196; 95%CI, 1.230-3.921). Therefore, hypertension is an independent risk factor for IA. Importantly, the TSL-C2A9 (rs7660895) and TOX (rs11777927) gene polymorphisms may be associated with formation of IAs, and rs7660895 may be associated with IA rupture.
Assuntos
Aneurisma Roto/genética , Proteínas Facilitadoras de Transporte de Glucose/genética , Proteínas de Grupo de Alta Mobilidade/genética , Hipertensão/genética , Aneurisma Intracraniano/genética , Polimorfismo de Nucleotídeo Único , Adulto , Idoso , Alelos , Aneurisma Roto/etnologia , Aneurisma Roto/patologia , Povo Asiático , Estudos de Casos e Controles , Feminino , Expressão Gênica , Frequência do Gene , Loci Gênicos , Proteínas Facilitadoras de Transporte de Glucose/metabolismo , Proteínas de Grupo de Alta Mobilidade/metabolismo , Humanos , Hipertensão/etnologia , Hipertensão/patologia , Aneurisma Intracraniano/etnologia , Aneurisma Intracraniano/patologia , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Fatores de RiscoRESUMO
BACKGROUND AND PURPOSE: There are differences in cerebrovascular disease incidence between racial and ethnic groups. Little is known about cerebrovascular disease among Hispanics living in the southwestern United States as compared to non-Hispanic whites. This is the first study which measures and compares the incidence of spontaneous subarachnoid hemorrhage (SAH) among Hispanics and non-Hispanic whites living in Bernalillo County, New Mexico. This information may help reduce the risk and incidence of SAH. METHODS: Medical records of all possible cases of spontaneous SAH occurring during a two-year period (January 1, 1993 to December 31, 1994) among residents of Bernalillo County, New Mexico, were reviewed in all local hospitals. Hospital records were identified by ICD-9-CM codes. Medical examiner records were also reviewed for additional SAH cases occurring during the same time period. The 1990 U.S. census provided the population base. RESULTS: There were 22 spontaneous SAHs among 267,965 non-Hispanic whites and 25 spontaneous SAHs among 178,310 Hispanics. Incidence of SAH increased with age in both groups. The age- and sex-adjusted total annual incidence of SAH per 100,000 people was 3.73 among non-Hispanic whites and 9.19 among Hispanics (relative risk for Hispanics 2.46, 95% confidence interval 1.37-4.43, P = 0.003). The incidence rates among men and women were not significantly different in either ethnic group. CONCLUSIONS: The incidence of SAH among Hispanic residents of Bernalillo County, New Mexico, is approximately two and a half times higher than that among non-Hispanic whites. This suggests a higher prevalence or a greater tendency to rupture of berry aneurysms among Hispanics as compared to non-Hispanic whites. The reasons for this difference require further investigation.