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1.
Eur J Investig Health Psychol Educ ; 14(6): 1700-1711, 2024 Jun 12.
Artigo em Inglês | MEDLINE | ID: mdl-38921078

RESUMO

The climacteric heralds a transition from reproductive to non-reproductive life in women, often accompanied by various clinical manifestations such as dry eye, impacting their quality of life. This study focuses on systematically developing and suitability an educational digital booklet to promote eye health practices and prevent problems among postmenopausal women. The methodological approach encompassed semi-structured interviews with women diagnosed with Dry Eye Syndrome (DES), then constructing the material integrating content, script, illustrations, and layout informed by the interview findings. Subsequent validation involved assessment by 24 health experts for content, appearance, and evaluation by a target audience of 22 women. The booklet attained high suitability scores, with a Global Content Validity Index (CVI) of 0.96, indicating superior suitability as judged by experts. Additionally, it achieved a Global CVI of 0.98 for validation by the target audience. In conclusion, the educational booklet emerges as a suitable and reliable resource for promoting eye heath among DES and non-syndrome women, offering significant potential for broader application in relevant populations.

2.
Int Urogynecol J ; 35(3): 561-569, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38206341

RESUMO

INTRODUCTION AND HYPOTHESIS: This study is aimed at comparing the effectiveness of pelvic floor muscle training (PFMT) and Pilates on the improvement of urinary incontinence (UI), strength, and endurance of the pelvic floor muscles (PFMs), and the impact of UI on the quality of life in postmenopausal women. METHODS: Forty postmenopausal women were randomly divided in to two groups: PFMT (n = 20) and Pilates (n = 20). The participants were followed for 12 weeks, three times a week on nonconsecutive days. UI was assessed using the pad test and the voiding diary, PFM strength and resistance using bidigital assessment and manometry, and the impact of UI on quality of life using the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF), before and after the 3-month treatment. RESULTS: There was a significant intra-group improvement in both groups for the pad test, mean daily urinary loss, and ICIQ-SF. The strength was significantly improved only in the PFMT group, and the endurance in both groups. Peak strength manometry was significantly improved only in the Pilates group, and the mean strength manometry in both groups. There was also an improvement in both groups for peak endurance manometry and mean endurance manometry. In the inter-group comparison, there was a significant improvement only in muscle strength, which was positive for group. CONCLUSIONS: There was no difference between Pilates and PFMT for the management of women in post-menopause with stress urinary incontinence, provided that voluntary contraction of the PFMs is performed. However, further randomized clinical trials need to be carried out.


Assuntos
Incontinência Urinária por Estresse , Incontinência Urinária , Feminino , Humanos , Terapia por Exercício , Diafragma da Pelve/fisiologia , Qualidade de Vida , Pós-Menopausa , Incontinência Urinária/terapia , Incontinência Urinária por Estresse/terapia , Resultado do Tratamento
3.
Iran J Public Health ; 52(3): 476-487, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-37124907

RESUMO

Background: Menopause is a natural phase in a woman's aging process. Menopause leads to the decrease of the estrogen levels, and in consequence the functionality worsening. Physical exercise can improve the functionality of postmenopausal woman. This review aimed to assess the effect of whole-body vibration exercise (WBVE) on the functionality of postmenopausal women. Methods: PRISMA guideline were used. Only English language were considered. Searches were conducted using relevant keywords for papers prior to Sep 16th, 2021, in Embase, Pubmed, The Cochrane Library, PED-ro, SPORTDiscus, Scopus, Web of Science and CINAHL databases. Results: Eight articles were selected to be in this systematic review. The mean score of methodological quality was moderate, the risk of bias was low for two studies, high for four studies, and unclear for two studies. The level of evidence of the studies was II. Improvements on muscle strength, jump, balance and maximum trunk flexion strength in the post menopause woman were reported. Conclusion: This systematic review demonstrated the functionality increase in postmenopausal women through WBVE. WBVE has been recommended as a non-pharmacological option relevant to postmenopausal management, helping to control the decline in bone density and symptoms related to osteoporosis and sarcopenia. However, further studies are needed to reinforce these findings.

4.
Trials ; 24(1): 94, 2023 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-36750904

RESUMO

BACKGROUND: There is no evidence of the use of beetroot juice with a previously recommended dose of nitrate (NO3) (> 300 mg) on the cardiovascular performance during and recovery following exercise in postmenopausal women with systemic arterial hypertension (SAH). METHODS: We will investigate the effects of beetroot juice rich in NO3 acutely (800 mg) and during a week with daily doses (400 mg) on blood pressure, heart rate (HR), cardiac autonomic control, endothelial function, inflammatory, hormonal, and stress biomarkers oxidative stress and enzymes involved in nitric oxide synthesis and mitochondrial regulation, under resting conditions, as well as mediated by submaximal aerobic exercise sessions. Through a randomized, crossover, triple-blind, placebo-controlled clinical trial, 25 physically inactive women with SAH will undergo an acute and 1-week trial, each with two intervention protocols: (1) placebo and (2) beetroot, in which will ingest beet juice with or without NO3 in its composition with a 7-day washout interval. On collection days, exercise will be performed on a treadmill for 40 min at a speed corresponding to 65-70% of VO2peak. The collection of variables (cardiovascular, autonomic, and blood samples for molecular analyses) of the study will take place at rest (135 min after ingestion of the intervention), during exercise (40 min), and in the effort recovery stage (during 60 min) based on previously validated protocols. The collections were arranged so that the measurement of one variable does not interfere with the other and that they have adequate intervals between them. DISCUSSION: The results of this research may help in the real understanding of the nutritional compounds capable of generating safety to the cardiovascular system during physical exercise, especially for women who are aging and who have cardiovascular limitations (e.g., arterial hypertension) to perform physical exercise. Therefore, our results will be able to help specific nutritional recommendations to optimize cardiovascular health. TRIAL REGISTRATION: ClinicalTrials.gov NCT05384340. Registered on May 20, 2022.


Assuntos
Beta vulgaris , Sistema Cardiovascular , Hipertensão , Humanos , Feminino , Nitratos/análise , Nitratos/uso terapêutico , Nitritos/análise , Pós-Menopausa , Exercício Físico/fisiologia , Suplementos Nutricionais , Estudos Cross-Over , Método Duplo-Cego , Ensaios Clínicos Controlados Aleatórios como Assunto
5.
Physiother Theory Pract ; 38(10): 1538-1544, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33283590

RESUMO

INTRODUCTION: Diastasis recti abdominis (DRA) and pelvic floor dysfunction (PFD) occurs commonly with aging; however, little is known about what leads to these changes. OBJECTIVE: We aimed to investigate and compare the presence or absence of DRA and PFD in peri- and postmenopausal women. METHODS: This cross-sectional study involved 150 participants who answered questions on their sociodemographic and clinical profiles related to urinary and fecal incontinence and pelvic organ prolapse. Diastasis recti abdominis was diagnosed with a digital caliper. RESULTS: Supra-umbilical diastasis occurred in 37.3% of cases, and 78.6% of participants with DRA had PFD. No significant differences existed between participants with and without DRA in terms of background and clinical variables. However, participants with DRA were 2.6 times more likely to have PFD than participants without DRA. Furthermore, the presence of DRA was significantly shown to be a risk factor for PFD on binary logistic regression analyses (p = .01, OR = 3.2). CONCLUSIONS: This cross-sectional study suggests that DRA is a predictive factor of PFD in women aged over 50 years.


Assuntos
Doenças Musculares , Prolapso de Órgão Pélvico , Estudos Transversais , Feminino , Humanos , Pessoa de Meia-Idade , Diafragma da Pelve , Pós-Menopausa , Reto do Abdome
6.
Motriz (Online) ; 28: e10220005822, 2022. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1406013

RESUMO

Abstract Aim: This study aimed to identify the prevalence and factors associated with dynapenia in older women, considering different cutoff points as diagnostic criteria. Methods: This epidemiological study was conducted with 205 older women (72.7 ± 7.1 years). Dynapenia was diagnosed using the handgrip strength test (HGS) using two cutoff points (< 16 or < 20 kgf). Socio-demographic, behavioral, and health status information was obtained from a specific form; nutritional status was assessed by body mass index, and the International Physical Activity Questionnaire identified the level of physical activity. Results: The prevalence of dynapenia was 14.1% (HGS < 16 kgf) and 46.3% (HGS < 20 kgf) (p < 0.001). It was also observed that older women with family income ≤ 1 minimum wage and those with low weight presented, respectively, 2.22 (95%CI: 1.12-4.39) and 4.72 (95%CI: 1.64-13.58) times higher probability of dynapenia identified by HGS < 16 kgf. Moreover, for the cutoff point < 20 kgf, the probability of dynapenia was higher in women aged ≥ 80 years (PR:1.91; 95%CI: 1.23-2.95), in insufficiently active women (PR: 1.34; 95%CI: 1.01-2.57), among those with low weight (PR: 1.61; 95%CI: 1.01-2.57), and in those who reported falls (PR:1.42; 95%CI: 1.04-1.96). Conclusion: Therefore, it is concluded that there is a difference between the prevalence and factors associated with dynapenia when different cutoff points are adopted.

7.
Exp Gerontol ; 150: 111355, 2021 07 15.
Artigo em Inglês | MEDLINE | ID: mdl-33865923

RESUMO

The hormonal modifications observed in post-menopausal are related to increased adiposity and alteration in the lipid profile besides physical and psychological changes. Physical exercises may attenuate these conditions and have been associated with low-grade inflammatory status, reducing the risk of cardiovascular diseases. This study aimed to evaluate the influence of dyslipidemia on the effect of physical exercise on inflammatory markers IL6, IL10, and TNF-α in obese post-menopausal women. A randomized clinical trial was carried out in seventy women divided into four groups: exercise without dyslipidemia (EG/n = 11); exercise with dyslipidemia (EGD = 24); control with dyslipidemia (CGD/n = 22); and control without dyslipidemia (CG/n = 13). The serum values of IL-6, IL-10, and TNF-α were measured before and after the intervention period, and the exercise program lasted 20 weeks, in three weekly sessions of 75 min each, with aerobic and strength exercises. The comparison of means was performed using the ANOVA test, repeated measures to analyze the interaction between the group and intervention time. There were a significant reduction in IL-6 values and an increase in IL-10/IL-6 and IL-10/TNF-α ratios only in the EG group. For serum TNF-α values, the EG and EGD groups showed significant reductions. The groups that practiced exercises did not present significant variation in the levels of IL-10. However, the CGD and GC groups showed a significant reduction in IL-10 after the intervention period.


Assuntos
Dislipidemias , Pós-Menopausa , Biomarcadores , Dislipidemias/terapia , Exercício Físico , Feminino , Humanos , Obesidade/terapia , Fator de Necrose Tumoral alfa
8.
Gac Med Mex ; 157(5): 484-493, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-35104267

RESUMO

INTRODUCTION: Low levels of vitamin D have been associated with muscle mass loss and cognitive function alteration. OBJECTIVE: To find out the relationship of vitamin D blood levels with muscle mass and cognitive function in postmenopausal women. MATERIALS AND METHODS: Ninety-nine postmenopausal women aged ≥ 50 years were studied. Calf circumference, and tricipital, bicipital, subscapular and suprailiac skinfolds were measured. Arm muscle area, bone-free arm muscle area, and muscle mass were calculated. The short physical performance battery (SPPB) was performed, and the sarcopenia rapid diagnostic questionnaire (SARC-F), as well as the Mini Mental State Examination (MMSE) were applied. A blood sample was taken to measure vitamin D blood concentration. For statistical analysis, Mann-Whitney's U-test and Spearman's correlation analysis were used. RESULTS: It was found that, the older the age, the higher the vitamin D levels, as well as higher SARC-F score. Vitamin D levels were negatively correlated with grip strength and SPPB. There was a negative correlation between vitamin D levels and MMSE global score. CONCLUSIONS: Vitamin D did not have a positive influence on muscle mass. A better MMSE performance was observed in those with lower vitamin D levels.


INTRODUCCIÓN: Las concentraciones bajas de vitamina D se han asociado con la pérdida de masa muscular y la alteración de la función cognitiva. OBJETIVO: Conocer la relación de la concentración sanguínea de vitamina D con la masa muscular y la función cognitiva en mujeres posmenopáusicas. MATERIALES Y MÉTODOS: Se estudiaron 99 mujeres posmenopáusicas ≥ 50 años. Se midió la circunferencia de la pantorrilla, los pliegues cutáneos tricipital, bicipital, subescapular y suprailíaco. Se calcularon: el área muscular del brazo, el área muscular libre de hueso y la masa muscular total. Se realizó la prueba corta de desempeño físico (PCDF), se aplicó el cuestionario de diagnóstico rápido de sarcopenia (SARC-F) y el Mini Examen del Estado Mental (MMSE). Se tomó una muestra de sangre para medir la concentración de vitamina D en sangre. Para el análisis estadístico se utilizó la prueba U de Mann-Whitney y análisis de correlación de Spearman. RESULTADOS: Se encontró que a mayor edad hubieron mayores concentraciones de vitamina D y mayor puntaje SARC-F. Las concentraciones de vitamina D se correlacionaron negativamente con la fuerza de agarre, la PCDF y la puntuación total del MMSE. CONCLUSIONES: La vitamina D no tuvo una influencia positiva sobre la masa muscular. Se observó un mejor desempeño en el MMSE en aquellas con concentraciones más bajas de vitamina D.


Assuntos
Pós-Menopausa , Vitamina D , Cognição , Feminino , Humanos , Força Muscular , Músculos
9.
Nutrients ; 12(8)2020 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-32751522

RESUMO

Menopause is a stage of hormonal imbalance in women which, in addition to other physiopathological consequences, poses a risk of deficiency of key micronutrients such as magnesium and vitamin D. A study was made of the influence of a magnesium intervention upon vitamin D status in a postmenopausal population from the province of Granada (Spain). Fifty-two healthy postmenopausal women between 44-76 years of age were included. Two randomized groups-placebo and magnesium (500 mg/day)-were treated during eight weeks. Nutrient intake was assessed using questionnaires based on 72-h recall. Vitamin D was analyzed by liquid chromatography-tandem mass spectrometry. Baseline vitamin D proved deficient in over 80% of the subjects. The administration of magnesium resulted in significantly increased vitamin D levels in the intervention group versus the controls (p < 0.05). Magnesium supplementation improved vitamin D status in the studied postmenopausal women.


Assuntos
Suplementos Nutricionais , Magnésio/administração & dosagem , Estado Nutricional/efeitos dos fármacos , Pós-Menopausa , Vitamina D/sangue , Adulto , Idoso , Inquéritos sobre Dietas , Feminino , Humanos , Pessoa de Meia-Idade , Espanha
10.
Lasers Med Sci ; 35(2): 355-363, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31197508

RESUMO

The aim of this study was to compare the effects of resistance training of low volume and high intensity with or without photobiomodulation (PBM) on muscle strength and functional performance in post-menopausal women. Thirty-four post-menopausal women were randomized into resistance training (RTG, n = 17) or resistance training plus PBM (PBMG, n = 17). Individuals from both groups received the same RT protocol consisting of leg-press 45°, front lat pulldown, leg curl, chest press, and squat performed in two sets of 10 repetitions with a workload of 75% of one repetition maximum (1RM), twice per week, during 8 weeks. PBMG individuals also received, prior to the exercise session, PBM through a cluster containing 7 visible diodes (630 nm) and 7 infrared diodes (850 nm) with power of 100 mW each and energy of 4 J per diode, applied to the quadriceps femoris muscle; individuals from RTG received placebo PBM prior to the sessions, applied with the same device switched off. Muscle strength (1RM; isometric dynamometer), functional performance (Time Up and Go; Berg Balance Scale; 6-min walk test), and quality of life (World Health Organization Quality of Life-Bref) were performed before and after 8 weeks. Both groups increased muscle strength (p < 0.001) for all exercises, without group differences (p = 0.651). Quality of life (p = 0.015) and balance (p = 0.006) increased only in the RTG. The results suggest that PBM were not able for inducing additional benefits to RT to improve muscle strength in post-menopausal women.


Assuntos
Terapia com Luz de Baixa Intensidade , Força Muscular/efeitos da radiação , Pós-Menopausa/efeitos da radiação , Treinamento Resistido , Exercício Físico/fisiologia , Terapia por Exercício , Feminino , Humanos , Joelho/fisiologia , Masculino , Pessoa de Meia-Idade , Músculo Quadríceps/fisiologia , Qualidade de Vida , Torque
11.
Arch. endocrinol. metab. (Online) ; 62(4): 438-445, July-Aug. 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-950087

RESUMO

ABSTRACT Objective: This study evaluated the effects of combination therapy of curcumin and alendronate on BMD and bone turnover markers in postmenopausal women with osteoporosis. Subjects and methods: In a randomized, double-blind trial study, 60 postmenopausal women were divided into three groups: control, alendronate, and alendronate + curcumin. Each group included 20 patients. Total body, total hip, lumbar spine and femoral neck BMDs were measured by dual-energy X-ray absorptiometry (DXA) at baseline and after 12 months of therapy. Bone turnover markers such as bone-specific alkaline phosphatase (BALP), osteocalcin and C-terminal cross-linking telopeptide of type I collagen (CTx) were measured at the outset and 6 months later. Results: Patients in the control group suffered a significant decrease in BMD and increased bone turnover markers at the end of study. The group treated with only alendronate showed significantly decreased levels of BALP and CTx and increased levels of osteocalcin compared to the control group. The alendronate group also showed significant increases in the total body, total hip, lumbar spine and femoral neck BMDs at the end of study compared to the control group. In the curcumin + alendronate group, BALP and CTx levels decreased and osteocalcin levels increased significantly at the end of study compared to the control and alendronate groups. BMD indexes also increased in four areas significantly at the end of study compared to the control and alendronate groups. Conclusion: The combination of curcumin and alendronate has beneficial effects on BMD and bone turnover markers among postmenopausal women with osteoporosis. Arch Endocrinol Metab. 2018;62(4):438-45


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Idoso , Densidade Óssea/efeitos dos fármacos , Osteoporose Pós-Menopausa/metabolismo , Alendronato/farmacologia , Curcumina/farmacologia , Conservadores da Densidade Óssea/farmacologia , Fragmentos de Peptídeos/efeitos dos fármacos , Fragmentos de Peptídeos/urina , Osteocalcina/análise , Osteocalcina/efeitos dos fármacos , Método Duplo-Cego , Remodelação Óssea/efeitos dos fármacos , Colágeno Tipo II/efeitos dos fármacos , Colágeno Tipo II/urina , Quimioterapia Combinada/métodos , Fosfatase Alcalina/análise , Fosfatase Alcalina/efeitos dos fármacos
12.
Gac. méd. boliv ; 41(1): 61-63, jun. 2018. ilus, graf, map, tab
Artigo em Espanhol | LILACS | ID: biblio-953624

RESUMO

El leiomioma parauretral es una patología poco frecuente, se trata de un tumor mesenquimatoso no dependiente de uretra y que ocasiona sintomatología uroginecológica en la paciente. Su manejo es principalmente quirúrgico. No se reportan casos de malignización, recidiva, ni metástasis y su diagnóstico diferencial se debe realizar con todas las patologías de masas uretrales y para-uretrales. El presente caso describe la presencia de este tumor en una mujer post-menopaúsica de 60 años, que además de presentar incontinencia urinaria mixta, refería signos obstructivos urinarios, fue diagnosticada y manejada de manera quirúrgica: Resección de tumor y posterior ubicación de cinta suburetral.


The paraurethral leiomyoma is a rare pathology, it is a mesenchymal tumor not dependent of the urethra which causes urogynecological symptoms in the patient. Its management is mainly surgical. No cases of malignancy, recurrence or metastasis are reported and its differential diagnosis must be performed with all pathologies of urethral and para-urethral masses. The present case describes the presence of this tumor in a 60-year-old post-menopausal woman who, in addition to presenting mixed urinary incontinence, referred obstructive urinary signs, was diagnosed and managed surgically: tumor resection and subsequent placement of suburethral tape.


Assuntos
Humanos , Técnicas de Diagnóstico Obstétrico e Ginecológico , Leiomioma/diagnóstico por imagem , Incontinência Urinária/tratamento farmacológico , Espectroscopia de Ressonância Magnética
13.
Med. leg. Costa Rica ; 35(1): 84-93, ene.-mar. 2018. tab
Artigo em Espanhol | LILACS | ID: biblio-894341

RESUMO

Resumen La osteoporosis es una enfermedad esquelétita caracterizada por compromiso en la fuerza ósea, que predispone a fracturas de fragilidad. El diagnóstico de la osteoporosis se establece tanto por fracturas de bajo impacto, así como por medio de la densitometría ósea.


Abstract Osteoporosis is a skeletal disorder characterized by compromised bone strenght, which predisposes to the development of fragility fractures. The diagnosis of osteoporosis is established by the presence of a true fragility or, in patients who have never sustained a fragility fracture, by measurement of bone mineral density.


Assuntos
Humanos , Osteoporose/diagnóstico por imagem , Densidade Óssea , Osteoporose Pós-Menopausa , Densitometria , Fraturas por Osteoporose
14.
Homeopathy ; 106(1): 3-10, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-28325221

RESUMO

BACKGROUND: Climacteric is associated with both depression and metabolic dysregulation. Scarce evidence suggests that metabolic dysregulation may predict poor response to conventional antidepressants. Response to depression treatment has not been studied in homeopathic medicine. The aim of this study was to investigate the prevalence of metabolic disorders in depressed climacteric women treated with homeopathic medicines, fluoxetine or placebo, and if these alterations have any association with response to depression treatment. METHODS: One hundred and thirty-three Mexican women (40-65 years) with depression, enrolled in the HOMDEP-MENOP study, a randomized, placebo-controlled, double-blind, double-dummy, three-arm trial with a 6 week follow-up, underwent a complete medical history and clinical examination. Metabolic parameters were assessed at baseline. Association between baseline metabolic parameters and response to depression treatment was analyzed with bivariate analysis in the three groups. Odds ratios (OR) with their 95% confidence interval (95% CI) were calculated. Metabolic parameters were considered for inclusion in the logistic regression model if they had a statistically significant relationship with response rate on bivariate analysis at p<0.05 or if they were clinically relevant. RESULTS: Overall combined prevalence (obesity and overweight) was 86.5%; 52.3% had hypertriglyceridemia; 44.7% hypercholesterolemia; 46.7% insulin resistance; and 16% subclinical hypothyroidism. There was no statistically significant association between dyslipidemia, overweight, or insulin resistance and non-response in the homeopathy group [OR (95% CI) 1.57 (0.46-5.32), p=0.467; 0.37 (0.003-1.11), p=0.059; 0.67 (0.16-2.7), p=0.579, respectively]. CONCLUSION: Metabolic dysregulation was not significantly associated with response to depression treatment in depressed climacteric women treated with individualized homeopathic treatment (IHT), fluoxetine or placebo. Due to the high prevalence of metabolic disorders and its relationship with depression in the climacteric, further investigation should be focused on whether individualized prescriptions based on classical homeopathy for depressed climacteric women have an effect on metabolic parameters, and/or if treating the metabolic disorders at the same time could lead to higher response rates. ClinicalTrials.gov Identifier: NCT01635218 URL: http://clinicaltrials.gov/ct2/show/NCT01635218?term=depression+homeopathy&rank=1.


Assuntos
Antidepressivos de Segunda Geração/uso terapêutico , Transtorno Depressivo/tratamento farmacológico , Fluoxetina/uso terapêutico , Homeopatia , Menopausa , Adulto , Idoso , Transtorno Depressivo/metabolismo , Transtorno Depressivo/psicologia , Método Duplo-Cego , Feminino , Humanos , México , Pessoa de Meia-Idade , Escalas de Graduação Psiquiátrica , Resultado do Tratamento , Serviços de Saúde da Mulher
15.
BMC Med Genet ; 17(1): 71, 2016 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-27724854

RESUMO

BACKGROUND: Genetic studies to date have not provided satisfactory evidence regarding risk polymorphisms for cardiovascular disease (CVD). Conversely, epigenetic mechanisms, including DNA methylation, seem to influence the risk of CVD and related conditions. Because postmenopausal women experience an increase in CVD, we set out to determine whether global DNA methylation was associated with cardiovascular risk in this population. METHODS: In this cross sectional study carried out in a university hospital, 90 postmenopausal women without prior CVD diagnosis (55.5 ± 4.9 years, 5.8 [3.0-10.0] years since menopause) were enrolled. DNA was extracted from peripheral leukocytes and global DNA methylation levels were obtained with an ELISA kit. Cardiovascular risk was estimated by the Framingham General Cardiovascular Risk Score (10-year risk) (FRS). Clinical and laboratory variables were assessed. Patients were stratified into two CVD risk groups: low (FRS: <10 %, n = 69) and intermediate/high risk (FRS ≥10 %, n = 21). RESULTS: Age, time since menopause, blood pressure, total cholesterol, and LDL-c levels were higher in FRS ≥10 % group vs. FRS <10 % group. BMI, triglycerides, HDL-c, HOMA-IR, glucose and hsC-reactive protein levels were similar in the two groups. Global DNA methylation (% 5mC) in the overall sample was 26.5 % (23.6-36.9). The FRS ≥10 % group presented lower global methylation levels compared with the FRS <10 % group: 23.9 % (20.6-29.1) vs. 28.8 % (24.3-39.6), p = 0.02. This analysis remained significant even after adjustment for time since menopause (p = 0.02). CONCLUSIONS: Our results indicate that lower global DNA methylation is associated with higher cardiovascular risk in postmenopausal women.


Assuntos
Doenças Cardiovasculares/genética , Metilação de DNA , DNA/sangue , Pós-Menopausa/genética , Estudos Transversais , Epigênese Genética , Feminino , Predisposição Genética para Doença , Humanos , Leucócitos , Pessoa de Meia-Idade , Fatores de Risco
16.
Clinics ; Clinics;71(5): 291-294, May 2016. tab, graf
Artigo em Inglês | LILACS | ID: lil-782837

RESUMO

OBJECTIVES: To evaluate the effect of Carbopol gel formulations containing pilocarpine on the morphology and morphometry of the vaginal epithelium of castrated rats. METHODS: Thirty-one female Wistar-Hannover rats were randomly divided into four groups: the control Groups I (n=7, rats in persistent estrus; positive controls) and II (n=7, castrated rats, negative controls) and the experimental Groups, III (n=8) and IV (n=9). Persistent estrus (Group I) was achieved with a subcutaneous injection of testosterone propionate on the second postnatal day. At 90 days postnatal, rats in Groups II, III and IV were castrated and treated vaginally for 14 days with Carbopol gel (vehicle alone) or Carbopol gel containing 5% and 15% pilocarpine, respectively. Next, all of the animals were euthanized and their vaginas were removed for histological evaluation. A non-parametric test with a weighted linear regression model was used for data analysis (p<0.05). RESULTS: The morphological evaluation showed maturation of the vaginal epithelium with keratinization in Group I, whereas signs of vaginal atrophy were present in the rats of the other groups. Morphometric examinations showed mean thickness values of the vaginal epithelium of 195.10±12.23 μm, 30.90±1.14 μm, 28.16±2.98 μm and 29.84±2.30 μm in Groups I, II, III and IV, respectively, with statistically significant differences between Group I and the other three groups (p<0.0001) and no differences between Groups II, III and IV (p=0.0809). CONCLUSION: Topical gel formulations containing pilocarpine had no effect on atrophy of the vaginal epithelium in the castrated female rats.


Assuntos
Animais , Feminino , Agonistas Muscarínicos/farmacologia , Pilocarpina/farmacologia , Vagina/patologia , Atrofia/tratamento farmacológico , Epitélio/efeitos dos fármacos , Epitélio/patologia , Modelos Animais , Distribuição Aleatória , Ratos Wistar , Vagina/efeitos dos fármacos
17.
Rev. Assoc. Med. Bras. (1992, Impr.) ; Rev. Assoc. Med. Bras. (1992, Impr.);61(6): 553-556, Nov.-Dec. 2015.
Artigo em Inglês | LILACS | ID: lil-771989

RESUMO

SUMMARY Female aging is a process that involves hypoestrogenism time, the individual impact on each woman, and what we can do as experts to reduce morbidity and provide quality of life. This natural process in the female life cycle has been of concern to women after menopause. Changes in different biophysical and psychosocial aspects, and their individual experiences, have repercussions on the lives of patients seeking specialized and multidisciplinary support to reduce the harmful effects of prolonged hypoestrogenism. Overweight and obesity, inadequate living habits and the presence of multi-morbidities cause damage to the quality of life and impact the functional capacity. Behavioral prescription and hormone therapy are among the treatments given to ease symptoms and reduce morbidity. A better understanding of these factors can help identify groups that require more care after menopause.


RESUMO O envelhecimento feminino é um processo em que devemos correlacionar o tempo do hipoestrogenismo com o impacto individual em cada mulher e o que poderemos fazer, enquanto especialistas, para reduzir morbidades e proporcionar qualidade de vida. Esse processo natural no ciclo de vida da mulher tem sido motivo de preocupação das mulheres na pós-menopausa. As transformações nos diferentes aspectos biofísicos, psicossociais e em suas vivências individuais trazem repercussões na vida das pacientes, que buscam apoio especializado e multiprofissional para reduzir os efeitos deletérios do hipoestrogenismo prolongado. O sobrepeso e a obesidade, inadequados hábitos de vida e a presença de multimorbidades trazem prejuízos à qualidade de vida e impactam a capacidade funcional. A prescrição comportamental e a terapia hormonal são tratamentos indicados para amenizar os sintomas e reduzir morbidades. Assim, uma melhor compreensão desses fatores pode ajudar a identificar grupos propensos a cuidados na pós-menopausa.


Assuntos
Humanos , Feminino , Envelhecimento/fisiologia , Pós-Menopausa/fisiologia , Qualidade de Vida , Envelhecimento/psicologia , Terapia de Reposição de Estrogênios/normas , Osteoporose Pós-Menopausa/complicações , Pós-Menopausa/psicologia , Doenças Urogenitais Femininas/complicações , Estilo de Vida , Obesidade/complicações
18.
Rev. bras. ciênc. mov ; 23(3): 122-134, jul.-set. 2015. tab
Artigo em Português | LILACS | ID: biblio-846504

RESUMO

A perda da autonomia funcional no idoso relaciona-se não somente com a limitação no estado físico, mas também a função cognitiva e psíquica, tornando-o mais inativo no meio social em que convive. Dessa forma, é de suma importância à inserção do idoso em programas que estimulem a prática regular de exercício físico e o convívio social. O presente estudo centrou-se em avaliar os efeitos de um programa de treinamento concorrente sobre a autonomia funcional de idosas pós-menopáusicas. Foram selecionadas 51 idosas, residentes no município de Muriaé (MG), voluntárias, distribuídas em dois grupos, um grupo treinamento concorrente (GTC=25), com média de idade de 69,44±6,82 anos e um grupo controle (GC=26) com média de idade de 68,30±6,34 anos. Os parâmetros biofísicos foram estimados por meio da massa corporal, estatura e índice de massa corporal. A avaliação da autonomia funcional foi feita pela bateria de testes do Grupo de Desenvolvimento Latino-Americano para a Maturidade (GDLAM), composta de: caminhar 10m (C10m), levantar-se da posição sentada (LPS), levantar-se da posição decúbito ventral (LPDV), levantar-se da cadeira e locomover-se pela casa (LCLC) e o teste de vestir e tirar uma camiseta (VTC). Após a intervenção, o GTC apresentou um valor fraco nos testes C10m e LPDV; regular nos testes LCLC, VTC e no índice de GDLAM e bom no teste LPS. Os resultados mostraram que o GTF no pós-teste apresentou melhores resultados em todas as variáveis da autonomia funcional, exceto no teste de LPDV (p=0,057) em relação ao GC (p<0,0125). Na avaliação intragrupos no GTC, encontrouse diferenças estatisticamente significativas para os testes de autonomia funcional C10m (p=0,007), LPS (p=0,000) e IG (p=0,007). Esta pesquisa confirma que a prática regular de exercício físico é essencial para a restauração e controle da autonomia funcional na população de idosos.(AU)


The loss of functional independence in the elderly is related not only to the limitation in physical state, but also the cognitive and mental function, making it inactive in the social environment in which lives. Thus, it is of paramount importance to the insertion of the elderly in programs that encourage the regular practice of physical exercise and social interaction. This study focused on evaluating the effects of a concurrent training program on functional autonomy of postmenopausal elderly. 51 elderly were selected residents in the city of Muriaé (MG), volunteers, divided into two groups, a concurrent training group (CTG=25), with a mean age of 69.44±6.82years and a control group (CG=26) with mean age of 68.30±6.34 years. The biophysical parameters were estimated using the body mass, height and body mass index. The assessment of function0061l autonomy was made by the test battery of the Latin American Development Group for Maturity (LADGM), composed of: walk 10m (W10m), rising from a sitting position (RSP), rising from a recumbent position ventral (RRPV), rising from a chair and walk around the house (RCWH) and the test of wear and take a T-shirt (WTT). After the intervention, the CTG offered very little value in W10m and RRPV tests; regular in RCWH testing, WTT and index LADGM and good in RSP test. The results showed that the CTG in the post-test showed better results in all the variables of the functional autonomy, except in the test RRPV (p=0.057) compared to the CG (p <0.0125). In intragroup evaluation in CTG, we found statistically significant differences in the functional autonomy tests W10m (p=0.007), RSP (p=0.000) and index LADGM (p=0.007). This research confirms that regular physical activity is essential for the restoration and control of the functional autonomy of the elderly population.(AU)


Assuntos
Humanos , Masculino , Idoso , Envelhecimento , Exercício Físico , Pós-Menopausa , Autonomia Pessoal
19.
Reprod. clim ; 30(2): 70-76, maio-ago. 2015. tab
Artigo em Inglês | LILACS | ID: biblio-973027

RESUMO

PURPOSES: To identify the socio-demographic and anthropometric profile and correlate them with the severity of menopausal symptoms in postmenopausal women. METHODS: Cross-sectional study with 201 postmenopausal women attended in a Gynecology Outpatient Department in Rio de Janeiro city (RJ, Brazil). A questionnaire was applied for collection of demographic, socioeconomic, clinical and lifestyle variables. The Blatt–Kupperman Menopausal Index was used to evaluate the menopausal symptoms. RESULTS: Women with moderate to severe symptoms ( ≥20) corresponded to 57.7% (116) of the sample. Obesity was not associated with the severity of menopausal symptoms (p < 0.90). Severe to moderate symptoms were inversely associated with age (PR 0.96; CI 95% 0.94–0.99;p < 0.01). Women within 6–10 years of menopause presented nearly 1.4 times higher prevalence of moderate to severe symptoms compared with those with more than 10 years of menopause. Unemployed women (PR 1.52; CI 95% 1.13–2.04; p < 0.01) and housewives (PR1.53; CI 95% 1.12–2.09; p < 0.01) presented higher prevalence of menopausal symptoms compared with working women. Tobaccoism was associated with higher prevalence of moderate to severe symptoms (p < 0.01). CONCLUSIONS: Age constituted a protection factor for moderate to severe symptoms, whereas having within 6–10 years of menopause, smoking and being unemployed or a housewife were factors related to higher prevalence of moderate to severe menopausal symptoms.


OBJETIVO: Identificar o perfil sociodemográfico e antropométrico e associá-los com a intensidade dos sintomas menopausais em mulheres na pós-menopausa.MÉTODOS: Estudo transversal com 201 mulheres na pós-menopausa atendidas em um ambulatório de ginecologia no Rio de Janeiro/RJ. Foi aplicado um questionário para coleta das variáveis demográficas, socioeconômicas, clínicas e hábitos de vida. O Índice Menopausal de Blatt–Kupperman (IMBK) foi utilizado para avaliar os sintomas menopausais.RESULTADOS: Mulheres com sintomas moderados a grave (≥20) corresponderam a 57,7% (116)da amostra. A obesidade não foi associada com a intensidade de sintomas menopausais (p < 0,90). Os sintomas moderados a intensos associaram-se inversamente com a idade (RP0,96; IC95% 0,94–0,99; p < 0,01). Mulheres com tempo de menopausa entre 6 e 10 anos apresentaram cerca de 1,4 vezes maior prevalência de sintomas moderados a intensos quando comparadas com aquelas com mais de 10 anos de menopausa. Mulheres desempregadas (RP 1,52; IC95% 1,13–2,04; p < 0,01) e donas de casa (RP 1,53; IC95% 1,12–2,09; p < 0,01) apresentaram maior prevalência de sintomas menopausais quando comparadas com mulheres trabalhando. O tabagismo foi associado a maior prevalência de sintomas moderados a intensos(p < 0,01). CONCLUSÕES: A idade constituiu fator de proteção para sintomas moderados a intensos. Enquanto que ter entre 6 à 10 anos de tempo de menopausa, ser tabagista e ser desempregada ou dona de casa foram fatores associados a uma maior prevalência de sintomas menopausais moderados a intensos.


Assuntos
Feminino , Humanos , Pessoa de Meia-Idade , Idoso , Pós-Menopausa , Qualidade de Vida , Estudos Transversais/métodos , Fatores de Risco , Brasil , Fatores de Tempo
20.
Rev. bras. geriatr. gerontol ; 17(4): 741-750, Oct-Dec/2014. tab, graf
Artigo em Português | LILACS | ID: lil-732850

RESUMO

INTRODUÇÃO: O envelhecimento da voz caracteriza-se por alterações decorrentes do envelhecimento do corpo, interferindo na entonação vocal reveladora de estados da alma e do corpo. Investigar a qualidade vocal de mulheres na pós-menopausa por meio dos parâmetros objetivos torna-se importante para fomentar as pesquisas nessa área, bem como auxiliar na melhoria da qualidade de vida desse grupo. OBJETIVO: Verificar os valores dos parâmetros acústicos das vozes de mulheres no período de pós-menopausa. Método: Realizou-se estudo de caráter quantitativo e corte transversal com 23 mulheres em período de pós-menopausa, utilizando o software Praat 5.2.0. Os parâmetros considerados foram frequência fundamental, jitter, shimmer, proporção harmônico ruído e análise espectrográfica. A amostra foi composta por mulheres matriculadas numa Universidade Aberta da Terceira Idade em Salvador-BA. A análise dos dados foi descritiva, por porcentagem simples, e usou-se o teste t para verificar a relação entre aumento de idade e piora vocal. RESULTADOS: Apresentaram valores da frequência fundamental abaixo de 150Hz 13% da amostra, e 34% entre 150 e 217Hz, demonstrando agravamento da voz. Observou-se significância estatística para piora desse parâmetro relacionado ao aumento da idade (p=0,02471). Houve diferença quanto aos parâmetros jitter e shimmer de acordo com o aumento da idade, porém sem significância estatística. Esses parâmetros acústicos estão relacionados a alterações no padrão vibratório das pregas vocais (ciclo vibratório). Os valores da proporção harmônico-ruído foram acima de 15.000 para todas as mulheres, mas também foram observados valores diminuídos com o aumento da idade, sem significância ...


INTRODUCTION: Voice aging is characterized by changes caused by body aging, interfering with the vocal intonations, revealing states of soul and body. To investigate the vocal quality of postmenopausal women using objective parameters is important to foster research in this area, as well as assisting in improving the quality of life of this group. OBJECTIVE: To determine the acoustic parameters of the voice of women in post-menopause. METHOD: Quantitative cross-sectional study was conducted with 23 women in the postmenopausal period, using the Praat software 5.2.0. The parameters considered were fundamental frequency, jitter, shimmer, harmonic noise and spectrographic analysis. The sample consisted of women enrolled in the Open University of Third Age in Salvador-BA. Data analysis was descriptive, using percentages, and t test to check the relationship between increasing age and vocal worsening. RESULTS: In this sample, 13% had values below the fundamental frequency of 150Hz and 34% between 150 and 217Hz, demonstrating voice deepening. There was a statistically significant worsening of this related to increasing age parameter (p=0.02471). There was difference between the jitter and shimmer parameters according to increasing age, but without statistical significance. These acoustic parameters are related to changes in the vibratory pattern of the vocal folds (vibration cycle). A harmonic noise ratio was above 15.000 in all women, but also had lower values with increasing age, with no statistical significance. CONCLUSION: The observed changes in acoustic parameters show that postmenopausal women had changes in vocal patterns, which can lead to decreased quality of life. Therefore, it requires a closer look at the need of speech therapy in this group. .

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