Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
1.
J Peripher Nerv Syst ; 22(2): 106-111, 2017 06.
Artigo em Inglês | MEDLINE | ID: mdl-28436077

RESUMO

The neuroprotective effect of epidermal growth factor (EGF) has been documented in different contexts, but its potential benefits in peripheral neuropathies have been little studied. We investigated the neuroprotective action of EGF in experimental neuropathy induced by acrylamide (ACR). Mice and rats were treated chronically with acrylamide for 6 and 8 weeks, respectively. Concurrently they received EGF in daily doses of 1 and 5 mg/kg in mice and 3 mg/kg in rats, or saline (PBS). ACR severely affected the neurological score, the muscle strength, and the muscle potential M, in mice, as well as F-waves (F-Wii), sensory potentials (SPii), and apomorphine-induced penile erection, in rats. EGF reduced the ACR effects in both species. A dose-dependent effect of EGF was manifested in the proportion of diseased animals at the end of treatments, as well as in the reduction of M amplitude throughout the treatment. F-Wii parameters were less protected by EGF than SP. The results show a protective effect of EGF in acrylamide-induced neuropathy and support previous studies concerning the neuroprotective action of this peptide.


Assuntos
Acrilamida/toxicidade , Fator de Crescimento Epidérmico/uso terapêutico , Fármacos Neuroprotetores/uso terapêutico , Doenças do Sistema Nervoso Periférico/induzido quimicamente , Doenças do Sistema Nervoso Periférico/tratamento farmacológico , Potenciais de Ação/fisiologia , Animais , Apomorfina/farmacologia , Modelos Animais de Doenças , Agonistas de Dopamina/farmacologia , Estimulação Elétrica , Fator de Crescimento Epidérmico/química , Força da Mão/fisiologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Exame Neurológico , Fármacos Neuroprotetores/química , Ereção Peniana/efeitos dos fármacos , Ratos , Ratos Wistar , Fatores de Tempo
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA