RESUMO
OBJECTIVE: To compare extrahepatic adverse events during fish oil lipid emulsion (FOLE) or soybean oil lipid emulsion (SOLE) treatment in children with intestinal failure-associated liver disease (IFALD). STUDY DESIGN: In this multicenter integrated analysis, bleeding, bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), infections, and signs of lipid emulsion intolerance were compared between FOLE recipients (1 g/kg/d) (n = 189) and historical controls who received SOLE (≤3 g/kg/d) (n = 73). RESULTS: When compared with SOLE recipients, FOLE recipients had a lower gestational age (30.5 vs 33.0 weeks; P = .0350) and higher baseline direct bilirubin (DB) (5.8 vs 3.0 mg/dL; P < .0001). FOLE recipients had a decreased incidence of bleeding (P < .0001), BPD (P < .001), ROP (P < .0156), bacterial and fungal infections (P < .0001), and lipid intolerance signs (P < .02 for all). Patients with bleeding vs patients without bleeding had higher baseline DB; the ORs for baseline DB (by mg/dL) and treatment (FOLE vs SOLE) were 1.20 (95% CI: 1.10, 1.31; P ≤ .0001) and 0.22 (95% CI: 0.11, 0.46; P ≤ .0001), respectively. In preterm infants, a higher BPD (P < .0001) and ROP incidence (P = .0071) was observed in SOLE recipients vs FOLE recipients. CONCLUSIONS: Children with IFALD who received FOLE had fewer extrahepatic adverse events, including a decreased incidence of bleeding, preterm comorbidities, and lipid intolerance signs compared with children with IFALD who received SOLE. TRIAL REGISTRATION CLINICALTRIALS.GOV: NCT00910104 and NCT00738101.
Assuntos
Emulsões Gordurosas Intravenosas/efeitos adversos , Óleos de Peixe/efeitos adversos , Insuficiência Intestinal/terapia , Hepatopatias/etiologia , Nutrição Parenteral/efeitos adversos , Óleo de Soja/efeitos adversos , Emulsões Gordurosas Intravenosas/uso terapêutico , Feminino , Óleos de Peixe/uso terapêutico , Humanos , Lactente , Recém-Nascido , Insuficiência Intestinal/complicações , Masculino , Nutrição Parenteral/métodos , Estudos Retrospectivos , Óleo de Soja/uso terapêutico , Resultado do TratamentoRESUMO
Fluid milk and its derivatives are important dietary ingredients that contribute to daily nutrient intake of the modern Homo sapiens. To produce milk that is healthier for human consumption, the present study evaluated the effect of adding soybean oil and linseed oil in the diet of lactating cows. The fatty acid profile of milk, milk composition, and the blood parameters of cows were evaluated. Eighteen Holstein cows were distributed in a replicated Latin square design and distributed according to the following treatments: 1) Control (CC): traditional dairy cow diet, without addition of oil; 2) Soybean oil (SO): 2.5% addition of soybean oil to the traditional diet, as a source of omega-6; 3) Linseed oil (LO): 2.5% addition of linseed oil in the diet as a source of omega-3. Milk production was not affected, but oil supplementation decreased feed intake by 1.93 kg/cow/day. The milk fat percentage was significantly lower when cows were supplemented with vegetable oil (3.37, 2.75 and 2.89% for CC, SO and LO, respectively). However, both soybean and linseed oils decreased the concentration of saturated fatty acids (66.89, 56.52 and 56.60 g/100g for CC, SO and LO respectively), increased the amount of unsaturated fatty acids in milk (33.05, 43.39, and 43.35 g/100g for CC, SO and LO respectively) and decreased the ratio between saturated/unsaturated fatty acids (2.12, 1.34, and 1.36 for CC, SO and LO respectively). Furthermore, SO and LO increased significantly the concentration of monounsaturated fatty acids (29.58, 39.55 and 39.47 g/100g for CC, SO and LO respectively), though it did not significantly alter the level of polyunsaturated fatty acids in milk fat (3.57, 3.93 and 3.98 g/100g for CC, SO and LO respectively). Supplementation with LO enhanced the concentration of omega-3 fatty acids on milk (0.32, 0.36, and 1.02 for CC, SO and LO respectively). Blood variables aspartate aminotransferase, gamma glutamyl transferase, urea, albumin, creatinine and total proteins were not altered. On the other hand, total cholesterol, HDL and LDL were greater in the group supplemented with vegetable oils. Supplementation with vegetable oils reduced the dry matter intake of cows, the fat content of milk, and improved saturated/unsaturated fatty acid ratio of milk fat. Compared to the SO treatment, animals fed LO produced milk with greater content of omega-3, and a more desirable omega-6/omega-3 ratio on a human nutrition perspective. Thus, the inclusion of SO and LO in the diet of lactating dairy cows makes the milk fatty acid profile nutritionally healthier for the human consumption.
Assuntos
Dieta/veterinária , Ácidos Graxos/análise , Lactação/efeitos dos fármacos , Óleo de Semente do Linho/uso terapêutico , Leite/química , Óleo de Soja/uso terapêutico , Animais , Bovinos , Dieta Saudável/métodos , Suplementos Nutricionais , Feminino , Humanos , Valor NutritivoRESUMO
OBJECTIVE: To examine whether parenteral nutrition using a mixed lipid emulsion containing fish oil improves the neurodevelopmental outcomes of extremely low birth weight infants. STUDY DESIGN: The study is a secondary outcome analysis of a double-blind randomized trial of 230 extremely low birth weight infants performed at a single level IV neonatal care unit (Medical University Vienna; June 2012 to June 2015). Participants received either a mixed lipid emulsion composed of soybean oil, medium chain triglycerides, olive oil, and fish oil, or a soybean oil-based lipid emulsion for parenteral nutrition. Neurodevelopment of study participants was assessed at 12 and 24 months corrected age (August 2013 to October 2017) using the Bayley Scales of Infant-Toddler Development, third edition. RESULTS: At discharge, 206 of the 230 study participants were eligible. At 12 and 24 months corrected age, 174 of 206 (85%) and 164 of 206 (80%) infants were evaluated. At 12 months, there was no significant difference in cognitive (mixed lipid: median, 95 [IQR, 85-101]; soybean oil: median, 95 [IQR, 85-100]; P = .71), language (mixed lipid: median, 86 [IQR, 77-94], soybean oil: median, 89 [IQR, 79-94]; P = .48), or motor scores (mixed lipid: median, 88 [IQR, 76-94], soybean oil: median, 88 [IQR, 79-94]; P = .69). At 24 months, there was again no significant difference in cognitive (mixed lipid: median, 95 [IQR, 80-105], soybean oil: median, 95 [IQR, 90-105]; P = .17), language (mixed lipid: median, 89 [IQR, 75-97], soybean oil 89 [IQR, 77-100]; P = .54), and motor scores (mixed lipid: median, 94 [IQR, 82-103], soybean oil: median, 94 [IQR, 85-103]; P = .53). CONCLUSIONS: Parenteral nutrition using a mixed lipid emulsion containing fish oil did not improve neurodevelopment of extremely low birth weight infants at 12 and 24 months corrected age. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01585935.
Assuntos
Emulsões Gordurosas Intravenosas/uso terapêutico , Óleos de Peixe/uso terapêutico , Transtornos do Neurodesenvolvimento/prevenção & controle , Nutrição Parenteral , Método Duplo-Cego , Feminino , Humanos , Recém-Nascido de Peso Extremamente Baixo ao Nascer , Recém-Nascido , Recém-Nascido Prematuro , Masculino , Transtornos do Neurodesenvolvimento/epidemiologia , Azeite de Oliva/uso terapêutico , Óleo de Soja/uso terapêutico , Triglicerídeos/uso terapêuticoRESUMO
BACKGROUND: Although it has been previously demonstrated that acute inflammation can promote the tumor growth of a sub-tumorigenic dose of melanoma cells through of 5-lipoxygenase inflammatory pathway and its product leukotriene B4, and also that the peritumoral treatment with eicosapentaenoic acid and its product, leukotriene B5, reduces the tumor development, the effect of the treatment by gavage with omega-3 and omega-6 in the tumor microenvironment favorable to melanoma growth associated with acute inflammation has never been studied. METHODS: C57BL/6 mice were coinjected with 1 × 106 apoptotic cells plus 1 × 103 viable melanoma cells into the subcutaneous tissue and treated by gavage with omega-3-rich fish oil or omega-6-rich soybean oil or a mixture of these oils (1:1 ratio) during five consecutive days. RESULTS: The treatment by gavage with a mixture of fish and soybean oils (1:1 ratio) both reduced the melanoma growth and the levels of leukotriene B4 (LTB4), prostaglandin E2 (PGE2), PGE2/prostaglandin E3 (PGE3) ratio, and CXC ligand 1 (CXCL1) and increased the levels of interleukin 10 (IL-10) to IL-10/CXCL1 ratio in the melanoma microenvironment. CONCLUSION: The oral administration of a 1:1 mixture of fish oil and soybean oil was able to alter the release of inflammatory mediators that are essential for a microenvironment favorable to the melanoma growth in mice, whereas fish oil or soybean oil alone was ineffective.
Assuntos
Ácidos Graxos Ômega-3/uso terapêutico , Ácidos Graxos Ômega-6/uso terapêutico , Inflamação/tratamento farmacológico , Melanoma/tratamento farmacológico , Microambiente Tumoral/efeitos dos fármacos , Animais , Anti-Inflamatórios/uso terapêutico , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Óleos de Peixe/uso terapêutico , Inflamação/imunologia , Inflamação/patologia , Melanoma/imunologia , Melanoma/patologia , Camundongos , Camundongos Endogâmicos C57BL , Óleo de Soja/uso terapêuticoRESUMO
A central venous catheter is a risk factor for deep vein thrombosis. We compared the incidence of deep vein thrombosis in children with intestinal failure patients receiving soy oil lipid emulsion (n = 35) vs fish oil lipid emulsion (n = 35). Ten deep vein thrombosis occurred in the soy oil lipid emulsion group, and none in the fish oil lipid emulsion group (P < .001).
Assuntos
Cateterismo Venoso Central/efeitos adversos , Cateteres Venosos Centrais/efeitos adversos , Emulsões Gordurosas Intravenosas/uso terapêutico , Óleos de Peixe/uso terapêutico , Enteropatias/terapia , Trombose Venosa/prevenção & controle , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Nutrição Parenteral , Estudos Retrospectivos , Óleo de Soja/uso terapêutico , Trombose Venosa/etiologia , Adulto JovemRESUMO
OBJECTIVES: To examine whether a mixed lipid emulsion reduces the incidence of parenteral nutrition associated cholestasis (PNAC) in extremely low birth weight (ELBW, <1000 g) infants. STUDY DESIGN: This double-blind randomized trial of 230 ELBW infants (June 2012-October 2015) was performed at a single level IV neonatal intensive care unit. Patients received either a mixed lipid emulsion composed of soybean oil, medium chain triglycerides, olive oil, and fish oil-(intervention) or a soybean oil-based lipid emulsion (control) for parenteral nutrition. The primary outcome measure was PNAC (conjugated bilirubin >1.5 mg/dL [25 µmol/L] at 2 consecutive measurements). The study was powered to detect a reduction of PNAC from 25% to 10%. RESULTS: Reasons for noneligibility of 274 infants screened were refusal to participate (n = 16), death (n = 10), withdrawal of treatment (n = 5), higher order multiples (n = 9), and parents not available for consent (n = 4). Intention to treat analysis was carried out in 223 infants (7 infants excluded after randomization). Parenteral nutrition associated cholestasis was 11 of 110 (10.1%) in the intervention and 18 of 113 (15.9%) in the control group (P = .20). Multivariable analyses showed no statistically significant difference in the intention to treat (aOR 0.428, 95% CI 0.155-1.187; P = .10) or per protocol population (aOR 0.457, 95% CI 0.155-1.347; P = .16). There was no statistically significant effect on any other neonatal morbidity. CONCLUSIONS: The incidence of parenteral nutrition associated cholestasis was not significantly reduced using a mixed lipid emulsion in ELBW infants. TRIAL REGISTRATION: ClinicalTrials.govNCT01585935.
Assuntos
Colestase/prevenção & controle , Óleos de Peixe/uso terapêutico , Azeite de Oliva/uso terapêutico , Nutrição Parenteral/efeitos adversos , Óleo de Soja/uso terapêutico , Triglicerídeos/uso terapêutico , Colestase/etiologia , Método Duplo-Cego , Emulsões , Feminino , Humanos , Recém-Nascido de Peso Extremamente Baixo ao Nascer , Recém-Nascido , Unidades de Terapia Intensiva Neonatal , MasculinoRESUMO
PURPOSE: To compare the hemodynamic changes following two different lipid emulsion therapies after bupivacaine intoxication in swines. METHODS: Large White pigs were anesthetized with thiopental, tracheal intubation performed and mechanical ventilation instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization (Swan-Ganz catheter). After a 30-minute resting period, 5 mg.kg-1 of bupivacaine by intravenous injection was administered and new hemodynamic measures were performed 1 minute later; the animals were than randomly divided into three groups and received 4 ml.kg-1 of one of the two different lipid emulsion with standard long-chaim triglyceride, or mixture of long and medium-chain triglyceride, or saline solution. Hemodynamic changes were then re-evaluated at 5, 10, 15, 20 and 30 minutes. RESULTS: Bupivacaine intoxication caused fall in arterial blood pressure, cardiac index, ventricular systolic work index mainly and no important changes in vascular resistances. Both emulsion improved arterial blood pressure mainly increasing vascular resistance since the cardiac index had no significant improvement. On the systemic circulation the hemodynamic results were similar with both lipid emulsions. CONCLUSION: Both lipid emulsions were efficient and similar options to reverse hypotension in cases of bupivacaine toxicity.
Assuntos
Anestésicos Locais/toxicidade , Bupivacaína/toxicidade , Emulsões Gordurosas Intravenosas/uso terapêutico , Hemodinâmica/efeitos dos fármacos , Animais , Pressão Sanguínea/efeitos dos fármacos , Óleo de Coco , Óleos de Plantas/uso terapêutico , Distribuição Aleatória , Reprodutibilidade dos Testes , Óleo de Soja/uso terapêutico , Suínos , Fatores de Tempo , Resultado do Tratamento , Triglicerídeos/uso terapêutico , Resistência Vascular/efeitos dos fármacosRESUMO
PURPOSE: To compare the hemodynamic changes following two different lipid emulsion therapies after bupivacaine intoxication in swines. METHODS: Large White pigs were anesthetized with thiopental, tracheal intubation performed and mechanical ventilation instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization (Swan-Ganz catheter). After a 30-minute resting period, 5 mg.kg-1 of bupivacaine by intravenous injection was administered and new hemodynamic measures were performed 1 minute later; the animals were than randomly divided into three groups and received 4 ml.kg-1 of one of the two different lipid emulsion with standard long-chaim triglyceride, or mixture of long and medium-chain triglyceride, or saline solution. Hemodynamic changes were then re-evaluated at 5, 10, 15, 20 and 30 minutes. RESULTS: Bupivacaine intoxication caused fall in arterial blood pressure, cardiac index, ventricular systolic work index mainly and no important changes in vascular resistances. Both emulsion improved arterial blood pressure mainly increasing vascular resistance since the cardiac index had no significant improvement. On the systemic circulation the hemodynamic results were similar with both lipid emulsions. CONCLUSION: Both lipid emulsions were efficient and similar options to reverse hypotension in cases of bupivacaine toxicity. .
Assuntos
Animais , Anestésicos Locais/toxicidade , Bupivacaína/toxicidade , Emulsões Gordurosas Intravenosas/uso terapêutico , Hemodinâmica/efeitos dos fármacos , Pressão Sanguínea/efeitos dos fármacos , Óleos de Plantas/uso terapêutico , Distribuição Aleatória , Reprodutibilidade dos Testes , Suínos , Óleo de Soja/uso terapêutico , Fatores de Tempo , Resultado do Tratamento , Triglicerídeos/uso terapêutico , Resistência Vascular/efeitos dos fármacosRESUMO
PURPOSE: A diet with polyunsaturated fatty acid (PUFA) supplementation has been reported to reduce renal and cardiac diseases. This study sought to elucidate whether PUFAs derived from plant or marine oils could have beneficial effects on the progression of experimental chronic renal failure (CRF). METHODS: Experimental CRF was achieved by a 5/6 nephrectomy model. Male Wistar rats were divided into groups and given daily supplements of fish oil (group FO), flaxseed oil (group FXO), or soybean oil (control-group SO) for 30 days. Serum creatinine (sCr), 24-h proteinuria, total cholesterol, triglycerides, and creatinine clearance (CLcr) were measured at day 0 and 30 days after surgery when the rats were euthanized for histological analysis of the remnant kidney. RESULTS: After 30 days, we observed lower levels of sCr in the groups supplemented with PUFA when compared with the control group (FO: 0.92 ± 0.13; FXO: 1.06 ± 0.28; SO: 1.32 ± 0.47 mg/dL) and significantly slower variations of sCr (ΔsCr) in the groups treated with PUFAs (FO = 0.35 ± 0.16; FXO = 0.47 ± 0.31; OS = 0.72 ± 0.43; mg/dL, P = 0.041). Similarly, the CLcr of both of the groups that received PUFAs was significantly slower than the rats in the control group (FO: 0.45 ± 0.15; FXO: 0.60 ± 0.09; SO: 0.28 ± 0.06 mL/min/day; P = 0.01). The rats that received PUFA supplements also presented significantly less histological lesions compared with the control group. CONCLUSIONS: These results suggest a beneficial effect of dietary supplementation with flaxseed or fish oil in rats with CRF.
Assuntos
Suplementos Nutricionais , Ácidos Graxos Insaturados/uso terapêutico , Falência Renal Crônica/tratamento farmacológico , Análise de Variância , Animais , Colesterol/sangue , Creatinina/sangue , Creatinina/urina , Progressão da Doença , Óleos de Peixe/uso terapêutico , Falência Renal Crônica/sangue , Falência Renal Crônica/patologia , Óleo de Semente do Linho/uso terapêutico , Masculino , Nefrectomia , Proteinúria/urina , Ratos , Ratos Wistar , Óleo de Soja/uso terapêutico , Triglicerídeos/sangue , Redução de PesoRESUMO
It was investigated whether dietary polyunsaturated fatty acids (PUFA) could influence colonic injury, tissue DNA damage, cytokines and myeloperoxidase activity (MPO) and plasma corticosterone in DSS-induced colitis rats. Male weaning Wistar rats were fed for 47 days with an AIN-93 diet with control (C), fish (F) or a mixture of fish and soybean oil (SF). The colitis was induced from day 36 until day 42 by 3% DSS in drinking water. On day 48, blood samples were collected for corticosterone determination. The distal colon was excised for histological analysis and to quantify the cytokine (IL-4, IL-10 and INF-gamma), MPO and DNA damage. The disease activity index (DAI) was recorded daily during colitis induction. The DAI, MPO, histological analyses showed decreases only in the SF group compared with the C group. IL-10 was increased and DNA damage was reduced in the groups F and SF, and an inverse correlation between these variables was found. There were no differences in corticosterone, IFN-gamma and IL-4 levels. Soybean and fish oil mixture may be effective in improving colonic injury and DNA damage, and it could be an important complementary therapy in UC to reduce the use of anti-inflammatory drugs and prevent colorectal cancer.
Assuntos
Colite/tratamento farmacológico , Dano ao DNA/efeitos dos fármacos , Óleos de Peixe/farmacologia , Interleucina-10/metabolismo , Óleo de Soja/farmacologia , Animais , Colite/induzido quimicamente , Colite/dietoterapia , Citocinas/análise , Sulfato de Dextrana/toxicidade , Óleos de Peixe/uso terapêutico , Masculino , Peroxidase/análise , Substâncias Protetoras , Ratos , Ratos Wistar , Óleo de Soja/uso terapêuticoRESUMO
Current evidence indicates that omega-3 polyunsaturated fatty acids (PUFAs), particularly eicosapentaenoic acid and docosahexaenoic acid found in fish oil, can prevent the development of inflammatory diseases by affecting different steps of the immune response. The capacity of omega-3 PUFAs to modulate synthesis of eicosanoids, activity of nuclear receptor and nuclear transcription factors, and production of resolvins may also mitigate inflammatory processes already present. Parenteral infusion of omega-3 PUFAs is advantageous, particularly in severely ill patients, because the fatty acids are rapidly incorporated by cells. In addition, when fatty acids are given parenterally, there are no losses from digestion and absorption as there are with enteral infusion. Recently, lipid emulsions enriched with omega-3 fish oil have been introduced as a component of parenteral nutrition. Currently, there is one lipid emulsion that contains only fish oil; it is infused together with conventionally used lipid emulsions. Other commercially available lipid emulsions contain fish oil in a fat mixture; one contains 10% fish oil and another 15% fish oil. Relevant experimental and clinical data from studies evaluating fish oil lipid emulsions are discussed in the present review. Administration of fish oil lipid emulsion, when compared with soybean oil lipid emulsion (rich in omega-6 PUFA), decreases the length of hospital and intensive care unit stay in surgical patients.
Assuntos
Anti-Inflamatórios/farmacologia , Emulsões Gordurosas Intravenosas/farmacologia , Ácidos Graxos Ômega-3/farmacologia , Óleos de Peixe/farmacologia , Fatores Imunológicos/farmacologia , Inflamação/prevenção & controle , Nutrição Parenteral , Anti-Inflamatórios/uso terapêutico , Emulsões Gordurosas Intravenosas/uso terapêutico , Ácidos Graxos Ômega-3/imunologia , Ácidos Graxos Ômega-3/uso terapêutico , Óleos de Peixe/imunologia , Óleos de Peixe/uso terapêutico , Humanos , Fatores Imunológicos/uso terapêutico , Nutrição Parenteral/métodos , Óleo de Soja/farmacologia , Óleo de Soja/uso terapêuticoRESUMO
The ketogenic diet (KD) is a high fat and low carbohydrate and protein diet. It is used in the clinical treatment of epilepsy, in order to decrease cerebral excitability. KD is usually composed by long-chain triglycerides (LCT) while medium-chain triglycerides (MCT) diet is beginning to be used in some clinical treatment of disorders of pyruvate carboxylase enzyme and long-chain fatty acid oxidation. Our study aimed to analyze the effects of medium- and long-chain KD on cerebral electrical activity, analyzing the propagation of the phenomenon of cortical spreading depression (CSD). Three groups of weaned rats (21 days old) received, for 7 weeks, either a control (AIN-93G diet), or a MCT-KD (rich in triheptanoin oil), or a LCT-KD (rich in soybean oil). They were compared to another three groups (21 days old) receiving the same diets for just 10 days. CSD propagation was evaluated just after ending the dietary treatments. Results showed that short-term KD treatment resulted in a significant reduction of the CSD velocity of propagation (control group: 4.02+/-1.04mm/min; MCT-KD: 0.81+/-1.46mm/min and LCT-KD: 2.26+/-0.41mm/min) compared to the control group. However, long-term treatment with both KDs had no effect on the CSD velocity (control group: 3.10+/-0.41mm/min, MCT-KD: 2.91+/-1.62mm/min, LCT-KD: 3.02+/-2.26mm/min) suggesting that both short-term KDs have a positive effect in decreasing brain cerebral excitability in young animals. These data show for the first time that triheptanoin has an effect on central nervous system.
Assuntos
Córtex Cerebral/efeitos dos fármacos , Córtex Cerebral/metabolismo , Depressão Alastrante da Atividade Elétrica Cortical/efeitos dos fármacos , Gorduras na Dieta/farmacologia , Triglicerídeos/metabolismo , Triglicerídeos/farmacologia , Animais , Córtex Cerebral/fisiopatologia , Depressão Alastrante da Atividade Elétrica Cortical/fisiologia , Gorduras na Dieta/uso terapêutico , Suplementos Nutricionais/normas , Modelos Animais de Doenças , Esquema de Medicação , Potenciais Evocados/efeitos dos fármacos , Potenciais Evocados/fisiologia , Ácidos Graxos/metabolismo , Alimentos Formulados/normas , Ácidos Heptanoicos/metabolismo , Ácidos Heptanoicos/farmacologia , Ácidos Heptanoicos/uso terapêutico , Cetonas/metabolismo , Metabolismo dos Lipídeos/efeitos dos fármacos , Metabolismo dos Lipídeos/fisiologia , Masculino , Ratos , Ratos Wistar , Óleo de Soja/metabolismo , Óleo de Soja/farmacologia , Óleo de Soja/uso terapêutico , Resultado do Tratamento , Triglicerídeos/uso terapêuticoRESUMO
Dietary fat influences dimethylbenzanthracene (DMBA)-induced tumorigenesis of several organs, including the salivary glands. There is not enough evidence to suggest that soy oil could also affect growth of salivary tumors. The main purpose of this work therefore was to study the effects of dietary soy oil on macroscopic parameters of chemically induced murine salivary gland tumors. Eighty BALB/c male mice were assigned to four groups: soy oil (SO), corn oil (CO, control), fish oil (FO) and olein (O). Two weeks later, tumors were induced by 9,10-dimethyl-1,2-benzanthracene (DMBA). At the 13th post-injection week, the animals were sacrificed. In vivo tumor diameter, gland volume (total resected mass), tumor volume (microscopically measured), tumor remission and tumor histopathology were analyzed. The initial in vivo tumor diameter, gland and tumor volume were significantly greater in soy oil than in fish oil group. 26.7% of animals on the soy oil diet showed tumor remission. Sarcomas were more often found in the SO group, carcinomas in FO and the mixed-type tumors both in SO and CO groups. This study shows that the soy oil treatment resulted in larger tumors, some of which later became undetectable. It is necessary to further investigate these divergent results.
Assuntos
Neoplasias das Glândulas Salivares/dietoterapia , Óleo de Soja/uso terapêutico , 9,10-Dimetil-1,2-benzantraceno , Animais , Cromatografia Gasosa , Óleos de Peixe/uso terapêutico , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Neoplasias das Glândulas Salivares/induzido quimicamente , Neoplasias das Glândulas Salivares/patologia , Neoplasias da Glândula Submandibular/induzido quimicamente , Neoplasias da Glândula Submandibular/dietoterapia , Neoplasias da Glândula Submandibular/patologiaRESUMO
O objetivo do experimento foi avaliar o desempenho de frangos de corte recebendo dietas com probiótico Biobac , contendo ingredientes ativos de Saccaromyces cerevisae, Lactobacillus acidophylus e Enterococcus faecium, em uso isolado ou associado com 3% de óleo de soja nas fases inicial, engorda e final; respectivamente 1 a 21; 22 a 42 e 43 a 47 dias de idade. Foram utilizadas 3.200 aves de corte de 1 dia de idade de ambos os sexos, distribuídos em um delineamento em blocos casualisados em oito tratamentos com quatro repetições, sendo: T1 - controle, T2 - probiótico em todas as fases, T3 - óleo de soja na fase final, T4 - (T2+T3), T5 - óleo de soja nas fases de engorda e final, T6-(T2+T5), T7 - óleo de soja em todas as fases, T8 - (T2 + T7). As rações continham 22; 20 e 18% de proteína bruta, com níveis de energia metabolizável entre 2.881 a 3.033 kcal/kg conforme a inclusão ou não de óleo de soja. Foram avaliados os ganhos de peso, consumo de ração e conversão alimentar. Somente os períodos de engorda e final cujos tratamentos foram adicionados concomitantemente probiótico e óleo de soja apresentaram os melhores resultados em ganho de peso e conversão alimentar.
The goal of this experiment was to assess broiler chickens performance receveing diet with probiotic Biobac®, contained actives ingredients of Saccaromycescerevisae, Lactobacillus acidophylus and Enterococcus faecium,in isolated use or associated with 3% soybean oil at initial, growing and fi nal phases, respectively 1-21; 22-42 and 43-47 day of age. A gross one 3.200 broilers chicken of both gender were used, distributed in a randomized blocks desing in eight treatments with four repetitions, being: T1- control, T2- probiotic all phases, T3-soybean oil at fi nal phase, T4- (T2 + T3), T5- soybean oil at growing and fi nal phases, T6- (T2 + T5), T7- soybean oil all phases, T8- (T2 + T7). The diets contained 22, 20 and 18% crude protein, with levels of metabolizable energy between 2.881 to 3.033 kcal/kg according to the inclusion or not of soybean oil. Weight gain, feed intake and feed:gain ratio were assessed. Only growing and fi nal phases whose treatments were additioned at the same time probiotic and soybean oil, showed the best results in weight gain and feed intake.
El objetivo del experimento fue avaluar el desempeño de los pollos de corte recibiendo dietas con probiótico Biobac®, conteniendo ingredientes activos del Saccaromyces cerevisae, Lactobacillus acidophylus y Enterococcus faecium, en el uso aislado o asociado con 3% de aceite de soja en las fases inicial, engorda y fi nal; respectivamente 1 al 21; 22 al 42 y del 43 al 47 días de edad. Fueran utilizadas 3.200 aves del corte de ambos los sexos con un día de edad, distribuidos en un diseño en bloques aleatorizados en ocho tratamientos con cuatro repeticiones sendo: T1- control, T2- probiótico en todas las fases, T3- aceite de soja en la fase fi nal, T4- (T2 + T3), T5- aceite de soja en las fases del engorda y fi nal, T6- ( T2 + T5), T7- aceite de soja en todas las fases, T8- (T2 + T7). Las raciones contenían 22; 20 e 18% de proteína bruta, con niveles de energía metabolizável entre 2.881 a 3.033 kcal/kg según la inclusión o no del aceite de soja. Fueron evaluados la ganancia del peso, consumo de ración y conversión alimentar. Solamente los periodos de engorda y fi nal cuyos tratamientos fueran adicionados conjuntamente probiótico y aceite de soja presentaran los mejores resultados en aumento de peso y conversión alimentar.
Assuntos
Animais , Masculino , Feminino , Aves , Probióticos/uso terapêutico , Óleo de Soja/uso terapêuticoRESUMO
O objetivo do experimento foi avaliar o desempenho de frangos de corte recebendo dietas com probiótico Biobac , contendo ingredientes ativos de Saccaromyces cerevisae, Lactobacillus acidophylus e Enterococcus faecium, em uso isolado ou associado com 3% de óleo de soja nas fases inicial, engorda e final; respectivamente 1 a 21; 22 a 42 e 43 a 47 dias de idade. Foram utilizadas 3.200 aves de corte de 1 dia de idade de ambos os sexos, distribuídos em um delineamento em blocos casualisados em oito tratamentos com quatro repetições, sendo: T1 - controle, T2 - probiótico em todas as fases, T3 - óleo de soja na fase final, T4 - (T2+T3), T5 - óleo de soja nas fases de engorda e final, T6-(T2+T5), T7 - óleo de soja em todas as fases, T8 - (T2 + T7). As rações continham 22; 20 e 18% de proteína bruta, com níveis de energia metabolizável entre 2.881 a 3.033 kcal/kg conforme a inclusão ou não de óleo de soja. Foram avaliados os ganhos de peso, consumo de ração e conversão alimentar. Somente os períodos de engorda e final cujos tratamentos foram adicionados concomitantemente probiótico e óleo de soja apresentaram os melhores resultados em ganho de peso e conversão alimentar.(AU)
The goal of this experiment was to assess broiler chickens performance receveing diet with probiotic Biobac®, contained actives ingredients of Saccaromyces cerevisae, Lactobacillus acidophylus and Enterococcus faecium, in isolated use or associated with 3% soybean oil at initial, growing and fi nal phases, respectively 1-21; 22-42 and 43-47 day of age. A gross one 3.200 broilers chicken of both gender were used, distributed in a randomized blocks desing in eight treatments with four repetitions, being: T1- control, T2- probiotic all phases, T3-soybean oil at fi nal phase, T4- (T2 + T3), T5- soybean oil atgrowing and fi nal phases, T6- (T2 + T5), T7- soybean oil all phases, T8- (T2 + T7). The diets contained 22, 20 and 18% crude protein, with levels of metabolizable energy between 2.881 to 3.033 kcal/kg according to the inclusion or not of soybean oil. Weight gain, feed intake and feed:gain ratio were assessed. Only growing and fi nal phases whose treatments were additioned at the same time probiotic and soybean oil, showed the best results in weight gain and feed intake.(AU)
El objetivo del experimento fue avaluar el desempeño de los pollos de corte recibiendo dietas con probiótico Biobac®, conteniendo ingredientes activos del Saccaromyces cerevisae, Lactobacillus acidophylus y Enterococcus faecium, en el uso aislado o asociado con 3% de aceite de soja en las fases inicial, engorda y fi nal; respectivamente 1 al 21; 22 al 42 y del 43 al 47 días de edad. Fueran utilizadas 3.200 aves del corte de ambos los sexos con un día de edad, distribuidos en un diseño en bloques aleatorizados en ocho tratamientos con cuatro repeticiones sendo: T1- control, T2- probiótico en todas las fases, T3- aceite de soja en la fase fi nal, T4- (T2 + T3), T5- aceite de soja en las fases del engorda y fi nal, T6- ( T2 + T5), T7- aceite de soja en todas las fases, T8- (T2 + T7). Las raciones contenían 22; 20 e 18% de proteína bruta, con niveles de energía metabolizável entre 2.881 a 3.033 kcal/kg según la inclusión o no del aceite de soja. Fueron evaluados la ganancia del peso, consumo de ración y conversión alimentar. Solamente los periodos de engorda y fi nal cuyos tratamientos fueran adicionados conjuntamente probiótico y aceite de soja presentaran los mejores resultados en aumento de peso y conversión alimentar.(AU)