RESUMO
The ibuprofen complex of diruthenium(II,III) was prepared and characterized by electronic (UV-Vis) and vibrational (FTIR) spectroscopies and thermogravimetry. The copper(II)-ibuprofenato complex was prepared by a different route from that described in the literature. Both complexes were tested in vivo for anti-inflammatory activity. Oral administration of the two complexes inhibited development of carrageenin-induced edema in rats, this inhibition being similar to that observed for oral administration of the parent drug (free ibuprofen). However, gastric irritation was lower as compared to that of ibuprofen. Diruthenium-ibuprofenato exhibited a protective effect at light intensity ulceration while the copper-ibuprofenato complex was more effective in the protection of severe intensity ulceration.
Assuntos
Anti-Inflamatórios não Esteroides/química , Anti-Inflamatórios não Esteroides/síntese química , Compostos Organometálicos/química , Compostos Organometálicos/síntese química , Animais , Anti-Inflamatórios não Esteroides/farmacologia , Carragenina , Edema/induzido quimicamente , Edema/tratamento farmacológico , Hemorragia Gastrointestinal/patologia , Hemorragia Gastrointestinal/prevenção & controle , Hemorragia Gastrointestinal/psicologia , Ibuprofeno/farmacologia , Indicadores e Reagentes , Masculino , Modelos Moleculares , Conformação Molecular , Compostos Organometálicos/farmacologia , Ratos , Ratos Wistar , Restrição Física , Gastropatias/patologia , Gastropatias/prevenção & controle , Gastropatias/psicologia , Úlcera Gástrica/patologia , Úlcera Gástrica/prevenção & controle , Úlcera Gástrica/psicologia , Estresse Psicológico/fisiopatologiaRESUMO
The possible relationship between psychosomatic medicine and gastroenterology is described and more specifically in the question of peptic ulcer which gave rise to the psychosomatic theory, prevalent in 1950-85. The infectious theory (H. pylori), that arose within the last decade, was discussed and the question was posed in the direction that one theory was not exclusive of the other but in fact were probably complementary of each other
Assuntos
Humanos , Transtornos Psicofisiológicos/etiologia , Úlcera Duodenal/psicologia , Úlcera Gástrica/psicologia , Helicobacter pylori , Infecções por Helicobacter/complicações , Úlcera Gástrica/microbiologia , Úlcera Duodenal/microbiologiaRESUMO
trans-Dehydrocrotonin (DHC), the major diterpene isolated from Croton cajucara Benth, was assayed for antiulcerogenic activity in four induced gastric ulcer models in the rat. At an oral dose of 100 mg/kg DHC showed a significant antiulcerogenic effect on ulcers induced by hypothermic restraint stress, ethanol, and pylorus ligature. No significant changes in indomethacin-induced gastric lesions or modifications in gastric parameters such as wall mucus, secretion rate, pH, and total acid content were found after DHC treatment. The acute toxicological effects of DHC were assessed in mice. The LD50 values were 876 mg/kg and 47.2 mg/kg for oral and intraperitoneal administrations, respectively. The cytotoxicity of DHC was also studied. A dose-dependent inhibition of cell viability was observed in V-79 fibroblast cell cultures with an IC50 of 240 microM. The high yields of DHC obtained from dried C. cajucara barks as well as its good antiulcerogenic activity and low toxicity support the pharmacological study of this compound as a potential new antiulcerogenic drug.
Assuntos
Antiulcerosos/uso terapêutico , Diterpenos Clerodânicos , Diterpenos/uso terapêutico , Plantas Medicinais , Úlcera Gástrica/prevenção & controle , Animais , Antiulcerosos/isolamento & purificação , Antiulcerosos/toxicidade , Linhagem Celular , Sobrevivência Celular/efeitos dos fármacos , Cimetidina/uso terapêutico , Diterpenos/isolamento & purificação , Diterpenos/toxicidade , Etanol , Indometacina , Mucosa Intestinal/efeitos dos fármacos , Mucosa Intestinal/patologia , Dose Letal Mediana , Masculino , Camundongos , Ratos , Ratos Wistar , Restrição Física , Úlcera Gástrica/induzido quimicamente , Úlcera Gástrica/psicologia , Estresse PsicológicoRESUMO
The possible relationship between psychosomatic medicine and gastroenterology is described and more specifically in the question of peptic ulcer which gave rise to the psychosomatic theory, prevalent in 1950-85. The infectious theory (H. pylori), that arose within the last decade, was discussed and the question was posed in the direction that one theory was not exclusive of the other but in fact were probably complementary of each other.
Assuntos
Úlcera Duodenal/psicologia , Transtornos Psicofisiológicos/etiologia , Úlcera Gástrica/psicologia , Úlcera Duodenal/microbiologia , Infecções por Helicobacter/complicações , Helicobacter pylori , Humanos , Úlcera Gástrica/microbiologiaRESUMO
Se realiza un estudio clínico y psicológico experimental de los factores psíquicos de la personalidad que se manifiestan en los enfermos portadores de úlcera duodenal y estomacal. Se plantean criterios sobre la interrelación que existe entre los factores psíquicos y somáticos en el surgimiento y evolución de la enfermedad ulcerosa.