RESUMO
Esta revisão enfoca o estudo das infecções causadas por herpesvírus bovino 1 (BoHV-1) e suas implicações na reprodução de bovinos, visto que as perdas mais expressivas na produtividade estão relacionadas a repetições de estro, abortamentos e nascimento de bezerros fracos ou natimortos decorrentes da infecção.
This work revises the infections caused by bovine herpesvirus 1 (BoHV-1) and its implications on the reproduction of cattle, as its most expressive productive losses are related to the repeating breeding, abortions, and the birth of weak or stillbirth calves due to the infection.
Assuntos
Animais , Bovinos , Herpesvirus Bovino 1 , Rinotraqueíte Infecciosa Bovina , Aborto Habitual/veterináriaRESUMO
Esta revisão enfoca o estudo das infecções causadas por herpesvírus bovino 1 (BoHV-1) e suas implicações na reprodução de bovinos, visto que as perdas mais expressivas na produtividade estão relacionadas a repetições de estro, abortamentos e nascimento de bezerros fracos ou natimortos decorrentes da infecção.(AU)
This work revises the infections caused by bovine herpesvirus 1 (BoHV-1) and its implications on the reproduction of cattle, as its most expressive productive losses are related to the repeating breeding, abortions, and the birth of weak or stillbirth calves due to the infection.(AU)
Assuntos
Animais , Bovinos , Rinotraqueíte Infecciosa Bovina , Herpesvirus Bovino 1 , Aborto Habitual/veterináriaRESUMO
The fetal-placental unit is a semi-allograft and immunological recognition of pregnancy, together with the subsequent response of the maternal immune system, is necessary for a successful pregnancy. Dendritic cells (DC) show a biological plasticity that confers them special characteristics regulating both immunity and tolerance. Therapy employing DC proved to diminish the abortion in the DBA/2J-mated CBA/J females; however, the underlying mechanisms remain unknown. Here, we evaluated whether DC therapy influences the presence of immunoregulatory populations of cells at the fetal-maternal interface. To address this hypothesis, we analysed the pregnancy-protective CD8, gammadelta cell populations as well as transforming growth factor (TGF)-beta1 and progesterone-induced blocking factor (PIBF) expression at the fetal-maternal interface from abortion-prone female mice that had previously received adoptive transfer of syngeneic DC. Syngeneic DC therapy induced an increase in the number of CD8 and gammadelta cells. Additionally, an upregulation of TGF-beta1 and PIBF expression could be detected after DC transfer. We suggest that DC therapy differentially upregulates a regulatory/protective population of cells at the fetal-maternal interface. It is reasonable to assure that this mechanism would be responsible for the lower abortion rate.
Assuntos
Aborto Espontâneo/prevenção & controle , Células Dendríticas/transplante , Prenhez/imunologia , Aborto Habitual/imunologia , Aborto Habitual/prevenção & controle , Aborto Habitual/veterinária , Aborto Induzido , Aborto Espontâneo/imunologia , Transferência Adotiva , Animais , Antígenos CD8/metabolismo , Meios de Cultivo Condicionados , Células Dendríticas/imunologia , Células Dendríticas/fisiologia , Feminino , Masculino , Camundongos , Camundongos Endogâmicos DBA , Placenta/metabolismo , Gravidez , Proteínas da Gravidez/metabolismo , Fator de Crescimento Transformador beta1/metabolismo , Regulação para Cima , Útero/anatomia & histologiaRESUMO
The purpose of this study was to investigate the association between seropositivity for the most frequent Leptospira serovars and reproductive losses in sows in Brazil. Serum samples from 351 sows from 18 herds (in the state of Rio de Janeiro, Brazil) with low reproductive efficiency were tested (microscopic agglutination) for antibodies against serovars of Leptospira. Antibodies were detected in serum samples of 66.1% of all sows, most frequently serovar icterohaemorrhagiae (43.1%), followed by pomona (18.1%) and tarassovi (9.9%). Seroreactivity to icterohaemorrhagiae and pomona were associated (P<0.05) with impaired reproductive performance (and substantial economic loss). Seroreactivity for pomona was associated (P<0.05) with stillborn piglets and mummified fetuses, whereas seroreactivity to icterohaemorrhagiae was associated (P<0.05) with the number of piglets born dead.