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Most children with functional constipation (FC) improve with conventional treatments. However, a proportion of children have poor treatment outcomes. Management of intractable FC may include botulinum toxin injections, transanal irrigation, antegrade enemas, colonic resections, and in some cases sacral nerve stimulation (SNS). SNS is surgically placed, not readily available and expensive. Posterior tibial nerve stimulation (PTNS) allows transmission of electronic impulses and retrograde stimulation to the sacral nerve plexus in a portable, simple and non-invasive fashion. To assess the efficacy and safety of transcutaneous PTNS for the treatment of FC in children. Single-center, prospective interventional study. Children 4-14 years with Rome IV diagnosis of FC received ten daily PTNS (30 min/day) sessions. Electrodes placed over skin of ankle. Strength of stimulus was below pain threshold. Outcomes were assessed during treatment and 7 days after. Twenty-three subjects enrolled. Two children excluded (acute gastroenteritis, COVID-19 contact). Twenty completed the study (4-14 years), (8.4 ± 3.2 years, 71.4% female). We found significant improvement in the consistency of bowel movements (BM) (p = 0.005), fecal incontinence (FI) (p = 0.005), abdominal pain presence (p = < 0.001) and intensity (p = 0.005), and a significant for improvement in blood in stools (p = 0.037). There was 86.3% improvement in abdominal pain. 96.7% reported treatment satisfaction. Only one child required rescue therapy. CONCLUSION: We found significant improvement in stool consistency, FI, abdominal pain, and hematochezia. This suggests that transcutaneous PTNS could be a promising noninvasive treatment for FC in children. Large studies are needed. WHAT IS KNOWN: • Functional constipation is one of the most common disorders in children. • Current management of functional constipation consists of an integrative approach that includes medications, diet and behavioral strategies. WHAT IS NEW: • Posterior tibial nerve stimulation is a novel noninvasive and easy to use therapy that can improve stool consistency, fecal incontinence and blood in stools.

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Introduction Tarsal tunnel syndrome (TTS) is caused by compression of the posterior tibial nerve. Objective To evaluate the effectiveness of surgical treatments compared to conser vative treatments in reducing the symptoms of the syndrome. Methods The PubMed, Lilacs, Cochrane Library, and PEDro databases were used for this review. Results Only 11 articles were selected. Conclusion The most common causes of TTS identified were presence of ganglia, bone prominence causing a talocalcaneal collision, trauma, varicose and idiopathic veins. The main symptom was pain in the medial plantar region and paresthesia that can radiate to the fingers or to the calf. Most patients have a positive Tinel sign upon physical examination. Electrodiagnostic test usually shows the presence of latency in sensory nerve conduction. There is no consensus suggesting that a longer time between diagnosis and surgical treatment leads to worse prognosis. In the group of operated patients, the ones who benefited most from the procedure were those who had a structure such as ganglion, cysts, or varicosities causing compression. The most cited surgical complications were postsurgical wound infection, wound dehiscence, and calcaneus hypoesthesia. Regarding surgical techniques, the release of the posterior tibial nerve via endoscopy had a favorable outcome in relation to the symptoms of pain and hypoesthesia, with no reports of infection of the operative site in the articles identified in this review. We observed a rate of good or excellent pain control of 68% (n » 204) for open surgery (n » 299), 100% (n » 8) for endoscopic surgery (n » 8), and 7% (n » 2) for conservative treatment (n » 28).

Introdução A síndrome do túnel do tarso (STT) é causada pela compressão do nervo tibial posterior. Objetivo Avaliar a eficácia dos tratamentos cirúrgicos em comparação aos conservadores na redução dos sintomas da síndrome. Métodos Foram utilizados as bases de dados PubMed, Lilacs, Cochrane Library e PEDro. Resultados Apenas 11 artigos foram selecionados. Conclusão As causas mais comuns de STT identificadas foram presença de gânglios, proeminência óssea causando colisão talocalcânea, trauma, varizes e veias. O principal sintoma foi dor na região plantar medial e parestesia, que pode irradiar para os dedos ou panturrilha. A grande maioria dos pacientes apresenta um sinal de Tinel positivo no exame físico. O teste eletrodiagnóstico geralmente mostra a presença de latência na condução nervosa sensorial. Não há consenso de que o maior tempo entre o diagnóstico e o tratamento cirúrgico leva a um pior prognóstico. No grupo de pacientes operados, os que mais se beneficiaram com o procedimento foram aqueles que apresentavam estrutura como gânglio, cistos ou varicosidades causando compressão. As complicações cirúrgicas mais citadas foram infecção da ferida operatória, deiscência da ferida e hipoestesia do calcâneo. A cirurgia endoscópica teve evolução favorável em relação aos sintomas de dor e hipoestesia, não havendo relato de infecção do sítio operatório. Observou-se que a taxa de bom ou excelente controle da dor foi de 68% (n » 204) para cirurgia aberta (n » 299), 100% (n » 8) para cirurgia endoscópica (n » 8), e 7% (n » 2) para o tratamento conservador (n » 28).

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Resumen OBJETIVO: Reportar dos casos de pacientes con el efecto de la estimulación del nervio tibial posterior en la retención urinaria posparto. CASOS CLÍNICOS: Caso 1: Paciente de 41 años, con dos cesáreas previas, sobrepeso (IMC 28 kg/m2), con 33 semanas de embarazo, hipertensión arterial crónica y preeclampsia sobreagregada asociada con datos de déficit neurológico. En el puerperio tardío tuvo dificultad para miccionar y dolor suprapúbico. Con base en la urodinamia se diagnosticó: disinergia detrusor-esfínter y se trató con estimulación del nervio tibial posterior durante 20 minutos cada semana con duración de fase de 200 µs y frecuencias de 10 Hz durante 12 sesiones. Los parámetros urodinámicos mejoraron y se restablecieron las micciones espontáneas, se redujo la frecuencia del cateterismo limpio intermitente y el efecto continuó a 31 meses de seguimiento. Caso 2: Paciente de 38 años, primigesta, IMC 21 kg/m2 , con antecedente de hipotiroidismo subclínico. A los cinco días de puerperio tuvo retención urinaria de 2000 mL; se le colocó una sonda Foley a drenaje contínuo y, posteriormente, un tapón con vaciado cada 2 horas. No obstante lo anterior tuvo nuevos episodios de retención urinaria que ameritaron el inicio del cateterismo limpio intermitente, 5 en 24 horas y estimulación del nervio tibial posterior con corriente bifásica asimétrica. Se consiguió una mejoría subjetiva del 100% y cambios urodinámicos. Las micciones espontáneas se reiniciaron sin requerir cateterismo limpio intermitente, fue dada de alta luego de un año de seguimiento. CONCLUSIÓN: De acuerdo con los desenlaces del estudio, la estimulación del nervio tibial posterior podría ofrecer una alternativa de tratamiento prometedora en pacientes con retención urinaria posparto.

Abstract OBJECTIVE: Case report of the effect of posterior tibial nerve stimulation on postpartum urinary retention. CASE REPORT: Case 1: 41-year-old patient, with two previous cesarean sections, overweight (BMI 28 kg/m2), 33 weeks of pregnancy, chronic arterial hypertension and over-aggregated preeclampsia associated with data of neurological deficit. In the late puerperium she had difficulty urinating and suprapubic pain. Based on urodynamics, detrusor-sphincter dyssynergia was diagnosed and she was treated with posterior tibial nerve stimulation for 20 minutes every week with phase duration 200 µs and frequency 10 Hz during 12 sessions. Urodynamic parameters improved and spontaneous micturition was restored, the frequency of intermittent clean catheterization was reduced, and the effect continued at 31 months follow-up. Case 2: 38-year-old primigravida patient, BMI 21 kg/m2, with a history of subclinical hypothyroidism. Five days postpartum she had urinary retention of 2000 mL; a Foley catheter was placed for continuous drainage and, subsequently, a plug with emptying every 2 hours. Notwithstanding the above, she had new episodes of urinary retention that warranted the initiation of intermittent clean catheterization, 5 in 24 hours and stimulation of the posterior tibial nerve with asymmetric biphasic current, she had a subjective improvement of 100% and urodynamic changes. Spontaneous urination resumed without requiring intermittent clean catheterization, she was discharged after one year of follow-up. CONCLUSION: According to the study outcomes, posterior tibial nerve stimulation could offer a promising treatment alternative in patients with postpartum urinary retention.

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Parkinson é uma doença de sintomas motores e não motores, podendo incluir neste último, a bexiga neurogênica, que se caracteriza por sintomas de urgência, com ou sem urge-incontinência, normalmente acompanhada de polaciúria e noctúria. Objetivo: Analisar a eletroestimulação transcutânea e a percutânea do nervo tibial para tratamento da bexiga hiperativa em Parkinsonianos. Metodologia: Foram incluí­dos todos os artigos que mencionaram o tratamento da bexiga hiperativa, com eletroestimulação transcutânea e percutânea do tibial posterior, em pacientes com Parkinson. Realizou-se a busca de março a novembro de 2017, nas bases de dados US National Library of Medicine (MEDLINE), Scientific Eletronic Library Online (SciELO), Physiotherapy Evidence Database (PEDro), Biblioteca Virtual em Saúde (BVS) e Google acadêmico, sem limites de data. Foram utilizados como descritores contidos nos Descritores em Ciências da Saúde (DeCS) as palavras-tí­tulo: bexiga hiperativa, Parkinson e eletroestimulação transcutânea e percutânea do tibial posterior. Foram utilizados como descritores contidos no Medical Subject Headings (MeSH) as palavras-tí­tulo: overactivity bladder, Parkinson"™s disease, electrical stimulation transcutaneous, percutaneous electrical stimulation. Resultados: Dos 8 artigos recuperados, 1 estava duplicado e 2 foram excluí­dos por não estarem disponí­veis, restando cinco artigos: 2 ECRs, 2 experimentais e 1 estudo piloto. Conclusão: a terapia de eletroestimulação tibial, tanto transcutânea, quanto percutânea, se mostra benéfica para tratamento da bexiga hiperativa, em pacientes com Parkinson, porém, se faz necessário a realização de novos estudos, principalmente os de intervenção, para padronização do método. (AU)

Parkinson's disease is a disease of motor and non-motor symptoms, and may include neurogenic bladder, which is characterized by urgency symptoms, with or without urge incontinence. Objective: To analyze the transcutaneous and percutaneous electrostimulation of the tibial nerve for treatment of overactive bladder in Parkinsonians. Methodology: All articles mentioning the treatment of overactive bladder, with transcutaneous and percutaneous electrostimulation of the posterior tibial, were included in patients with Parkinson's disease. The search was carried out from March to November 2017, in the databases National Library of Medicine (Medline), Scientific Electronic Library Online (SciELO), Physiotherapy Evidence Database (PEDro), Virtual Health Library (VHL) and Google academic, without date limits. The descriptors included were: hyperactive bladder, Parkinson's and transcutaneous and percutaneous electrostimulation of the posterior tibial. The descriptors included in the Medical Subject Headings (MeSH) were: overactivity bladder, Parkinson's disease, electrical stimulation transcutaneous, percutaneous electrical stimulation. Results: Of the 8 articles retrieved, 1 was duplicated and 2 were excluded because they were not available, leaving five articles: 2 RCTs, 2 experimental and 1 pilot study. Conclusion: Transcutaneous and percutaneous tibial electrostimulation therapy is beneficial for the treatment of overactive bladder in patients with Parkinson disease. However, it is necessary to carry out new studies, especially interventional ones, to standardize the method. (AU)

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La incontinencia urinaria es cualquier pérdida involuntaria de orina. El tratamiento actual consiste en ejercicios de fortalecimiento pélvico y cirugía en los casos severos. Dado que el nervio tibial posterior y músculos del piso pélvico presentan inervación común originada en las raíces sacras se plantea que la estimulación eléctrica de dicho nervio es un método terapéutico de la incontinencia urinaria de esfuerzo. Se realizó un estudio cuasi-experimental, longitudinal, analítico de tipo prospectivo en 22 mujeres entre 20 y 60 años durante el periodo de Junio a Diciembre del año 2014, las cuales cumplieron 6 semanas de terapia y se dividieron en dos grupos: el grupo A que realizó ejercicios de Kegel y Grupo B que realizaron electroestimulación del tibial posterior y ejercicios de Kegel. Las pacientes respondieron el cuestionario de incontinencia urinaria ICIQ-SF al inicio de la terapia y a la finalización. Existió una mejoría global del 26% posterior a la terapia con ejercicios de Kegel y 69% en el grupo que realizó la electroestimulación del tibial posterior al finalizar las 6 semanas de tratamiento.

Urinary incontinence consists in any involuntary loss of urine. -The current treatment consists in pelvic strengthening exercises and surgery in severe cases. Since the tibial posterior nerve and the pelvic floor muscles present common innervation originated in the sacral roots a hypothesis arises: Electrical stimulation of the nerve is a therapeutic method of urinary incontinence. A quasi-experimental, longitudinal, prospective analytical study was performed on 22 women between 20 and 60 years during the period from June to December 2014, which met six weeks of therapy and were divided into two groups: group A who performed Kegel exercises and group B who made electrostimulation of the posterior tibial nerve and Kegel exercises. The patients answered the questionnaire urinary incontinence ICIQ-SF at the start of therapy and termination. There was an overall improvement of 26% after therapy with Kegel exercises and 69% in the group that performed electrostimulation of the posterior tibial nerve at the end of 6 weeks of treatment.

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PURPOSE: Parasacral transcutaneous electrical nerve stimulation and posterior tibial nerve stimulation have emerged as effective methods to treat overactive bladder in children. However, to our knowledge no study has compared the 2 methods. We evaluated the results of parasacral transcutaneous electrical nerve stimulation and posterior tibial nerve stimulation in children with overactive bladder. MATERIALS AND METHODS: We prospectively studied children with overactive bladder without dysfunctional voiding. Success of treatment was evaluated by visual analogue scale and dysfunctional voiding symptom score, and by level of improvement of each specific symptom. Parasacral transcutaneous electrical nerve stimulation was performed 3 times weekly and posterior tibial nerve stimulation was performed once weekly. RESULTS: A total of 22 consecutive patients were treated with posterior tibial nerve stimulation and 37 with parasacral transcutaneous electrical nerve stimulation. There was no difference between the 2 groups regarding demographic characteristics or types of symptoms. Concerning the evaluation by visual analogue scale, complete resolution of symptoms was seen in 70% of the group undergoing parasacral transcutaneous electrical nerve stimulation and in 9% of the group undergoing posterior tibial nerve stimulation (p = 0.02). When the groups were compared, there was no statistically significant difference (p = 0.55). The frequency of persistence of urgency and diurnal urinary incontinence was nearly double in the group undergoing posterior tibial nerve stimulation. However, this difference was not statistically significant. CONCLUSIONS: We found that parasacral transcutaneous electrical nerve stimulation is more effective in resolving overactive bladder symptoms, which matches parental perception. However, there were no statistically significant differences in the evaluation by dysfunctional voiding symptom score, or in complete resolution of urgency or diurnal incontinence.

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Fecal incontinence is a condition that creates a huge impact on quality of life, it affects up to 45 percent of patients of the elderly. Treatment is initially conservative with dietary changes, drugs and perineal biofeedback. Surgery is reserved for those who do not respond to medical treatment. The most frequently performed procedure is anal sphincteroplasty, useful in patients with proven lesions of the external anal sphincter. Other alternatives include the implantation of an artificial anal sphincter and dynamic graciloplasty, which are very expensive techniques with high rate of complications. If there is no other alternative, a permanent ostomy can be done. In recent years, less invasive techniques have been developed for the treatment of fecal incontinence. Among these, central neuromodulation or sacral root stimulation (SRS) and peripheral neuromodulation or posterior tibial nerve stimulation (PTNS) have shown promising results. The aim of this paper is to present 2 cases of patients with fecal incontinence refractory to conventional treatment (medical and surgical) that are successfully treated with central and peripheral neuromodulation respectively. We present 2 cases and a review of the literature available to date.

La incontinencia fecal (IF) es una patología que genera un enorme impacto en la calidad de vida, afectando hasta el 45 por ciento de los pacientes de la tercera edad. El tratamiento es inicialmente conservador mediante cambios dietéticos, fármacos y rehabilitación perineal. La cirugía se reserva para quienes no responden a tratamiento medico. El procedimiento efectuado con más frecuencia es la esfinteroplastía anal, de utilidad en pacientes con lesión demostrada del esfínter anal externo. En casos de IF grave, otras alternativas son la instalación de un esfínter anal artificial y/o la graciloplastía dinámica, procedimientos de alto costo y con un alto porcentaje de complicaciones. En caso de no existir otra alternativa se puede realizar una ostomía definitiva. Durante los últimos años se han desarrollado técnicas mínimamente invasivas para el tratamiento de la incontinencia fecal. Entre éstas, la neuromodulación central o de las raíces sacras (NMS) y últimamente la neuromodulación periférica o estimulación del nervio tibial posterior (ENTP) han mostrado resultados promisorios. Los objetivos de este trabajo son presentar 2 casos clínicos de pacientes con incontinencia fecal refractaria al tratamiento convencional (medico y quirúrgico) que son tratados exitosamente con neuromodulación central y periférica, respectivamente, y realizar una revisión de la literatura disponible a la fecha.

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La respuesta cortical del Potencial Evocado Somatosensorial del nervio tibial posterior ha mostrado en diferentes investigaciones una gran variabilidad en cuanto a los resultados obtenidos por diferentes autores. Los objetivos de este trabajo fueron evaluar en una muestra de sujetos adultos sanos la distribución topográfica de la respuesta cortical del potencial evocado somatosensorial del nervio tibial posterior empleando un protocolo de registro con 19 derivaciones del Sistema Internacional 10/20 en el equipo MEDICID-4. Se estudiaron 18 sujetos adultos sanos. En todos los sujetos se obtuvo la respuesta cortical P40, manteniéndose los 19 canales de registro, modificándose los filtros a valores entre 0.5 y 300 Hz, y la frecuencia de muestreo se modificó a 1000 Hz. Los resultados muestran una máxima amplitud de la P 40 en línea media. Además, simultáneamente se obtiene dicha respuesta en la propia región centro-parietal ipsilateral, sin existir gran variabilidad intra e interindividuos. De esto se concluye que la estimulación del nervio tibial el pico P40 mostró una distribución cortical centro-parietal tanto en línea media como ipsilateral, con máxima amplitud en esta última, es decir, la P40 se obtuvo paradójicamente con mayor amplitud hacia la misma región del lado estimulado.

The cortical response of the somatosensorial evoked potential of the posterior tibial nerve has shown, in different research works, a great variability in terms of the results obtained by different authors. The aims of this paper were to evaluate in a sample of healthy adult individuals the topographical distribution of the cortical response of the somatosensorial evoked potential of the posterior tibial nerve by using a protocol registration with 19 derivations from the International System 10/20 in the MEDICID-4 team. Eighteen adult individuals were studied. In each individual the cortical response was P40, remaining the 19 registration canals, modifying the filter between 0.5 and 300 Hz, and the sampling frequency was modified to 1000 Hz. Results show a maximum amplitude of the P40 in the middle line. In addition, simultaneously, such response is registered in the central parietal ipsilateral region, with no great intraindividual and interindividual variability. As a conclusion, the stimulation of the tibial nerve and peak P40 showed a cortical central parietal distribution in the middle line, as well as ipsilaterally, with maximum amplitude in the latter. P40 was obtained paradoxically with a greater amplitude towards the same region of the stimulated site.